[go: up one dir, main page]

HUE068134T2 - Rendszer egy gyógyszer rákos sejtekbe történõ szonoporációjának indukálására - Google Patents

Rendszer egy gyógyszer rákos sejtekbe történõ szonoporációjának indukálására

Info

Publication number
HUE068134T2
HUE068134T2 HUE18839880A HUE18839880A HUE068134T2 HU E068134 T2 HUE068134 T2 HU E068134T2 HU E18839880 A HUE18839880 A HU E18839880A HU E18839880 A HUE18839880 A HU E18839880A HU E068134 T2 HUE068134 T2 HU E068134T2
Authority
HU
Hungary
Prior art keywords
drug
cancer cells
sonoporation
inducing
inducing sonoporation
Prior art date
Application number
HUE18839880A
Other languages
English (en)
Inventor
Daniele Faletto
Pierangela Giustetto
Original Assignee
Freedom Waves S R L
Pierangela Giustetto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Freedom Waves S R L, Pierangela Giustetto filed Critical Freedom Waves S R L
Publication of HUE068134T2 publication Critical patent/HUE068134T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/0207—Driving circuits
    • B06B1/0215—Driving circuits for generating pulses, e.g. bursts of oscillations, envelopes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/40—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B2201/00—Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
    • B06B2201/50—Application to a particular transducer type
    • B06B2201/55—Piezoelectric transducer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B2201/00—Indexing scheme associated with B06B1/0207 for details covered by B06B1/0207 but not provided for in any of its subgroups
    • B06B2201/70—Specific application
    • B06B2201/76—Medical, dental

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Primary Health Care (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Data Mining & Analysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Databases & Information Systems (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
HUE18839880A 2017-12-22 2018-12-21 Rendszer egy gyógyszer rákos sejtekbe történõ szonoporációjának indukálására HUE068134T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT201700148858 2017-12-22

Publications (1)

Publication Number Publication Date
HUE068134T2 true HUE068134T2 (hu) 2024-12-28

Family

ID=61731766

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18839880A HUE068134T2 (hu) 2017-12-22 2018-12-21 Rendszer egy gyógyszer rákos sejtekbe történõ szonoporációjának indukálására

Country Status (10)

Country Link
US (2) US11648312B2 (hu)
EP (1) EP3727585B1 (hu)
JP (1) JP7408563B2 (hu)
CN (1) CN111511440B (hu)
BR (1) BR112020012452A2 (hu)
CA (1) CA3122353A1 (hu)
ES (1) ES2989606T3 (hu)
HU (1) HUE068134T2 (hu)
PL (1) PL3727585T3 (hu)
WO (1) WO2019123411A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022020354A1 (en) * 2020-07-21 2022-01-27 Sanuwave Inc. Pressure waves for vaccines, genetic modification and medical treatments
CN116209470A (zh) * 2020-08-07 2023-06-02 阿尔菲斯医疗股份有限公司 用于治疗癌症的用于增强的声动力疗法的超声阵列
CN113893469B (zh) * 2021-09-15 2024-02-09 复旦大学 缓解阿霉素心脏毒性的低强度脉冲超声系统
CN114099990A (zh) * 2021-11-29 2022-03-01 中国医科大学附属第一医院 一种增强三氧化二砷对颅内肿瘤效果的方法及其应用
CN120676990A (zh) * 2023-01-27 2025-09-19 医视特有限公司 聚焦超声阵列中改善的稀疏度

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004520852A (ja) * 1999-11-02 2004-07-15 ユニバーシティ・オブ・ヴァーモント・アンド・ステイト・アグリカルチュアル・カレッジ 皮膚に微細孔を形成する方法
US20050020945A1 (en) * 2002-07-02 2005-01-27 Tosaya Carol A. Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy
EP1888035A2 (en) * 2005-05-23 2008-02-20 University of Utah Research Foundation Echogenic microbubbles and microemulsions for ultrasound-enhanced nanoparticle-mediated delivery of agents
US7713200B1 (en) * 2005-09-10 2010-05-11 Sarvazyan Armen P Wireless beacon for time-reversal acoustics, method of use and instrument containing thereof
US20070088345A1 (en) * 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
US8961441B2 (en) 2008-05-07 2015-02-24 Sanuwave, Inc. Medical treatment system including an ancillary medical treatment apparatus with an associated data storage medium
US20120116221A1 (en) * 2009-04-09 2012-05-10 The Trustees Of The University Of Pennsylvania Methods and systems for image-guided treatment of blood vessels
CN101991851A (zh) * 2009-08-24 2011-03-30 中国医学科学院药物研究所 一种低强度聚焦超声治疗肿瘤的超声微泡剂及其制备方法
CN101642607B (zh) * 2009-09-01 2012-11-28 西安交通大学 基于阵列换能器的低强度聚焦超声药物控释与监控装置
CN101829326B (zh) * 2009-12-19 2012-02-29 刘政 微泡在制备用于联合超声产生高强度空化作为抗肿瘤新生血管药物的用途
US9669203B2 (en) * 2011-03-01 2017-06-06 University Of Cincinnati Methods of enhancing delivery of drugs using ultrasonic waves and systems for performing the same
JP2012200454A (ja) 2011-03-25 2012-10-22 Hitachi Medical Corp 薬剤導入装置及び薬剤導入システム
EP2869815A4 (en) * 2012-07-08 2016-03-16 Sunnybrook Health Sciences Ct A SYSTEM AND METHOD FOR THE USE OF ULTRASOUND STIMULATED MICROBUBBLE EXPOSURES FOR THE INDUCTION OF CERAMIDA CUMULATION IN ENDOTHELIC AND TUMOR CELLS
CN103230648B (zh) * 2013-04-24 2016-09-14 重庆医科大学 低强度聚焦超声分子显像与治疗系统
US10279201B2 (en) * 2014-07-17 2019-05-07 Elwha Llc Monitoring and treating pain with epidermal electronics
CN104174027A (zh) * 2014-09-15 2014-12-03 中国科学院上海硅酸盐研究所 肿瘤血管-肿瘤细胞膜-细胞核连续靶向药物输运体系及其制备方法和应用
EP3302264B1 (en) * 2015-06-03 2025-03-19 Montefiore Medical Center Low intensity focused ultrasound for treating cancer and metastasis
GB201509935D0 (en) * 2015-06-08 2015-07-22 Globalacorn Ltd And King S College London Precision therapeutics
US20180243418A1 (en) * 2017-02-27 2018-08-30 American University Of Sharjah Systems and methods for targeted cancer therapies
CN106924186A (zh) * 2017-05-04 2017-07-07 浙江大学医学院附属邵逸夫医院 一种新型载药声敏脂质体靶向释放应用系统

Also Published As

Publication number Publication date
US11648312B2 (en) 2023-05-16
ES2989606T3 (es) 2024-11-27
WO2019123411A1 (en) 2019-06-27
EP3727585B1 (en) 2024-06-05
BR112020012452A2 (pt) 2020-11-24
CN111511440B (zh) 2022-08-23
US20210069332A1 (en) 2021-03-11
EP3727585A1 (en) 2020-10-28
JP2021507797A (ja) 2021-02-25
PL3727585T3 (pl) 2024-10-14
CN111511440A (zh) 2020-08-07
CA3122353A1 (en) 2019-06-27
US20240382595A1 (en) 2024-11-21
JP7408563B2 (ja) 2024-01-05
EP3727585C0 (en) 2024-06-05
US12397056B2 (en) 2025-08-26

Similar Documents

Publication Publication Date Title
SG10201913631TA (en) Rna for cancer therapy
ZA201806819B (en) Pharmaceutical combinations for the treatment of cancer
EP3174577A4 (en) Temporary suspension for closed-loop medicament therapy
EP3302265A4 (en) Drug delivery capsule
LT3245988T (lt) Ultragarsu pagerinto transsklerinio vaistų pristatymo sistema
PT3139986T (pt) Sistema para administração de gás terapêutico
SG11202002528SA (en) Radioactive drug
PL3338768T3 (pl) Transdermalny system terapeutyczny zawierający asenapinę
EP3148532A4 (en) Pharmaceutical combination for the treatment of cancer
PL3727585T3 (pl) System do indukowania sonoporacji leku do komórek nowotworowych
EP3389628A4 (en) PHARMACEUTICAL FORMULATIONS OF MOUSE CHEESE TABLETS
IL267622A (en) Method for modifying the therapeutic effects of drugs
EP3164121A4 (en) Combination drug therapies for cancer and methods of making and using them
EP3215213A4 (en) Microneedle arrays for cancer therapy applications
ZA201700313B (en) Affixed groups of pharmaceutical vials including frangible connectors
EP3132802A4 (en) Therapeutic agent for solid cancer
EP3263155A4 (en) Drug solution administering device
EP3281626A4 (en) Soluble microneedle for delivering poorly-soluble drug
GB201707212D0 (en) Gene therapy for ciliopathies
EP3560494A4 (en) MEDICINAL PRODUCT TARGETING A CARCINOUS STEM CELL
EP3100724A4 (en) Medicine for preventing ischemic diseases
EP3351286A4 (en) DEVICE FOR THE ADMINISTRATION OF A MEDICAMENT SOLUTION
EP3280330A4 (en) RISK ASSESSMENT OF THERAPEUTIC DRUGS
GB201522223D0 (en) Therapeutic T cells
SG11201606005TA (en) Drug delivery system