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HK66587A - Process and intermediates for penicillanic acid 1,1-dioxide and esters thereof - Google Patents

Process and intermediates for penicillanic acid 1,1-dioxide and esters thereof

Info

Publication number
HK66587A
HK66587A HK665/87A HK66587A HK66587A HK 66587 A HK66587 A HK 66587A HK 665/87 A HK665/87 A HK 665/87A HK 66587 A HK66587 A HK 66587A HK 66587 A HK66587 A HK 66587A
Authority
HK
Hong Kong
Prior art keywords
penicillanic acid
esters
dioxide
vivo
readily hydrolyzable
Prior art date
Application number
HK665/87A
Inventor
Shields Moore Bernard
D. Carroll Ronnie
Alfred Volkmann Robert
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HK66587A publication Critical patent/HK66587A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)

Abstract

A process for the preparation of penicillanic acid 1,1-dioxide and esters thereof readily hydrolyzable in vivo. Said process involves dehalogenation of a 6-halo or 6,6-dihalo derivative of penicillanic acid 1,1-dioxide or ester thereof readily hydrolyzable in vivo or a carboxy protected derivative thereof (e.g. by hydrogenolysis). The 6-halo and 6,6-dihalo derivatives of penicillanic acid 1,1-dioxides, esters thereof readily hydrolyzable in vivo, and carboxy protected derivatives thereof are novel intermediates. Penicillanic acid 1,1-dioxide, and esters thereof readily hydrolyzable in vivo, are known compounds which are useful as beta- lactamase inhibitors and for enhancing the effectiveness of certain beta-lactam antibiotics (e.g. the penicillins) in the treatment of bacterial infections in mammals, particularly humans.
HK665/87A 1979-03-05 1987-09-17 Process and intermediates for penicillanic acid 1,1-dioxide and esters thereof HK66587A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1781079A 1979-03-05 1979-03-05
US1780879A 1979-03-05 1979-03-05

Publications (1)

Publication Number Publication Date
HK66587A true HK66587A (en) 1987-09-25

Family

ID=26690337

Family Applications (1)

Application Number Title Priority Date Filing Date
HK665/87A HK66587A (en) 1979-03-05 1987-09-17 Process and intermediates for penicillanic acid 1,1-dioxide and esters thereof

Country Status (36)

Country Link
KR (1) KR850001339B1 (en)
AR (1) AR225031A1 (en)
AT (1) AT366693B (en)
AU (1) AU522572B2 (en)
BG (1) BG33292A3 (en)
CH (1) CH644608A5 (en)
CS (1) CS215130B2 (en)
DD (1) DD149367A5 (en)
DE (1) DE3008257C2 (en)
DK (2) DK159852C (en)
EG (1) EG14437A (en)
ES (1) ES489185A0 (en)
FI (1) FI70024C (en)
FR (1) FR2450836B1 (en)
GB (1) GB2045755B (en)
GR (1) GR67234B (en)
HK (1) HK66587A (en)
HU (1) HU186304B (en)
IE (1) IE49535B1 (en)
IL (1) IL59515A (en)
IN (1) IN153685B (en)
IT (1) IT1130300B (en)
KE (1) KE3464A (en)
LU (1) LU82215A1 (en)
MX (1) MX6032E (en)
MY (1) MY8500319A (en)
NL (1) NL180317C (en)
NO (2) NO800618L (en)
PL (1) PL125197B1 (en)
PT (1) PT70897A (en)
RO (1) RO80112A (en)
SE (2) SE449103B (en)
SG (1) SG55884G (en)
SU (1) SU1192626A3 (en)
UA (1) UA6342A1 (en)
YU (1) YU42328B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN159362B (en) * 1981-03-23 1987-05-09 Pfizer
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
US4360463A (en) 1981-09-02 1982-11-23 Pfizer Inc. Pure 6,6-diiodopenicillanic acid and process for its preparation
PT76527B (en) * 1982-04-19 1985-12-09 Gist Brocades Nv A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof
IT1190897B (en) * 1982-06-29 1988-02-24 Opos Biochimica Srl PROCEDURE FOR THE PREPARATION OF THE 1-ETHOXYCARBONYLOXYETHYL ACID ACID 6- (D (-) - ALPHA AMINOALPHA-PHENYLACETAMIDE) -PENICILLANIC
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
EP0139048A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4596677A (en) * 1984-04-06 1986-06-24 Bristol-Myers Company Anhydropenicillin intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN149747B (en) * 1977-06-07 1982-04-03 Pfizer
CA1158639A (en) * 1978-12-11 1983-12-13 Eric M. Gordon 6-bromopenicillanic acid sulfone
EP0013617B1 (en) * 1979-01-10 1984-07-04 Beecham Group Plc Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates

Also Published As

Publication number Publication date
DK166353B (en) 1993-04-13
YU58580A (en) 1983-02-28
IE800429L (en) 1980-09-05
DE3008257A1 (en) 1980-09-11
ES8103094A1 (en) 1981-02-16
DK159852B (en) 1990-12-17
FR2450836A1 (en) 1980-10-03
NO823127L (en) 1980-09-08
ATA119080A (en) 1981-09-15
MX6032E (en) 1984-10-04
PL125197B1 (en) 1983-04-30
DK159852C (en) 1991-05-06
CH644608A5 (en) 1984-08-15
PL222448A1 (en) 1981-01-02
IE49535B1 (en) 1985-10-16
IT8020367A0 (en) 1980-03-05
YU42328B (en) 1988-08-31
BG33292A3 (en) 1983-01-14
SE8603309D0 (en) 1986-08-04
DK92680A (en) 1980-09-06
NL8001285A (en) 1980-09-09
SG55884G (en) 1985-03-08
IT1130300B (en) 1986-06-11
IN153685B (en) 1984-08-04
DE3008257C2 (en) 1984-03-01
AU522572B2 (en) 1982-06-17
NL180317C (en) 1987-02-02
IL59515A (en) 1983-02-23
CS215130B2 (en) 1982-07-30
FI70024C (en) 1986-09-12
SE449103B (en) 1987-04-06
FR2450836B1 (en) 1986-03-21
GB2045755B (en) 1983-01-26
ES489185A0 (en) 1981-02-16
HU186304B (en) 1985-07-29
AU5610480A (en) 1980-09-11
GR67234B (en) 1981-06-25
AT366693B (en) 1982-04-26
FI800661A7 (en) 1980-09-06
AR225031A1 (en) 1982-02-15
LU82215A1 (en) 1980-09-24
DK145690A (en) 1990-06-14
SE8603309L (en) 1986-08-04
DK145690D0 (en) 1990-06-14
SU1192626A3 (en) 1985-11-15
NO800618L (en) 1980-09-08
MY8500319A (en) 1985-12-31
DD149367A5 (en) 1981-07-08
KE3464A (en) 1984-10-12
EG14437A (en) 1984-09-30
SE8000512L (en) 1980-09-06
RO80112A (en) 1982-10-26
KR850001339B1 (en) 1985-09-19
GB2045755A (en) 1980-11-05
UA6342A1 (en) 1994-12-29
NL180317B (en) 1986-09-01
DK166353C (en) 1993-09-06
PT70897A (en) 1980-04-01
FI70024B (en) 1986-01-31
IL59515A0 (en) 1980-06-30

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Legal Events

Date Code Title Description
PE Patent expired