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HUE055634T2 - Dopamin D3 receptor szelektív antagonisták/részleges antagonisták; eljárás azok elõállítására; és alkalmazásuk - Google Patents

Dopamin D3 receptor szelektív antagonisták/részleges antagonisták; eljárás azok elõállítására; és alkalmazásuk

Info

Publication number
HUE055634T2
HUE055634T2 HUE17711971A HUE17711971A HUE055634T2 HU E055634 T2 HUE055634 T2 HU E055634T2 HU E17711971 A HUE17711971 A HU E17711971A HU E17711971 A HUE17711971 A HU E17711971A HU E055634 T2 HUE055634 T2 HU E055634T2
Authority
HU
Hungary
Prior art keywords
dopamine
making
partial agonists
selective antagonists
receptor selective
Prior art date
Application number
HUE17711971A
Other languages
English (en)
Inventor
Amy Hauck Newman
Vivek Kumar
Anver Basha Shaik
Original Assignee
The United States Of America As Represented By
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America As Represented By filed Critical The United States Of America As Represented By
Publication of HUE055634T2 publication Critical patent/HUE055634T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE17711971A 2016-03-14 2017-03-08 Dopamin D3 receptor szelektív antagonisták/részleges antagonisták; eljárás azok elõállítására; és alkalmazásuk HUE055634T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662307600P 2016-03-14 2016-03-14

Publications (1)

Publication Number Publication Date
HUE055634T2 true HUE055634T2 (hu) 2021-12-28

Family

ID=58358971

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17711971A HUE055634T2 (hu) 2016-03-14 2017-03-08 Dopamin D3 receptor szelektív antagonisták/részleges antagonisták; eljárás azok elõállítására; és alkalmazásuk

Country Status (13)

Country Link
US (1) US12162861B2 (hu)
EP (2) EP3848351B1 (hu)
AU (1) AU2017233716B2 (hu)
CA (1) CA3017342A1 (hu)
DK (1) DK3429993T3 (hu)
ES (1) ES2881267T3 (hu)
HR (1) HRP20211182T1 (hu)
HU (1) HUE055634T2 (hu)
PL (1) PL3429993T3 (hu)
PT (1) PT3429993T (hu)
RS (1) RS62156B1 (hu)
SI (1) SI3429993T1 (hu)
WO (1) WO2017160552A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3111785A1 (en) 2018-09-11 2020-03-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3 receptor selective antagonists/partial agonists and uses thereof
US20240336604A1 (en) * 2021-08-03 2024-10-10 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services D3 dopamine receptor-selective negative allosteric modulators
CN114409621B (zh) * 2022-02-09 2023-09-08 江苏省原子医学研究所 一种靶向多巴胺d3受体的诊疗药物及其应用
US20250206702A1 (en) * 2022-03-30 2025-06-26 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Synthesis of dopamine d3 receptor selective antagonists/partial agonists
WO2025006982A1 (en) * 2023-06-30 2025-01-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Potent and selective dopamine d3 receptor antagonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710274A (en) 1996-02-28 1998-01-20 Neurogen Corporation N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands
US5763609A (en) 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5892041A (en) 1996-08-12 1999-04-06 Neurogen Corporation Fused indolecarboxamides: dopamine receptor subtype specific ligands
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
US20050197343A1 (en) 2002-07-04 2005-09-08 Peter Gmeiner Utilization of heteroarene carboxamide as dopamine-d3 ligands for the treatment of cns diseases
AU2003267201B2 (en) 2002-09-14 2009-04-23 The Gov't Of The U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services Structurally rigid dopamine D3 receptor selective ligands and process for making them
US20080051409A1 (en) 2004-08-02 2008-02-28 Peter Gmeiner Indolizine Carboxamides and Aza and Diaza Derivatives Thereof
DE102004054634A1 (de) 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
WO2006072608A2 (en) 2005-01-03 2006-07-13 Universitá Degli Studi Di Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
FR2903986A1 (fr) 2006-07-21 2008-01-25 Pierre Fabre Medicament Sa Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique
US8748608B2 (en) 2007-06-15 2014-06-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 4-phenylpiperazine derivatives with functionalized linkers as dopamine D3 receptor selective ligands and methods of use
DK2906221T3 (da) * 2012-10-11 2019-07-22 Southern Res Inst Urinstof og amidderivater af aminoalkylpiperaziner og anvendelse deraf
CA3111785A1 (en) 2018-09-11 2020-03-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3 receptor selective antagonists/partial agonists and uses thereof

Also Published As

Publication number Publication date
WO2017160552A1 (en) 2017-09-21
PL3429993T3 (pl) 2021-11-15
ES2881267T3 (es) 2021-11-29
EP3429993A1 (en) 2019-01-23
US12162861B2 (en) 2024-12-10
EP3429993B1 (en) 2021-05-26
AU2017233716B2 (en) 2020-10-29
CA3017342A1 (en) 2017-09-21
EP3848351B1 (en) 2025-01-15
SI3429993T1 (sl) 2021-09-30
DK3429993T3 (da) 2021-08-09
EP3848351A1 (en) 2021-07-14
RS62156B1 (sr) 2021-08-31
AU2017233716A1 (en) 2018-10-04
HRP20211182T1 (hr) 2021-10-15
US20220185798A1 (en) 2022-06-16
PT3429993T (pt) 2021-07-19

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