HUE066467T2 - Nukleinsav-irányított nukleázok - Google Patents
Nukleinsav-irányított nukleázokInfo
- Publication number
- HUE066467T2 HUE066467T2 HUE18821213A HUE18821213A HUE066467T2 HU E066467 T2 HUE066467 T2 HU E066467T2 HU E18821213 A HUE18821213 A HU E18821213A HU E18821213 A HUE18821213 A HU E18821213A HU E066467 T2 HUE066467 T2 HU E066467T2
- Authority
- HU
- Hungary
- Prior art keywords
- nucleic acid
- guided nucleases
- nucleases
- guided
- nucleic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/631,989 US10011849B1 (en) | 2017-06-23 | 2017-06-23 | Nucleic acid-guided nucleases |
| US15/632,001 US9982279B1 (en) | 2017-06-23 | 2017-06-23 | Nucleic acid-guided nucleases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE066467T2 true HUE066467T2 (hu) | 2024-08-28 |
Family
ID=64737785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE18821213A HUE066467T2 (hu) | 2017-06-23 | 2018-05-25 | Nukleinsav-irányított nukleázok |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP3642334B1 (hu) |
| JP (2) | JP7136816B2 (hu) |
| KR (2) | KR102558931B1 (hu) |
| CN (1) | CN111511906A (hu) |
| AU (3) | AU2018289077B2 (hu) |
| CA (1) | CA3067951A1 (hu) |
| ES (1) | ES2971549T3 (hu) |
| HU (1) | HUE066467T2 (hu) |
| IL (1) | IL271342B2 (hu) |
| MX (1) | MX2019015047A (hu) |
| NZ (1) | NZ760730A (hu) |
| RU (2) | RU2769475C2 (hu) |
| WO (1) | WO2018236548A1 (hu) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| WO2019238911A1 (en) | 2018-06-15 | 2019-12-19 | KWS SAAT SE & Co. KGaA | Methods for improving genome engineering and regeneration in plant ii |
| AU2019285083B2 (en) | 2018-06-15 | 2024-01-25 | KWS SAAT SE & Co. KGaA | Methods for improving genome engineering and regeneration in plant |
| EP3997221A4 (en) * | 2019-07-08 | 2023-07-05 | Inscripta, Inc. | INCREASED NUCLEIC ACID-DRIVEN CELL EDIT VIA A LEXA-RAD51 FUSION PROTEIN |
| CN114269941A (zh) * | 2019-09-04 | 2022-04-01 | 博雅辑因（北京）生物科技有限公司 | 基于脱靶评估评价基因编辑治疗的方法 |
| KR20250033331A (ko) * | 2019-12-10 | 2025-03-07 | 인스크립타 인코포레이티드 | 신규 mad 뉴클레아제 |
| US10704033B1 (en) * | 2019-12-13 | 2020-07-07 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US12098372B2 (en) | 2019-12-30 | 2024-09-24 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| US11746352B2 (en) | 2019-12-30 | 2023-09-05 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| US11584781B2 (en) | 2019-12-30 | 2023-02-21 | Eligo Bioscience | Chimeric receptor binding proteins resistant to proteolytic degradation |
| EP4110930A1 (en) | 2020-02-28 | 2023-01-04 | KWS SAAT SE & Co. KGaA | Method for rapid genome modification in recalcitrant plants |
| CN115605600A (zh) | 2020-02-28 | 2023-01-13 | 科沃施种子欧洲股份两合公司（De） | 未成熟花序分生组织编辑 |
| EP3922719A1 (en) | 2020-06-12 | 2021-12-15 | Eligo Bioscience | Specific decolonization of antibiotic resistant bacteria for prophylactic purposes |
| WO2022002989A1 (en) | 2020-06-29 | 2022-01-06 | KWS SAAT SE & Co. KGaA | Boosting homology directed repair in plants |
