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HK1244843A1 - 载脂蛋白c3(apoc3)irna组合物及其使用方法 - Google Patents

载脂蛋白c3(apoc3)irna组合物及其使用方法 Download PDF

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Publication number
HK1244843A1
HK1244843A1 HK18104187.5A HK18104187A HK1244843A1 HK 1244843 A1 HK1244843 A1 HK 1244843A1 HK 18104187 A HK18104187 A HK 18104187A HK 1244843 A1 HK1244843 A1 HK 1244843A1
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HK
Hong Kong
Prior art keywords
apoc3
methods
apolipoprotein
irna compositions
rnai agents
Prior art date
Application number
HK18104187.5A
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English (en)
Inventor
Kevin Fitzgerald
William Querbes
James Butler
Stephanie Williams
Abigail LIEBOW
Gregory Hinkle
Martin Maier
Stuart Milstein
Satyanarayana Kuchimanchi
Muthiah Manoharan
Original Assignee
Alnylam Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals, Inc. filed Critical Alnylam Pharmaceuticals, Inc.
Publication of HK1244843A1 publication Critical patent/HK1244843A1/zh

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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HK18104187.5A 2014-11-17 2015-11-17 载脂蛋白c3(apoc3)irna组合物及其使用方法 HK1244843A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462080941P 2014-11-17 2014-11-17
US201462080941P 2014-11-17
US201562136159P 2015-03-20 2015-03-20
US201562136159P 2015-03-20
PCT/US2015/061065 WO2016081444A1 (en) 2014-11-17 2015-11-17 Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1244843A1 true HK1244843A1 (zh) 2018-08-17

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HK18104187.5A HK1244843A1 (zh) 2014-11-17 2015-11-17 载脂蛋白c3(apoc3)irna组合物及其使用方法

Country Status (8)

Country Link
US (7) US10407679B2 (zh)
EP (1) EP3221451A1 (zh)
JP (4) JP2017535552A (zh)
CN (2) CN107250362B (zh)
AU (3) AU2015350120B2 (zh)
CA (1) CA2968114A1 (zh)
HK (1) HK1244843A1 (zh)
WO (1) WO2016081444A1 (zh)

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