[go: up one dir, main page]

HUE053571T2 - Fluid mixing and delivery in microfluidic systems - Google Patents

Fluid mixing and delivery in microfluidic systems

Info

Publication number
HUE053571T2
HUE053571T2 HUE10788178A HUE10788178A HUE053571T2 HU E053571 T2 HUE053571 T2 HU E053571T2 HU E10788178 A HUE10788178 A HU E10788178A HU E10788178 A HUE10788178 A HU E10788178A HU E053571 T2 HUE053571 T2 HU E053571T2
Authority
HU
Hungary
Prior art keywords
delivery
fluid mixing
microfluidic systems
microfluidic
systems
Prior art date
Application number
HUE10788178A
Other languages
Hungarian (hu)
Inventor
Enqing Tan
Vincent Linder
Jason Taylor
David Steinmiller
Original Assignee
Opko Diagnostics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opko Diagnostics Llc filed Critical Opko Diagnostics Llc
Publication of HUE053571T2 publication Critical patent/HUE053571T2/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0684Venting, avoiding backpressure, avoid gas bubbles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0694Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/0318Processes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/0318Processes
    • Y10T137/0324With control of flow by a condition or characteristic of a fluid
    • Y10T137/0329Mixing of plural fluids of diverse characteristics or conditions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/86292System with plural openings, one a gas vent or access opening
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/87571Multiple inlet with single outlet
    • Y10T137/87652With means to promote mixing or combining of plural fluids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Accessories For Mixers (AREA)
  • Multiple-Way Valves (AREA)
HUE10788178A 2009-11-24 2010-11-24 Fluid mixing and delivery in microfluidic systems HUE053571T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26398109P 2009-11-24 2009-11-24

Publications (1)

Publication Number Publication Date
HUE053571T2 true HUE053571T2 (en) 2021-07-28

Family

ID=43430651

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE10788178A HUE053571T2 (en) 2009-11-24 2010-11-24 Fluid mixing and delivery in microfluidic systems

Country Status (17)

