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HK1246799A1 - 替诺福韦单苄酯磷酰胺前药、其制备方法及应用 - Google Patents

替诺福韦单苄酯磷酰胺前药、其制备方法及应用 Download PDF

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Publication number
HK1246799A1
HK1246799A1 HK18106521.5A HK18106521A HK1246799A1 HK 1246799 A1 HK1246799 A1 HK 1246799A1 HK 18106521 A HK18106521 A HK 18106521A HK 1246799 A1 HK1246799 A1 HK 1246799A1
Authority
HK
Hong Kong
Prior art keywords
tenofovir
monobenzyl ester
compounds
compound
compound according
Prior art date
Application number
HK18106521.5A
Other languages
English (en)
Other versions
HK1246799B (zh
Inventor
王国成
王國成
吴会敏
吳會敏
Original Assignee
江苏天士力帝益药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏天士力帝益药业有限公司 filed Critical 江苏天士力帝益药业有限公司
Publication of HK1246799A1 publication Critical patent/HK1246799A1/zh
Publication of HK1246799B publication Critical patent/HK1246799B/zh

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK18106521.5A 2015-05-29 2016-05-26 替诺福韦单苄酯磷酰胺前药、其制备方法及应用 HK1246799B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510290530 2015-05-29
CN201510290530 2015-05-29
PCT/CN2016/083407 WO2016192560A1 (zh) 2015-05-29 2016-05-26 替诺福韦单苄酯磷酰胺前药、其制备方法及应用

Publications (2)

Publication Number Publication Date
HK1246799A1 true HK1246799A1 (zh) 2018-09-14
HK1246799B HK1246799B (zh) 2021-02-05

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Also Published As

Publication number Publication date
AU2016270101B2 (en) 2020-01-23
WO2016192560A1 (zh) 2016-12-08
KR20180016437A (ko) 2018-02-14
IL255892A (en) 2018-01-31
MY191515A (en) 2022-06-28
AU2016270101A1 (en) 2017-12-14
JP6679624B2 (ja) 2020-04-15
CN107709340A (zh) 2018-02-16
US10233202B2 (en) 2019-03-19
CN106188139B (zh) 2020-02-18
JP2018517698A (ja) 2018-07-05
EP3305795A4 (en) 2019-02-06
IL255892B (en) 2020-11-30
CA2987473A1 (en) 2016-12-08
CN106188139A (zh) 2016-12-07
US20180127445A1 (en) 2018-05-10
RU2719594C2 (ru) 2020-04-21
SG11201709786WA (en) 2017-12-28
RU2017145357A (ru) 2019-07-01
ES2806726T3 (es) 2021-02-18
RU2017145357A3 (zh) 2019-09-04
TWI692479B (zh) 2020-05-01
EP3305795A1 (en) 2018-04-11
CN107709340B (zh) 2020-03-17
EP3305795B1 (en) 2020-05-06
TW201702246A (zh) 2017-01-16

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