HUE056593T2 - Fuzionált pentaciklusos imidazolszármazékok mint a TNF-aktivitás modulátorai - Google Patents

Fuzionált pentaciklusos imidazolszármazékok mint a TNF-aktivitás modulátorai

Info

Publication number: HUE056593T2
Authority: HU; Hungary
Prior art keywords: modulators; imidazole derivatives; tnf activity; fused pentacyclic; pentacyclic imidazole
Prior art date: 2017-04-25

Application number

HUE18719178A

Other languages

English (en)

Inventor

Daniel Christopher Brookings

Original Assignee

UCB Biopharma SRL

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-04-25

Filing date

2018-04-24

Publication date

2022-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58632834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE056593(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2018-04-24 Application filed by UCB Biopharma SRL, Sanofi Sa filed Critical UCB Biopharma SRL

2022-02-28 Publication of HUE056593T2 publication Critical patent/HUE056593T2/hu

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HUE18719178A 2017-04-25 2018-04-24 Fuzionált pentaciklusos imidazolszármazékok mint a TNF-aktivitás modulátorai HUE056593T2 (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP17168027		2017-04-25

Publications (1)

Publication Number	Publication Date
HUE056593T2 true HUE056593T2 (hu)	2022-02-28

Family

ID=58632834

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HUE18719178A HUE056593T2 (hu)	2017-04-25	2018-04-24	Fuzionált pentaciklusos imidazolszármazékok mint a TNF-aktivitás modulátorai

Country Status (32)

Country	Link
US (4)	US10980814B2 (hu)
EP (2)	EP3615534B1 (hu)
JP (2)	JP7083358B2 (hu)
KR (1)	KR102565132B1 (hu)
CN (1)	CN110582495B (hu)
AR (1)	AR111426A1 (hu)
AU (1)	AU2018259040B2 (hu)
CA (1)	CA3058980A1 (hu)
CL (1)	CL2019002875A1 (hu)
CO (1)	CO2019012856A2 (hu)
CR (1)	CR20190526A (hu)
DK (1)	DK3615534T3 (hu)
EA (1)	EA039049B1 (hu)
ES (2)	ES2893807T3 (hu)
HR (1)	HRP20211927T1 (hu)
HU (1)	HUE056593T2 (hu)
IL (1)	IL269890B (hu)
LT (1)	LT3615534T (hu)
MA (2)	MA49055B1 (hu)
MX (1)	MX2019012443A (hu)
MY (1)	MY197212A (hu)
PE (1)	PE20200662A1 (hu)
PH (1)	PH12019502182B1 (hu)
PL (2)	PL3615534T3 (hu)
PT (2)	PT3939980T (hu)
RS (1)	RS62596B1 (hu)
SG (1)	SG11201908871SA (hu)
SI (1)	SI3615534T1 (hu)
TW (1)	TWI801378B (hu)
UY (1)	UY37700A (hu)
WO (1)	WO2018197503A1 (hu)
ZA (1)	ZA201906255B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA201892144A1 (ru) *	2016-04-01	2019-04-30	Юсб Байофарма Спрл	Конденсированные гексациклические производные имидазола в качестве модуляторов активности tnf
EP4467565A3 (en)	2016-12-21	2025-03-12	Amgen Inc.	Anti-tnf alpha antibody formulations
ES2951837T3 (es) *	2018-10-24	2023-10-25	UCB Biopharma SRL	Derivados de imidazol pentacíclicos condensados como moduladores de la actividad de TNF
US12384808B2 (en)	2022-11-23	2025-08-12	Forward Therapeutics, Inc.	Modulators of TNF-α activity
CN121038791A (zh)	2023-04-26	2025-11-28	赛诺菲	使用肿瘤坏死因子α的小分子抑制剂治疗银屑病
TW202513567A (zh) *	2023-06-09	2025-04-01	大陸商上海翰森生物醫藥科技有限公司	五環類衍生物抑制劑、其製備方法與應用
WO2025008402A1 (en)	2023-07-04	2025-01-09	Sanofi	Crystalline form
TW202521544A (zh)	2023-08-16	2025-06-01	美商雷瑟拉股份有限公司	TNFα活性調節劑及其用途
WO2025068505A1 (en)	2023-09-29	2025-04-03	Sanofi	Preparation of bridged pentacyclic imidazole derivatives as modulators of tnf activity, intermeditates and their preparation
WO2025201449A1 (zh) *	2024-03-27	2025-10-02	海思科医药集团股份有限公司	一种杂环衍生物及其在医药上的应用
WO2025218735A1 (zh) *	2024-04-17	2025-10-23	上海翰森生物医药科技有限公司	五环类衍生物抑制剂、其制备方法和应用
WO2025247401A1 (zh) *	2024-05-31	2025-12-04	海思科医药集团股份有限公司	一种稠合杂环衍生物及其在医药上的应用
WO2025252251A1 (zh) *	2024-06-07	2025-12-11	上海翰森生物医药科技有限公司	含氧杂环类衍生物抑制剂、其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR201807207T4 (tr) *	2012-06-11	2018-06-21	Ucb Biopharma Sprl	Tnf-alfa modüle edici benzimidazol bileşikleri.
CN104619709B (zh) *	2012-07-13	2016-11-09	Ucb生物制药私人有限公司	作为tnf活性调节剂的咪唑并吡啶衍生物
GB201212513D0 (en) *	2012-07-13	2012-08-29	Ucb Pharma Sa	Therapeutic agents
GB201321728D0 (en)	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
CR20170167A (es) *	2014-10-03	2017-08-10	Sanofi Sa	Derivados de imidazol pentacíclicos fusionados
US9856253B2 (en)	2015-04-17	2018-01-02	Abbvie, Inc.	Tricyclic modulators of TNF signaling

2018
- 2018-04-24 CN CN201880025894.6A patent/CN110582495B/zh active Active
- 2018-04-24 ES ES18719178T patent/ES2893807T3/es active Active
- 2018-04-24 WO PCT/EP2018/060489 patent/WO2018197503A1/en not_active Ceased
- 2018-04-24 EP EP18719178.8A patent/EP3615534B1/en active Active
- 2018-04-24 PL PL18719178T patent/PL3615534T3/pl unknown
- 2018-04-24 TW TW107113777A patent/TWI801378B/zh active
- 2018-04-24 MX MX2019012443A patent/MX2019012443A/es unknown
- 2018-04-24 PH PH1/2019/502182A patent/PH12019502182B1/en unknown
- 2018-04-24 EP EP21189378.9A patent/EP3939980B1/en active Active
- 2018-04-24 PT PT211893789T patent/PT3939980T/pt unknown
- 2018-04-24 PE PE2019002028A patent/PE20200662A1/es unknown
- 2018-04-24 SI SI201830491T patent/SI3615534T1/sl unknown
- 2018-04-24 CR CR20190526A patent/CR20190526A/es unknown
- 2018-04-24 SG SG11201908871S patent/SG11201908871SA/en unknown
- 2018-04-24 MY MYPI2019005903A patent/MY197212A/en unknown
- 2018-04-24 EA EA201992407A patent/EA039049B1/ru unknown
- 2018-04-24 KR KR1020197034032A patent/KR102565132B1/ko active Active
- 2018-04-24 LT LTEPPCT/EP2018/060489T patent/LT3615534T/lt unknown
- 2018-04-24 MA MA49055A patent/MA49055B1/fr unknown
- 2018-04-24 JP JP2019556874A patent/JP7083358B2/ja active Active
- 2018-04-24 DK DK18719178.8T patent/DK3615534T3/da active
- 2018-04-24 US US16/497,217 patent/US10980814B2/en active Active
- 2018-04-24 ES ES21189378T patent/ES2956555T3/es active Active
- 2018-04-24 RS RS20211403A patent/RS62596B1/sr unknown
- 2018-04-24 PL PL21189378.9T patent/PL3939980T3/pl unknown
- 2018-04-24 HR HRP20211927TT patent/HRP20211927T1/hr unknown
- 2018-04-24 HU HUE18719178A patent/HUE056593T2/hu unknown
- 2018-04-24 CA CA3058980A patent/CA3058980A1/en active Pending
- 2018-04-24 PT PT187191788T patent/PT3615534T/pt unknown
- 2018-04-24 AU AU2018259040A patent/AU2018259040B2/en active Active
- 2018-04-25 AR ARP180101067A patent/AR111426A1/es unknown
- 2018-04-25 UY UY0001037700A patent/UY37700A/es not_active Application Discontinuation
- 2018-08-24 MA MA57699A patent/MA57699B1/fr unknown
2019
- 2019-09-20 ZA ZA2019/06255A patent/ZA201906255B/en unknown
- 2019-10-07 IL IL269890A patent/IL269890B/en unknown
- 2019-10-09 CL CL2019002875A patent/CL2019002875A1/es unknown
- 2019-11-18 CO CONC2019/0012856A patent/CO2019012856A2/es unknown
2021
- 2021-02-15 US US17/176,018 patent/US20210252012A1/en not_active Abandoned
2022
- 2022-05-31 JP JP2022088172A patent/JP7299382B2/ja active Active
2023
- 2023-02-27 US US18/175,030 patent/US20230250105A1/en not_active Abandoned
2024
- 2024-08-29 US US18/819,527 patent/US20250127795A1/en active Pending