Country Link
US (8) US8567425B2 (en)
EP (1) EP2504105B1 (en)
JP (2) JP5977674B2 (en)
CN (1) CN102740975B (en)
BR (1) BR112012012512A2 (en)
CL (1) CL2012001340A1 (en)
CO (1) CO6541593A2 (en)
DK (1) DK2504105T3 (en)
EA (1) EA024999B1 (en)
ES (1) ES2859481T3 (en)
HU (1) HUE053571T2 (en)
MX (2) MX336714B (en)
PE (1) PE20130172A1 (en)
PL (1) PL2504105T3 (en)
PT (1) PT2504105T (en)
UA (2) UA120744C2 (en)
WO (1) WO2011066361A1 (en)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102357352B (en) 2004-01-26 2015-08-12 哈佛大学 Fluid delivery system and method
EP2285491A1 (en) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
JP5609648B2 (en) * 2008-11-26 2014-10-22 住友ベークライト株式会社 Microchannel device
MX336714B (en) 2009-11-24 2016-01-28 Opko Diagnostics Llc Fluid mixing and delivery in microfluidic systems.
BR112012026406B1 (en) 2010-04-16 2020-06-09 Opko Diagnostics Llc method of conducting quality control to determine abnormalities in the operation of a microfluidic system
WO2012096480A2 (en) * 2011-01-10 2012-07-19 Lg Electronics Inc. Diagnostic cartridge and control method for diagnostic cartridge
US8871500B2 (en) * 2011-01-21 2014-10-28 Innovative Micro Technology MEMS particle sorting actuator and method of manufacturing
KR101193566B1 (en) * 2011-08-10 2012-10-22 고려대학교 산학협력단 Apparatus of platelet multi-function analysis based on micro-chip
US11389800B2 (en) 2011-09-28 2022-07-19 President And Fellows Of Harvard College Systems and methods for droplet production and/or fluidic manipulation
US9475013B2 (en) 2012-02-08 2016-10-25 President And Fellows Of Harvard College Droplet formation using fluid breakup
WO2013183013A1 (en) * 2012-06-06 2013-12-12 De Oliva Novo Pedro Jose Autonomous and programmable sequential flow of solutions in capillary microfluidics
CN102886280B (en) * 2012-08-28 2014-06-11 博奥生物有限公司 Microfluidic chip and application thereof
GB201216454D0 (en) * 2012-09-14 2012-10-31 Carclo Technical Plastics Ltd Sample metering device
GB201219014D0 (en) * 2012-10-23 2012-12-05 Cambridge Entpr Ltd Fluidic device
EP2969156B1 (en) 2013-03-13 2019-04-10 Opko Diagnostics, LLC Mixing of fluids in fluidic systems
US9138746B2 (en) 2013-05-01 2015-09-22 Honeywell International Inc. Fluid stop for measured sample containment
CN103332663B (en) * 2013-07-08 2015-06-17 南京理工大学 Microfluidics-based initiating explosive synthesis system and method thereof
US9440233B2 (en) * 2013-08-09 2016-09-13 Shark Kabushiki Kaisha Microfluidic device for serial fluidic operations
WO2015099162A1 (en) * 2013-12-26 2015-07-02 京セラ株式会社 Liquid specimen sensor, liquid specimen sensor unit, and liquid specimen testing method
WO2015183871A1 (en) * 2014-05-27 2015-12-03 Illumina, Inc. Systems and methods for biochemical analysis including a base instrument and a removable cartridge
US10279345B2 (en) 2014-12-12 2019-05-07 Opko Diagnostics, Llc Fluidic systems comprising an incubation channel, including fluidic systems formed by molding
JP6764870B2 (en) 2015-02-24 2020-10-07 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア Continuous flow microfluidic system
JP2018525209A (en) * 2015-04-28 2018-09-06 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア Disposable microfluidic cartridge
CN107405633A (en) * 2015-05-22 2017-11-28 香港科技大学 Drop generator for inducing generation of drops based on high aspect ratio
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
