HK1178070A - Vesicle composition and cosmetic comprising same - Google Patents

Description

Vesicle composition and cosmetic containing same

Technical Field

The present invention relates to a vesicle composition having a specific cationic surfactant, sterols and water as components and having good long-term stability, and a cosmetic containing the same, and more particularly, to a hair cosmetic containing the composition, which is capable of being applied to hair, of rapidly adhering to the hair, having good penetration into the hair, and giving a good moisturized feeling.

Background

Conventionally, studies have been made on the formulation of cosmetics for hair containing sterols such as cholesterol and phytosterol as components effective for hair. In particular, cholesterol is originally present in hair as a component affecting the hair moisturizing function, but it is known that its content decreases after about ten years of age (see non-patent document 1), and is an important component for maintaining moist and beautiful hair without split ends.

However, it is known that sterol derivatives such as cholesterol are generally poorly soluble substances that are poorly soluble in both water and oil (see patent document 1), and it is very difficult to stably mix them into emulsion-based preparations using water as a medium. Therefore, various techniques for stably blending these sparingly soluble sterol derivatives into water-soluble media have been studied.

For example, it is known that a lamellar liquid-crystal bilayer vesicle, i.e., a vesicle having an inner aqueous phase, is formed by mixing an alkyl quaternary ammonium salt type cationic surfactant with an amphiphilic substance, a sterol derivative, and water at a specific mixing ratio (see patent document 2).

In other studies, it is known that vesicles are formed by mixing an alkyl quaternary ammonium cationic surfactant with a sterol derivative, a ceramide, a cationic polymer (see patent document 3), or silicone (see patent document 4).

Further, as a cationic surfactant different from the above-mentioned patent documents 2 to 4, there is also an example in which methyl dicocoylethyl ammonium sulfate having an ester structure in a hydrophobic group (dicocoyloxyethyl hydroxyethyl methyl ammonium methyl sulfate) is used in combination with a sterol such as cholesterol (see patent document 5).

Non-patent document 1: the society of perfumery (Vol.13, No. 3, 1989, pp.134-139).

Patent document 1: japanese patent application laid-open No. 2006-176410.

Patent document 2: japanese patent application laid-open No. 2001-97811.

Patent document 3: japanese patent laid-open No. 2006-199634.

Patent document 4: japanese patent laid-open No. 2006-199635.

Patent document 5: japanese patent application laid-open No. 2006-182743.

Disclosure of Invention

Problems to be solved by the invention

However, in the techniques of patent documents 2 to 4, all of which use an alkyl quaternary ammonium salt type cationic surfactant, there is a case where vesicles are broken with time and precipitated to precipitate crystals when the vesicle formation of sterols is insufficient due to the use of an alkyl quaternary ammonium salt type cationic surfactant, and the stability is insufficient.

Further, even when a hair cosmetic containing such vesicles is applied to hair, it is difficult to obtain a feeling of adhesion to hair, penetration into hair, and a feeling of wetting, and it is difficult to obtain a moist texture.

Further, according to patent document 5, since a poorly soluble component such as cholesterol may not be stably incorporated into the vesicle, cholesterol or the like completely precipitates with time, and it is difficult to maintain an effective effect on hair.

Accordingly, an object of the present invention is to provide a vesicle composition which can stably contain a sterol such as cholesterol as an active ingredient for hair in an aqueous medium and has excellent long-term stability, and a cosmetic containing the same. The problem is to provide a hair cosmetic composition, particularly a hair cosmetic composition blended with the composition, which, when applied to hair, quickly adheres to the hair, has good penetration into the hair, and produces a good moist texture.

Means for solving the problems

The present inventors have made intensive studies in order to solve the above problems, and as a result, have found that a vesicle composition having good long-term stability can be obtained by combining a cationic surfactant having a specific chemical structure with a sterol and water, and that the composition can be stably incorporated into an aqueous cosmetic composition, and further that when the composition is incorporated into a hair cosmetic composition and applied to hair, the composition is quickly applied without staying on the hair surface, and the composition has good permeability into the hair, and can reliably feel the penetration of an active ingredient, and a hair cosmetic composition having a good effect of producing a moist texture can be obtained, thereby completing the present invention.

