ID30057A - Turunan fenilalaninol - Google Patents
Turunan fenilalaninolInfo
- Publication number
- ID30057A ID30057A IDW00200101769A ID20011769A ID30057A ID 30057 A ID30057 A ID 30057A ID W00200101769 A IDW00200101769 A ID W00200101769A ID 20011769 A ID20011769 A ID 20011769A ID 30057 A ID30057 A ID 30057A
- Authority
- ID
- Indonesia
- Prior art keywords
- alkyl
- lower alkyl
- alkanoyl
- aryl
- halo
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 17
- 125000001589 carboacyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000003435 aroyl group Chemical group 0.000 abstract 4
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 2
- STVVMTBJNDTZBF-VIFPVBQESA-N L-phenylalaninol Chemical class OC[C@@H](N)CC1=CC=CC=C1 STVVMTBJNDTZBF-VIFPVBQESA-N 0.000 abstract 2
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 2
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 perfluoro Chemical group 0.000 abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical group NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 abstract 1
- 230000002456 anti-arthritic effect Effects 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 210000003651 basophil Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003979 eosinophil Anatomy 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12049899P | 1999-02-18 | 1999-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID30057A true ID30057A (id) | 2001-11-01 |
Family
ID=22390691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW00200101769A ID30057A (id) | 1999-02-18 | 2000-02-12 | Turunan fenilalaninol |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6420600B1 (id) |
| EP (1) | EP1154987B1 (id) |
| JP (1) | JP2002537283A (id) |
| KR (1) | KR100636458B1 (id) |
| CN (1) | CN1213020C (id) |
| AT (1) | ATE264835T1 (id) |
| AU (1) | AU771938B2 (id) |
| BR (1) | BR0008368A (id) |
| CA (1) | CA2362833C (id) |
| CZ (1) | CZ20012984A3 (id) |
| DE (1) | DE60010049T2 (id) |
| DK (1) | DK1154987T3 (id) |
| ES (1) | ES2218116T3 (id) |
| HR (1) | HRP20010594B1 (id) |
| HU (1) | HUP0200343A3 (id) |
| ID (1) | ID30057A (id) |
| IL (2) | IL144641A0 (id) |
| MA (1) | MA26772A1 (id) |
| MX (1) | MXPA01008178A (id) |
| NO (1) | NO20013946D0 (id) |
| PL (1) | PL349463A1 (id) |
| PT (1) | PT1154987E (id) |
| RU (1) | RU2238265C2 (id) |
| SI (1) | SI1154987T1 (id) |
| TR (1) | TR200102395T2 (id) |
| WO (1) | WO2000048988A1 (id) |
| YU (1) | YU58601A (id) |
| ZA (1) | ZA200106075B (id) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6939855B2 (en) * | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
| RS50470B (sr) * | 1999-08-13 | 2010-03-02 | Biogen Idec Ma Inc. | Inhibitori ćelijske adhezije |
| US6388084B1 (en) | 1999-12-06 | 2002-05-14 | Hoffmann-La Roche Inc. | 4-pyridinyl-n-acyl-l-phenylalanines |
| US6380387B1 (en) | 1999-12-06 | 2002-04-30 | Hoffmann-La Roche Inc. | 4-Pyrimidinyl-n-acyl-l phenylalanines |
| AU2004240940A1 (en) | 2003-05-20 | 2004-12-02 | Genentech, Inc. | Thiocarbamate inhibitors of alpha-4 integrins |
| WO2006081986A1 (en) * | 2005-02-07 | 2006-08-10 | F.Hoffmann-La Roche Ag | Bambuterol and integrin inhibitor combination |
| WO2006094640A2 (en) * | 2005-03-04 | 2006-09-14 | F.Hoffmann-La Roche Ag | Roflumilast and integrin inhibitor combination and method of treatment |
| RU2394560C2 (ru) * | 2005-07-19 | 2010-07-20 | Дайити Санкио Компани, Лимитед | Замещенное пропанамидное производное и фармацевтическая композиция, содержащая такое производное |
| IL172896A0 (en) * | 2005-12-29 | 2006-06-11 | Yeda Res & Dev | Cxcr4 inhibition |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE584914A (id) | 1958-11-24 | |||
| US3527793A (en) | 1967-08-18 | 1970-09-08 | Bristol Myers Co | Phenylglycine derivatives |
| SU961297A1 (ru) * | 1981-02-16 | 1990-12-07 | Институт биохимии АН ЛитССР | Этиловый эфир N @ ,О-дифенилацетил-трео-DL-фенилсерина, про вл ющий противовоспалительное действие |