US10022720B2 (en) 2015-06-12 2018-07-17 Cytochip Inc. Fluidic units and cartridges for multi-analyte analysis
WO2017001436A1 (en) * 2015-06-29 2017-01-05 Imec Vzw Valve-less mixing method and mixing device
CN108027310B (en) 2015-07-14 2020-12-22 芯易诊有限公司 Volume Sensing in Fluid Cartridges
US11491482B2 (en) * 2015-07-17 2022-11-08 Delta Electronics, Inc. Method for extracting nucleic acid and extraction cassette thereof
EP3325157A4 (en) * 2015-07-24 2018-12-12 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
US9956557B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: microwell plate interface
US9733239B2 (en) 2015-07-24 2017-08-15 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
US9956558B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
JPWO2017056748A1 (en) * 2015-09-28 2018-07-19 Phcホールディングス株式会社 Sensor for analyzing analyte and method for analyzing analyte
JP6989496B2 (en) 2015-10-16 2022-01-05 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーOpko Diagnostics, Llc Articles and methods for preparing the surface to obtain a patient's sample
US10852310B2 (en) 2015-12-11 2020-12-01 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
AU2016381254B2 (en) 2015-12-29 2022-04-21 Opko Diagnostics, Llc Fluid collection device and related methods
US10913648B2 (en) 2016-01-04 2021-02-09 Micro Infinity Flow, Llc Motor and pump system
JP7349788B2 (en) 2016-01-06 2023-09-25 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア Branch mixer and its use and manufacturing method
US20190329240A1 (en) * 2016-02-17 2019-10-31 Hitachi High-Technologies Corporation Analysis Apparatus
CN106226545B (en) * 2016-07-06 2017-12-22 苏州大学 Microfluidic three-dimensional chip with programmable sample introduction function
USD812766S1 (en) * 2016-07-12 2018-03-13 EMULATE, Inc. Microfluidic chip for use with a fluid perfusion module
CN106119085B (en) * 2016-08-23 2018-12-11 闫维新 A kind of real-time fluorescence PCR mixing microchannel chip
CA3032062A1 (en) * 2016-08-30 2018-03-08 Bracco Suisse Sa Preparation of size-controlled microparticles
USD816861S1 (en) * 2016-09-07 2018-05-01 EMULATE, Inc. Transparent microfluidic chip without pressure features for use with a fluid perfusion module
USD842493S1 (en) * 2016-09-07 2019-03-05 EMULATE, Inc. Microfluidic chip without pressure features for use with a fluid perfusion module
JP6884562B2 (en) * 2016-11-30 2021-06-09 シスメックス株式会社 Specimen processing method and sample processing equipment
EP3558524A1 (en) * 2016-12-22 2019-10-30 IMEC vzw A microfluidic device for sorting out droplets
GB201704747D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Reagent mixing system and methods
GB201704758D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Reagent channel mixing systema and method
CN108339578B (en) * 2017-01-25 2020-07-07 清华大学 Droplet sampler and droplet sampling method using the same
WO2018148498A1 (en) 2017-02-09 2018-08-16 Karcher North America, Inc. Floor cleaning device with disinfection capabilities
CN106824006B (en) * 2017-02-16 2018-09-04 中国科学院半导体研究所 A kind of more reagent sequence feeding devices preventing cross contamination
WO2018160175A1 (en) * 2017-03-01 2018-09-07 Ubidia Fernando A Motor and pump system
EP3583228A4 (en) 2017-04-07 2020-04-01 Hewlett-Packard Development Company, L.P. MICROFLUIDIC DEVICES
US11364498B2 (en) 2017-04-07 2022-06-21 Hewlett-Packard Development Company, L.P. Microfluidic devices
