HK1236816A1 - Replenisher containing dietary fiber - Google Patents

Description

Supplement liquid comprising dietary fiber

Technical Field

The present invention relates to a supplement solution for enteral nutrition.

Background

Nutritional therapies are used for nutrient supplementation when food intake is insufficient or unavailable, such as patients with low digestive function, infants, elderly people, and caregivers. The enteral nutrition method is widely used as a safe and low-cost nutrition therapy as compared with the intravenous nutrition method. Furthermore, the intravenous nutrition method is a nutrition therapy not via the digestive tract, and therefore, metabolic complications such as abnormal glucose metabolism, digestive organ complications such as atrophy of the mucous membrane of the digestive tract, and infection due to a catheter have been problematic. Therefore, in recent years, the following principles have been gradually established: as long as the digestive organs are still functioning, the transvenous feeding method is not selected, but the enteral feeding method is selected.

In general, the formulation of commercial products of liquid foods for enteral nutrition is designed from the viewpoint of energy (calorie) required and the concentration of various nutritional components. In medical sites, nursing sites, and the like, it is necessary to adjust the energy, water content, salt conversion amount (sodium amount), and the like of a meal in accordance with the state of a subject who actually takes liquid food. For example, liquid foods obtained by adding dietary fibers to enteral nutritional compositions have been tried (patent documents 1 to 3), but in the present situation, as general commercial products, preparation is carried out with limited compositions, particularly energy, moisture content, and salt, in order to enable most of the objects to be used. However, since energy, water content, salt conversion amount, and the like required in a prescription made by a doctor or the like vary widely depending on the state of a subject to which the liquid food is actually taken, it is necessary to calculate the required amounts of these components depending on the respective states and then to supplement the shortage in the liquid food.

For example, in a medical site or a nursing site, in general, in order to supplement a deficient portion of water in liquid food, a method of opening a container for liquid food, directly adding cold boiled water thereto, and mixing the liquid food and the cold boiled water is adopted. In addition, in order to supplement the insufficient part of the salt, the following method is adopted: a method in which salt is dissolved in cold boiled water to prepare an aqueous solution of the salt, and then the aqueous solution of the salt is administered after the administration of the liquid food is completed; or a method in which salt is dissolved in cold boiled water to prepare an aqueous solution of the salt, and the aqueous solution of the salt is injected into a feeding tube using a syringe.

So far, in terms of nutritional compositions of liquid foods that can be used in enteral nutrition regimens, according to the needs of the medical or nursing site, the applicant of the present patent application has provided nutritional compositions such as the following: a nutritional composition in which energy, water content, and a salt-converted amount (sodium amount) can be easily adjusted (patent documents 4 and 5); a copper or zinc nutrient composition can be effectively provided for the purpose of preventing/treating bedsores in bedridden patients (patent document 6). Further, as a diluent used together with a nutritional composition, for example, a diluent for a fluid food composition capable of diluting the concentration of an ingredient to be an energy source without diluting a mineral ingredient and a vitamin ingredient (patent document 7) and the like have been provided.

Prior art documents

Patent document

Patent document 1: japanese patent laid-open publication No. 2009-213367

Patent document 2: japanese laid-open patent publication No. H06-298650

Patent document 3: japanese patent laid-open publication No. 2011-

Patent document 4: japanese patent No. 5160569

Patent document 5: japanese patent No. 5404558

Patent document 6: japanese patent No. 3871262

Patent document 7: japanese patent No. 5449783

Summary of the invention

Technical problem to be solved by the invention

In the course of intensive studies in the present technical field, the present inventors have focused on the fact that many subjects who actually ingest liquid foods are accompanied by side effects such as diarrhea and constipation, and have thought to provide a supplement liquid which can contribute to the improvement, which is extremely useful in terms of both simplicity and safety.

Accordingly, an object of the present invention is to provide a novel supplement liquid for enteral nutrition which can reduce side effects such as diarrhea and constipation while easily and rapidly supplementing a water content, table salt, and the like as a supplement liquid for liquid foods in enteral nutrition.

