IE42354B1 - In-( -hydroxy- -aminoalkanoyl)-6'n-methyl-3',4'-dideoxykanamycin b and the production thereof - Google Patents

In-( -hydroxy- -aminoalkanoyl)-6'n-methyl-3',4'-dideoxykanamycin b and the production thereof

Info

Publication number: IE42354B1
Authority: IE; Ireland
Prior art keywords: amino; dideoxykanamycin; group; compound; methyl
Prior art date: 1974-10-08

Application number

IE2043/75A

Other languages

English (en)

Other versions

IE42354L (en

Original Assignee

Microbial Chem Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-10-08

Filing date

1975-09-17

Publication date

1980-07-30

1975-09-17 Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found

1976-04-08 Publication of IE42354L publication Critical patent/IE42354L/xx

1980-07-30 Publication of IE42354B1 publication Critical patent/IE42354B1/en

Links

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239000000203 mixture Substances 0.000 claims description 30
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238000000034 method Methods 0.000 claims description 26
230000008569 process Effects 0.000 claims description 22
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NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 claims description 3
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims description 2
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WREOTYWODABZMH-DTZQCDIJSA-N [[(2r,3s,4r,5r)-3,4-dihydroxy-5-[2-oxo-4-(2-phenylethoxyamino)pyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N(C=C\1)C(=O)NC/1=N\OCCC1=CC=CC=C1 WREOTYWODABZMH-DTZQCDIJSA-N 0.000 claims 1
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239000002994 raw material Substances 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Physical Vapour Deposition (AREA)

IE2043/75A 1974-10-08 1975-09-17 In-( -hydroxy- -aminoalkanoyl)-6'n-methyl-3',4'-dideoxykanamycin b and the production thereof IE42354B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP49115199A JPS5148634A (en)	1974-10-08	1974-10-08	Taiseikinnyukona 11nn * arufua hidorokishi omega aminoashiru * 6*nn mechiru 3 *hh jideokishikanamaishin b no seizoho

Publications (2)

Publication Number	Publication Date
IE42354L IE42354L (en)	1976-04-08
IE42354B1 true IE42354B1 (en)	1980-07-30

Family

ID=14656799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE2043/75A IE42354B1 (en)	1974-10-08	1975-09-17	In-( -hydroxy- -aminoalkanoyl)-6'n-methyl-3',4'-dideoxykanamycin b and the production thereof

Country Status (16)

Country	Link
JP (1)	JPS5148634A (xx)
BE (1)	BE834236A (xx)
CA (1)	CA1050537A (xx)
CH (1)	CH615685A5 (xx)
DE (1)	DE2543535C3 (xx)
DK (1)	DK148262C (xx)
FR (1)	FR2287233A1 (xx)
GB (1)	GB1475481A (xx)
HU (1)	HU173702B (xx)
IE (1)	IE42354B1 (xx)
LU (1)	LU73533A1 (xx)
NL (1)	NL181503C (xx)
SE (1)	SE431216B (xx)
SU (1)	SU965359A3 (xx)
YU (1)	YU39659B (xx)
ZA (1)	ZA756291B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57175198A (en) *	1981-04-20	1982-10-28	Microbial Chem Res Found	1-n-acyl derivative of 5,3,4-trideoxy-6-n-methylkanamycin b and their preparation
JPS60179468U (ja) *	1984-05-11	1985-11-28	大成プラス株式会社	多色スタンプ
DE102006004062A1 (de)	2006-01-28	2007-08-09	Degussa Gmbh	Kautschukmischungen
CN102942603B (zh) *	2006-06-02	2016-01-20	明治制果药业株式会社	新的氨基糖苷类抗生素

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4001208A (en) *	1972-10-06	1977-01-04	Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai	1-N-[(S)-α-hydroxy-ω-aminoacyl]

1974
- 1974-10-08 JP JP49115199A patent/JPS5148634A/ja active Granted
1975
- 1975-09-16 GB GB3806475A patent/GB1475481A/en not_active Expired
- 1975-09-17 IE IE2043/75A patent/IE42354B1/en unknown
- 1975-09-30 DE DE2543535A patent/DE2543535C3/de not_active Expired
- 1975-10-03 ZA ZA00756291A patent/ZA756291B/xx unknown
- 1975-10-03 NL NLAANVRAGE7511662,A patent/NL181503C/xx not_active IP Right Cessation
- 1975-10-06 LU LU73533A patent/LU73533A1/xx unknown
- 1975-10-06 BE BE160728A patent/BE834236A/xx not_active IP Right Cessation
- 1975-10-07 HU HU75BI525A patent/HU173702B/hu not_active IP Right Cessation
- 1975-10-07 CH CH1303375A patent/CH615685A5/de not_active IP Right Cessation
- 1975-10-07 YU YU2530/75A patent/YU39659B/xx unknown
- 1975-10-07 CA CA237,157A patent/CA1050537A/en not_active Expired
- 1975-10-07 FR FR7531209A patent/FR2287233A1/fr active Granted
- 1975-10-07 SE SE7511229A patent/SE431216B/xx not_active IP Right Cessation
- 1975-10-07 DK DK451475A patent/DK148262C/da not_active IP Right Cessation
- 1975-10-08 SU SU752180255A patent/SU965359A3/ru active

Also Published As

Publication number	Publication date
JPS5653558B2 (xx)	1981-12-19
YU39659B (en)	1985-03-20
DE2543535C3 (de)	1978-06-01
DE2543535B2 (de)	1977-10-13
ZA756291B (en)	1976-06-30
GB1475481A (en)	1977-06-01
SE431216B (sv)	1984-01-23
NL181503B (nl)	1987-04-01
NL181503C (nl)	1987-09-01
FR2287233B1 (xx)	1978-11-10
HU173702B (hu)	1979-07-28
IE42354L (en)	1976-04-08
CA1050537A (en)	1979-03-13
DK451475A (da)	1976-04-09
BE834236A (fr)	1976-04-06
FR2287233A1 (fr)	1976-05-07
DK148262B (da)	1985-05-20
AU8518975A (en)	1977-03-31
DE2543535A1 (de)	1976-04-22
CH615685A5 (en)	1980-02-15
DK148262C (da)	1986-02-10
NL7511662A (nl)	1976-04-12
SE7511229L (sv)	1976-04-09
JPS5148634A (en)	1976-04-26
SU965359A3 (ru)	1982-10-07
LU73533A1 (xx)	1976-08-19
YU253075A (en)	1982-05-31

Publication	Publication Date	Title
US3940382A (en)	1976-02-24	1,2'-Di-N-substituted kanamycin B compounds
US4001208A (en)	1977-01-04	1-N-[(S)-α-hydroxy-ω-aminoacyl]
US3925353A (en)	1975-12-09	4-0-(6-alkylamino-6-deoxy-alpha-d-hexopyranosyl)-deoxystreptamine derivatives and the production thereof
US4170642A (en)	1979-10-09	Derivatives of kanamycin A
US4117221A (en)	1978-09-26	Aminoacyl derivatives of aminoglycoside antibiotics
US4107424A (en)	1978-08-15	1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics
US3997524A (en)	1976-12-14	Process for the manufacture of 6'-N-alkyl derivatives of sisomicin and verdamicin; novel intermediates useful therein, and novel 6'-N-alkylverdamicins prepared thereby
US3808198A (en)	1974-04-30	Lividomycin b derivatives
US4120955A (en)	1978-10-17	Method for production of kanamycin C and its derivatives
US4104372A (en)	1978-08-01	1-N-(α-hydroxy-ω-aminoalkanoyl) derivatives of 3'-deoxykanamycin A and the production thereof
US3925354A (en)	1975-12-09	Process for the production of an 1-n-(s)-alpha- substituted-w-aminoacyl) derivative of neamine, 3', 4'-dideoxyneamine, ribostamycin or 3',4'-dideoxyribostamycin
NL7907671A (nl)	1980-04-22	Aminoglycoside-antibiotica.
US3939143A (en)	1976-02-17	1-N-isoserylkanamycins and the production thereof
IE42354B1 (en)	1980-07-30	In-( -hydroxy- -aminoalkanoyl)-6'n-methyl-3',4'-dideoxykanamycin b and the production thereof
US4147861A (en)	1979-04-03	1N-(α-Hydroxy-ω-aminoalkanoyl)-6'N-methyl-3',4'-dideoxykanamycin B and the production thereof
CA1044229A (en)	1978-12-12	Antibiotic derivatives of xk-62-2 and method of production thereof
US4140849A (en)	1979-02-20	Kanamycin C derivatives
US4547492A (en)	1985-10-15	1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same
US4283528A (en)	1981-08-11	1-N-aminohydroxyacyl derivatives of gentamicin B
GB1572530A (en)	1980-07-30	Fortimicin antbiotics and the preparation thereof
GB2088851A (en)	1982-06-16	Istamycins a and b derivatives
CA1081693A (en)	1980-07-15	Kanamycin c derivatives
US3923783A (en)	1975-12-02	5{41 -amino-4{40 ,5{41 -dideoxyambutyrosin
US4479943A (en)	1984-10-30	3-Demethoxyistamycin B, the 2"-N-formimidoyl derivative thereof and pharmaceutical composition containing same
EP0236942B1 (en)	1991-09-04	2'-deamino-2'-hydroxyistamycin bo derivatives of low toxicity