WO2018220742A1 (en) * 2017-05-31 2018-12-06 株式会社島津製作所 Sample plate for pesi ion source and mass spectrometer using said sample plate
US10753954B2 (en) 2017-07-11 2020-08-25 International Business Machines Corporation Vacuum-driven microfluidic probes
CN107376750A (en) * 2017-08-03 2017-11-24 青岛科技大学 A kind of micro-fluid chip that can be achieved efficiently to mix
US11491487B2 (en) 2017-10-23 2022-11-08 Cytochip Inc. Devices and methods for measuring analytes and target particles
JP6950956B2 (en) * 2017-12-28 2021-10-13 国立研究開発法人産業技術総合研究所 Assay device
US11376589B2 (en) 2018-04-30 2022-07-05 Protein Fluidics, Inc. Valveless fluidic switching flowchip and uses thereof
US10898871B2 (en) 2018-07-02 2021-01-26 International Business Machines Corporation Micro electrical mechanical system (MEMS) multiplexing mixing
JP7143257B2 (en) * 2018-07-12 2022-09-28 株式会社神戸製鋼所 Reactor and reactor system with the same
CN108977358B (en) * 2018-07-13 2022-03-25 广州诺诚生物制品股份有限公司 Closed bioreactor and cell culture method thereof
US11331674B2 (en) * 2019-04-29 2022-05-17 Hach Company Liquid mixing
KR102416982B1 (en) * 2019-05-24 2022-07-06 주식회사 앱솔로지 Rapid kit comprising icrofluidic device with intermediate venthole
CN112403539A (en) * 2019-08-23 2021-02-26 无锡源清天木生物科技有限公司 Micro-fluidic chip
CN114430773B (en) * 2019-09-25 2024-08-02 豪夫迈·罗氏有限公司 Interface for automated fluid injection
JP7164505B2 (en) * 2019-10-02 2022-11-01 積水化学工業株式会社 microfluidic chip
WO2021090745A1 (en) * 2019-11-08 2021-05-14 積水化学工業株式会社 Sample collection method and inspection chip
WO2021094585A1 (en) * 2019-11-15 2021-05-20 miDiagnostics NV Pressure-assisted flow in a microfluidic system
EP4065973B1 (en) * 2019-11-27 2024-11-13 Waters Technologies Corporation Active dampening gradient proportioning valve for liquid chromatography, associated method of mixing fluid in liquid chromatography and associated liquid chromatography system
KR102363459B1 (en) * 2019-12-31 2022-02-15 한국과학기술원 Modular micro-fluidic chip and method for controlling micro-fluid using the same
CN116887910A (en) * 2020-11-30 2023-10-13 精密纳米系统无限责任公司 Non-aggregating microfluidic mixer and methods therefor
GB202105032D0 (en) * 2021-04-08 2021-05-26 Kromek Ltd Microfludic system and method
CN216663090U (en) * 2021-05-21 2022-06-03 广州万孚生物技术股份有限公司 Card box and detection equipment
KR102704928B1 (en) * 2021-08-25 2024-09-10 한국기계연구원 Microfluidic device being capable of initiating flow sequentially from multiple reservoirs
CN113634294A (en) * 2021-08-27 2021-11-12 江苏溢康辰医疗科技有限公司 Active bidirectional microfluidic structure and application method thereof
US12415183B1 (en) * 2021-12-09 2025-09-16 Amazon Technologies, Inc. Microfluidic systems and methods
CN116408155A (en) * 2021-12-29 2023-07-11 洛阳华清天木生物科技有限公司 A method for avoiding droplet fusion in a microfluidic system
WO2025005221A1 (en) * 2023-06-29 2025-01-02 国立大学法人大阪大学 Apparatus and method for manufacturing composite
EP4603186A1 (en) * 2024-02-16 2025-08-20 Innotive Diagnostics Limited Sample cartridge
FR3159804A1 (en) * 2024-03-04 2025-09-05 Commissariat A L' Energie Atomique Et Aux Energies Alternatives Method for analyzing a biological object, implemented within a microfluidic perfusion system.
GB202403476D0 (en) * 2024-03-11 2024-04-24 Panacea Diagnostics Ltd Improvements in or relating to control of a combined sample collection and filtration device
WO2025197314A1 (en) * 2024-03-19 2025-09-25 パナソニックIpマネジメント株式会社 Production apparatus

