ID26420A - NEW SUBSTITUTED INDOLINONS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL COMPOSITIONS - Google Patents

NEW SUBSTITUTED INDOLINONS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL COMPOSITIONS

Info

Publication number: ID26420A
Authority: ID; Indonesia
Prior art keywords: indolinons; production; pharmaceutical compositions; new substituted; substituted
Prior art date: 1998-04-15

Application number

IDW20002062A

Other languages

Indonesian (id)

Inventor

Heckel Armin

Walter Rainer

Grell Wolfgang

Meel Jacobus Constant Antonius

Redemann Norbert

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

1999-04-10

Publication date

2000-12-21

1999-04-10 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2000-12-21 Publication of ID26420A publication Critical patent/ID26420A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

IDW20002062A 1998-04-15 1999-04-10 NEW SUBSTITUTED INDOLINONS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL COMPOSITIONS ID26420A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19816624A DE19816624A1 (en)	1998-04-15	1998-04-15	Novel substituted indolinones, their preparation and their use as pharmaceuticals

Publications (1)

Publication Number	Publication Date
ID26420A true ID26420A (en)	2000-12-21

Family

ID=7864562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDW20002062A ID26420A (en)	1998-04-15	1999-04-10	NEW SUBSTITUTED INDOLINONS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL COMPOSITIONS

Country Status (31)

Country	Link
EP (1)	EP1071665B1 (en)
JP (1)	JP4015365B2 (en)
KR (1)	KR100588250B1 (en)
CN (1)	CN100338036C (en)
AR (1)	AR015763A1 (en)
AT (1)	ATE251138T1 (en)
AU (1)	AU749829B2 (en)
BG (1)	BG64443B1 (en)
BR (1)	BR9909688A (en)
CA (1)	CA2323111C (en)
CO (1)	CO5011040A1 (en)
DE (2)	DE19816624A1 (en)
DK (1)	DK1071665T3 (en)
EA (1)	EA003532B1 (en)
EE (1)	EE04432B1 (en)
ES (1)	ES2207209T3 (en)
HU (1)	HUP0101568A3 (en)
ID (1)	ID26420A (en)
IL (1)	IL138036A0 (en)
MY (1)	MY122357A (en)
NO (1)	NO317298B1 (en)
NZ (1)	NZ507967A (en)
PL (1)	PL343314A1 (en)
PT (1)	PT1071665E (en)
SK (1)	SK283824B6 (en)
TR (1)	TR200002980T2 (en)
TW (1)	TW510897B (en)
UA (1)	UA63009C2 (en)
WO (1)	WO1999052869A1 (en)
YU (1)	YU59800A (en)
ZA (1)	ZA200004623B (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6569868B2 (en)	1998-04-16	2003-05-27	Sugen, Inc.	2-indolinone derivatives as modulators of protein kinase activity
GB9904933D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
GB9904995D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Substituted aza-oxindole derivatives
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
GB9904932D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
DE19924401A1 (en) *	1999-05-27	2000-11-30	Boehringer Ingelheim Pharma	Novel substituted indolinones, their preparation and their use as pharmaceuticals
MXPA02002097A (en) *	1999-08-27	2002-11-07	Boehringer Ingelheim Pharma	Substituted indolinones as tyrosine kinase inhibitors.
US6762180B1 (en)	1999-10-13	2004-07-13	Boehringer Ingelheim Pharma Kg	Substituted indolines which inhibit receptor tyrosine kinases
UA75054C2 (en) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Substituted in position 6 indolinones, producing and use thereof as medicament
MXPA02008021A (en)	2000-02-15	2004-04-05	Sugen Inc	Pyrrole substituted 2 indolinone protein kinase inhibitors.
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128449A (en)	2000-05-24	2007-02-28	Sugen Inc	Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
AU2001268154A1 (en)	2000-06-02	2001-12-17	Sugen, Inc.	Indolinone derivatives as protein kinase/phosphatase inhibitors
JP2004517840A (en) *	2000-11-27	2004-06-17	フアルマシア・イタリア・エツセ・ピー・アー	Phenylacetamide-pyrazole derivatives and their use as antitumor agents
AR042586A1 (en)	2001-02-15	2005-06-29	Sugen Inc	3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
DE10117204A1 (en)	2001-04-06	2002-10-10	Boehringer Ingelheim Pharma	Indolinones substituted in the 6-position, their preparation and their use as medicaments
WO2002096361A2 (en)	2001-05-30	2002-12-05	Sugen, Inc.	5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
UA80120C2 (en)	2002-03-26	2007-08-27	Boehringer Ingelheim Pharma	Glucocorticoid mimetics, pharmaceutical composition based thereon
US7169936B2 (en)	2002-07-23	2007-01-30	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233500A1 (en) *	2002-07-24	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Z- [1- (4- (N - ((4-methyl-piperazin-1-yl) -methylcarbonyl) -N-methyl-amino) -anilino) -1-phenyl-methylene] -6-methoxycarbonyl- 2-indolinone monoethanesulfonate and its use as a medicament
DE10237423A1 (en)	2002-08-16	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Treating immunological (or related) diseases, e.g. inflammatory bowel disease, rheumatoid arthritis or psoriasis, comprises administration of 3-methylene-2-indolinone derivative or quinazoline compound
JP4879492B2 (en) *	2002-11-27	2012-02-22	アラーガン、インコーポレイテッド	Kinase inhibitors for the treatment of diseases
US20050043233A1 (en)	2003-04-29	2005-02-24	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (en)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
CA2541059C (en) *	2003-10-03	2013-09-17	Boehringer Ingelheim Pharmaceuticals, Inc.	Fluorescent probes for use in protein kinase inhibitor binding assay
DE102004012070A1 (en) *	2004-03-12	2005-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (en)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
ES2326907T3 (en)	2004-12-27	2009-10-21	Boehringer Ingelheim Pharmaceuticals Inc.	GLUCOCORTICOID MIMETICS, METHODS FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND USE.
AU2006254758B2 (en) *	2005-06-10	2012-04-05	Merck Patent Gmbh	Oxindoles as kinase inhibitors
WO2007057399A2 (en) *	2005-11-15	2007-05-24	Boehringer Ingelheim International Gmbh	Treatment of cancer with indole derivatives
MX2009005264A (en)	2006-12-06	2009-05-28	Boehringer Ingelheim Int	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof.
DK2300472T3 (en)	2008-06-06	2012-04-10	Boehringer Ingelheim Int	Glucocorticoid mimetics, methods of their preparation, pharmaceutical compositions and uses thereof
US20170065529A1 (en)	2015-09-09	2017-03-09	Boehringer Ingelheim International Gmbh	Pharmaceutical dosage form for immediate release of an indolinone derivative
WO2011032320A1 (en) *	2009-09-21	2011-03-24	F. Hoffmann-La Roche Ag	Novel alkene oxindole derivatives
CN109293551A (en) *	2011-11-14	2019-02-01	利亘制药公司	Method and composition relevant to granulocyte colony stimulating factor receptor
WO2014150252A1 (en) *	2013-03-15	2014-09-25	Ligand Pharmaceuticals Incorporated	Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CN107033064B (en) *	2017-04-28	2019-07-09	西安医学院	A kind of 3- (morpholine replaces fragrant imido grpup) Benzazole compounds and its preparation method and application
CN111285872B (en) *	2018-12-06	2022-05-17	北京志健金瑞生物医药科技有限公司	Indole-2-ketone derivative and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9501567D0 (en) *	1995-01-26	1995-03-15	Pharmacia Spa	Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
GB9718913D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
DE19824922A1 (en) *	1998-06-04	1999-12-09	Boehringer Ingelheim Pharma	Novel substituted indolinones, their preparation and their use as pharmaceuticals
UA75054C2 (en) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Substituted in position 6 indolinones, producing and use thereof as medicament

