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HUP0301493A2 - Indolszármazékok, eljárás előállításukra és alkalmazásuk - Google Patents

Indolszármazékok, eljárás előállításukra és alkalmazásuk

Info

Publication number
HUP0301493A2
HUP0301493A2 HU0301493A HUP0301493A HUP0301493A2 HU P0301493 A2 HUP0301493 A2 HU P0301493A2 HU 0301493 A HU0301493 A HU 0301493A HU P0301493 A HUP0301493 A HU P0301493A HU P0301493 A2 HUP0301493 A2 HU P0301493A2
Authority
HU
Hungary
Prior art keywords
group
alkoxy
hydroxy
cyano
alkyl
Prior art date
Application number
HU0301493A
Other languages
English (en)
Inventor
Kaoru Kobayashi
Fumio Nambu
Kazuhiko Torisu
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Publication of HUP0301493A2 publication Critical patent/HUP0301493A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgyát az általános képletű vegyületek - ahol R1hidroxi-, alkoxi- vagy -NR8R9 általános képletű csoport; R2 és R3hidrogénatom, alkil- vagy alkoxicsoport, halogénatom, trihalogénezettmetil-, ciano- vagy hidroxicsoport; R4 és R5 egymástól függetlenülhidrogénatom, alkil-, alkoxi- vagy alkoxi-alkil-csoport, halogénatom,nitro-, amino-, trihalogénezett metil-, ciano- vagy hidroxicsoport; Gegyes kötés, adott esetben heteroatomokkal szubsztituált alkilén-,alkenilén- vagy alkiniléncsoport; R6 3-15 szénatomos telített vagytelítetlen karbociklusos gyűrű vagy 4-15-tagú heterociklusos gyűrű -és nemtoxikus sóik, eljárás előállításukra és az ezeket tartalmazógyógyszerkészítmények képezik. Ó
HU0301493A 2000-03-09 2001-03-08 Indolszármazékok, eljárás előállításukra és alkalmazásuk HUP0301493A2 (hu)

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BR0109050A (pt) 2004-04-27
AU2001241068A1 (en) 2001-09-17
RU2002123882A (ru) 2004-03-20
US20040180885A1 (en) 2004-09-16
US6743793B2 (en) 2004-06-01
RU2259998C2 (ru) 2005-09-10
MXPA02008801A (es) 2003-07-07
US20030176400A1 (en) 2003-09-18
WO2001066520A1 (en) 2001-09-13
US7098234B2 (en) 2006-08-29
CN1179945C (zh) 2004-12-15
CN1427824A (zh) 2003-07-02
EP1262475A4 (en) 2005-01-05
CA2402174A1 (en) 2001-09-13
KR20030010589A (ko) 2003-02-05
EP1262475A1 (en) 2002-12-04
NZ521192A (en) 2005-01-28
JP4292742B2 (ja) 2009-07-08
NO20024281D0 (no) 2002-09-06

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