Family Cites Families (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2374921A (en) * 1941-08-18 1945-05-01 E J Gray And Arthur M Smith Photographic developer
US3394005A (en) * 1964-10-16 1968-07-23 Du Pont Increased development rate of photosoluble silver halide emulsions by the action of water-soluble iodide
US3735640A (en) 1972-03-10 1973-05-29 L Chizhov Apparatus for injecting a sample into a gas chromatograph
US4318994A (en) 1979-08-30 1982-03-09 Mcdonnell Douglas Corporation Enterobacteriaceae species biochemical test card
US4517302A (en) 1982-11-15 1985-05-14 Technicon Instruments Corporation Continuous flow metering apparatus
CA1211157A (en) 1982-11-22 1986-09-09 Richard L. Columbus Capillary transport device having means for increasing the viscosity of the transported liquid
JPS627664U (en) * 1985-06-26 1987-01-17
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4761381A (en) * 1985-09-18 1988-08-02 Miles Inc. Volume metering capillary gap device for applying a liquid sample onto a reactive surface
JPS6276664U (en) 1985-11-01 1987-05-16
US5051237A (en) 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
JPH02176466A (en) 1988-12-27 1990-07-09 Mochida Pharmaceut Co Ltd Method and instrument for measuring specified material in liquid specimen
US5286454A (en) 1989-04-26 1994-02-15 Nilsson Sven Erik Cuvette
GB8915512D0 (en) 1989-07-06 1989-08-23 Sec Dep For Health Silver enhanced gold-labelled immuno assay method
US6176962B1 (en) 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
SE470347B (en) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure for fluid flow systems and process for manufacturing such a system
US5268147A (en) * 1992-02-26 1993-12-07 Miles, Inc. Reversible direction capsule chemistry sample liquid analysis system and method
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US5205322A (en) * 1992-06-17 1993-04-27 Puritan-Bennett Corporation Method and apparatus for flow control for sensor calibration
CA2105515A1 (en) 1993-09-03 1995-03-04 Carlos A. Santizo Lescaille Visual immunoassay method for the detection of ligands, based on the use of opaque plastic supports
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US20040077074A1 (en) 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US5478751A (en) 1993-12-29 1995-12-26 Abbott Laboratories Self-venting immunodiagnositic devices and methods of performing assays
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
EP0739240B1 (en) 1994-11-14 2004-06-16 The Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5580689A (en) 1994-12-09 1996-12-03 Xerox Corporation Migration imaging members
US5731212A (en) 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
GB9502112D0 (en) 1995-02-03 1995-03-22 British Biocell Int Assay device and method
US5582960A (en) 1995-02-17 1996-12-10 Eastman Kodak Company Photographic print material
US5594047A (en) 1995-02-17 1997-01-14 Eastman Kodak Company Method for forming photographic dispersions comprising loaded latex polymers
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
EP0839337B1 (en) 1995-07-18 2002-05-22 Agfa-Gevaert Photothermographic recording material
US5972556A (en) 1995-09-14 1999-10-26 Agfa-Gevaert N.V. Thermographic and photothermographic materials for producing lithographic printing elements and processes therefor
US6911183B1 (en) 1995-09-15 2005-06-28 The Regents Of The University Of Michigan Moving microdroplets
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US6709869B2 (en) 1995-12-18 2004-03-23 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US5968714A (en) 1996-03-14 1999-10-19 Agfa-Gevaert Sensitivity-increasing recording process for a photosensitive thermally developable photographic material
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
CA2253710A1 (en) 1996-04-25 1997-10-30 Spectrametrix Inc. Analyte assay using particulate labels
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
EP0909385B1 (en) 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Method of transporting fluid samples within a microfluidic channel
JP3834357B2 (en) * 1996-07-10 2006-10-18 オリンパス株式会社 Compact analyzer and driving method thereof
US5876915A (en) 1996-07-24 1999-03-02 Agfa-Gevaert Photothermographic recording material comprising sensitizing dyes and a recording process therefor
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
ES2181028T3 (en) * 1996-09-16 2003-02-16 Alphahelix Ab CARTRIDGE AND SYSTEM TO STORE AND DISTRIBUTE REAGENTS.
WO1998028623A1 (en) 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US6632619B1 (en) 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
WO1998056956A1 (en) 1997-06-09 1998-12-17 Caliper Technologies Corporation Apparatus and methods for correcting for variable velocity in microfluidic systems
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US20020092767A1 (en) 1997-09-19 2002-07-18 Aclara Biosciences, Inc. Multiple array microfluidic device units
US6136272A (en) 1997-09-26 2000-10-24 University Of Washington Device for rapidly joining and splitting fluid layers
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
WO1999025475A1 (en) 1997-11-19 1999-05-27 Peter Miethe Device for sequential discharge of flowable reagents
US6100541A (en) 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6794197B1 (en) 1998-07-14 2004-09-21 Zyomyx, Inc. Microdevice and method for detecting a characteristic of a fluid