Also Published As

Publication number	Publication date
SG11201908871SA (en)	2019-10-30
DK3615534T3 (da)	2021-10-18
EA201992407A1 (ru)	2020-04-06
US10980814B2 (en)	2021-04-20
WO2018197503A1 (en)	2018-11-01
MA49055A (fr)	2021-05-05
AU2018259040B2 (en)	2022-04-28
BR112019020314A2 (pt)	2020-04-28
CN110582495B (zh)	2022-04-01
UY37700A (es)	2018-11-30
CL2019002875A1 (es)	2020-03-06
CN110582495A (zh)	2019-12-17
KR20190141200A (ko)	2019-12-23
JP2020517637A (ja)	2020-06-18
CO2019012856A2 (es)	2020-01-17
PT3939980T (pt)	2023-08-07
EP3939980A1 (en)	2022-01-19
HRP20211927T1 (hr)	2022-03-18
JP2022116233A (ja)	2022-08-09
EA039049B1 (ru)	2021-11-26
MA57699B1 (fr)	2023-11-30
EP3939980B1 (en)	2023-07-26
MY197212A (en)	2023-06-01
PH12019502182A1 (en)	2020-06-08
PT3615534T (pt)	2021-10-21
PL3615534T3 (pl)	2022-01-31
PL3939980T3 (pl)	2024-02-05
US20230250105A1 (en)	2023-08-10
MA49055B1 (fr)	2021-12-31
US20200046723A1 (en)	2020-02-13
JP7083358B2 (ja)	2022-06-10
IL269890B (en)	2022-03-01
AR111426A1 (es)	2019-07-10
ES2893807T3 (es)	2022-02-10
CR20190526A (es)	2020-01-07
AU2018259040A1 (en)	2019-10-31
TW201841918A (zh)	2018-12-01
SI3615534T1 (sl)	2022-01-31
RS62596B1 (sr)	2021-12-31
PH12019502182B1 (en)	2024-01-31
LT3615534T (lt)	2021-11-25
JP7299382B2 (ja)	2023-06-27
MX2019012443A (es)	2020-01-13
EP3615534B1 (en)	2021-09-15
US20250127795A1 (en)	2025-04-24
ES2956555T3 (es)	2023-12-22
TWI801378B (zh)	2023-05-11
NZ758198A (en)	2024-01-26
US20210252012A1 (en)	2021-08-19
CA3058980A1 (en)	2018-11-01
EP3615534A1 (en)	2020-03-04
KR102565132B1 (ko)	2023-08-08
ZA201906255B (en)	2021-01-27
PE20200662A1 (es)	2020-06-11

Publication	Publication Date	Title
IL269890B (en)	2022-03-01	Condensed pentacyclic imidazole derivatives as modulators of tnf activity
PT3870586T (pt)	2023-07-19	Derivados de imidazole pentacíclico fundido como moduladores da atividade do tnf
EP3383386B8 (en)	2024-03-20	Modulators of chemokine receptors
ZA201701946B (en)	2018-07-25	Fused pentacyclic imidazole derivatives
ZA201800716B (en)	2019-07-31	Heterocyclic compounds useful as modulators of tnf alpha
EP3408268B8 (en)	2023-12-06	Benzimidazole derivatives as modulators of ror-gamma
IL267993A (en)	2019-09-26	Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation
PL3585791T3 (pl)	2025-03-17	Nowe pochodne bicyklicznego pirazolu
IL247705B (en)	2020-03-31	History of azaindole acetic acid and their use as prostaglandin d2 receptor modulators
IL255420A0 (en)	2017-12-31	Selective modulators of gpr55 receptor activity: chromopyrazole derivatives
IL274231A (en)	2020-06-30	Modulators of ENAC expression
IL275127A (en)	2020-07-30	Glycosidic antecedents of treprostinil
HK40037114A (en)	2021-06-04	Modulators of enac expression
HK40017959A (en)	2020-09-25	Stable modulators of gamma-c-cytokine activity
PT3201196T (pt)	2021-09-02	Derivados de imidazol pentacíclicos fusionados
HK40003043A (en)	2020-04-03	Constitutively active cytokine receptors for cell therapy
ZA201704416B (en)	2019-06-26	Heterocyclylalkyne derivatives and their use as modulators of mglur5 receptors
HK40001214A (en)	2020-02-21	Benzimidazole derivatives as modulators of ror-gamma
HK1242301A1 (en)	2018-06-22	Heterocyclylalkyne derivatives and their use as modulators of mglur5 receptors