Means of technical solution for solving technical problem

The present inventors have found, in order to solve the above-mentioned problems, that a conventional supplement liquid for liquid foods, that is, a supplement liquid obtained by adding dietary fibers to mineral components such as salt and water can be used to supplement mineral components and water components such as insufficient sodium content and can provide a supplement liquid capable of alleviating side effects such as diarrhea and constipation very easily and safely without administering a cathartic, and have completed the present invention after further research.

That is, the present invention relates to the following.

[1] A supplement liquid for enteral nutrition, wherein the supplement liquid is formed from mineral components, water and dietary fiber.

[2] The supplement liquid according to [1] above, wherein the mineral component comprises sodium.

[3] The supplement liquid according to [1] or [2], further comprising a vitamin component.

[4] The supplement liquid according to any one of [1] to [3], wherein the sodium content is 0.3 to 26g/100mL in terms of salt.

[5] The replenishment solution according to any one of the above [1] to [4], wherein the total amount of the sodium ions and the chlorine ions is 80 to 100% by weight based on the total weight of the mineral components.

[6] The replenishment solution according to any one of the above [1] to [5], wherein the weight of sodium ions is 60 to 200% by weight based on the weight of chlorine ions.

[7] A refill liquid to be put into a container, wherein the refill liquid is obtained by heat-sterilizing a container in which the refill liquid according to any one of the above items [1] to [6] is stored.

[8] The refill liquid for a container according to [7], wherein the container is closed.

[9] The refill liquid according to the above [7] or [8], wherein the container has one or more than two fine-mouthed portions for discharge and/or mixing.

[10] A method for producing the replenishment solution according to any one of the above [1] to [9], comprising:

a mixing step of mixing the mineral components and dietary fibers in water;

a filling step of filling the water mixed with the mineral component and the dietary fiber obtained in the mixing step into a container; and

and a heat sterilization step of heat sterilizing the water mixed with the mineral component and the dietary fiber obtained in the filling step.

The present invention also relates to the following.

[11] Use of a supplement in enteral nutrition, wherein the supplement is formed solely from mineral components, water and dietary fibre.

[12] The use as claimed in [11] above, wherein the mineral component of the supplementary liquid comprises sodium.

[13] The use according to the above [11] or [12], wherein the supplement liquid further comprises a vitamin component.

[14] The use according to any one of the above [11] to [13], wherein the sodium content of the replenisher is 0.3 to 26g/100mL in terms of salt.

[15] The use according to any one of the above [11] to [14], wherein the total amount of the sodium ions and the chloride ions is 80 to 100% by weight based on the total weight of the mineral components in the replenishment liquid.

[16] The use according to any one of the above [11] to [15], wherein the weight of sodium ions is 60 to 200 wt% based on the weight of chlorine ions.

[17] The use according to any one of the above [11] to [16], in which the replenishment liquid is contained in a container, and the container containing the replenishment liquid is heat-sterilized.

[18] The use according to the above [17], wherein the container is closed.

[19] The use according to the above [17] or [18], wherein the container has one or more than two fine-mouthed portions for outflow and/or mixing.

ADVANTAGEOUS EFFECTS OF INVENTION

According to the present invention, in the enteral nutrition method, not only can the required mineral components be supplemented separately in accordance with the prescription of each subject, but also the constipation symptom and the like of the subject can be improved without using a laxative or the like. Further, since the mineral component and dietary fiber are integrated in advance as a supplement liquid, there is no need for complicated and unsanitary operations such as preparing a saline solution by dissolving saline in cold boiled water and adding the saline solution to a composition for enteral nutrition as in the conventional art, and there is no need for separate operations for supplementing the mineral component and dietary fiber. Therefore, the number of times of supplementation to the subject can be set to only one time, and thus, when the enteral nutrition method is performed, not only can the amount of work be saved, but also the possibility of contamination by microorganisms and the like can be greatly reduced, and mineral components or dietary fibers can be hygienically supplemented.

Further, since the components of the supplement liquid of the present invention are basically three components, i.e., mineral components, water and dietary fiber, it is possible to supply only the required amount of the components of the supplement liquid depending on the state of each subject to be actually ingested, and therefore, it is possible to allow subjects to ingest only sodium and dietary fiber which are likely to be insufficient by many of subjects who actually ingest liquid foods, such as elderly persons, without ingesting excessive amounts of other unnecessary components, and it is possible to provide versatility and to allow subjects to ingest easily, quickly and safely.