In other words, the present invention provides a vesicle composition characterized by containing the following components (a) to (C):

(A) the following general formula (1)

(shown in the formula, R¹CO-、R²CO-is a saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which may be identical or different; r³is-CH₃or-CH₂OH or-C₂H₄OH; m and n are the same or different and are 2 or 3; x is halogen, methyl sulfate, ethyl sulfate or methyl phosphate),

(B) a sterol compound selected from the group consisting of sterols,

(C) and (3) water.

Further, the present invention provides a vesicle composition characterized in that the molar ratio (a)/(B) of the component (a) and the component (B) is in the range of 100/1 to 1/4.

Further, the present invention provides a vesicle composition characterized in that the component (B) is cholesterol and/or phytosterol.

The present invention also provides a cosmetic characterized by blending the vesicle composition. A preferred form of the cosmetic of the present invention is a hair cosmetic.

In addition, the present invention is characterized in that a monovalent lower alcohol (or monovalent lower alcohol) as the component (D) is further blended in the vesicle composition or the cosmetic.

ADVANTAGEOUS EFFECTS OF INVENTION

The vesicle composition of the present invention has good long-term stability and can be stably incorporated into a cosmetic. In particular, when the hair cosmetic composition is applied to hair, the composition adheres to hair quickly, has good penetration into the hair, can reliably feel the penetration, and has a good effect of producing a moist texture.

Drawings

FIG. 1: a photograph of the vesicle composition of invention product 1 was observed with a transmission electron microscope.

FIG. 2: in the vesicle composition of invention product 1, a polarization microscope photograph showing the presence of a black cross extinction image (Maltese cross) was observed with a crossed nicols using vesicles as an index.

FIG. 3: photograph of hair cross section for evaluating penetrating ability into hair.

FIG. 3-1: photographs of hair cross sections soaked in samples of inventive article 5. FIG. 3-2: photograph of hair cross section soaked in sample of comparative sample 2 (no fluorescent label added). FIGS. 3-3: photograph of hair cross section soaked in the sample of comparative product 3. FIGS. 3-4: photograph of hair cross section soaked in sample of comparative product 4.

FIG. 4: a graph showing the evaluation results of the ratio of bound water in hair for the sample of invention product 5.

FIG. 5: the results of evaluating the long-term stability of vesicle compositions containing dipalmitoyloxyethyl hydroxyethylammonium methosulfate (DEQ).

FIG. 6: results of evaluating the long-term stability of vesicle compositions containing distearyldimethylammonium chloride (DSAC).

FIG. 7: differential Scanning Calorimetry (DSC) measurements of vesicle compositions containing dipalmitoyloxyethyl hydroxyethylmethylammonium methylsulfate (DEQ).

Detailed Description

The present invention will be explained.

The present invention relates to vesicle compositions containing specified components (a) - (C).

In addition, the term "vesicle composition" as used herein means a spherical closed vesicle in water, and a dark cross extinction image is observed by a polarization microscope, and a multilamellar vesicle having a multilamellar structure is observed by a transmission electron microscope by another observation method.

The cationic surfactant used for the component (A) of the present invention is represented by the following general formula (1)

(shown in the formula, R¹CO-、R²CO-is a saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which may be identical or different; r³is-CH₃or-CH₂OH or-C₂H₄OH; m and n are the same or different and are 2 or 3; x is halogen, methyl sulfate, sulfuric acidEthyl ester or methyl phosphate) is a main component of the bilayer membrane forming vesicles in the present invention. Having ester linkages in the hydrophobic chain [ also known as esters クオ - ト (quart)]In general, the hair care effect is better and the biodegradability is better than that of a long-chain alkane type cationic surfactant having the same carbon number.

In the present invention, since the vesicle composition having good long-term stability and good micro-membrane fluidity (hereinafter, simply referred to as "deformability of the vesicle membrane") for evaluating the deformability of the bilayer membrane in the vesicle structure can be prepared by using the component (a), the hair active ingredient such as the component (B) does not precipitate with time and can be kept stable until the time of use because the component (B) is contained in the vesicle formed by the component (a). Moreover, when the hair conditioner is applied to hair, the hair conditioner effectively penetrates into the hair, so that the hair active ingredients such as the ingredient (B) are stably delivered into the hair, and good moist texture is obtained.