1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/en not_active Withdrawn
1999
- 1999-04-10 EP EP99920635A patent/EP1071665B1/en not_active Expired - Lifetime
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/en unknown
- 1999-04-10 CN CNB998050296A patent/CN100338036C/en not_active Expired - Fee Related
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/en not_active Application Discontinuation
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/en not_active Expired - Lifetime
- 1999-04-10 PT PT99920635T patent/PT1071665E/en unknown
- 1999-04-10 ID IDW20002062A patent/ID26420A/en unknown
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/en unknown
- 1999-04-10 ES ES99920635T patent/ES2207209T3/en not_active Expired - Lifetime
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/en not_active Ceased
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/en unknown
- 1999-04-10 YU YU59800A patent/YU59800A/en unknown
- 1999-04-10 DK DK99920635T patent/DK1071665T3/en active
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/en not_active Expired - Fee Related
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-10 NZ NZ507967A patent/NZ507967A/en unknown
- 1999-04-10 EE EEP200000598A patent/EE04432B1/en not_active IP Right Cessation
- 1999-04-10 AT AT99920635T patent/ATE251138T1/en active
- 1999-04-10 IL IL13803699A patent/IL138036A0/en not_active IP Right Cessation
- 1999-04-10 DE DE59907199T patent/DE59907199D1/en not_active Expired - Lifetime
- 1999-04-10 PL PL99343314A patent/PL343314A1/en not_active Application Discontinuation
- 1999-04-10 EA EA200001021A patent/EA003532B1/en not_active IP Right Cessation
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 TW TW088105963A patent/TW510897B/en active
- 1999-04-14 CO CO99022218A patent/CO5011040A1/en unknown
- 1999-04-14 AR ARP990101700A patent/AR015763A1/en active IP Right Grant
- 1999-10-04 UA UA2000116456A patent/UA63009C2/en unknown
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/en unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/en unknown
- 2000-10-13 NO NO20005151A patent/NO317298B1/en unknown

