HUE047918T2 - Fused bicyclic heteroaryl derivatives having activity as phd inhibitors - Google Patents

Fused bicyclic heteroaryl derivatives having activity as phd inhibitors

Info

Publication number: HUE047918T2
Authority: HU; Hungary
Prior art keywords: activity; bicyclic heteroaryl; fused bicyclic; heteroaryl derivatives; phd inhibitors
Prior art date: 2015-03-18

Application number

HUE16715122A

Other languages

Hungarian (hu)

Inventor

Saleh Ahmed

Gregory Barker

Hannah Canning

Richard Davenport

David Harrison

Kerry Jenkins

David Livermore

Susanne Wright

Natasha Kinsella

Original Assignee

Takeda Pharmaceuticals Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-03-18

Filing date

2016-03-17

Publication date

2020-05-28

2016-03-17 Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co

2020-05-28 Publication of HUE047918T2 publication Critical patent/HUE047918T2/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Epidemiology (AREA)
Plural Heterocyclic Compounds (AREA)

HUE16715122A 2015-03-18 2016-03-17 Fused bicyclic heteroaryl derivatives having activity as phd inhibitors HUE047918T2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB1504565.1A GB201504565D0 (en)	2015-03-18	2015-03-18	Novel compounds

Publications (1)

Publication Number	Publication Date
HUE047918T2 true HUE047918T2 (en)	2020-05-28

Family

ID=53051992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HUE16715122A HUE047918T2 (en)	2015-03-18	2016-03-17	Fused bicyclic heteroaryl derivatives having activity as phd inhibitors

Country Status (31)

Country	Link
US (1)	US10287286B2 (en)
EP (1)	EP3271357B1 (en)
JP (1)	JP6726681B2 (en)
KR (1)	KR102609431B1 (en)
CN (1)	CN107531698B (en)
AU (1)	AU2016234209B2 (en)
BR (1)	BR112017019653B1 (en)
CA (1)	CA2979024C (en)
CL (1)	CL2017002354A1 (en)
CO (1)	CO2017009353A2 (en)
CR (1)	CR20170468A (en)
DK (1)	DK3271357T3 (en)
DO (1)	DOP2017000209A (en)
EA (1)	EA035739B1 (en)
EC (1)	ECSP17069696A (en)
ES (1)	ES2774052T3 (en)
GB (1)	GB201504565D0 (en)
GE (1)	GEP20207095B (en)
HU (1)	HUE047918T2 (en)
IL (1)	IL254277B (en)
MX (1)	MX2017011902A (en)
MY (1)	MY194873A (en)
NZ (1)	NZ735631A (en)
PE (1)	PE20180656A1 (en)
PH (1)	PH12017501699B1 (en)
PT (1)	PT3271357T (en)
SG (1)	SG11201707280VA (en)
TN (1)	TN2017000384A1 (en)
UA (1)	UA123668C2 (en)
WO (1)	WO2016148306A1 (en)
ZA (1)	ZA201706612B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3712153B1 (en)	2016-02-24	2021-12-01	Pfizer Inc.	Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors
US11254668B2 (en)	2017-08-14	2022-02-22	Pfizer Inc.	Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
MY207239A (en) *	2018-09-13	2025-02-08	Kissei Pharmaceutical	Imidazopyridinone compound
CN110950806A (en) *	2019-11-14	2020-04-03	安庆博曼生物技术有限公司	Preparation method of pyrimidine cyclic hydroxy chloride by catalysis of tetraethylammonium chloride
JP7504822B2 (en) *	2020-03-12	2024-06-24	キッセイ薬品工業株式会社	Pharmaceutical Compositions Containing Imidazopyridinone Compounds
US11718622B2 (en)	2020-03-16	2023-08-08	Exelixis Inc.	Heterocyclic adenosine receptor antagonists
WO2021213380A1 (en) *	2020-04-20	2021-10-28	深圳市塔吉瑞生物医药有限公司	Solid form of pyrazine substituted nicotinamide, and preparation and use thereof
TW202233629A (en) *	2020-10-20	2022-09-01	美商安進公司	Heterocyclic spiro compounds and methods of use
US12492178B2 (en)	2021-09-01	2025-12-09	Empathbio, Inc.	Stable polymorph of R-MDMA HCl
CA3235718A1 (en)	2021-10-28	2023-05-04	Insilico Medicine Ip Limited	Prolyl hydroxylase domain-containing protein (phd) inhibitors and uses thereof
CN118715015A (en) *	2021-12-17	2024-09-27	阿克比治疗有限公司	Selective PHD1 inhibitor compounds, compositions and methods of use
EP4457222A4 (en)	2021-12-28	2025-12-24	Empathbio Inc	Nitrogen oxide-releasing prodrugs of MDA and MDMA