In addition, when a commercially available beverage or the like containing dietary fiber is used as a supplement liquid, for example, the beverage often contains unnecessary nutrients depending on the taste or the like, or the concentration of salt is adjusted to be low, so that there is a problem that the amount of water is excessive in order to obtain a desired amount of sodium.

Modes for carrying out the invention

The replenishing liquid in the present invention is a liquid for replenishing and administering components not enough to a required amount to a subject to be administered with liquid food or the like. In principle, it means a liquid in which only a component to be administered (i.e., a component insufficient for administration) is mixed in a solvent such as water. The supplement liquid of the present invention can be clearly distinguished from, for example, a liquid food designed to incorporate various ingredients for the purpose of comprehensively taking nutrition, a diluent used for diluting a specific ingredient in a liquid food to a certain concentration, and the like.

The enteral feeding regimen in the present invention includes an oral regimen in which a subject takes a supplement solution orally and a tube feeding regimen in which a tube is used to administer the supplement solution to the subject, and as a typical form, the tube feeding regimen is preferable. Further, tube feeding methods include oral methods, nasal tube methods, and fistula methods.

The form of the supplement liquid for enteral nutrition according to the present invention is liquid, fluid (viscous paste), gel, paste, or the like, and is preferably liquid or fluid as a typical form. Further, the following modes of use are possible: the supplement liquid for enteral nutrition is concentrated and/or dried to prepare a powder (solid) or the like, and when the enteral nutrition is applied, water or the like is added to prepare a liquid or fluid. In addition, the supplement liquid used in the enteral nutrition method is classified into a component nutrient, a digestive fluid food or a digestive nutrient, a semi-digestive fluid food or a semi-digestive nutrient, or a natural thick fluid food, and the like, and as a typical form, a digestive fluid food or a digestive nutrient, or a semi-digestive fluid food or a semi-digestive nutrient, and more preferably a digestive nutrient, or a semi-digestive nutrient is preferable.

The supplement liquid of the present invention is a supplement liquid for enteral nutrition, and in one form, the supplement liquid is composed of only three components, namely, a mineral component, water, and dietary fiber.

Here, the mineral component may be exemplified by sodium, calcium, iron, phosphorus, magnesium, potassium, copper, zinc, chromium, selenium, manganese, molybdenum, iodine, etc., preferably sodium, calcium, magnesium, potassium, more preferably sodium, calcium, further preferably sodium.

Examples of the mineral component which serves as a sodium supply source include common salt (sodium chloride), sodium acetate, sodium citrate, sodium hydroxide, sodium carbonate, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium metaphosphate, sodium pyrophosphate, and sodium tripolyphosphate, and common salt, sodium acetate, and sodium citrate are preferred, and common salt is more preferred. One or two or more of these sodium supply sources may be used.

When the supplement liquid of the present invention contains sodium, the content thereof may be, for example, 0.3 to 26g/100mL, preferably 0.3 to 10g/100mL, more preferably 0.3 to 2g/100mL in terms of common salt. In the present invention, the amount in terms of common salt is a numerical value obtained by converting the amount of sodium contained in the nutritional composition into the amount of sodium chloride (common salt).

In addition, when the replenishment solution of the present invention contains sodium ions and chloride ions, the total amount of the sodium ions and the chloride ions in the replenishment solution may be, for example, 80 to 100% by weight, preferably 85 to 100% by weight, and more preferably 90 to 100% by weight, based on the weight of the total mineral components. In addition, the weight of the sodium ion may be, for example, 60 to 200 wt%, preferably 60 to 150 wt%, and more preferably 60 to 100 wt% with respect to the weight of the chloride ion.

Examples of the water used in the replenishment liquid of the present invention include tap water, well water, activated carbon, pure water, ultrapure water, purified water, and ion-exchanged water, and the concentration of the total mineral component is preferably known. Further, pure water, ultrapure water, purified water, ion-exchanged water, and more preferably ion-exchanged water are preferable because the treatment can be performed with the concentration of the total mineral components being 0.