Also Published As

Publication number	Publication date
KR100588250B1 (en)	2006-06-13
EP1071665A1 (en)	2001-01-31
MY122357A (en)	2006-04-29
AU749829B2 (en)	2002-07-04
TR200002980T2 (en)	2001-02-21
WO1999052869A1 (en)	1999-10-21
EA003532B1 (en)	2003-06-26
BG64443B1 (en)	2005-02-28
BR9909688A (en)	2000-12-19
ATE251138T1 (en)	2003-10-15
DE19816624A1 (en)	1999-10-21
NO317298B1 (en)	2004-10-04
SK283824B6 (en)	2004-02-03
EE200000598A (en)	2002-04-15
JP4015365B2 (en)	2007-11-28
PL343314A1 (en)	2001-08-13
CO5011040A1 (en)	2001-02-28
BG104813A (en)	2001-08-31
EA200001021A1 (en)	2001-06-25
KR20010042731A (en)	2001-05-25
NZ507967A (en)	2003-04-29
CA2323111A1 (en)	1999-10-21
ZA200004623B (en)	2001-05-30
AU3814999A (en)	1999-11-01
ES2207209T3 (en)	2004-05-16
CA2323111C (en)	2009-09-15
YU59800A (en)	2003-04-30
AR015763A1 (en)	2001-05-16
HUP0101568A3 (en)	2002-12-28
HUP0101568A2 (en)	2001-09-28
NO20005151D0 (en)	2000-10-13
IL138036A0 (en)	2001-10-31
UA63009C2 (en)	2004-01-15
DK1071665T3 (en)	2004-01-05
EE04432B1 (en)	2005-02-15
EP1071665B1 (en)	2003-10-01
NO20005151L (en)	2000-10-13
DE59907199D1 (en)	2003-11-06
PT1071665E (en)	2004-02-27
TW510897B (en)	2002-11-21
CN1297438A (en)	2001-05-30
JP2002511449A (en)	2002-04-16
SK15132000A3 (en)	2001-03-12
CN100338036C (en)	2007-09-19

Publication	Publication Date	Title
ID26420A (en)	2000-12-21	NEW SUBSTITUTED INDOLINONS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL COMPOSITIONS
ID27757A (en)	2001-04-26	NEW SUBSTITUTED INDOLINONA, PREPARATION AND USE AS MEDICINES
ID27035A (en)	2001-02-22	NEW SUBSTITUTED INDOLINONA, THEIR PRODUCTION AND USE AS A PHARMACY COMPOSITION
ID26305A (en)	2000-12-14	NEW SUBSTITUTED BENZAMIDES, PRODUCTION AND USE
EE200000468A (en)	2002-04-15	The compounds, their use and the pharmaceutical composition
HUP0200312A3 (en)	2002-12-28	Substituted 2-phenylbenzimidazoles, pharmaceutical compositions containing them, the production thereof and their use
ID25528A (en)	2000-10-12	SUBSTITUTED CARBOXAMMOTOTIAZOL, THE PRODUCTION AND THE PHARMACY COMPOSITION THAT CONTAINS IT
IS5665A (en)	2000-10-13	Pharmaceutical pressure spray composition
ID30299A (en)	2001-11-22	OKSAZOLIDINON DERIVES, THE PROCESS OF MAKING IT AND THE PHARMACY COMPOSITION THAT CONTAINS IT
ID27415A (en)	2001-04-05	PHARMACEUTICAL COMPOSITION
FI991485A0 (en)	1999-06-30	New pharmaceutical composition
ID16420A (en)	1997-09-25	NEW PHARMACEUTICAL COMPOSITION WITH ANASTESIA EFFECTS
IS5046A (en)	1999-11-16	pharmaceutical compositions
EE200200175A (en)	2003-04-15	Substituted 2-Thio-3,5-Dicyano-4-aryl-6-aminopyridines and their Uses
ID26774A (en)	2001-02-08	BENZIMIDAZOL COMPOUNDS, MAKING AND USE AS A PHARMACY COMPOSITION
ID29089A (en)	2001-07-26	MOKSIFLOXASIN PHARMACEUTICAL PROPERTIES
ID26310A (en)	2000-12-14	PRODUCTION OF CONTINUED-1,3-DIOXOL-2-ONA
EE05020B1 (en)	2008-06-16	The pharmaceutical composition of G1buride
ID29262A (en)	2001-08-16	PHARMACEUTICAL COMPOSITION
ID24714A (en)	2000-08-03	SUBSTITUTION OF TIAZOLIDINDION DERIVATES, THE PROCESS OF PRODUCTION AND USE OF THE PHARMACEUTICAL MATERIALS
ID27201A (en)	2001-03-08	PHARMACEUTICAL COMPOSITION
ID21525A (en)	1999-06-24	NEW BLOCK COMPOSITION
ID20855A (en)	1999-03-18	THE NEW IMIDAZOLIDIN COMPOUND COMPOUND, THE PRODUCTION, THE USE AND THE PHARMACEUTICAL SUPPLY THAT CONTAINS THE COMPOUND
NO20010873L (en)	2001-02-21	The microparticle composition
ID26611A (en)	2001-01-25	HETEROARIL SUBSTITUTED PIROLS, ITS MANUFACTURE AND ITS APPLICATION USES