Specific examples of the component (A) include dicocooyloxyethylhydroxyethylmethylammonium methylsulfate, bisstearoyloxyethylmethylammonium methylsulfate, and dipalmitoyloxyethylmethylammonium methylsulfate, combinations of 1 or 2 or more of these may be used, and commercially available products such as DEHYQUART L80, DEHYQUART F75, DEHYQUART AU56/G, and DEHYQUART C4046 (all of which are available from コグニス (Kukuniss)). Among them, dicocoyloxyethyl hydroxyethylmethylammonium methylsulfate is particularly preferable in terms of long-term stability of the obtained vesicle composition and penetration (penetration feeling) of the hair cosmetic composition with which the vesicle composition is blended when the hair is applied.

The amount of the component (a) of the present invention to be incorporated in the vesicle composition is not particularly limited, but is preferably 0.001 to 10% by mass (hereinafter, abbreviated as "%"), more preferably 0.01 to 5%.

When the amount is within the above range, the obtained vesicle composition is excellent in long-term stability and deformation of vesicle membrane, and therefore, when a cosmetic is blended therewith, it is very stable until use, and when applied to hair, for example, the hair active ingredient such as the ingredient (B) effectively penetrates into the hair, and a good moist texture is obtained.

The sterol used in the component (B) of the present invention is blended as a component (B) which contributes to the formation and stabilization of vesicles and also contributes to the moisturizing texture of hair when the obtained vesicle composition is blended into a cosmetic for hair.

For example, in the case of a conventional cationic surfactant, in a vesicle system containing distearyl dimethyl ammonium chloride [ ライオン. アクゾ (manufactured by rayonacaozo) corporation ] having a long-chain alkyl group containing no ester group, when a sterol is added, the vesicle system is aggregated. However, in contrast to the expectation that adding sterols to a vesicle system containing a cationic surfactant as represented by formula (1) as specified above, wherein the cationic surfactant comprises a long-chain alkane chain containing an ester group, the present inventors found significant stabilization of the vesicle system.

The sterol of the component (B) may be a substance retaining a sterol skeleton or a derivative thereof, and examples thereof include cholesterol, phytosterol (β -sitosterol, campesterol, stigmasterol, umeprostenol, etc.), lanosterol, polyoxyethylene cholesterol ether, nut oil fatty acid cholesterol of Queensland, nut oil fatty acid phytosterol of Queensland, coconut fatty acid cholesterol, oleic acid phytosterol, N-lauroyl-L-glutamic acid bis (cholesteryl behenyl octyldodecyl), N-lauroyl-L-glutamic acid bis (octyldodecyl phytosterol behenyl), N-lauroyl-L-glutamic acid bis (phytosterol octyldodecyl), oleic acid phytosterol, etc., and one or two or more of them may be used, among which a sterol skeleton represented by the following general formula (2) is preferable, and sterols in which R is an aliphatic group (e.g., a linear or branched alkyl group, and a linear or branched alkenyl group), and cholesterol and phytosterol are particularly preferable.

As commercially available products, ニツスイマリン (Neem Marlin) cholesterol (manufactured by Nippon Shuzo), マリン (Marlin) cholesterol [ manufactured by cozaar テクノス (Tekuno), phytosterol [ (エ - ザイ - フ - ドケミカル (manufactured by Shikoku Mika Co) ], sitosterol [ ( field ライスフアインケミカルズ (manufactured by Lesion Critical Mika) Co) ], EMAEX CS-10[ (manufactured by Nippon エマルジヨン (manufactured by Wako Jun Co) ], エルデユウ (manufactured by Wako Jun Co.), PS-203, エルデユウ (commercially available Lo) PS-304, エルデユウ (commercially available Lo) PS-306 (all manufactured by Wako Jun Su Co.), and the like can be used.

The amount of the component (B) of the present invention to be incorporated is not particularly limited, but is preferably 0.001 to 5%, more preferably 0.01 to 3%, in the vesicle composition. When used in the above range, the vesicle composition is formed well and has good long-term stability, and the component (B) effectively penetrates into the hair, and a sufficient moist texture can be felt.

In the present invention, the component (A) and the component (B) are mixed in a molar ratio (A)/(B) of the component (A) to the component (B) of preferably 100/1 to 1/4, more preferably 9/1 to 3/7. (A) When the molar ratio of (B) is within the above range, a vesicle composition having excellent microscopic membrane fluidity (deformability of vesicle membrane) and excellent long-term stability is formed, and the component (B) effective for hair can be effectively permeated into the hair, and the effect of the component (B) can be more effectively exerted.