| US20230235361A1 (en) | 2020-07-03 | 2023-07-27 | Eligo Bioscience | Method of containment of nucleic acid vectors introduced in a microbiome population |
| US20240026369A1 (en) | 2020-10-27 | 2024-01-25 | KWS SAAT SE & Co. KGaA | Use of enhanced pol theta activity for eukaryotic genome engineering |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| TW202237827A (zh) | 2020-12-03 | 2022-10-01 | 美商世紀治療股份有限公司 | 經基因工程改造之細胞及其用途 |
| WO2022144382A1 (en) | 2020-12-30 | 2022-07-07 | Eligo Bioscience | Chimeric receptor binding proteins resistant to proteolytic degradation |
| EP4271805A4 (en) * | 2020-12-31 | 2025-02-12 | Gigamune, Inc. | NEW NUCLEIC ACID-GUIDED NUCLEASES |
| WO2022150269A1 (en) * | 2021-01-07 | 2022-07-14 | Inscripta, Inc. | Mad nucleases |
| CN114277015B (zh) * | 2021-03-16 | 2023-12-15 | 山东舜丰生物科技有限公司 | Crispr酶以及应用 |
| IL308147A (en) | 2021-05-12 | 2023-12-01 | Eligo Bioscience | Production of bacterial cells and their use in production methods |
| WO2022243437A1 (en) | 2021-05-19 | 2022-11-24 | KWS SAAT SE & Co. KGaA | Sample preparation with oppositely oriented guide polynucleotides |
| WO2022256440A2 (en) | 2021-06-01 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| EP4166670A1 (en) | 2021-10-18 | 2023-04-19 | KWS SAAT SE & Co. KGaA | Plant-tag-based weeding control |
| CN113846075A (zh) * | 2021-11-29 | 2021-12-28 | 科稷达隆(北京)生物技术有限公司 | Mad7-nls融合蛋白、用于植物基因组定点编辑的核酸构建物及其应用 |
| WO2023240169A1 (en) | 2022-06-08 | 2023-12-14 | Century Therapeutics, Inc. | Immunoeffector cells derived from induced pluripotent stem cells genetically engineered with membrane bound il12 and uses thereof |
| CN119630695A (zh) | 2022-06-08 | 2025-03-14 | 世纪治疗股份有限公司 | 表达cd16变体和nkg2d的遗传工程化细胞及其用途 |
| EP4580663A1 (en) | 2022-09-02 | 2025-07-09 | Janssen Biotech, Inc. | Materials and processes for engineering hypoimmunogenicity |
| WO2024062138A1 (en) | 2022-09-23 | 2024-03-28 | Mnemo Therapeutics | Immune cells comprising a modified suv39h1 gene |
| WO2024102838A1 (en) | 2022-11-09 | 2024-05-16 | Century Therapeutics, Inc. | Engineered interleukin-7 receptors and uses thereof |
| JP2025537284A (ja) | 2022-11-10 | 2025-11-14 | センチュリー セラピューティクス，インコーポレイテッド | 抗ネクチン４キメラ抗原受容体を有する遺伝子操作細胞、およびその使用 |
| WO2024173645A1 (en) | 2023-02-15 | 2024-08-22 | Arbor Biotechnologies, Inc. | Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript |
| WO2024175308A1 (en) | 2023-02-22 | 2024-08-29 | KWS SAAT SE & Co. KGaA | Plants with improved performance |
| WO2025021861A1 (en) | 2023-07-24 | 2025-01-30 | Eligo Bioscience | Detection and treatment of c. acnes bacteria-associated diseases |
| AR133438A1 (es) | 2023-08-01 | 2025-10-01 | Kws Saat Se & Co Kgaa | Método para mejorar las propiedades de gelificación de proteínas alternativas |
| AR133439A1 (es) | 2023-08-01 | 2025-10-01 | Kws Saat Se & Co Kgaa | Método para reducir los sabores desagradables en proteínas alternativas |
| WO2025132866A1 (en) | 2023-12-21 | 2025-06-26 | KWS SAAT SE & Co. KGaA | Maize plants with improved disease resistance |
| CN119432813A (zh) * | 2023-12-29 | 2025-02-14 | 武汉艾迪晶生物科技有限公司 | Cas蛋白、组合蛋白、核酸分子、核糖核蛋白复合物、重组载体、转基因细胞及其应用 |
