IL114968A - 1,4-dihydropyridine compounds and pharmaceutical compositions containing them - Google Patents
1,4-dihydropyridine compounds and pharmaceutical compositions containing themInfo
- Publication number
- IL114968A IL114968A IL11496895A IL11496895A IL114968A IL 114968 A IL114968 A IL 114968A IL 11496895 A IL11496895 A IL 11496895A IL 11496895 A IL11496895 A IL 11496895A IL 114968 A IL114968 A IL 114968A
- Authority
- IL
- Israel
- Prior art keywords
- pct
- pharmaceutical compositions
- compositions containing
- dihydropyridine compounds
- sec
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1994/001398 WO1996006083A1 (en) | 1994-08-24 | 1994-08-24 | 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL114968A0 IL114968A0 (en) | 1995-12-08 |
| IL114968A true IL114968A (en) | 1999-08-17 |
Family
ID=14098614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11496895A IL114968A (en) | 1994-08-24 | 1995-08-17 | 1,4-dihydropyridine compounds and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5859011A (xx) |
| EP (1) | EP0777653B1 (xx) |
| JP (1) | JP3001978B2 (xx) |
| KR (1) | KR100235285B1 (xx) |
| CN (1) | CN1087737C (xx) |
| AT (1) | ATE204567T1 (xx) |
| AU (1) | AU689587B2 (xx) |
| CA (1) | CA2198231C (xx) |
| DE (1) | DE69522332T2 (xx) |
| DK (1) | DK0777653T3 (xx) |
| ES (1) | ES2159637T3 (xx) |
| FI (1) | FI970745A0 (xx) |
| GR (1) | GR3036907T3 (xx) |
| IL (1) | IL114968A (xx) |
| MX (1) | MX9701363A (xx) |
| MY (1) | MY115372A (xx) |
| NO (1) | NO970806L (xx) |
| NZ (1) | NZ285155A (xx) |
| TW (1) | TW500722B (xx) |
| WO (2) | WO1996006083A1 (xx) |
| ZA (1) | ZA977057B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4345062A1 (de) * | 1993-12-31 | 1995-07-13 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen |
| MX9701245A (es) * | 1996-02-19 | 1998-04-30 | Pfizer | Compuestos de 1,4 dihidropiridina. |
| TNSN97037A1 (fr) * | 1996-02-19 | 2005-03-15 | Pfizer | Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| JP3823388B2 (ja) * | 1996-09-04 | 2006-09-20 | カシオ計算機株式会社 | 印刷装置 |
| JPH11106375A (ja) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物 |
| KR100579792B1 (ko) * | 1998-05-13 | 2006-05-12 | 동화약품공업주식회사 | 신규 2,5-피리딘디카복실산 유도체 |
| TR200400220T4 (tr) * | 1999-12-10 | 2004-02-23 | Pfizer Inc. | Bradikinin antagonistleri olarak, 5 üyeli heteroaril ile ikame edilmiş 1,4-dihidropiridin bileşikleri. |
| ATE233760T1 (de) * | 1999-12-10 | 2003-03-15 | Pfizer | Substituierte 1,4-dihydropyridinverbindungen zur verwendung als bradykininantagonisten |
| EP1110962A1 (en) * | 1999-12-10 | 2001-06-27 | Pfizer Inc. | Process for preparing 1,4-dihydropyridine compounds |
| US6653313B2 (en) * | 2000-08-10 | 2003-11-25 | Warner-Lambert Company Llc | 1,4-dihydropyridine compounds as bradykinin antagonists |
| RS55977B1 (sr) | 2013-06-14 | 2017-09-29 | Dompé Farm S P A | Antagonisti receptora za bradikinin i farmaceutske kompozicije koje ih sadrže |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162497A (en) * | 1987-09-24 | 1992-11-10 | The Administrators Of The Tulane Educational Fund | Bradykinin analogs with non-peptide bond |