The water used as component (C) in the present invention is used as a dispersion medium for vesicles, and is an essential component for vesicle compositions and a vehicle for cosmetics containing the same. The amount of the component (a) to be blended may be appropriately determined depending on the amount of the component (D) to be blended, which is an arbitrary amount of other components, and is about 5 to 99%, more preferably 20 to 90%, and still more preferably 60 to 90%.

In addition to the components (a) to (C), a higher fatty acid that is liquid at 25 ℃ may be blended in the vesicle composition of the present invention for the purpose of further improving the long-term stability against crystallization of the precipitated component (B). Any higher fatty acid that is liquid at 25 ℃ can be used, and examples thereof include saturated branched fatty acids such as isomyristic acid, isopalmitic acid, and isostearic acid, and unsaturated fatty acids such as oleic acid and linoleic acid. Further, the vegetable oil containing unsaturated fatty acid may be avocado oil, almond oil, refined jojoba oil, grapeseed oil, sesame oil, wheat germ oil, rice bran oil, soybean oil, corn germ oil, rapeseed oil, nut oil of queen stephania, メドウホ - ム (thaumatin), peanut oil, rose hip oil, or the like. The content of the higher fatty acid which is liquid at 25 ℃ is preferably 0.5 to 1.5 times by mass relative to the component (B).

The method for producing the vesicle composition of the present invention is not particularly limited, and for example, the vesicle composition can be obtained by dispersing the components (a) and (B) heated to 100 ℃ or higher in the component (C) heated to 90 ℃ or higher, and then gradually cooling to room temperature while continuing stirring. In addition, in the case of preparing vesicles, the components described below may be added in any possible ratio depending on their appropriate properties in order to expect a feeling of use and further effects on hair.

The average particle diameter of the vesicle composition obtained is approximately 100nm to 10 μm, and it is preferable that the average particle diameter is 50 to 500nm, and the vesicle is not broken even after a long time, and has a small change (increase) in the average particle diameter and good stability when an apparatus such as an extruder described later is used.

The vesicle composition of the present invention prepared by the above method can be used in combination with various cosmetics such as cosmetics for hair. In particular, a cosmetic for hair containing the vesicle composition of the present invention preferably has a good penetration of the active ingredient into the hair.

The present invention also relates to a cosmetic product compounded with the vesicle composition of the present invention. A lower monovalent alcohol (or lower monovalent alcohol) as the component (D) may be blended in a cosmetic preparation blended with the vesicle composition of the present invention.

In general, in hair cosmetics, a lower monovalent alcohol as the component (D) is an important component that gives quick-drying and refreshing feeling when applied, and contributes to good adhesion to hair, but it is known that it is difficult to ensure long-term stability by blending a lower monovalent alcohol in a vesicle composition blending system.

However, in the present invention, by preparing the vesicle composition using the component (a), even when the lower monovalent alcohol of the component (D) is blended, a vesicle composition having good long-term stability is obtained, and when the cosmetic for hair blended with the vesicle composition is applied to hair, a cosmetic having rapid adhesion, good penetration into the hair, a feeling of penetration of the active ingredient being reliably sensed, and a good moisturizing effect being produced is obtained.

The lower monovalent alcohol as the component (D) is not particularly limited as long as it is generally used for cosmetics, and examples thereof include ethanol, propanol, and isopropanol, but ethanol is preferred in the present invention.

The amount of the component (D) of the present invention to be blended is not particularly limited, and desirable characteristics for the target properties of the blended cosmetic may be appropriately determined depending on, for example, the adhesion and the permeability into the hair, but is preferably from about 0.1 to 30%, more preferably from about 1 to 30%, further preferably from about 1 to 25%, and still further preferably from about 5 to 20% by weight of the total weight of the cosmetic.

The method for producing the cosmetic of the present invention is not particularly limited, and for example, as described above, the vesicle composition can be produced by dispersing the components (a) and (B) in the component (C) and then cooling to room temperature, or the vesicle composition can be produced by a method comprising blending the component (D) and optional components described later in the vesicle composition. The optional components to be blended are blended in the expectation of the feeling of use and further effects on the hair.

The vesicle composition of the present invention can provide a hair cosmetic which has a higher long-term stability, a better actual feeling of penetration into the hair and a feeling of wetting during use, and a much better moisturizing effect than a hair cosmetic in which an active ingredient such as the ingredient (B) is blended without forming vesicles.

In particular, in the cosmetic containing the component (D), although the component (D) is a component which tends to be difficult to ensure long-term stability, the vesicle composition of the present invention has good long-term stability when prepared, and can be quickly attached to hair in the form of a cosmetic for hair, for example, and has good penetration into the hair and a good feeling of wetting, and a good moist texture is produced.

