[go: up one dir, main page]

HUP9802324A2 - Ribavirin és alfa-interferon felhasználása hepatitis C kezelésére - Google Patents

Ribavirin és alfa-interferon felhasználása hepatitis C kezelésére

Info

Publication number
HUP9802324A2
HUP9802324A2 HU9802324A HUP9802324A HUP9802324A2 HU P9802324 A2 HUP9802324 A2 HU P9802324A2 HU 9802324 A HU9802324 A HU 9802324A HU P9802324 A HUP9802324 A HU P9802324A HU P9802324 A2 HUP9802324 A2 HU P9802324A2
Authority
HU
Hungary
Prior art keywords
ribavirin
hepatitis
treatment
interferon alpha
interferon
Prior art date
Application number
HU9802324A
Other languages
English (en)
Inventor
Janice K. Albrecht
Paul C. Grint
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of HUP9802324A2 publication Critical patent/HUP9802324A2/hu
Publication of HUP9802324A3 publication Critical patent/HUP9802324A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU9802324A 1995-05-19 1996-05-15 Use of ribavirin and interferon alpha for the treatment of hepatitis c HUP9802324A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/444,584 US6387365B1 (en) 1995-05-19 1995-05-19 Combination therapy for chronic hepatitis C infection

Publications (2)

Publication Number Publication Date
HUP9802324A2 true HUP9802324A2 (hu) 1999-05-28
HUP9802324A3 HUP9802324A3 (en) 2001-04-28

Family

ID=23765515

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802324A HUP9802324A3 (en) 1995-05-19 1996-05-15 Use of ribavirin and interferon alpha for the treatment of hepatitis c

Country Status (15)