| US5120750A (en) * | 1989-01-17 | 1992-06-09 | Synphar Laboratories, Inc. | Generation of 1,4-dihydropyridine derivatives |
| US5610142A (en) * | 1992-10-08 | 1997-03-11 | Scios Inc. | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids |
-
1994
- 1994-08-24 WO PCT/JP1994/001398 patent/WO1996006083A1/en not_active Ceased
-
1995
- 1995-05-26 WO PCT/IB1995/000400 patent/WO1996006082A1/en not_active Ceased
- 1995-05-26 DE DE69522332T patent/DE69522332T2/de not_active Expired - Fee Related
- 1995-05-26 CA CA002198231A patent/CA2198231C/en not_active Expired - Fee Related
- 1995-05-26 JP JP8507896A patent/JP3001978B2/ja not_active Expired - Fee Related
- 1995-05-26 AU AU24166/95A patent/AU689587B2/en not_active Ceased
- 1995-05-26 US US08/793,561 patent/US5859011A/en not_active Expired - Fee Related
- 1995-05-26 DK DK95918113T patent/DK0777653T3/da active
- 1995-05-26 AT AT95918113T patent/ATE204567T1/de not_active IP Right Cessation
- 1995-05-26 CN CN95194758A patent/CN1087737C/zh not_active Expired - Fee Related
- 1995-05-26 MX MX9701363A patent/MX9701363A/es not_active IP Right Cessation
- 1995-05-26 KR KR1019970701151A patent/KR100235285B1/ko not_active Expired - Fee Related
- 1995-05-26 EP EP95918113A patent/EP0777653B1/en not_active Expired - Lifetime
- 1995-05-26 ES ES95918113T patent/ES2159637T3/es not_active Expired - Lifetime
- 1995-07-11 TW TW084107170A patent/TW500722B/zh not_active IP Right Cessation
- 1995-08-17 IL IL11496895A patent/IL114968A/xx not_active IP Right Cessation
- 1995-08-22 MY MYPI95002477A patent/MY115372A/en unknown
- 1995-08-23 ZA ZA9707057A patent/ZA977057B/xx unknown
-
1997
- 1997-02-21 NO NO970806A patent/NO970806L/no not_active Application Discontinuation
- 1997-02-21 FI FI970745A patent/FI970745A0/fi not_active Application Discontinuation
- 1997-02-24 NZ NZ285155A patent/NZ285155A/en unknown
-
2001
- 2001-10-16 GR GR20010401777T patent/GR3036907T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3001978B2 (ja) | 2000-01-24 |
| IL114968A0 (en) | 1995-12-08 |
| DK0777653T3 (da) | 2001-10-08 |
| GR3036907T3 (en) | 2002-01-31 |
| DE69522332T2 (de) | 2002-01-03 |
| ZA977057B (en) | 1997-02-24 |
| NO970806D0 (no) | 1997-02-21 |
| AU689587B2 (en) | 1998-04-02 |
| AU2416695A (en) | 1996-03-14 |
| MX9701363A (es) | 1997-05-31 |
| NZ285155A (en) | 1998-06-26 |
| US5859011A (en) | 1999-01-12 |
| KR100235285B1 (ko) | 2000-02-01 |
| WO1996006082A1 (en) | 1996-02-29 |
| NO970806L (no) | 1997-04-21 |
| FI970745A7 (fi) | 1997-02-21 |
| ATE204567T1 (de) | 2001-09-15 |
| CA2198231A1 (en) | 1996-02-29 |
| CN1156449A (zh) | 1997-08-06 |
| CA2198231C (en) | 1999-12-07 |
| CN1087737C (zh) | 2002-07-17 |
| EP0777653A1 (en) | 1997-06-11 |
| MY115372A (en) | 2003-05-31 |
| ES2159637T3 (es) | 2001-10-16 |
| FI970745A0 (fi) | 1997-02-21 |
| WO1996006083A1 (en) | 1996-02-29 |
| DE69522332D1 (de) | 2001-09-27 |
| EP0777653B1 (en) | 2001-08-22 |
| KR970705555A (ko) | 1997-10-09 |
| TW500722B (en) | 2002-09-01 |
| JPH09510992A (ja) | 1997-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |