IE45700L - PYRAZOLO (3,4-b) PYRIDINES - Google Patents
PYRAZOLO (3,4-b) PYRIDINESInfo
- Publication number
- IE45700L IE45700L IE771988A IE198877A IE45700L IE 45700 L IE45700 L IE 45700L IE 771988 A IE771988 A IE 771988A IE 198877 A IE198877 A IE 198877A IE 45700 L IE45700 L IE 45700L
- Authority
- IE
- Ireland
- Prior art keywords
- benzyl
- methyl
- hydrogen
- compounds
- carbon atoms
- Prior art date
Links
- 150000005230 pyrazolo[3,4-b]pyridines Chemical class 0.000 title 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- -1 di-substituted piperidino Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of the formula wherein R1 is unsubstituted, mono-substituted or di-substituted piperidino, where the substituents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl; R2 is hydrogen, methyl or benzyl; and R3 is hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiphlogistics and antithrombotics. (From US4260621 A) [FR2366290A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762643753 DE2643753A1 (en) | 1976-09-29 | 1976-09-29 | NEW 1H-PYRAZOLO ANGLE CLAMP ON 3.4-B ANGLE CLAMP TO PYRIDINE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE45700L true IE45700L (en) | 1978-03-29 |
| IE45700B1 IE45700B1 (en) | 1982-11-03 |
Family
ID=5989097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1988/77A IE45700B1 (en) | 1976-09-29 | 1977-09-28 | 1h-pyrazolo (3,4-b) pyridines |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US4182887A (en) |
| JP (1) | JPS5344588A (en) |
| AT (1) | AT359064B (en) |
| AU (1) | AU513406B2 (en) |
| BE (1) | BE859152A (en) |
| DE (1) | DE2643753A1 (en) |
| DK (1) | DK143183C (en) |
| ES (1) | ES462700A1 (en) |
| FI (1) | FI61899C (en) |
| FR (1) | FR2366290A1 (en) |
| GB (1) | GB1552730A (en) |
| GR (1) | GR64049B (en) |
| IE (1) | IE45700B1 (en) |
| IL (1) | IL52997A (en) |
| LU (1) | LU78179A1 (en) |
| NL (1) | NL7710573A (en) |
| NO (1) | NO147913C (en) |
| NZ (1) | NZ185292A (en) |
| PT (1) | PT67091B (en) |
| SE (1) | SE7710873L (en) |
| ZA (1) | ZA775784B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2643753A1 (en) * | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | NEW 1H-PYRAZOLO ANGLE CLAMP ON 3.4-B ANGLE CLAMP TO PYRIDINE |
| AR036873A1 (en) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | PIRIDINAS ARIL REPLACED A, PHARMACEUTICAL COMPOSITIONS AND THE USE OF THE SAME FOR THE PREPARATION OF A MEDICINAL PRODUCT |
| AR037233A1 (en) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | PIRIDINAS ARIL REPLACED, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF A MEDICINAL PRODUCT |
| JP2007534624A (en) * | 2003-07-16 | 2007-11-29 | ニューロジェン・コーポレーション | Biaryl piperazinyl-pyridine analogues |
| CA2545258A1 (en) | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Pyridine compounds |
| WO2006002860A1 (en) * | 2004-07-06 | 2006-01-12 | F. Hoffmann-La Roche Ag | Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists |
| KR100881240B1 (en) | 2004-07-06 | 2009-02-05 | 에프. 호프만-라 로슈 아게 | Method for producing carboxamide pyridine derivatives used as intermediates in the synthesis of NX-1 receptor antagonists |
| MY145822A (en) * | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
| CA2585934C (en) * | 2004-10-29 | 2013-09-10 | Abbott Laboratories | Novel pyrazolopyridine urea kinase inhibitors |
| DE102004061288A1 (en) * | 2004-12-14 | 2006-06-29 | Schering Ag | New 3-amino-pyrazolo(3,4b)pyridine derivatives are protein tyrosine kinases inhibitors useful e.g. for treating hyperproliferation of body cells, neurodegenerative disease, blood vessel disease and angiogenic disease |
| US7725056B2 (en) * | 2006-01-10 | 2010-05-25 | Ricoh Co., Ltd. | Triboelectric charging device and field assisted toner transporter |