The amount of the vesicle composition blended in the cosmetic of the present invention is not particularly limited, but is preferably 0.5% or more, more preferably 10% or more, by weight of the total cosmetic. In addition, the vesicle composition of the present invention can be used as a 100% cosmetic product as it is.

The formulation of the cosmetic of the present invention is not particularly limited, and a cosmetic formulation in which the external phase is aqueous is preferably prepared from the viewpoint of stably maintaining the vesicles. The external phase may contain various agents (for example, ethanol, polyvalent alcohol (polyhydric alcohol), salts, surfactants, and the like) other than water, which can be dissolved and/or dispersed in water.

In the vesicle composition of the present invention and the cosmetic containing the same, other than the above-mentioned components (a) to (C) and (D), cosmetic components for hair care such as oils, surfactants, alcohols, metal soaps, gelling agents, powders, water-soluble polymers, film-forming agents, resins, moisturizers, antibacterial agents, perfumes, deodorizing agents, salts, pH adjusting agents, cooling agents, ultraviolet absorbers, plant extracts, amino acids, saccharides, vitamins and the like may be added to the composition, as long as the effects of the present invention are not impaired.

As the oil agent, there can be used oily components such as hydrocarbons, waxes, esters, fatty acids (which may be the above higher fatty acid liquid at 25 ℃ or the above higher fatty acid non-liquid at 25 ℃), and oils and fats which are liquid, pasty, or solid at ordinary temperature. Specifically, for example, hydrocarbons, oils and fats, waxes, hydrogenated oils, ester oils, fatty acids, silicone oils, fluorine-containing oils, lanolin derivatives, and the like can be used, and more specifically, there are exemplified waxes such as ozokerite, ceresin, liquid paraffin, wax, microcrystalline wax, cetyl myristate, cetyl palmitate, and the like, hydrocarbons such as vaseline, liquid paraffin, lakeda, polyisobutylene, squalane, squalene, liquid paraffin, beeswax, carnauba wax, candelilla wax, spermaceti, waxes such as cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, shea butter, and the like solid oils such as beef tallow, beef foot fat, beef bone fat, hardened beef tallow, hardened oils, turtle oil, lard, horse fat, mink oil, liver oil, egg yolk oil, and the like, animal oils such as coconut oil, olive oil, rice germ oil, rice bran oil, sesame oil, nut oil, macadamia oil, lanolin derivatives, and the like, Olive oil, almond oil, avocado oil, camellia oil, palmarosa oil, safflower oil, sunflower oil and other vegetable oils, jojoba oil and other liquid waxes, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl oleate, cetyl caprylate, hexyl laurate, decyl oleate, oleyl oleate, isostearate laurate, isostearate myristate, isocetyl myristate, octyldodecyl myristate, 2-ethylhexyl palmitate, isocetyl palmitate, 2-ethylhexyl stearate, isocetyl stearate, decyl oleate, octyldodecyl oleate, cetyl 2-ethylhexanoate, hexyl isostearate, octyldodecyl neopentanoate, isostearyl octanoate, 2-ethylhexyl isononanoate, decyl oleate, octyl dodecyl neopentanoate, isopropyl octanoate, isopropyl, Hexyl decyl dimethyloctanoate, octyl dodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate, isocetyl isostearate, isostearic acid isostearate, isononyl isononanoate, ethylene glycol dioctanoate, propylene glycol dihexate, neopentyl glycol dioctanoate, glyceryl trioleate, glyceryl tri-2-ethylhexanoate, glyceryl triisostearate, trimethylolpropane tri-2-ethylhexanoate, ester oils such as trimethylolpropane triisostearate, etc., fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, moringanic acid, undecylenic acid, oleic acid, linoleic acid, arachidonic acid, docosahexaenoic acid (DHA), 12-hydroxystearic acid, isostearic acid, 2-ethylhexanoic acid, etc., silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, etc., fluorine-containing oils such as perfluorodecane, etc., lanolin derivatives such as lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, and lanolin fatty acid isopropyl ester.