| WO2025153582A1 (en) | 2024-01-17 | 2025-07-24 | KWS SAAT SE & Co. KGaA | Maize plants with improved disease resistance |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
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| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
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| JPH10510433A (ja) | 1995-06-06 | 1998-10-13 | アイシス・ファーマシューティカルス・インコーポレーテッド | 高いキラル純度のホスホロチオエート結合を有するオリゴヌクレオチド |
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| US9982279B1 (en) * | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
-
2018
- 2018-05-25 HU HUE18821213A patent/HUE066467T2/hu unknown
- 2018-05-25 AU AU2018289077A patent/AU2018289077B2/en active Active
- 2018-05-25 RU RU2020102451A patent/RU2769475C2/ru active
- 2018-05-25 MX MX2019015047A patent/MX2019015047A/es unknown
- 2018-05-25 ES ES18821213T patent/ES2971549T3/es active Active
- 2018-05-25 EP EP18821213.8A patent/EP3642334B1/en active Active
- 2018-05-25 NZ NZ760730A patent/NZ760730A/en unknown
- 2018-05-25 JP JP2019571011A patent/JP7136816B2/ja active Active
- 2018-05-25 KR KR1020217035078A patent/KR102558931B1/ko active Active
- 2018-05-25 EP EP21167880.0A patent/EP3916086A1/en active Pending
- 2018-05-25 WO PCT/US2018/034779 patent/WO2018236548A1/en not_active Ceased
- 2018-05-25 CA CA3067951A patent/CA3067951A1/en active Pending
- 2018-05-25 CN CN201880054732.5A patent/CN111511906A/zh active Pending
- 2018-05-25 RU RU2022103603A patent/RU2022103603A/ru unknown
- 2018-05-25 KR KR1020207002319A patent/KR102321388B1/ko active Active
-
2019
- 2019-12-11 IL IL271342A patent/IL271342B2/en unknown
-
2022
- 2022-04-04 AU AU2022202248A patent/AU2022202248B2/en active Active
- 2022-09-01 JP JP2022138875A patent/JP7577713B2/ja active Active
-
2024
- 2024-12-05 AU AU2024278142A patent/AU2024278142A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2020102451A (ru) | 2021-07-26 |
| RU2022103603A (ru) | 2022-03-11 |
| CN111511906A (zh) | 2020-08-07 |
| RU2020102451A3 (hu) | 2021-11-25 |
| KR20210132244A (ko) | 2021-11-03 |
| RU2769475C2 (ru) | 2022-04-01 |
| EP3642334A1 (en) | 2020-04-29 |
| MX2019015047A (es) | 2020-08-03 |
| JP2022169775A (ja) | 2022-11-09 |
| EP3642334B1 (en) | 2023-12-27 |
| AU2018289077B2 (en) | 2022-03-10 |
| ES2971549T3 (es) | 2024-06-05 |
| KR102321388B1 (ko) | 2021-11-03 |
| CA3067951A1 (en) | 2018-12-27 |
| EP3642334C0 (en) | 2023-12-27 |
| WO2018236548A1 (en) | 2018-12-27 |
| JP7577713B2 (ja) | 2024-11-05 |
| AU2022202248B2 (en) | 2024-09-19 |
| AU2022202248A1 (en) | 2022-04-21 |
| NZ760730A (en) | 2023-04-28 |
| IL271342A (en) | 2020-01-30 |
| JP2020530264A (ja) | 2020-10-22 |
| KR102558931B1 (ko) | 2023-07-21 |
| AU2018289077A1 (en) | 2020-01-30 |
| KR20200020903A (ko) | 2020-02-26 |
| AU2024278142A1 (en) | 2025-02-13 |
| EP3642334A4 (en) | 2021-03-24 |
| EP3916086A1 (en) | 2021-12-01 |
| IL271342B2 (en) | 2025-12-01 |
| JP7136816B2 (ja) | 2022-09-13 |
| IL271342B1 (en) | 2025-08-01 |
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