| AU2008225766B2 (en) * | 2007-03-15 | 2012-06-07 | Novartis Ag | Organic compounds and their uses |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| JP5689069B2 (en) | 2008-11-20 | 2015-03-25 | ジェネンテック， インコーポレイテッド | Pyrazolopyridine PI3K inhibitor compounds and methods of use |
| US8846673B2 (en) | 2009-08-11 | 2014-09-30 | Bristol-Myers Squibb Company | Azaindazoles as kinase inhibitors and use thereof |
| CA3098988A1 (en) * | 2018-05-02 | 2019-11-07 | Jw Pharmaceutical Corporation | Heterocycle derivative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2232038A1 (en) * | 1972-06-30 | 1974-01-10 | Hoechst Ag | 3-AMINO-1H-PYRAZOLO SQUARE CLAMP ON 3.4-ANGLE BRACKET FOR PYRIDINE, THEIR PRODUCTION AND USE |
| DE2643753A1 (en) * | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | NEW 1H-PYRAZOLO ANGLE CLAMP ON 3.4-B ANGLE CLAMP TO PYRIDINE |
| US4048184A (en) * | 1976-11-15 | 1977-09-13 | E. R. Squibb & Sons, Inc. | 6-Phenyl-2H-pyrazolo[3,4-b]pyridines |
-
1976
- 1976-09-29 DE DE19762643753 patent/DE2643753A1/en not_active Withdrawn
-
1977
- 1977-09-07 FI FI772655A patent/FI61899C/en not_active IP Right Cessation
- 1977-09-19 AT AT670077A patent/AT359064B/en not_active IP Right Cessation
- 1977-09-19 US US05/834,114 patent/US4182887A/en not_active Expired - Lifetime
- 1977-09-22 AU AU29037/77A patent/AU513406B2/en not_active Expired
- 1977-09-26 IL IL52997A patent/IL52997A/en unknown
- 1977-09-26 LU LU78179A patent/LU78179A1/xx unknown
- 1977-09-27 GR GR54440A patent/GR64049B/en unknown
- 1977-09-28 BE BE181275A patent/BE859152A/en unknown
- 1977-09-28 JP JP11657277A patent/JPS5344588A/en active Pending
- 1977-09-28 DK DK428477A patent/DK143183C/en active
- 1977-09-28 NL NL7710573A patent/NL7710573A/en not_active Application Discontinuation
- 1977-09-28 SE SE7710873A patent/SE7710873L/en not_active Application Discontinuation
- 1977-09-28 IE IE1988/77A patent/IE45700B1/en unknown
- 1977-09-28 NO NO773327A patent/NO147913C/en unknown
- 1977-09-28 GB GB40364/77A patent/GB1552730A/en not_active Expired
- 1977-09-28 ES ES462700A patent/ES462700A1/en not_active Expired
- 1977-09-28 ZA ZA00775784A patent/ZA775784B/en unknown
- 1977-09-28 PT PT67091A patent/PT67091B/en unknown
- 1977-09-28 NZ NZ185292A patent/NZ185292A/en unknown
- 1977-09-29 FR FR7729322A patent/FR2366290A1/en active Granted
-
1979
- 1979-09-13 US US06/075,493 patent/US4224322A/en not_active Expired - Lifetime
- 1979-09-13 US US06/075,100 patent/US4260621A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK143183C (en) | 1981-11-16 |
| GB1552730A (en) | 1979-09-19 |
| NL7710573A (en) | 1978-03-31 |
| NZ185292A (en) | 1980-05-08 |
| US4224322A (en) | 1980-09-23 |
| ZA775784B (en) | 1979-06-27 |
| NO773327L (en) | 1978-03-30 |
| IL52997A (en) | 1980-09-16 |
| FI772655A7 (en) | 1978-03-30 |
| DK143183B (en) | 1981-07-13 |
| LU78179A1 (en) | 1978-11-03 |
| US4182887A (en) | 1980-01-08 |
| BE859152A (en) | 1978-03-28 |
| GR64049B (en) | 1980-01-19 |
| DE2643753A1 (en) | 1978-04-06 |
| JPS5344588A (en) | 1978-04-21 |
| PT67091B (en) | 1979-09-12 |
| SE7710873L (en) | 1978-03-30 |
| FI61899B (en) | 1982-06-30 |
| DK428477A (en) | 1978-03-30 |
| PT67091A (en) | 1977-10-01 |
| IE45700B1 (en) | 1982-11-03 |
| US4260621A (en) | 1981-04-07 |
| FR2366290B1 (en) | 1982-07-09 |
| ES462700A1 (en) | 1978-06-01 |
| ATA670077A (en) | 1980-03-15 |
| AU513406B2 (en) | 1980-11-27 |
| NO147913C (en) | 1983-07-06 |
| AU2903777A (en) | 1979-03-29 |
| NO147913B (en) | 1983-03-28 |
| FR2366290A1 (en) | 1978-04-28 |
| IL52997A0 (en) | 1977-11-30 |
| FI61899C (en) | 1982-10-11 |
| AT359064B (en) | 1980-10-27 |
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