The surfactant may be any of anionic, cationic, amphoteric and nonionic surfactants, and examples of the anionic surfactant include fatty acid soaps such as sodium stearate and triethanolamine palmitate, alkyl ether carboxylic acids and salts thereof, carboxylates such as amino acids and fatty acid condensation, alkylsulfonic acids, alkenyl sulfonates, sulfonates of fatty acid esters, sulfonates of fatty acid amides, sulfonates of alkylsulfonic acids and formalin condensates thereof, alkyl sulfate salts, secondary higher alcohol sulfate salts, alkyl and allyl ether sulfate salts, sulfate salts of fatty acid esters, sulfate salts of fatty acid alkanolamides, sulfate salts of turkey red oil and the like, alkyl phosphates, ether phosphates, alkyl allyl ether phosphates, amide phosphates, and N-acyl amino acid series surfactants.

Examples of the cationic surfactant include alkyl ammonium salts other than the component (A), ammonium salts such as polyammonium and aminoalcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridinium salts, and imidazolium salts.

Examples of the amphoteric surfactant include betaine, aminocarboxylate, imidazoline derivative, and the like.

Examples of the nonionic surfactant include sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyethylene glycol fatty acid esters, sucrose fatty acid esters, polyethylene oxide alkyl ethers, polyoxypropylene alkyl ethers, polyethylene oxide alkylphenyl ethers, polyethylene oxide fatty acid esters, polyethylene oxide sorbitan fatty acid esters, polyethylene oxide sorbitol fatty acid esters, polyethylene oxide glycerin fatty acid esters, polyethylene oxide propylene glycol fatty acid esters, polyethylene oxide sesame oils, polyethylene oxide hardened sesame oils, polyethylene oxide plant stanol ethers, polyethylene oxide plant sterol ethers, polyethylene oxide cholesterol ethers, polyoxyethylene cholesterol ethers, polyoxyalkylene modified organopolysiloxanes, polyoxyalkylene alkyl-modified organopolysiloxanes, lauric acid diethanolamine, coconut fatty acid diethanolamine, coconut oil fatty acid diethanolamine, and mixtures thereof, Coconut oil fatty acid monoethanolamine, polyethylene oxide coconut oil fatty acid monoethanolamine, lauric acid monoisopropanolamine, coconut oil fatty acid monoisopropanolamine, sugar ether, sugar amide and the like.

The alcohol may be a polyhydric alcohol such as glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1, 3-butanediol, 1, 2-pentanediol, or polyethylene glycol other than the component (D).

Examples of the metal soap include aluminum 12-hydroxystearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, zinc cetyl phosphate, calcium cetyl phosphate, sodium zinc cetyl phosphate, zinc laurate, and zinc undecylenate.

Examples of the gelling agent include amino acid derivatives such as N-lauroyl-L-glutamic acid and α, γ -di-N-butylamine, dextrin fatty acid esters such as dextrin palmitate, dextrin stearate and dextrin 2-ethylhexanoate palmitate, sucrose fatty acid esters such as sucrose palmitate and sucrose stearate, benzylidene derivatives of sorbitol such as monobenzylidene sorbitol and dibenzylidene sorbitol, and organically modified clay minerals such as xylene methyl dodecyl montmorillonite and dimethyl dioctadecyl montmorillonite.

Any powder may be used regardless of its shape (spherical, needle-like, plate-like, etc.) and particle size (aerosol, fine particle, pigment grade, etc.) and particle structure (porous, nonporous, etc.), and examples of the powder include inorganic powders such as magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, kaolin, sericite, muscovite, synthetic mica, phlogopite, lepidolite, biotite, lepidolite, silicic acid, anhydrous silicic acid, aluminum silicate, magnesium silicate, aluminum magnesium silicate, calcium silicate, barium silicate, strontium silicate, metal tungstate, hydroxyapatite, vermiculite, ハイジライト (heulanedi), montmorillonite, zeolite, ceramic powder, secondary calcium phosphate, alumina, aluminum hydroxide, boric nitride, boron nitride, etc.; polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethacrylate powder, cellulose, silk powder, nylon powder, 12 nylon, 6 nylon, styrene-acrylic copolymer, divinylbenzene-styrene copolymer, vinyl resin, urea resin, phenol resin, fluororesin, silicone resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, microcrystalline cellulose powder, lauroyl lysine ester, and the like, which are organic powder; iron oxide as a colored pigment, iron hydroxide, an inorganic red pigment of iron titanate, an inorganic brown pigment such as γ -iron oxide, an inorganic yellow pigment such as yellow iron oxide or yellow soil, an inorganic black pigment such as black iron oxide or carbon black, an inorganic purple pigment such as manganese violet or cobalt violet, an inorganic green pigment such as chromium hydroxide, chromium oxide, cobalt oxide or cobalt titanate, an inorganic blue pigment such as berlin blue or ultramarine blue, a pigment obtained by laking a tar-based pigment, a pigment obtained by laking a natural pigment, a composite powder obtained by compositing these powders, and the like; titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated talc, fish scale foil, titanium oxide-coated colored mica, and the like; aluminum powder, copper powder, stainless steel powder, etc. of metal powder pigments; red No. 3, red No. 104, red No. 106, red No. 201, red No. 202, red No. 204, red No. 205, red No. 220, red No. 226, red No. 227, red No. 228, red No. 230, red No. 401, red No. 505, yellow No. 4, yellow No. 5, yellow No. 202, yellow No. 203, yellow No. 204, yellow No. 401, blue No. 1, blue No. 2, blue No. 201, blue No. 404, green No. 3, green No. 201, green No. 204, green No. 205, orange No. 201, orange No. 203, orange No. 204, orange No. 206, orange No. 207, etc. of tar pigments; the natural pigments such as carminic acid, laccaic acid, カルサミン (Karlasamin), brazilin, crocin, and the like may be selected from the above-mentioned powders, or may be a composite of these powders and surface-treated with an oil agent, silicone, or fluoride.