| IT1190378B (it) | 1985-06-21 | 1988-02-16 | Isf Spa | Derivati pirrolidonici |
| US5039805A (en) | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
| US5463116A (en) | 1991-07-30 | 1995-10-31 | Ajinomoto Co., Inc. | Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them |
| ATE210663T1 (de) | 1994-06-20 | 2001-12-15 | Takeda Chemical Industries Ltd | Kondensierte imidazolderivate, ihre herstellung und verwendung |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| US5804595A (en) | 1995-12-05 | 1998-09-08 | Regents Of The University Of Minnesota | Kappa opioid receptor agonists |
| ES2172780T3 (es) * | 1996-03-29 | 2002-10-01 | Searle & Co | Derivados de acido fenilpropanoico sustituidos en para como antagonistas de integrina. |
| ES2162676T3 (es) | 1996-03-29 | 2002-01-01 | Searle & Co | Derivados de fenileno sustituidos en meta y su uso como antagonistas o inhibidores de integrina alfav,beta3. |
| ID19155A (id) * | 1996-12-13 | 1998-06-18 | Tanabe Seiyaku Co | Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya |
| EP1001764A4 (en) * | 1997-05-29 | 2005-08-24 | Merck & Co Inc | HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION |
| DK1005445T3 (da) * | 1997-08-22 | 2004-10-04 | Hoffmann La Roche | N-alkanoylphenylaninderivater |
| JP3727536B2 (ja) * | 1997-08-22 | 2005-12-14 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎ−アルカノイルフェニルアラニン誘導体 |
| WO1999043642A1 (en) | 1998-02-26 | 1999-09-02 | Celltech Therapeutics Limited | Phenylalanine derivatives as inhibitors of alpha4 integrins |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
-
2000
- 2000-02-12 TR TR2001/02395T patent/TR200102395T2/xx unknown
- 2000-02-12 YU YU58601A patent/YU58601A/sh unknown
- 2000-02-12 JP JP2000599729A patent/JP2002537283A/ja active Pending
- 2000-02-12 CN CNB008038694A patent/CN1213020C/zh not_active Expired - Fee Related
- 2000-02-12 ES ES00903692T patent/ES2218116T3/es not_active Expired - Lifetime
- 2000-02-12 MX MXPA01008178A patent/MXPA01008178A/es active IP Right Grant
- 2000-02-12 DE DE60010049T patent/DE60010049T2/de not_active Expired - Lifetime
- 2000-02-12 AU AU25486/00A patent/AU771938B2/en not_active Ceased
- 2000-02-12 IL IL14464100A patent/IL144641A0/xx active IP Right Grant
- 2000-02-12 BR BR0008368-2A patent/BR0008368A/pt not_active Application Discontinuation
- 2000-02-12 CZ CZ20012984A patent/CZ20012984A3/cs unknown
- 2000-02-12 EP EP00903692A patent/EP1154987B1/en not_active Expired - Lifetime
- 2000-02-12 PT PT00903692T patent/PT1154987E/pt unknown
- 2000-02-12 RU RU2001124601A patent/RU2238265C2/ru not_active IP Right Cessation
- 2000-02-12 SI SI200030405T patent/SI1154987T1/xx unknown
- 2000-02-12 DK DK00903692T patent/DK1154987T3/da active
- 2000-02-12 HR HR20010594A patent/HRP20010594B1/xx not_active IP Right Cessation
- 2000-02-12 HU HU0200343A patent/HUP0200343A3/hu unknown
- 2000-02-12 WO PCT/EP2000/001168 patent/WO2000048988A1/en not_active Ceased
- 2000-02-12 CA CA002362833A patent/CA2362833C/en not_active Expired - Fee Related
- 2000-02-12 PL PL00349463A patent/PL349463A1/xx not_active Application Discontinuation
- 2000-02-12 KR KR1020017010537A patent/KR100636458B1/ko not_active Expired - Fee Related
- 2000-02-12 AT AT00903692T patent/ATE264835T1/de not_active IP Right Cessation
- 2000-02-12 ID IDW00200101769A patent/ID30057A/id unknown
- 2000-02-17 US US09/506,062 patent/US6420600B1/en not_active Expired - Fee Related
-
2001
- 2001-07-24 ZA ZA200106075A patent/ZA200106075B/en unknown
- 2001-07-30 IL IL144641A patent/IL144641A/en not_active IP Right Cessation
- 2001-08-14 NO NO20013946A patent/NO20013946D0/no not_active Application Discontinuation
- 2001-08-17 MA MA26298A patent/MA26772A1/fr unknown
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