IE37929L - Decahydro-isoquinoline derivatives. - Google Patents
Decahydro-isoquinoline derivatives.Info
- Publication number
- IE37929L IE37929L IE731229A IE122973A IE37929L IE 37929 L IE37929 L IE 37929L IE 731229 A IE731229 A IE 731229A IE 122973 A IE122973 A IE 122973A IE 37929 L IE37929 L IE 37929L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- formula
- isoquinoline derivatives
- diketo
- acetoxyl
- Prior art date
Links
- NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical class C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical group C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 2
- 229960003328 benzoyl peroxide Drugs 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- FSVPKHBCGLKONR-UHFFFAOYSA-N 4a,5,6,7,8,8a-hexahydro-4h-isoquinoline-1,3-dione Chemical compound C1CCCC2C(=O)NC(=O)CC21 FSVPKHBCGLKONR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1436376 Isoquinoline derivatives E I DU PONT DE NEMOURS & CO 19 July 1973 [20 July 1972 1 June 1973] 34438/73 Heading C2C The invention comprises compounds of the formula where R<SP>1</SP> is C 1 -C 6 alkyl, benzyl, phenethyl or cycloalkylmethy of the formula -CH 2 CH(CH 2 ) n where n is 2-5, R<SP>2</SP> is divalent oxygen, A is H or OH, Ar is a group of the formula where R<SP>3</SP> is H, OH, OCH 3 or acetoxyl, R<SP>4</SP> is OH, OCH 3 or acetoxyl or two of R<SP>3</SP> or of R<SP>4</SP> situated on adjacent carbons may be combined to form a divalent methylenedioxy group, and pharmaceutically acceptable acid addition salts thereof. Compounds wherein A is H and R<SP>2</SP> is or may be prepared by reducing the corresponding 1,3-diketo decahydroisoquinoline. Compounds wherein A is OH and R<SP>2</SP> is or may be prepared by reducing the corresponding 1, - diketo - 8,8a - epoxydecahydroisoquinoline. The products may be converted into compounds having different R<SP>2</SP> values by known methods.
[GB1436376A]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE1574/76A IE37930B1 (en) | 1972-07-20 | 1973-07-19 | Improvements in isoquinoline derivatives |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27380672A | 1972-07-20 | 1972-07-20 | |
| US36584373A | 1973-06-01 | 1973-06-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37929L true IE37929L (en) | 1974-01-20 |
| IE37929B1 IE37929B1 (en) | 1977-11-09 |
Family
ID=26956443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1229/73A IE37929B1 (en) | 1972-07-20 | 1973-07-19 | Improvements in isoquinoline derivatives |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS4985075A (en) |
| AR (1) | AR208650A1 (en) |
| CA (1) | CA1024149A (en) |
| DE (2) | DE2336559A1 (en) |
| ES (1) | ES417127A1 (en) |
| FR (1) | FR2193600B1 (en) |
| GB (2) | GB1436377A (en) |
| HU (1) | HU167738B (en) |
| IE (1) | IE37929B1 (en) |
| IL (3) | IL42790A (en) |
| LU (1) | LU68066A1 (en) |
| NL (1) | NL7310078A (en) |
| SE (1) | SE7602150L (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7509337L (en) * | 1974-09-23 | 1976-03-24 | Du Pont | PAINING ASSOCIATIONS |
| NZ189230A (en) * | 1977-12-27 | 1981-05-15 | Lilly Co Eli | Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines |
| DE69125099T2 (en) * | 1990-06-05 | 1997-06-19 | Toray Industries, Inc., Tokio/Tokyo | INDOLDER DERIVATIVES |
| US5441956A (en) * | 1991-07-05 | 1995-08-15 | Smithkline Beecham Farmaceutici S.P.A. | Hydroisoquinoline derivatives |
| IT1307327B1 (en) * | 1995-09-12 | 2001-10-30 | Smithkline Beecham Spa | REPLACED HYDROISOKINOLINIC DERIVATIVES |
-
1973
- 1973-07-18 DE DE19732336559 patent/DE2336559A1/en active Pending
- 1973-07-18 DE DE19732351599 patent/DE2351599A1/en active Pending
- 1973-07-18 CA CA176,763A patent/CA1024149A/en not_active Expired
- 1973-07-19 GB GB3938775A patent/GB1436377A/en not_active Expired
- 1973-07-19 IE IE1229/73A patent/IE37929B1/en unknown
- 1973-07-19 AR AR249168A patent/AR208650A1/en active
- 1973-07-19 GB GB3443873A patent/GB1436376A/en not_active Expired
- 1973-07-19 NL NL7310078A patent/NL7310078A/xx not_active Application Discontinuation
- 1973-07-19 IL IL42790A patent/IL42790A/en unknown
- 1973-07-19 FR FR7326508A patent/FR2193600B1/fr not_active Expired
- 1973-07-19 HU HUDU206A patent/HU167738B/hu unknown
- 1973-07-19 IL IL48667A patent/IL48667A/en unknown
- 1973-07-20 JP JP48082484A patent/JPS4985075A/ja active Pending
- 1973-07-20 ES ES417127A patent/ES417127A1/en not_active Expired
- 1973-07-20 LU LU68066A patent/LU68066A1/xx unknown
-
1975
- 1975-12-15 IL IL48667A patent/IL48667A0/en unknown
-
1976
- 1976-02-23 SE SE7602150A patent/SE7602150L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5820773A (en) | 1975-01-23 |
| FR2193600A1 (en) | 1974-02-22 |
| LU68066A1 (en) | 1973-09-26 |
| HU167738B (en) | 1975-12-25 |
| ES417127A1 (en) | 1976-04-01 |
| IL48667A (en) | 1976-11-30 |
| IL42790A (en) | 1976-11-30 |
| AR208650A1 (en) | 1977-02-28 |
| DE2336559A1 (en) | 1974-01-31 |
| FR2193600B1 (en) | 1976-10-22 |
| GB1436377A (en) | 1976-05-19 |
| SE7602150L (en) | 1976-02-23 |
| DE2351599A1 (en) | 1974-01-31 |
| IL48667A0 (en) | 1976-02-29 |
| IE37929B1 (en) | 1977-11-09 |
| JPS4985075A (en) | 1974-08-15 |
| NL7310078A (en) | 1974-01-22 |
| GB1436376A (en) | 1976-05-19 |
| CA1024149A (en) | 1978-01-10 |
| IL42790A0 (en) | 1973-10-25 |
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