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4209621A (en)	1979-04-27	1980-06-24	American Cyanamid Company	(Substituted-phenyl)-1,2,4-triazolo[4,3-a]-pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-a]pyrimidines
US4572910A (en) *	1983-03-03	1986-02-25	Riker Laboratories, Inc.	Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
DK135184A (en)	1983-03-03	1984-10-10	Riker Laboratories Inc	TRIAZOL (4.3-C) - AND TRIAZOL (1.5-C) PYRIMIDINES
BR0112038A (en)	2000-06-30	2003-04-01	Wyeth Corp	Triazolopyrimidines substituted as anticancer agents
JP2010065026A (en)	2008-08-13	2010-03-25	Ishihara Sangyo Kaisha Ltd	Pyridyl-triazolopyrimidine derivative or salt of the same, and noxious organism remover containing them
JP2010065024A (en)	2008-08-14	2010-03-25	Ishihara Sangyo Kaisha Ltd	Pest control agent containing triazolopyrimidine derivative or salt thereof
HRP20140705T1 (en) *	2009-07-17	2014-09-12	Japan Tobacco, Inc.	Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer
JP2011168582A (en)	2010-01-21	2011-09-01	Ishihara Sangyo Kaisha Ltd	Triazolopyridine derivative or salt thereof, process for production of the same, and noxious organism control agent comprising the same
US20150239889A1 (en)	2012-08-23	2015-08-27	Mitsubishi Tanabe Pharma Corporation	Pyrazolopyrimidine compound

2015
- 2015-03-18 GB GBGB1504565.1A patent/GB201504565D0/en not_active Ceased
2016
- 2016-03-17 HU HUE16715122A patent/HUE047918T2/en unknown
- 2016-03-17 MX MX2017011902A patent/MX2017011902A/en active IP Right Grant
- 2016-03-17 DK DK16715122.4T patent/DK3271357T3/en active
- 2016-03-17 WO PCT/JP2016/059782 patent/WO2016148306A1/en not_active Ceased
- 2016-03-17 PH PH1/2017/501699A patent/PH12017501699B1/en unknown
- 2016-03-17 ES ES16715122T patent/ES2774052T3/en active Active
- 2016-03-17 KR KR1020177030091A patent/KR102609431B1/en active Active
- 2016-03-17 MY MYPI2017703420A patent/MY194873A/en unknown
- 2016-03-17 CR CR20170468A patent/CR20170468A/en unknown
- 2016-03-17 SG SG11201707280VA patent/SG11201707280VA/en unknown
- 2016-03-17 BR BR112017019653-0A patent/BR112017019653B1/en active IP Right Grant
- 2016-03-17 PT PT167151224T patent/PT3271357T/en unknown
- 2016-03-17 UA UAA201708877A patent/UA123668C2/en unknown
- 2016-03-17 JP JP2017549107A patent/JP6726681B2/en active Active
- 2016-03-17 EA EA201792057A patent/EA035739B1/en unknown
- 2016-03-17 AU AU2016234209A patent/AU2016234209B2/en active Active
- 2016-03-17 CA CA2979024A patent/CA2979024C/en active Active
- 2016-03-17 PE PE2018000126A patent/PE20180656A1/en unknown
- 2016-03-17 TN TNP/2017/000384A patent/TN2017000384A1/en unknown
- 2016-03-17 GE GEAP201614608A patent/GEP20207095B/en unknown
- 2016-03-17 NZ NZ735631A patent/NZ735631A/en unknown
- 2016-03-17 US US15/558,824 patent/US10287286B2/en active Active
- 2016-03-17 CN CN201680022416.0A patent/CN107531698B/en active Active
- 2016-03-17 EP EP16715122.4A patent/EP3271357B1/en active Active
2017
- 2017-09-03 IL IL254277A patent/IL254277B/en active IP Right Grant
- 2017-09-14 CO CONC2017/0009353A patent/CO2017009353A2/en unknown
- 2017-09-15 CL CL2017002354A patent/CL2017002354A1/en unknown
- 2017-09-18 DO DO2017000209A patent/DOP2017000209A/en unknown
- 2017-10-02 ZA ZA2017/06612A patent/ZA201706612B/en unknown
- 2017-10-18 EC ECIEPI201769696A patent/ECSP17069696A/en unknown