Country Link
US (2) US6387365B1 (hu)
EP (2) EP0707855A3 (hu)
JP (1) JPH10506640A (hu)
KR (1) KR19990014925A (hu)
CN (1) CN1190895A (hu)
AU (1) AU5919296A (hu)
BR (1) BR9608758A (hu)
CA (1) CA2221314A1 (hu)
CZ (1) CZ365497A3 (hu)
HU (1) HUP9802324A3 (hu)
NO (1) NO975309L (hu)
NZ (1) NZ309217A (hu)
PL (1) PL323477A1 (hu)
SK (1) SK155997A3 (hu)
WO (1) WO1996036351A1 (hu)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
CA2236591C (en) * 1995-11-02 2012-01-03 Schering Corporation Continuous low-dose cytokine infusion therapy
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US20020137696A1 (en) * 1996-01-23 2002-09-26 Robert Tam Specific modulation of TH1/TH2 cytokine expression by ribavirin in activated T-lymphocytes
EP1240899A3 (en) * 1996-01-23 2004-05-19 Ribapharm, Inc. Modulation of Th1/Th2 Cytokine expression by Ribavirin and Ribavirin analogs in actived T-Lymphocytes for treating HCV infections
DK0879056T3 (da) * 1996-01-23 2002-08-19 Icn Pharmaceuticals Modulation af Th1/Th2-cytokinekspression med ribavirin i aktiverede T-lymfocytter
DE69706657T2 (de) * 1996-02-28 2002-06-20 Unihart Corp., Dublin Natürliches menschliches alpha interferon enthaltende pharmazeutische zusammensetzungen
WO1998019670A2 (en) * 1996-11-01 1998-05-14 Thomas Najarian Combination therapy of hepatitis c infections
US6172046B1 (en) * 1997-09-21 2001-01-09 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
DE69801970T2 (de) * 1997-09-21 2002-06-13 Schering Corp., Kenilworth Kombinationstherapie zur Entfernung von nachweisbarer HCV-RNS in Patienten mit chronischer Hepatitis C-Infektion
US6472373B1 (en) 1997-09-21 2002-10-29 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
EP1321147A1 (en) * 1997-12-22 2003-06-25 Schering Corporation Orally administrable solid ribavirin dosage forms and process for making them
TWI277424B (en) * 1998-05-15 2007-04-01 Schering Corp Combination therapy for eradicating detectable NCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
IL139786A0 (en) * 1998-06-08 2002-02-10 Hoffmann La Roche Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
AU751201B2 (en) * 1998-09-04 2002-08-08 Viropharma Incorporated Methods for treating or preventing viral infections and associated diseases
US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
ID29187A (id) * 1998-10-16 2001-08-09 Schering Corp Terapi kombinasi alfa internferon-ribavirin untuk memusnahkan hcv-rna yang dapat ditemukan pada pasien-pasien yang mengalami infeksi hepatitis c kronis
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
CA2354536A1 (en) * 1998-12-18 2000-06-29 Schering Corporation Ribavirin-pegylated interferon alfa induction hcv combination therapy
AU2156900A (en) * 1998-12-18 2000-07-12 Schering Corporation Ribavirin-interferon alfa induction hcv combination therapy
US6824768B2 (en) * 1998-12-18 2004-11-30 Schering Corporation Ribavirin-pegylated interferon alfa induction HCV combination therapy
CN1420723A (zh) * 1999-12-23 2003-05-28 Icn药品公司 L－核苷、l－核苷酸及其类似物的组合物和方法
JP2003530838A (ja) * 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
US6924270B2 (en) * 2000-04-20 2005-08-02 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
WO2002010743A1 (en) * 2000-08-02 2002-02-07 Ortho-Mcneil Pharmaceutical, Inc. Improved anti-viral and anti-tumor chemotherapy by administration of erythropoeitin
US20060024270A1 (en) * 2000-08-23 2006-02-02 The New York Hospital Medical Center Of Queens Compositions and methods for preventing or treating encephalitis with interferon
US6946125B2 (en) * 2000-08-23 2005-09-20 The New York Hospital Medical Center Of Queens Methods of treating West Nile virus infection
MXPA03003456A (es) * 2000-10-18 2003-07-14 Schering Corp Terapia de combinacion de ribavirina e interferon alfa pegilado contra el hcv.
US6720000B2 (en) 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets
EP1401477A4 (en) * 2001-05-25 2005-02-02 Human Genome Sciences CHIMIOKINE BETA-1 HYBRID PROTEINS
EP1461067A1 (en) * 2001-12-07 2004-09-29 Intermune, Inc. Compositions and method for treating hepatitis virus infection
KR101271635B1 (ko) * 2001-12-21 2013-06-12 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
ES2425738T3 (es) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
WO2004004653A2 (en) * 2002-07-02 2004-01-15 Corcept Therapeutics, Inc. Methods for treating psychosis associated with interferon-alpha therapy
WO2004022593A2 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7538094B2 (en) 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
JP2004143113A (ja) * 2002-10-25 2004-05-20 Shinya Nakajima インターフェロン製剤及びその投与システム
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
GB0301879D0 (en) * 2003-01-27 2003-02-26 Regent Res Llp HCV combination therapy
MXPA05010419A (es) * 2003-03-28 2006-05-31 Pharmasset Inc Compuestos para el tratamiento de infecciones por flaviviridae.
CN1852920B (zh) 2003-07-18 2010-12-15 沃泰克斯药物股份有限公司 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂
JPWO2006033453A1 (ja) * 2004-09-22 2008-05-15 学校法人順天堂 インターフェロン作用物質の活性増強剤
US7723310B2 (en) 2004-10-18 2010-05-25 Three Rivers Pharmaceuticals, Llc Large dose ribavirin formulations
US20060159658A1 (en) * 2005-01-19 2006-07-20 Avigenics, Inc. Methods of treating disease with glycosylated interferon
WO2007013677A1 (ja) * 2005-07-27 2007-02-01 Ajinomoto Co., Inc. インターフェロン作用物質の活性増強剤
KR20090040906A (ko) * 2006-08-02 2009-04-27 유나이티드 세러퓨틱스 코오포레이션 바이러스 감염의 리포솜 치료
US20080131398A1 (en) * 2006-08-21 2008-06-05 United Therapeutics Corporation Combination therapy for treatment of viral infections
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
EP2175865A4 (en) * 2007-07-25 2012-01-11 Biolex Therapeutics Inc INTERFERON DRUG PRODUCTS WITH CONTROLLED RELEASE AND TREATMENT OF HCV INFECTIONS THEREWITH
JP2011518124A (ja) * 2008-03-26 2011-06-23 ユニバーシティ・オブ・オックスフォード 小胞体ターゲッティングリポソーム
AU2009293493B2 (en) * 2008-09-17 2014-09-18 Boehringer Ingelheim International Gmbh Combination of HCV NS3 protease inhibitor with interferon and ribavirin
CN102427804A (zh) * 2009-03-27 2012-04-25 牛津大学之校长及学者 降低胆固醇水平的脂质体
WO2011014882A1 (en) 2009-07-31 2011-02-03 Medtronic, Inc. CONTINUOUS SUBCUTANEOUS ADMINISTRATION OF INTERFERON-α TO HEPATITIS C INFECTED PATIENTS
KR20120106942A (ko) 2009-10-30 2012-09-27 베링거 인겔하임 인터내셔날 게엠베하 Ｂｉ２０１３３５, 인터페론 알파 및 리바비린을 포함하는 ｈｃｖ 병용 치료요법을 위한 투여 용법
DE112012003510T5 (de) 2011-10-21 2015-03-19 Abbvie Inc. Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
MX2014004729A (es) 2011-10-21 2014-07-28 Abbvie Inc Tratamiento en combinacion (por ejemplo, con abt-072 o abt-333) de agentes antivirales de accion directa para utilizarse en el tratamiento del virus de la hepatitis c.
US20140363396A1 (en) * 2012-02-01 2014-12-11 Kadmon Pharmaceuticals Llc Once daily treatment of hepatitis c with ribavirin and taribavirin
CN109689063A (zh) 2016-04-28 2019-04-26 埃默里大学 含有炔烃的核苷酸和核苷治疗组合物及其相关用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE29835E (en) 1971-06-01 1978-11-14 Icn Pharmaceuticals 1,2,4-Triazole nucleosides
US4211771A (en) 1971-06-01 1980-07-08 Robins Ronald K Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
US4530901A (en) 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US5676942A (en) * 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof

Also Published As

Publication number Publication date
AU5919296A (en) 1996-11-29
CZ365497A3 (cs) 1998-07-15
WO1996036351A1 (en) 1996-11-21
US6299872B1 (en) 2001-10-09
NZ309217A (en) 2000-08-25
NO975309D0 (no) 1997-11-19
EP1005868A1 (en) 2000-06-07
SK155997A3 (en) 1998-10-07
NO975309L (no) 1997-11-19
MX9708885A (es) 1998-03-31
EP0707855A3 (en) 1996-11-27
KR19990014925A (ko) 1999-02-25
HUP9802324A3 (en) 2001-04-28
CN1190895A (zh) 1998-08-19
EP0707855A2 (en) 1996-04-24
JPH10506640A (ja) 1998-06-30
PL323477A1 (en) 1998-03-30
BR9608758A (pt) 1999-07-06
CA2221314A1 (en) 1996-11-21
US6387365B1 (en) 2002-05-14

Similar Documents

Publication Publication Date Title
HUP9802324A3 (en) Use of ribavirin and interferon alpha for the treatment of hepatitis c
PL344794A1 (en) Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
GB9609932D0 (en) Use of IL-12 and IFN alpha for the treatment of infectious diseases
AU6588598A (en) Treatment of hepatitis b infection with thymosin alpha 1 and famciclovir
HUP9900929A3 (en) Methods for retreatment of patients afflicted with hepatitis c using consensus interferon
IL129352A0 (en) Benzimidazole-2- carbamates for the treatment of viral infections and cancer
ZA956318B (en) Hepatitis C E1 and E2 truncated polypeptides and methods of obtaining the same
ZA896864B (en) Method and composition for the treatment and prevention of viral infections
HU9403655D0 (en) Methods of inhibiting atrophy of the skin and vagina
KR100321237B1 (ko) 적층구조물
EP0719791A3 (en) Drugs for the treatment of restenosis and arterial sclerosis
EP0973510A4 (en) USE OF AMANTADINE FOR TREATING HEPATITIS C
EP0531365A4 (en) Diagnosis and treatment of viral hepatitis
GB9219425D0 (en) Therapeutic agent and its use
EP0786001A4 (en) CHEMOKIN-LIKE PROTEINS AND THEIR USE
EP0702080A3 (en) Azeotropic compositions containing octamethyltrisiloxane and n-propoxypropanol
IL115320A0 (en) Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
IL113992A0 (en) Use of copolymer-1
EP0656116A4 (en) METHOD FOR MONITORING THE EFFECTIVENESS OF INTERFERON THERAPY ON HEPATITIS-C INFECTED INDIVIDURES.
ZA988519B (en) Use of IFN-alpha and amantadine for the treatment of chronic hepatitis C
HU9301621D0 (en) Treatment of gas flow
EP0490250A3 (en) Use of interferon and an antimalarial agent for the treatment of malarial infections
EP0731064A3 (de) Aufarbeitung und Verwendung der Rückstände der Direkten Synthese von Organochlor- u./o. Chlorsilanen
IL105387A0 (en) Treatment of hepatitis with gm-csf
SI1077068T1 (en) Utilization of interferon alpha 5 in the treatment of viral hepatopathies