Dietary fiber used in the supplement liquid of the present invention may, for example, be galactomannan decomposition products, indigestible dextrin, reduced indigestible dextrin, cellulose, and the like, and either water-soluble or water-insoluble dietary fiber may be used. Further, for the reason that the dispersion is easy to be stably and uniformly dispersed in the supplement liquid of the present invention, water-soluble dietary fibers such as galactomannan decomposition products, indigestible dextrins, reduced indigestible dextrins, and the like are preferable, and galactomannan decomposition products are more preferable. Also, the galactomannan decomposition products may be exemplified by locust bean gum decomposition products, Tara gum (Tara gum) decomposition products, Guar gum (Guar gum) decomposition products, Guar gum hydrolysis products, etc., preferably Guar gum decomposition products, Guar gum hydrolysis products, more preferably Guar gum hydrolysis products. The dietary fiber used in the supplement liquid of the present invention may be contained in an amount of, for example, 0.5 to 15 wt%, preferably 1 to 12 wt%, and more preferably 2 to 10 wt%.

The supplement liquid of the present invention is composed of mineral components, water and dietary fibers, and by using the supplement liquid of the present invention, a desired amount of water, mineral components and dietary fibers can be easily and quickly ingested by a subject in accordance with the state of the subject actually ingested. Therefore, the present invention is a supplement liquid containing only water, mineral components, and dietary fibers, and does not contain components such as proteins or lipids. In addition, because the present invention is a supplement containing only water, mineral components, dietary fiber, and is very low in energy, it may be, for example, less than 1kcal/mL, preferably less than 0.5kcal/mL, and more preferably less than 0.2kcal/mL, unlike conventional nutritional compositions such as liquid foods.

In addition, in the supplement liquid of the present invention, a vitamin component may be used as a component in addition to a mineral component, water, dietary fiber, and the like. According to this form, it is possible to easily and rapidly add and supplement vitamin components to the subject in addition to mineral components, water, and dietary fiber. The vitamin component may, for example, be vitamin B1, vitamin B2, nicotinic acid, pantothenic acid, vitamin B6, biotin, folic acid, vitamin B12, vitamin C, vitamin a, vitamin D, vitamin E or vitamin K.

The replenishment solution of the present invention can be produced by a production method including the steps of: a mixing step of mixing the mineral component and the dietary fiber in water; a filling step of filling the water mixed with the mineral component and the dietary fiber obtained in the mixing step into a container; and a heat sterilization step of heat sterilizing the water mixed with the mineral component and the dietary fiber obtained in the filling step.

In the mixing step, a predetermined amount of mineral components and dietary fibers are mixed with water to prepare a liquid composition. At this time, vitamin components may be mixed. Further, the respective components can be sufficiently dissolved by heating or stirring as necessary. Therefore, in the liquid composition, the respective components are mixed and dissolved, dispersed or suspended. In the filling step, the liquid composition is filled into a retort pouch (retort pouch) or a soft package (soft pack). In the heat sterilization step, the subject is heat sterilized for hygienic ingestion (administration) of the liquid composition, and contamination by microorganisms or the like is suppressed or prevented to a desired extent.

In the method for producing a replenishing liquid of the present invention, the liquid composition may be subjected to heat sterilization (ultra high temperature (UHT) sterilization, High Temperature Short Time (HTST) sterilization, etc.) and then aseptically filled (aseptic packaging method, etc.) into a predetermined container; or the liquid composition may be filled into a predetermined container and then heat-sterilized (sterilization in a sterilization pot (autoclave, etc.)). In this case, since it is easy to produce a liquid composition aseptically and easily, it is preferable to fill the liquid composition into a retort pouch or a flexible pouch and then sterilize the pouch by sterilizing a retort.

Here, as the heat sterilization method, an indirect heat sterilization method (a plate sterilizer (heat exchanger), a tubular sterilizer (heat exchanger), etc.), a direct heat sterilization method (a steam jet sterilizer, a steam injection sterilizer, etc.), an electric heat sterilization method (a joule sterilizer, etc.), a sterilizer, etc. can be used. In this case, a sterilizer is preferably used because it is easy to produce a liquid composition aseptically and easily.