US6333200B1 (en) 1998-07-27 2001-12-25 University Of Delaware Miniaturized immunosensor assembled from colloidal particles between micropatterned electrodes
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
US6168048B1 (en) * 1998-09-22 2001-01-02 American Air Liquide, Inc. Methods and systems for distributing liquid chemicals
UA67804C2 (en) 1998-10-02 2004-07-15 Роналд Нортедж Valve
KR20010089295A (en) 1998-10-13 2001-09-29 마이클 알. 맥닐리 Fluid circuit components based upon passive fluid dynamics
US6146489A (en) 1998-11-19 2000-11-14 General Electric Company Method and apparatus for depositing scintillator material on radiation imager
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US20020019059A1 (en) 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
US6297020B1 (en) 1999-03-01 2001-10-02 Bayer Corporation Device for carrying out lateral-flow assays involving more than one analyte
US6677111B1 (en) 1999-03-26 2004-01-13 Fuji Photo Film Co., Ltd. Silver halide emulsion, production process thereof, and silver halide photographic light-sensitive material and photothermographic material using the same
JP3985884B2 (en) 1999-04-12 2007-10-03 富士フイルム株式会社 Thermally developed image recording material
JP2000323241A (en) 1999-05-12 2000-11-24 Honda Tsushin Kogyo Co Ltd connector
EP1054259A1 (en) 1999-05-19 2000-11-22 Remacle, José Method for the identification of a target compound
KR100677860B1 (en) 1999-07-23 2007-02-05 보드 오브 트러스티스 오브 유니버스티 오브 일리노이즈 Finely manufactured device and manufacturing method thereof
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6906797B1 (en) 1999-09-13 2005-06-14 Aclara Biosciences, Inc. Side light activated microfluid channels
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6620625B2 (en) 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
JP4733331B2 (en) 2000-03-14 2011-07-27 マイクロニックス、インコーポレーテッド Microfluidic analysis device
CN1218037C (en) 2000-03-31 2005-09-07 佐佐木康晴 Firmicutes and production method thereof
US20050118073A1 (en) 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
AU2001252973A1 (en) 2000-04-17 2001-10-30 Purdue Research Foundation Biosensor and related method
CA2406718A1 (en) 2000-05-11 2001-11-15 Caliper Technologies Corp. Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
US8383043B2 (en) 2004-05-14 2013-02-26 Honeywell International Inc. Analyzer system
US20030118486A1 (en) 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
US7277166B2 (en) 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US20020142618A1 (en) 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US6794123B2 (en) 2000-09-11 2004-09-21 Agfa-Gevaert Aqueous dispersion comprising photosensitive silver halide and a substantially light-insensitive silver salt of an organic carboxylic acid
GB2366529A (en) 2000-09-11 2002-03-13 Univ Sheffield Fluidic control valve for an assembly containing a plurality of microreactors
WO2002023167A1 (en) * 2000-09-11 2002-03-21 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
AU2002213423B2 (en) 2000-09-18 2007-09-06 President And Fellows Of Harvard College Method and apparatus for gradient generation
US6780584B1 (en) 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US6934836B2 (en) 2000-10-06 2005-08-23 Protasis Corporation Fluid separation conduit cartridge with encryption capability
US6827095B2 (en) 2000-10-12 2004-12-07 Nanostream, Inc. Modular microfluidic systems
JP2002236131A (en) 2000-12-08 2002-08-23 Minolta Co Ltd Microchip
US6878755B2 (en) 2001-01-22 2005-04-12 Microgen Systems, Inc. Automated microfabrication-based biodetector
WO2002064253A2 (en) 2001-02-09 2002-08-22 Microchem Solutions Method and apparatus for sample injection in microfabricated devices
US6949377B2 (en) 2001-03-05 2005-09-27 Ho Winston Z Chemiluminescence-based microfluidic biochip
DE10111457B4 (en) 2001-03-09 2006-12-14 Siemens Ag diagnostic device
US6605422B2 (en) 2001-03-16 2003-08-12 Fuji Photo Film Co., Ltd. Process for producing a silver halide photographic emulsion
US6742661B1 (en) 2001-04-03 2004-06-01 Micronics, Inc. Well-plate microfluidics
US7723123B1 (en) * 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US7077152B2 (en) 2001-07-07 2006-07-18 Nanostream, Inc. Microfluidic metering systems and methods
KR100425536B1 (en) 2001-07-16 2004-03-30 학교법인 포항공과대학교 Bread board for microfluidic chip
US7094379B2 (en) 2001-10-24 2006-08-22 Commissariat A L'energie Atomique Device for parallel and synchronous injection for sequential injection of different reagents
US20030138969A1 (en) 2002-01-24 2003-07-24 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
US20040195728A1 (en) 2001-10-26 2004-10-07 Dennis Slomski System and method for injection molded micro-replication of micro-fluidic substrates
EP1461606A4 (en) 2001-12-05 2005-06-29 Univ Washington MICROFLUIDIC DEVICE AND SURFACE DECORATION METHOD FOR SOLID PHASE AFFINITY BINDING ASSAYS
AU2002365278A1 (en) 2001-12-20 2003-07-09 Radius Biosciences Centrifugal array processing device
US6982787B1 (en) 2002-01-02 2006-01-03 The United States Of America As Represented By The Secretary Of The Air Force Modification of the degree of liquid contact with a solid by control of surface and micro-channel capillary geometry
