HK1203060A1 - Low hygroscopic aripiprazole drug substance and processes for the preparation thereof - Google Patents

Low hygroscopic aripiprazole drug substance and processes for the preparation thereof Download PDF

Info

Publication number: HK1203060A1
Authority: HK; Hong Kong
Prior art keywords: crystals; aripiprazole; aripiprazole anhydride; anhydride; hydrate
Prior art date: 2001-09-25

Application number

HK15103617.0A

Other languages

English (en)

Chinese (zh)

Inventor

坂東卓治

坂东卓治

青木聰之

青木聪之

川崎淳

川崎淳一

石上誠

石上诚

谷口洋

谷口洋一

藪內剛

薮内刚

藤本聖

藤本圣

西岡佳宏

西冈佳宏

小林功幸

藤村勤

高橋正典

高桥正典

阿部薰

仲川知則

仲川知则

新濱光

新滨光一

宇積尚登

宇积尚登

富永道明

大井祥博

山田昌平

富川憲次

富川宪次

Original Assignee

大塚制药株式会社

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-25

Filing date

2004-04-22

Publication date

2015-10-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36049773&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1203060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-03-27 Priority claimed from CA 2379005 external-priority patent/CA2379005A1/en

2004-04-22 Application filed by 大塚制药株式会社 filed Critical 大塚制药株式会社

2015-10-16 Publication of HK1203060A1 publication Critical patent/HK1203060A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Psychology (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Otolaryngology (AREA)
Diabetes (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HK15103617.0A 2001-09-25 2004-04-22 Low hygroscopic aripiprazole drug substance and processes for the preparation thereof HK1203060A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2001290645		2001-09-25
JP2001348276		2001-11-14
CA 2379005 CA2379005A1 (en)	2001-09-25	2002-03-27	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
CA2379005		2002-03-27

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
HK04102856.5A Addition HK1060046A (en)	2001-09-25	2002-09-25	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
HK04102856.5A Division HK1060046A (en)	2001-09-25	2002-09-25	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

Publications (1)

Publication Number	Publication Date
HK1203060A1 true HK1203060A1 (en)	2015-10-16

Family

ID=36049773

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
HK15103616.1A HK1203059A1 (en)	2001-09-25	2004-04-22	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK16111449.6A HK1223043A1 (zh)	2001-09-25	2004-04-22	低吸湿性阿立哌唑药物及其制备方法
HK15103617.0A HK1203060A1 (en)	2001-09-25	2004-04-22	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK15111240.8A HK1210468A1 (en)	2001-09-25	2015-11-13	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK16103439.5A HK1215397A1 (zh)	2001-09-25	2016-03-23	低吸湿性阿立哌唑药物及其制备方法

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
HK15103616.1A HK1203059A1 (en)	2001-09-25	2004-04-22	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK16111449.6A HK1223043A1 (zh)	2001-09-25	2004-04-22	低吸湿性阿立哌唑药物及其制备方法

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
HK15111240.8A HK1210468A1 (en)	2001-09-25	2015-11-13	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK16103439.5A HK1215397A1 (zh)	2001-09-25	2016-03-23	低吸湿性阿立哌唑药物及其制备方法

Country Status (21)

Country	Link
EP (1)	EP3081216A1 (xx)
KR (2)	KR100490222B1 (xx)
CN (12)	CN104945321A (xx)
AR (3)	AR073111A2 (xx)
CA (1)	CA2713466C (xx)
CL (1)	CL2010000405A1 (xx)
CY (4)	CY1110070T1 (xx)
DK (1)	DK1925308T3 (xx)
ES (1)	ES2596354T3 (xx)
HK (5)	HK1203059A1 (xx)
IL (3)	IL204707A (xx)
LT (1)	LT1925308T (xx)
MY (1)	MY138669A (xx)
NO (1)	NO337844B1 (xx)
PE (1)	PE20030445A1 (xx)
PH (1)	PH12014500782A1 (xx)
PL (7)	PL221536B1 (xx)
PT (1)	PT1925308T (xx)
RU (1)	RU2279429C2 (xx)
SI (1)	SI1927357T1 (xx)
TW (2)	TWI332839B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA06004489A (es) *	2003-10-23	2006-06-20	Otsuka Pharma Co Ltd	Formulacion y metodo de aripiprazol inyectable esteril de liberacion controlada.
JOP20200109A1 (ar) *	2012-04-23	2017-06-16	Otsuka Pharma Co Ltd	مستحضر قابل للحقن
KR102128883B1 (ko) *	2019-10-02	2020-07-01	(주)삼화바이오팜	고순도 아리피프라졸의 신규 결정형 및 이의 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54130587A (en) *	1978-03-30	1979-10-09	Otsuka Pharmaceut Co Ltd	Carbostyryl derivative
JP2608788B2 (ja)	1988-10-31	1997-05-14	大塚製薬株式会社	精神分裂病治療剤
US5006528A (en) *	1988-10-31	1991-04-09	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives
JP3638447B2 (ja) *	1998-09-10	2005-04-13	積水ハウス株式会社	笠木取付金具および笠木取付構造
GB9930061D0 (en) *	1999-12-20	2000-02-09	Glaxo Group Ltd	Quinolone compounds for use in treating viral infections
HK1049004A1 (en) *	2000-01-20	2003-04-25	Eisai Co., Ltd.	Nitrogenous cyclic compounds and pharmaceutical compositions containing the same
US20020076437A1 (en) *	2000-04-12	2002-06-20	Sanjeev Kothari	Flashmelt oral dosage formulation
CA2311734C (en) *	2000-04-12	2011-03-08	Bristol-Myers Squibb Company	Flash-melt oral dosage formulation
JP4197088B2 (ja)	2000-06-05	2008-12-17	電気化学工業株式会社	低密度かつ低ガス透過性六方晶窒化硼素焼結体及びその製造方法
JP2002193915A (ja) *	2000-12-28	2002-07-10	Otsuka Pharmaceut Co Ltd	ベンゼンスルフォナート化合物