The container for containing the refill liquid of the present invention is preferably a closed container (hermetically sealed package) because the refill liquid as the content can be effectively isolated from the outside. The form of the container may typically be a paper box, retort pouch, soft package, set container, can container or the like, and preferably a paper box, retort pouch, soft package, more preferably a retort pouch, soft package. The material of the container may typically be paper, plastic, glass, metal, etc., preferably paper or plastic, more preferably plastic.

The container for storing the refill liquid of the present invention is preferably a closed paper container made of a paper material obtained by laminating an aluminum foil and a synthetic resin (e.g., polyethylene), or a closed plastic container made of a soft synthetic resin material (e.g., a plastic vinyl chloride resin, a polyurethane resin, a polyethylene resin, a polyolefin such as an ethylene-vinyl acetate copolymer or an ethylene- α -olefin copolymer, a polyfluorocarbon, a polyimide, or the like), more preferably a closed plastic container. In this case, a soft container capable of heat sterilization (sterilization) after the replenishment liquid of the present invention is stored is preferable.

The container for storing the refill liquid of the present invention is preferably a container having one or more narrow-mouth portions for outflow and/or mixing, and more preferably a container having the following means as the narrow-mouth portion: the mechanism is sealed before the enteral feeding method is performed, and can be directly connected to a narrow opening portion of a pipe or other container when the enteral feeding method is performed. In this case, by using the sealed container, the nutrient composition and the like can be added to the replenishment liquid of the present invention without opening the container over a large area or by opening the narrow opening portion only to a minimum extent, and the contact between the replenishment liquid as the content and the outside air can be effectively reduced, whereby the contamination of microorganisms and the like can be suppressed or prevented to a desired extent.

In one form, the present invention relates to the use of the above-described supplement solution in enteral nutrition.

In the above-described application, for the sake of convenience, the content of the mineral component, water and dietary fiber as the constituent components may be set to be integral multiple of a predetermined content in the supplement liquid of the present invention. By combining two or more types of supplementary liquids having different contents of one or more types of components selected from the group consisting of mineral components, water, and dietary fiber, the contents of mineral components, water, and dietary fiber of the combined supplementary liquid can be adjusted while freely designing and adjusting the same. In this case, it is not necessary to separately add the mineral component, water, and dietary fiber by calculating the required amount according to the prescription corresponding to the state of the subject who takes the supplement liquid of the present invention, and labor can be saved.

In the above aspect of the replenishment liquid of the present invention, the combination refers to a combination of monomers of the replenishment liquid of the present invention with each other as monomers and a combination of a part of the replenishment liquid mixed by a combination of monomers with a part of the replenishment liquid mixed by a combination of monomers and/or a combination of monomers. The replenisher in which the contents of mineral components, water and dietary fibers are adjusted by combining two or more replenishers of the present invention may be administered in a single dose of the monomers of the respective replenishers to be combined, or may be administered in a single dose of all or a part of the replenisher obtained by mixing the monomers of two or more replenishers after mixing them with each other.

In the above aspect of the replenishment liquid of the present invention, the number of the other one or more replenishment liquids to be combined is, for example, 1 to 5 from the viewpoint that the combined replenishment liquid can cope with various recipes, and in consideration of the difficulty of calculation and the work load of preparation, 1 to 4 are preferable, and 1 to 3 are more preferable.

In the above aspect of the replenisher of the present invention, the content of the mineral component in the replenisher after combination is preferably an integral multiple of 1g, 5g, 10g or 20g in terms of salt equivalent in terms of sodium amount converted to salt amount, and more preferably an integral multiple of 1g, 5g or 10g, particularly preferably an integral multiple of 1g or 5g in terms of reducing the number of products, from the viewpoint that the content of the mineral component in the replenisher can be adjusted to various prescriptions and the content of the mineral component can be easily calculated.

In the above-described embodiment of the replenisher of the present invention, the water content of the replenisher after combination is preferably an integral multiple of 10mL, 25mL, 50mL or 100mL, more preferably an integral multiple of 25mL, 50mL or 100mL, particularly preferably an integral multiple of 50mL or 100mL, from the viewpoint of reducing the number of products, also from the viewpoint that the water content of the replenisher after combination can be applied to various prescriptions and the calculation of the water content is easy.