US7611616B2 (en) 2002-05-07 2009-11-03 Microfabrica Inc. Mesoscale and microscale device fabrication methods using split structures and alignment elements
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
US7244961B2 (en) 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
US6867114B2 (en) 2002-08-29 2005-03-15 Micron Technology Inc. Methods to form a memory cell with metal-rich metal chalcogenide
DE60312186T2 (en) 2002-09-06 2007-11-08 Epigem Ltd. MODULAR MICROFLUID SYSTEM
US6878271B2 (en) 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
EP1419818B1 (en) 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Device for sequential transport of liquids by capillary forces
US20050221281A1 (en) 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
US7645574B2 (en) 2003-01-23 2010-01-12 Integrated Nano-Technologies, Llc Methods of metallizing nucleic acid molecules and methods of attaching nucleic acid molecules to conductive surfaces
DE10315074A1 (en) 2003-04-02 2004-10-14 Clondiag Chip Technologies Gmbh Device for the duplication and detection of nucleic acids
WO2004096986A2 (en) 2003-04-29 2004-11-11 Integrated Nano-Technologies, Llc Method for quantitative detection of nucleic acid molecules
US7011793B2 (en) 2003-05-15 2006-03-14 Kionix, Inc. Reconfigurable modular microfluidic system and method of fabrication
US20060246526A1 (en) * 2003-06-02 2006-11-02 Gyros Patent Ab Microfluidic affinity assays with improved performance
US7028536B2 (en) 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
WO2005056186A1 (en) 2003-12-10 2005-06-23 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A modular biochip assembly
CA2834041C (en) 2003-12-31 2017-05-16 President And Fellows Of Harvard College Assay device and method
US8030057B2 (en) 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
CN102357352B (en) 2004-01-26 2015-08-12 哈佛大学 Fluid delivery system and method
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
EP1611954A1 (en) 2004-07-03 2006-01-04 Roche Diagnostics GmbH Liquid reservoir connector
WO2006018044A1 (en) 2004-08-18 2006-02-23 Agilent Technologies, Inc. Microfluidic assembly with coupled microfluidic devices
GB0426082D0 (en) 2004-11-26 2004-12-29 Norchip As A device for carrying out biological assays
CA2599657A1 (en) 2005-03-09 2006-09-21 The Regents Of The University Of California Microfluidic valve for liquids
EP1712903B1 (en) * 2005-04-11 2015-07-15 Roche Diagnostics GmbH Method for Integrated 2D gel electrophoresis
JP2008537146A (en) 2005-04-19 2008-09-11 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ Fluid structure with a serpentine wide channel
CA2610875A1 (en) 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
JP2007017354A (en) 2005-07-08 2007-01-25 Sumitomo Bakelite Co Ltd Chemical reaction detection system
US20070048189A1 (en) 2005-08-26 2007-03-01 Applera Corporation Fluid processing device, system, kit, and method
GB0520116D0 (en) 2005-10-03 2005-11-09 Smart Holograms Ltd Use of holographic sensors
DE102005048236A1 (en) 2005-10-07 2007-04-12 Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg Apparatus and method for determining the volume fractions of the phases in a suspension
US8133456B2 (en) 2005-11-07 2012-03-13 Konica Minolta Medical & Graphic, Inc. Microreactor and method of liquid feeding making use of the same
US7915053B2 (en) * 2005-12-22 2011-03-29 Canon Kabushiki Kaisha Substrate for target substance detecting device, target substance detecting device, target substance detecting apparatus and method using the same, and kit therefor
JP2007232172A (en) 2006-03-03 2007-09-13 Nippon Sheet Glass Co Ltd Microvalve device
CN100588127C (en) 2006-07-18 2010-02-03 王亦兵 Integrated local area network of switching interface, electric power communication and its networking method
EP1884494A1 (en) 2006-07-26 2008-02-06 SOLVAY (Société Anonyme) Process for the monitoring of solids which release oxygen when decomposing and bulk container
US20080085219A1 (en) 2006-10-05 2008-04-10 Beebe David J Microfluidic platform and method
EP2071026A1 (en) 2007-03-23 2009-06-17 Kabushiki Kaisha Toshiba Nucleic acid detection cassette and nucleic acid detection apparatus
WO2008118098A1 (en) 2007-03-26 2008-10-02 Agency For Science, Technology And Research Fluid cartridge, pump and fluid valve arrangement
CN103495439B (en) * 2007-05-04 2015-09-16 欧普科诊断有限责任公司 Fluid connector and microfluid system
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
DE202010018623U1 (en) 2009-02-02 2018-12-07 Opko Diagnostics, Llc Structures for controlling the light interaction with microfluidic devices
US8573792B2 (en) 2009-03-18 2013-11-05 Konica Minolta Opto, Inc. Reflective mirror for solar thermal power generation
JPWO2010106997A1 (en) * 2009-03-19 2012-09-20 株式会社カネカ Nucleic acid detection method, kit and device
CA2761698A1 (en) * 2009-05-19 2010-11-25 The Regents Of The University Of California Multi-directional microfluidic devices and methods
MX336714B (en) 2009-11-24 2016-01-28 Opko Diagnostics Llc Fluid mixing and delivery in microfluidic systems.
BR112012026406B1 (en) 2010-04-16 2020-06-09 Opko Diagnostics Llc method of conducting quality control to determine abnormalities in the operation of a microfluidic system
WO2012142397A2 (en) * 2011-04-13 2012-10-18 Akonni Biosystems, Inc. Microarray based sample detection system

Also Published As

Publication number Publication date
US20130236375A1 (en) 2013-09-12
CO6541593A2 (en) 2012-10-16
PE20130172A1 (en) 2013-03-03
PL2504105T3 (en) 2021-06-28
EP2504105B1 (en) 2021-02-17
US9075051B2 (en) 2015-07-07
ES2859481T3 (en) 2021-10-04
US20180078938A1 (en) 2018-03-22
US10953398B2 (en) 2021-03-23
PT2504105T (en) 2021-03-31
JP2015143708A (en) 2015-08-06
UA120744C2 (en) 2020-02-10
DK2504105T3 (en) 2021-03-15
US10413899B2 (en) 2019-09-17
US20140093866A1 (en) 2014-04-03
US20170165664A1 (en) 2017-06-15
US20150251178A1 (en) 2015-09-10
US8567425B2 (en) 2013-10-29
BR112012012512A2 (en) 2017-06-13
MX336714B (en) 2016-01-28
US9555408B2 (en) 2017-01-31
EA024999B1 (en) 2016-11-30
CN102740975B (en) 2015-11-25
UA110927C2 (en) 2016-03-10
US9731291B2 (en) 2017-08-15
US20170304822A1 (en) 2017-10-26
JP2013512438A (en) 2013-04-11
US20150044760A1 (en) 2015-02-12
US9861980B2 (en) 2018-01-09
MX2012005951A (en) 2012-10-01
US20110120562A1 (en) 2011-05-26
CN102740975A (en) 2012-10-17
CL2012001340A1 (en) 2013-05-17
JP5977674B2 (en) 2016-08-24
EP2504105A1 (en) 2012-10-03
WO2011066361A1 (en) 2011-06-03
EA201200789A1 (en) 2014-02-28
US8915259B2 (en) 2014-12-23

Similar Documents

Publication Publication Date Title
PT2504105T (en) Fluid mixing and delivery in microfluidic systems
ZA201105873B (en) Burstable liquid packaging and uses thereof
GB2479112B (en) Micro-valve and micro-fluidic device using such
EP2349550A4 (en) Multiple component mixing and delivery system
PL2475598T3 (en) Mixing and dispensing container
EP2347818A4 (en) Helical fluid mixer and device using helical fluid mixer
IL218554A0 (en) Fluid delivery device
EP2311552A4 (en) Fluid mixer and device using a fluid mixer
IL212498A0 (en) Reagent dispensing apparatuses and delivery methods
IL216469A0 (en) Content delivery systems and methods
EP2235248A4 (en) Material delivery systems and methods
EP2188002A4 (en) Fluid delivery system
EP2656907A4 (en) Fluid mixer and fluid mixing method
EP2188431A4 (en) Material delivery systems and methods
GB0801770D0 (en) Fluid delivery device and method
GB2487340B (en) Thermophilic mannanohydrolase and fracturing fluids containing the same
PT2246604E (en) Fluid flow distribuitor or collector device and molding system comprising such device
PL2515632T3 (en) Fluid delivery device
GB0913523D0 (en) Improved cross flow and counter flow fluid processing devices
GB0806560D0 (en) Flow in fluid conduits
GB201015712D0 (en) Particle concentration in a liquid flow
EP2422061A4 (en) Fluid mixing system
GB201013159D0 (en) Liquid compositions comprising vitamin d and uses thereof
IL200236A0 (en) Methods and systems for pumping fluids
GB0901115D0 (en) Microfluidic single use valve and microfluidic systems incorporating said valve