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HUE050530T2 - Method for the production of l-serine using genetically engineered microorganisms deficient in serine degradation pathways - Google Patents

Method for the production of l-serine using genetically engineered microorganisms deficient in serine degradation pathways

Info

Publication number
HUE050530T2
HUE050530T2 HUE16701661A HUE16701661A HUE050530T2 HU E050530 T2 HUE050530 T2 HU E050530T2 HU E16701661 A HUE16701661 A HU E16701661A HU E16701661 A HUE16701661 A HU E16701661A HU E050530 T2 HUE050530 T2 HU E050530T2
Authority
HU
Hungary
Prior art keywords
serine
production
genetically engineered
engineered microorganisms
degradation pathways
Prior art date
Application number
HUE16701661A
Other languages
Hungarian (hu)
Inventor
Hemanshu Mundhada
Alex Toftgaard Nielsen
Original Assignee
Cysbio Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cysbio Aps filed Critical Cysbio Aps
Publication of HUE050530T2 publication Critical patent/HUE050530T2/en

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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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    • C12Y403/01017—L-Serine ammonia-lyase (4.3.1.17)

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HUE16701661A 2015-01-27 2016-01-27 Method for the production of l-serine using genetically engineered microorganisms deficient in serine degradation pathways HUE050530T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15152643 2015-01-27

Publications (1)

Publication Number Publication Date
HUE050530T2 true HUE050530T2 (en) 2020-12-28

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US (3) US10513682B2 (en)
EP (3) EP3250701B8 (en)
JP (2) JP6835725B2 (en)
CN (2) CN107429275B (en)
CA (2) CA2975011C (en)
DK (2) DK3250701T3 (en)
ES (2) ES2807448T3 (en)
HU (1) HUE050530T2 (en)
LT (1) LT3250701T (en)
MY (2) MY186949A (en)
PL (1) PL3250700T3 (en)
SI (1) SI3250701T1 (en)
WO (2) WO2016120326A1 (en)

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Publication number Priority date Publication date Assignee Title
MY186949A (en) * 2015-01-27 2021-08-26 Cysbio Aps Genetically modified microorganisms having improved tolerance towards l-serine
US10858676B2 (en) * 2017-05-22 2020-12-08 Ajinomoto Co., Inc. Method for producing objective substance
CN110229853B (en) * 2019-07-02 2021-06-01 武汉轻工大学 Preparation method of L-serine
CN111019877B (en) * 2019-12-31 2022-04-19 浙江工业大学 A kind of L-cysteine-producing genetically engineered bacteria, construction method and application
EP3960879A1 (en) * 2020-09-01 2022-03-02 Metabolic Explorer Microorganism and method for the improved production of alanine
WO2024013258A1 (en) * 2022-07-15 2024-01-18 Cysbio Aps Production of cysteine or cystine from serine in fermentation medium
CA3225234A1 (en) 2022-08-04 2024-02-08 Metabolic Explorer Microorganism and method for the improved production of serine and/or cysteine
CN120476201A (en) 2022-10-20 2025-08-12 赛斯生物私营有限责任公司 Genetically modified host cells producing L-serine
WO2024149616A1 (en) 2023-01-09 2024-07-18 Evonik Operations Gmbh Fermentative production guanidinoacetic acid (gaa) from serine using a microorganism having an enhanced l-serine hydroxymethyltransferase activity
CN120476203A (en) 2023-01-09 2025-08-12 赢创运营有限公司 Fermentative production of guanidine acetate (GAA) from serine by attenuating L-serine ammonia lyase activity in microorganisms
WO2024224355A1 (en) 2023-04-26 2024-10-31 Cysbio Aps A low dose formulation of l-serine for liver health and fatty liver diseases
KR102869970B1 (en) * 2023-06-23 2025-10-14 씨제이제일제당 (주) A polynucleotide comprising a mutated RBS nucleotide sequence, a microorganism comprising the polynucleotide, and a method for producing glycine using the same
EP4556561A1 (en) 2023-11-14 2025-05-21 CysBio ApS Expression of biomolecules with improved promoter and tir
CN119662748A (en) * 2024-12-30 2025-03-21 诸城市浩天药业有限公司 L-serine production method

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