In the above aspect of the supplement liquid of the present invention, the dietary fiber content of the combined supplement liquid is preferably an integral multiple of 1g, 5g, 10g or 20g, and more preferably an integral multiple of 1g, 5g or 10g, particularly preferably an integral multiple of 5g or 10g, from the viewpoint of reducing the number of products, also from the viewpoint of enabling the combined supplement liquid to cope with various prescriptions and facilitating calculation of the dietary fiber content.

In the above-described aspect of the supplement liquid of the present invention, as a specific preparation example of the mineral component, water and dietary fiber, from the viewpoint that the contents of the mineral component, water and dietary fiber in the combined supplement liquid can be applied to various formulations, calculation is easy, and the number of products to be reduced, for example, the supplement liquid may include 1g, 200mL and 5g, 1g, 300mL and 5g, 1g, 200mL and 10g, 2g, 300mL and 10g, 2g, 200mL and 5g, respectively, in salt-converted amount, water and dietary fiber, which are obtained by converting the amount of sodium as a mineral component into the amount of salt; preferably, the mineral component is a supplementary liquid containing 1g, 200mL or 5g of salt in terms of sodium, water and dietary fiber, and 2g, 200mL or 10g of dietary fiber.

The present invention will be described in further detail below with reference to examples, but the present invention is not limited to these examples, and various modifications can be made without departing from the technical spirit of the present invention.

Example 1 preparation of liquid composition (replenishment liquid) (1)

2g of common salt and 10g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Sun chemical Co., Ltd.)) were added to 200mL of warm water (60 ℃ C.) to prepare a liquid composition (1 a). After 200mL of the liquid composition (1a) was stored (filled) in a flexible container made of a polyethylene resin, autoclave sterilization (sterilization in a sterilization pot (120 ℃ C., 10 minutes)) was carried out to prepare a liquid composition (1 b). The sodium (Na) concentration was 400mg/100mL, and the chlorine (Cl) concentration was 600mg/100 mL.

In this case, even when the liquid composition (1b) was stored under predetermined conditions (40 ℃ C., 2 months), no putrefaction or deterioration in flavor occurred. Further, when the liquid composition (1b) is circulated by connecting the liquid composition (1b) through a pipe, the liquid composition (1b) is not exposed to the atmosphere, and hygienic transfer of water, salt, and dietary fiber is realized.

Example 2 preparation of liquid composition (replenishment liquid) (2)

1g of common salt and 5g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Sun chemical Co., Ltd.)) were added to 200mL of warm water (60 ℃ C.) to prepare a liquid composition (2 a). After 200mL of the liquid composition (2a) was stored (filled) in a flexible container made of a polyethylene resin, autoclave sterilization (sterilization in a sterilization pot (120 ℃ C., 10 minutes)) was carried out to prepare a liquid composition (2 b). The sodium (Na) concentration was 200mg/100mL, and the chlorine (Cl) concentration was 300mg/100 mL.

In this case, even when the liquid composition (2b) was stored under predetermined conditions (40 ℃ C., 2 months), no putrefaction or deterioration in flavor occurred. Further, when the liquid composition (2b) is circulated by connecting the liquid composition with a pipe, the liquid composition (2b) is not exposed to the atmosphere, and hygienic transfer of water, salt, and dietary fiber is realized.

Example 3 preparation of liquid composition (replenishment liquid) (3)

1g of common salt and 10g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Sun chemical Co., Ltd.)) were added to 200mL of warm water (60 ℃ C.) to prepare a liquid composition (3 a). After 200mL of the liquid composition (3a) was stored (filled) in a flexible container made of a polyethylene resin, autoclave sterilization (sterilization in a sterilization pot (120 ℃ C., 10 minutes)) was carried out to prepare a liquid composition (3 b). The sodium (Na) concentration was 200mg/100mL, and the chlorine (Cl) concentration was 300mg/100 mL.

In this case, even when the liquid composition (3b) was stored under predetermined conditions (40 ℃ C., 2 months), no putrefaction or deterioration in flavor occurred. Further, when the liquid composition (3b) is circulated by connecting the liquid composition with a pipe, the liquid composition (3b) is not exposed to the atmosphere, and hygienic transfer of water, salt, and dietary fiber is realized.