2002
- 2002-09-20 PE PE2002000922A patent/PE20030445A1/es active IP Right Grant
- 2002-09-20 MY MYPI20023512A patent/MY138669A/en unknown
- 2002-09-23 TW TW098116881A patent/TWI332839B/zh not_active IP Right Cessation
- 2002-09-23 TW TW091121771A patent/TWI318572B/zh not_active IP Right Cessation
- 2002-09-25 ES ES08000358.5T patent/ES2596354T3/es not_active Expired - Lifetime
- 2002-09-25 DK DK08000358.5T patent/DK1925308T3/en active
- 2002-09-25 CN CN201510333215.XA patent/CN104945321A/zh active Pending
- 2002-09-25 PL PL393603A patent/PL221536B1/pl unknown
- 2002-09-25 PT PT80003585T patent/PT1925308T/pt unknown
- 2002-09-25 KR KR10-2003-7000818A patent/KR100490222B1/ko not_active Expired - Lifetime
- 2002-09-25 CN CN201310728318.7A patent/CN103755632B/zh not_active Expired - Fee Related
- 2002-09-25 CN CN2013100996412A patent/CN103191118A/zh active Pending
- 2002-09-25 CN CN201410053619.9A patent/CN103751093A/zh active Pending
- 2002-09-25 CA CA2713466A patent/CA2713466C/en not_active Expired - Lifetime
- 2002-09-25 PL PL417178A patent/PL230869B1/pl unknown
- 2002-09-25 CN CN201510615759.5A patent/CN105267151A/zh active Pending
- 2002-09-25 PL PL393596A patent/PL393596A1/pl not_active Application Discontinuation
- 2002-09-25 CN CN201310191361.4A patent/CN103288727B/zh not_active Expired - Lifetime
- 2002-09-25 EP EP16169141.5A patent/EP3081216A1/en not_active Withdrawn
- 2002-09-25 CN CN2012100054661A patent/CN102579446A/zh active Pending
- 2002-09-25 CN CN201410053920.XA patent/CN103751119A/zh active Pending
- 2002-09-25 PL PL393601A patent/PL219565B1/pl unknown
- 2002-09-25 PL PL393608A patent/PL219564B1/pl unknown
- 2002-09-25 SI SI200230906T patent/SI1927357T1/sl unknown
- 2002-09-25 RU RU2004126636/04A patent/RU2279429C2/ru not_active IP Right Cessation
- 2002-09-25 LT LTEP08000358.5T patent/LT1925308T/lt unknown
- 2002-09-25 PL PL393598A patent/PL221521B1/pl unknown
- 2002-09-25 KR KR10-2004-7007990A patent/KR100530731B1/ko not_active Expired - Fee Related
- 2002-09-25 CN CN201410468156.2A patent/CN104306374A/zh active Pending
- 2002-09-25 CN CN201410053617.XA patent/CN103751118A/zh active Pending
- 2002-09-25 CN CN201410466919.XA patent/CN104306337A/zh active Pending
- 2002-09-25 CN CN201610186509.9A patent/CN105832677A/zh active Pending
- 2002-09-25 PL PL393607A patent/PL393607A1/pl unknown
2004
- 2004-04-22 HK HK15103616.1A patent/HK1203059A1/xx unknown
- 2004-04-22 HK HK16111449.6A patent/HK1223043A1/zh unknown
- 2004-04-22 HK HK15103617.0A patent/HK1203060A1/xx unknown
2009
- 2009-08-21 AR ARP090103228A patent/AR073111A2/es not_active Application Discontinuation
2010
- 2010-03-24 IL IL204707A patent/IL204707A/en not_active IP Right Cessation
- 2010-04-23 CL CL2010000405A patent/CL2010000405A1/es unknown
- 2010-06-11 CY CY20101100531T patent/CY1110070T1/el unknown
- 2010-06-11 CY CY20101100530T patent/CY1110212T1/el unknown
- 2010-06-11 CY CY20101100529T patent/CY1110208T1/el unknown
- 2010-07-05 AR ARP100102387A patent/AR077635A2/es not_active Application Discontinuation
- 2010-07-05 CY CY20101100614T patent/CY1110244T1/el unknown
2012
- 2012-08-15 AR ARP120102986A patent/AR087544A2/es not_active Application Discontinuation
2013
- 2013-04-23 IL IL225902A patent/IL225902A0/en unknown
2014
- 2014-04-08 PH PH12014500782A patent/PH12014500782A1/en unknown
- 2014-09-22 IL IL234770A patent/IL234770A0/en unknown
- 2014-10-06 NO NO20141193A patent/NO337844B1/no not_active IP Right Cessation
2015
- 2015-11-13 HK HK15111240.8A patent/HK1210468A1/xx unknown
2016
- 2016-03-23 HK HK16103439.5A patent/HK1215397A1/zh unknown