Also Published As

Publication number	Publication date
BR112017019653B1 (en)	2023-10-03
ECSP17069696A (en)	2018-02-28
EP3271357B1 (en)	2019-11-27
KR20170129874A (en)	2017-11-27
PH12017501699A1 (en)	2018-03-12
SG11201707280VA (en)	2017-10-30
JP6726681B2 (en)	2020-07-22
GEP20207095B (en)	2020-04-10
EP3271357A1 (en)	2018-01-24
DK3271357T3 (en)	2020-02-17
GB201504565D0 (en)	2015-05-06
IL254277B (en)	2020-10-29
CN107531698A (en)	2018-01-02
CO2017009353A2 (en)	2017-11-30
EA201792057A1 (en)	2018-04-30
TN2017000384A1 (en)	2019-01-16
PE20180656A1 (en)	2018-04-17
EA035739B1 (en)	2020-08-03
CL2017002354A1 (en)	2018-05-04
UA123668C2 (en)	2021-05-12
WO2016148306A1 (en)	2016-09-22
AU2016234209A1 (en)	2017-10-12
BR112017019653A2 (en)	2018-05-15
US20180072714A1 (en)	2018-03-15
CA2979024A1 (en)	2016-09-22
MY194873A (en)	2022-12-21
ZA201706612B (en)	2019-01-30
CA2979024C (en)	2024-02-20
MX2017011902A (en)	2017-12-15
IL254277A0 (en)	2017-10-31
US10287286B2 (en)	2019-05-14
JP2018512408A (en)	2018-05-17
DOP2017000209A (en)	2017-10-15
PH12017501699B1 (en)	2023-06-30
AU2016234209B2 (en)	2020-08-27
ES2774052T3 (en)	2020-07-16
KR102609431B1 (en)	2023-12-04
CN107531698B (en)	2024-08-13
NZ735631A (en)	2023-07-28
HK1249512A1 (en)	2018-11-02
CR20170468A (en)	2018-04-27
PT3271357T (en)	2020-02-21

Publication	Publication Date	Title
ZA201706612B (en)	2019-01-30	Fused bicyclic heteroaryl derivatives having activity as phd inhibitors
IL256808A (en)	2018-03-29	Heteroaryl derivatives as parp inhibitors
IL246140B (en)	2019-09-26	Bicyclic heterocyclic derivatives as bromodomain inhibitors
ZA201801032B (en)	2018-12-19	Bicyclic compounds as atx inhibitors
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IL253869B (en)	2021-12-01	Bicyclic heterocycles as fgfr4 inhibitors
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IL255570A (en)	2018-01-31	Bicyclic compounds as atx inhibitors
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SG11201706729SA (en)	2017-09-28	Derivatives of sobetirome
IL253588A0 (en)	2017-09-28	Bicyclic quinazolinone derivatives
IL255511B (en)	2020-01-30	New bicyclic compounds as dual atx/ca inhibitors
EP3323809A4 (en)	2019-01-02	Bicyclic heterocyclic amide derivative
IL255357A0 (en)	2017-12-31	Bicyclic compounds
EP3275874A4 (en)	2018-08-08	Fused heterocyclic compound
ZA201706038B (en)	2019-01-30	Bicyclic pyridine compound