HUE037673T2 - Szulfonil-piperidin-származékok és alkalmazásuk prokineticin-mediált betegségek kezelésére - Google Patents
Szulfonil-piperidin-származékok és alkalmazásuk prokineticin-mediált betegségek kezeléséreInfo
- Publication number
- HUE037673T2 HUE037673T2 HUE13728238A HUE13728238A HUE037673T2 HU E037673 T2 HUE037673 T2 HU E037673T2 HU E13728238 A HUE13728238 A HU E13728238A HU E13728238 A HUE13728238 A HU E13728238A HU E037673 T2 HUE037673 T2 HU E037673T2
- Authority
- HU
- Hungary
- Prior art keywords
- prokinetic
- treatment
- mediated diseases
- piperidine derivatives
- sulfonyl
- Prior art date
Links
- XPYOORHZRLSTSG-UHFFFAOYSA-N 2-sulfonylpiperidine Chemical class O=S(=O)=C1CCCCN1 XPYOORHZRLSTSG-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201209587A GB201209587D0 (en) | 2012-05-30 | 2012-05-30 | Therapeutic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE037673T2 true HUE037673T2 (hu) | 2018-09-28 |
Family
ID=46546171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13728238A HUE037673T2 (hu) | 2012-05-30 | 2013-05-29 | Szulfonil-piperidin-származékok és alkalmazásuk prokineticin-mediált betegségek kezelésére |
Country Status (24)
| Country | Link |
|---|---|
| US (6) | US20130324576A1 (hu) |
| EP (1) | EP2855449B1 (hu) |
| JP (1) | JP6177896B2 (hu) |
| CN (1) | CN104520292B (hu) |
| AR (1) | AR091208A1 (hu) |
| CA (1) | CA2873850C (hu) |
| CY (1) | CY1120420T1 (hu) |
| DK (1) | DK2855449T3 (hu) |
| ES (1) | ES2671629T3 (hu) |
| GB (1) | GB201209587D0 (hu) |
| HR (1) | HRP20180729T1 (hu) |
| HU (1) | HUE037673T2 (hu) |
| LT (1) | LT2855449T (hu) |
| ME (1) | ME03078B (hu) |
| NO (1) | NO2855449T3 (hu) |
| PL (1) | PL2855449T3 (hu) |
| PT (1) | PT2855449T (hu) |
| RS (1) | RS57329B1 (hu) |
| SI (1) | SI2855449T1 (hu) |
| SM (1) | SMT201800274T1 (hu) |
| TR (1) | TR201807666T4 (hu) |
| TW (1) | TWI612041B (hu) |
| UY (1) | UY34835A (hu) |
| WO (1) | WO2013179024A1 (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
| EA029430B1 (ru) * | 2013-06-21 | 2018-03-30 | Такеда Фармасьютикл Компани Лимитед | Производные 1-сульфонилпиперидина в качестве модуляторов рецепторов прокинетицина |
| GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
| GB201420095D0 (en) * | 2014-11-12 | 2014-12-24 | Takeda Pharmaceutical | New use |
| CN106699635B (zh) * | 2015-11-12 | 2019-10-22 | 北京福元医药股份有限公司 | 一种制备Delamanid中间体的方法 |
| US10780095B2 (en) | 2016-04-06 | 2020-09-22 | The Regents Of The University Of California | Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists |
| US10865194B2 (en) | 2017-11-03 | 2020-12-15 | Fondazione Istituto Italiano Di Tecnologia | Therapeutically active bicyclic-sulphonamides and pharmaceutical compositions |
| CN111566105A (zh) | 2018-01-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物 |
| ES2942319T3 (es) | 2018-03-22 | 2023-05-31 | Hoffmann La Roche | Inhibidores de oxacina monoacilglicerol lipasa (MAGL) |
| HUE067912T2 (hu) | 2018-08-13 | 2024-11-28 | Hoffmann La Roche | Új heterociklusos vegyületek, mint monoacil-glicerin-lipáz inhibitorok |
| CA3151516A1 (en) | 2019-09-12 | 2021-03-18 | F. Hoffmann-La Roche Ag | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
| CA3190277A1 (en) | 2020-09-03 | 2022-03-10 | Joerg Benz | Heterocyclic compounds |
| CN115974785A (zh) * | 2022-12-09 | 2023-04-18 | 南京先进生物材料与过程装备研究院有限公司 | 一种3,5-二取代吡唑类化合物的制备方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ289512B6 (cs) | 1994-08-24 | 2002-02-13 | Astra Aktiebolag | Spiro-azabicyklické sloučeniny pouľitelné při terapii |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| AR013184A1 (es) | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
| SE9702799D0 (sv) | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
| CA2386517A1 (en) | 1999-10-07 | 2001-04-12 | Takeda Chemical Industries, Ltd. | Amine derivatives |
| SE9903760D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
| SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| CO5300399A1 (es) | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
| PL359416A1 (en) | 2000-07-18 | 2004-08-23 | Yamanouchi Pharmaceutical Co, Ltd. | Medicine comprising dicyanopyridine derivative |
| SE0002729D0 (sv) | 2000-07-20 | 2000-07-20 | Astrazeneca Ab | Novel compound form |
| US7229994B2 (en) | 2001-05-18 | 2007-06-12 | Astrazeneca Ab | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
| CN1294136C (zh) | 2001-06-01 | 2007-01-10 | 阿斯特拉曾尼卡有限公司 | 用于治疗的烟碱乙酰胆碱受体新型配体 |
| EP1676844A1 (en) | 2004-12-28 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | 5-HT7 receptor antagonists |
| CN1325500C (zh) | 2002-04-18 | 2007-07-11 | 阿斯特拉曾尼卡有限公司 | 呋喃基化合物 |
| AU2003224545B2 (en) | 2002-04-18 | 2009-08-13 | Astrazeneca Ab | Thienyl compounds |
| MXPA04010190A (es) | 2002-04-18 | 2005-02-03 | Astrazeneca Ab | Compuestos heterociclicos. |
| SE0202465D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| SE0202430D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202598D0 (sv) | 2002-09-02 | 2002-09-02 | Astrazeneca Ab | Alpha-7 Nicotinic receptor agonists and statins in combination |
| US8580782B2 (en) * | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| CA2501611A1 (en) | 2002-10-11 | 2004-04-22 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
| MXPA05005111A (es) | 2002-11-12 | 2005-07-01 | Pfizer Prod Inc | Derivados de quinolina. |
| EP1597256A1 (en) | 2003-02-21 | 2005-11-23 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
| EP2426120A1 (en) | 2003-08-18 | 2012-03-07 | Fujifilm Finechemicals Co., Ltd. | Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them |
| EP2153832B1 (en) | 2003-12-15 | 2016-03-09 | Merck Sharp & Dohme Corp. | Heterocyclic aspartyl protease inhibitors |
| US20080108600A1 (en) | 2004-04-13 | 2008-05-08 | Icagen, Inc. | Polycyclic Pyridines as Potassium Ion Channel Modulators |
| CN103396398A (zh) | 2005-12-29 | 2013-11-20 | 詹森药业有限公司 | 激肽原1受体拮抗剂 |
| EP1976528A2 (en) | 2005-12-29 | 2008-10-08 | Janssen Pharmaceutica, N.V. | Prokineticin 2 receptor antagonists |
| US7964728B2 (en) | 2006-07-06 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition |
| WO2008130718A1 (en) * | 2007-04-23 | 2008-10-30 | Atherogenics, Inc. | Sulfonamide containing compounds for treatment of inflammatory disorders |
| WO2010077976A2 (en) | 2008-12-17 | 2010-07-08 | The Regents Of The University Of California | Prokineticin receptor antagonists and uses thereof |
| WO2010114909A1 (en) * | 2009-03-31 | 2010-10-07 | Vanderbilt University | Sulfonyl-piperidin-4-yl methylamine amide analogs as glyt1 inhibitors, methods for making same, and use of same in treating psychiatric disorders |
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
-
2012
- 2012-05-30 GB GB201209587A patent/GB201209587D0/en not_active Ceased
-
2013
- 2013-05-20 TW TW102117795A patent/TWI612041B/zh not_active IP Right Cessation
- 2013-05-29 WO PCT/GB2013/051415 patent/WO2013179024A1/en not_active Ceased
- 2013-05-29 HU HUE13728238A patent/HUE037673T2/hu unknown
- 2013-05-29 HR HRP20180729TT patent/HRP20180729T1/hr unknown
- 2013-05-29 SM SM20180274T patent/SMT201800274T1/it unknown
- 2013-05-29 US US13/904,198 patent/US20130324576A1/en not_active Abandoned
- 2013-05-29 EP EP13728238.0A patent/EP2855449B1/en active Active
- 2013-05-29 DK DK13728238.0T patent/DK2855449T3/en active
- 2013-05-29 CA CA2873850A patent/CA2873850C/en active Active
- 2013-05-29 PT PT137282380T patent/PT2855449T/pt unknown
- 2013-05-29 TR TR2018/07666T patent/TR201807666T4/tr unknown
- 2013-05-29 PL PL13728238T patent/PL2855449T3/pl unknown
- 2013-05-29 RS RS20180673A patent/RS57329B1/sr unknown
- 2013-05-29 SI SI201331026T patent/SI2855449T1/en unknown
- 2013-05-29 CN CN201380037673.8A patent/CN104520292B/zh active Active
- 2013-05-29 ME MEP-2018-154A patent/ME03078B/me unknown
- 2013-05-29 ES ES13728238.0T patent/ES2671629T3/es active Active
- 2013-05-29 NO NO13728238A patent/NO2855449T3/no unknown
- 2013-05-29 JP JP2015514586A patent/JP6177896B2/ja active Active
- 2013-05-29 US US14/402,751 patent/US9475795B2/en active Active
- 2013-05-29 LT LTEP13728238.0T patent/LT2855449T/lt unknown
- 2013-05-30 UY UY34835A patent/UY34835A/es not_active Application Discontinuation
- 2013-05-30 AR ARP130101895 patent/AR091208A1/es active IP Right Grant
-
2016
- 2016-09-12 US US15/262,436 patent/US10167273B2/en active Active
-
2018
- 2018-05-31 CY CY20181100581T patent/CY1120420T1/el unknown
- 2018-11-19 US US16/194,762 patent/US10544126B2/en active Active
-
2019
- 2019-12-09 US US16/707,079 patent/US11512066B2/en active Active
-
2022
- 2022-10-10 US US17/962,781 patent/US12054474B2/en active Active
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