Example 4 preparation of liquid composition (replenishment liquid) (4)

2g of common salt and 5g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Sun chemical Co., Ltd.)) were added to 200mL of warm water (60 ℃ C.) to prepare a liquid composition (4 a). After 200mL of the liquid composition (4a) was stored (filled) in a flexible container made of a polyethylene resin, autoclave sterilization (sterilization in a sterilization pot (120 ℃ C., 10 minutes)) was carried out to prepare a liquid composition (4 b). The sodium (Na) concentration was 400mg/100mL, and the chlorine (Cl) concentration was 600mg/100 mL.

In this case, even when the liquid composition (4b) was stored under predetermined conditions (40 ℃ C., 2 months), no putrefaction or deterioration in flavor occurred. Further, when the liquid composition (4b) is circulated by connecting the liquid composition with a pipe, the liquid composition (4b) is not exposed to the atmosphere, and hygienic transfer of water, salt, and dietary fiber is realized.

Example 5 preparation of liquid composition (replenishment liquid) (5)

To 300mL of warm water (60 ℃), 1g of common salt and 5g of dietary fiber (galactomannan decomposition product, "Sunfiber R" (manufactured by Sun chemical Co., Ltd.) were added to prepare a liquid composition (5 a). After 300mL of the liquid composition (5a) was stored (filled) in a flexible container made of a polyethylene resin, autoclave sterilization (sterilization in a sterilization pot (120 ℃ C., 10 minutes)) was performed to prepare a liquid composition (5 b). The sodium (Na) concentration was 133mg/100mL, and the chlorine (Cl) concentration was 200mg/100 mL.

In this case, even when the liquid composition (5b) was stored under predetermined conditions (40 ℃ C., 2 months), no putrefaction or deterioration in flavor occurred. Further, when the liquid composition (5b) is circulated by connecting the liquid composition with a pipe, the liquid composition (5b) is not exposed to the atmosphere, and hygienic transfer of water, salt, and dietary fiber is realized.

By combining two or more liquid compositions (replenishers) according to examples 1 to 5, the contents of mineral components, water and dietary fiber in the replenisher after the combination can be adjusted to the optimum levels, and the prescription of various replenishers can be quickly and flexibly adapted to the cases of patients and the like required in medical practice. The methods of administration of nutritional compositions and the like using conventional products were used as comparative examples 1 to 3, and the methods of administration of a combination of two or more of the liquid compositions (replenishers) of examples 1 to 5 were used as examples 6 to 8. The results of the comparison are shown in Table 1.

[ Table 1]

As is clear from the results shown in table 1, in the administration methods of comparative examples 1 to 3, the addition work of the salt and the dietary fiber occurred for each administration amount of the nutritional composition prescribed by the patient, and the salt amount and the dietary fiber amount had to be adjusted. In addition, it is found that when the amount of the conventional product is zero in terms of the amount of the salt or the dietary fiber, an error occurs between the required amount and the administered amount of the patient's prescription.

On the other hand, it is found that the administration methods of examples 6 to 8 can easily and rapidly prepare a nutritional composition completely suitable for the prescription of a patient by combining two or more supplementary liquids of examples 1 and 3 to 5.

Claims (9)

1. A supplement liquid for enteral nutrition, wherein the supplement liquid is formed from mineral components, water and dietary fiber.

2. The supplement of claim 1, wherein the mineral component comprises sodium.

3. The supplement liquid according to claim 1 or 2, further comprising a vitamin component.

4. The supplement liquid according to any one of claims 1 to 3, wherein the sodium content is 0.3 to 26g/100mL in terms of common salt.

5. The replenishment solution according to any one of claims 1 to 4, wherein the total of the weight of sodium ions and the weight of chloride ions is 80 to 100% by weight based on the weight of the total mineral component.

6. A replenishment solution according to any one of claims 1 to 5, wherein the weight of sodium ions is 60 to 200% by weight relative to the weight of chloride ions.

7. A refill liquid to be put into a container, wherein the refill liquid is obtained by heat sterilization of the container in which the refill liquid according to any one of claims 1 to 6 is stored.

8. A refill liquid for filling containers according to claim 7, wherein the container is closed.

9. The refill liquid filled in a container according to claim 7 or 8, wherein the container has one or more than two fine-mouthed portions for outflow and/or mixing.