Also Published As

Publication number	Publication date
HK1196128A1 (zh)	2014-12-05
TW200942238A (en)	2009-10-16
CN103751118A (zh)	2014-04-30
PE20030445A1 (es)	2003-07-26
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HK1136961A1 (en)	2010-07-16
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NO20141193L (no)	2003-01-17
IL204707A (en)	2016-06-30
PL417178A1 (pl)	2016-07-04
CN103751119A (zh)	2014-04-30
AR077635A2 (es)	2011-09-14
KR100490222B1 (ko)	2005-05-18
HK1203059A1 (en)	2015-10-16
PL393598A1 (pl)	2011-04-26
KR20030060871A (ko)	2003-07-16
CY1110070T1 (el)	2015-01-14
HK1092808A1 (en)	2007-02-16
KR20040053372A (ko)	2004-06-23
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RU2279429C2 (ru)	2006-07-10
KR100530731B1 (ko)	2005-11-23
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PL230869B1 (pl)	2018-12-31
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AR073111A2 (es)	2010-10-13
CN103755632A (zh)	2014-04-30
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CN104945321A (zh)	2015-09-30
NO337844B1 (no)	2016-06-27
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CA2713466C (en)	2012-01-03
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TWI332839B (en)	2010-11-11
CA2713466A1 (en)	2003-04-03
CN105267151A (zh)	2016-01-27
HK1223043A1 (zh)	2017-07-21
CN103288727A (zh)	2013-09-11
IL225902A0 (en)	2013-06-27
HK1215397A1 (zh)	2016-08-26
CN103191118A (zh)	2013-07-10
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SI1927357T1 (sl)	2010-09-30
PH12014500782A1 (en)	2018-09-10
HK1136959A1 (en)	2010-07-16
AR087544A2 (es)	2014-04-03

Publication	Publication Date	Title
CN101574348B (zh)	2012-02-22	低吸湿性阿立哌唑药物及其制备方法
AU2002334413A1 (en)	2003-06-26	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1210468A1 (en)	2016-04-22	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1231772A1 (en)	2017-12-29	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1196078A (en)	2014-12-05	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1195878A (en)	2014-11-28	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1196077A (en)	2014-12-05	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1231773A1 (en)	2017-12-29	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1168288A (en)	2012-12-28	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1092808B (en)	2011-12-16	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1185565A (en)	2014-02-21	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1130048A (en)	2009-12-18	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1129891B (en)	2012-06-08	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1129889B (en)	2012-09-07	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1129373A (en)	2009-11-27	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1145326A (en)	2011-04-15	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1136958B (en)	2012-12-07	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1136959B (en)	2012-08-10	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1129892A (zh)	2009-12-11	低吸湿性阿立哌唑药物及其制备方法
HK1129892B (en)	2014-02-28	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1136960B (en)	2012-08-10	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1136961B (en)	2012-09-21	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1196128B (en)	2017-04-28	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
HK1187048B (en)	2017-01-06	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof