IE40649B1 - Butyramides, their preparation and pharmaceutical compositions containing theam - Google Patents
Butyramides, their preparation and pharmaceutical compositions containing theamInfo
- Publication number
- IE40649B1 IE40649B1 IE1819/74A IE181974A IE40649B1 IE 40649 B1 IE40649 B1 IE 40649B1 IE 1819/74 A IE1819/74 A IE 1819/74A IE 181974 A IE181974 A IE 181974A IE 40649 B1 IE40649 B1 IE 40649B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- acids
- butyrimidic
- pharmaceutical compositions
- theam
- Prior art date
Links
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical class CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical class CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- BVHBUZXMSOHVPC-UHFFFAOYSA-N 4-[3-(4-chlorobenzoyl)-2-methylphenyl]butanoyl chloride Chemical compound CC1=C(CCCC(Cl)=O)C=CC=C1C(=O)C1=CC=C(Cl)C=C1 BVHBUZXMSOHVPC-UHFFFAOYSA-N 0.000 abstract 1
- -1 CF 3 Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1444492 Butyrimidic acids ROUSSEL UCLAF 2 Sept 1974 [3 Sept 1973] 38291/74 Heading C2C Novel butyrimidic acids of the formula wherein X<SP>1</SP> 1 , X<SP>11</SP> 1 , X<SP>1</SP> 2 and X<SP>11</SP> 2 each are H, halogen, C 1-5 alkyl, C 1-5 alkoxy, C 1-5 alkylthio, CF 3 , trifluoromethoxy, trifluoromethylthio, OH or di(C 1-5 alkyl)amino, X, Y and Z each are H or C 1-5 alkyl, R 1 is H or C 1-5 alkyl, R 2 is OH or C 1-5 alkoxy and the symbols # either both represent single C-C bonds or one represents a C-C bond and the other represents a C=C bond are prepared by reacting the corresponding butyric acids or functional derivatives thereof with compounds of the formula HN(R<SP>1</SP>)R 2 . 4 - (3 - p - Chlorobenzoyl - 2 - methylphenyl)- butyryl chloride is obtained by reacting the corresponding butyric acid with thionyl chloride. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above butyrimidic acids and pharmaceutical carriers or excipients. The compounds possess analgesic and anti-inflammatory properties.
[GB1444492A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7331699A FR2242077B1 (en) | 1973-09-03 | 1973-09-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40649L IE40649L (en) | 1975-03-03 |
| IE40649B1 true IE40649B1 (en) | 1979-07-18 |
Family
ID=9124547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1819/74A IE40649B1 (en) | 1973-09-03 | 1974-09-03 | Butyramides, their preparation and pharmaceutical compositions containing theam |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5050345A (en) |
| AT (1) | AT335998B (en) |
| BE (1) | BE819456A (en) |
| CA (1) | CA1030552A (en) |
| CH (1) | CH587799A5 (en) |
| DD (1) | DD116028A5 (en) |
| DE (1) | DE2442124A1 (en) |
| DK (1) | DK464674A (en) |
| ES (1) | ES429717A1 (en) |
| FR (1) | FR2242077B1 (en) |
| GB (1) | GB1444492A (en) |
| HU (1) | HU168678B (en) |
| IE (1) | IE40649B1 (en) |
| IL (1) | IL45506A (en) |
| LU (1) | LU70832A1 (en) |
| NL (1) | NL7411702A (en) |
| SE (1) | SE414496B (en) |
| SU (1) | SU576919A3 (en) |
| ZA (1) | ZA745400B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8531839D0 (en) * | 1985-12-30 | 1986-02-05 | Wellcome Found | Aryl derivatives |
| DK117986A (en) * | 1985-03-16 | 1986-09-17 | Wellcome Found | ARYLET DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE |
| DE3869692D1 (en) * | 1987-07-29 | 1992-05-07 | Takeda Chemical Industries Ltd | CELL POLLIFERATION INHIBITOR. |
| US5028629A (en) * | 1990-03-28 | 1991-07-02 | Eli Lilly And Company | 5-Lipoxygenase inhibitors |
| AU6701694A (en) | 1993-04-16 | 1994-11-08 | Mccormick & Company, Inc. | Encapsulation compositions |
| ATE517987T1 (en) * | 2004-06-01 | 2011-08-15 | Scripps Research Inst | PROTEOMIC ANALYSIS |
-
1973
- 1973-09-03 FR FR7331699A patent/FR2242077B1/fr not_active Expired
-
1974
- 1974-08-05 SE SE7410046-2A patent/SE414496B/en unknown
- 1974-08-13 DD DD180466A patent/DD116028A5/xx unknown
- 1974-08-20 IL IL45506A patent/IL45506A/en unknown
- 1974-08-22 ZA ZA00745400A patent/ZA745400B/en unknown
- 1974-08-28 JP JP49098005A patent/JPS5050345A/ja active Pending
- 1974-08-30 CA CA208,178A patent/CA1030552A/en not_active Expired
- 1974-08-30 HU HURO793A patent/HU168678B/hu unknown
- 1974-08-30 LU LU70832A patent/LU70832A1/xx unknown
- 1974-09-02 BE BE148139A patent/BE819456A/en unknown
- 1974-09-02 GB GB3829174A patent/GB1444492A/en not_active Expired
- 1974-09-02 ES ES429717A patent/ES429717A1/en not_active Expired
- 1974-09-02 SU SU7402063057A patent/SU576919A3/en active
- 1974-09-02 CH CH1190174A patent/CH587799A5/xx not_active IP Right Cessation
- 1974-09-03 DK DK464674A patent/DK464674A/da not_active Application Discontinuation
- 1974-09-03 NL NL7411702A patent/NL7411702A/en not_active Application Discontinuation
- 1974-09-03 AT AT710474A patent/AT335998B/en not_active IP Right Cessation
- 1974-09-03 IE IE1819/74A patent/IE40649B1/en unknown
- 1974-09-03 DE DE2442124A patent/DE2442124A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| GB1444492A (en) | 1976-07-28 |
| FR2242077B1 (en) | 1977-01-28 |
| ATA710474A (en) | 1976-08-15 |
| AU7260674A (en) | 1976-02-26 |
| BE819456A (en) | 1975-03-03 |
| FR2242077A1 (en) | 1975-03-28 |
| ES429717A1 (en) | 1977-04-01 |
| CH587799A5 (en) | 1977-05-13 |
| DK464674A (en) | 1975-05-05 |
| CA1030552A (en) | 1978-05-02 |
| HU168678B (en) | 1976-06-28 |
| IE40649L (en) | 1975-03-03 |
| NL7411702A (en) | 1975-03-05 |
| AT335998B (en) | 1977-04-12 |
| ZA745400B (en) | 1975-10-29 |
| DE2442124A1 (en) | 1975-03-06 |
| IL45506A (en) | 1978-07-31 |
| SE7410046L (en) | 1975-03-04 |
| DD116028A5 (en) | 1975-11-05 |
| SE414496B (en) | 1980-08-04 |
| JPS5050345A (en) | 1975-05-06 |
| IL45506A0 (en) | 1974-11-29 |
| SU576919A3 (en) | 1977-10-15 |
| LU70832A1 (en) | 1975-06-11 |
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