The water-soluble polymer is plant polymer such as gum arabic, tragacanth gum, galactan, carob gum, guar gum, carrageenan, pectin, agar, クインスシ - ド (Cochinensis), alginate, トラントガム (degummed by bluing), locust bean gum, and galactomannan; microbial polymers such as xanthan gum, dextran, succinoglucan, and pullulan; starch polymers such as starch, carboxymethyl starch, and methylhydroxypropyl starch; cellulose polymers such as methyl cellulose, ethyl cellulose, methylhydroxypropyl cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, nitrocellulose, sodium cellulose sulfate, sodium carboxymethyl cellulose, crystalline cellulose, and cellulose powder; alginic polymers such as sodium alginate and propylene glycol alginate; vinyl polymers such as polyvinyl methyl ether, carboxyvinyl polymer, and alkyl-modified carboxyvinyl polymer; a polyethylene oxide-based polymer; polyethylene oxide polyoxypropylene copolymer-based polymers; acrylic polymers such as sodium polyacrylate, polyethylacrylate and polyacrylamide, and inorganic water-soluble polymers such as polyethyleneimine, cationic polymer, bentonite, laponite and hectorite. In addition, the paint also comprises film forming agents such as polyvinyl alcohol or polyvinylpyrrolidone.

Examples of the humectant include mucopolysaccharides such as chondroitin sulfate, hyaluronic acid, mucin, dermatan sulfate, heparin, and keratan sulfate; proteins such as soybean protein and wheat protein, or derivatives thereof; collagen, elastin, keratin, and the like.

Examples of the antibacterial agent include benzoic acid, sodium benzoate, salicylic acid, phenol, sorbic acid, potassium sorbate, parabens, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, zinc bis (2-pyridylthio-1-oxide), phenoxyethanol, and isopropylmethylphenol.

Examples of the ultraviolet absorber include benzophenone series, and include 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 2 '-dihydroxy-4, 4' -dimethoxybenzophenone, sodium 2, 2 '-dihydroxy-4, 4' -dimethoxybenzophenone-5-sulfonate, 2, 4-dihydroxybenzophenone, 2 ', 4, 4' -tetrahydroxybenzophenone and the like; PABA series, can cite para aminobenzoic acid, ethyl para aminobenzoate, para aminobenzoic acid glyceride, para two methyl aminobenzoic acid amyl ester, para two methyl aminobenzoic acid-2-ethylhexyl ester, para two hydroxy propyl benzoic acid ethyl ester; the cinnamic acid series includes 2-ethylhexyl p-methoxycinnamate, 2-ethoxyethyl 4-methoxycinnamate, etc.; examples of the salicylic acid include 2-ethylhexyl salicylate, phenyl salicylate, and homomenthyl salicylate; further, 2- (2-hydroxy-5-methylphenyl) benzotriazole, 4-tert-butyl-4' -methoxybenzoylmethane, oxybenzone, and the like.

Examples of the pH adjusting agent include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, phosphoric acid and salts thereof, potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate, and the like, and L-menthol and camphor, which are the laminate of the cooling and refreshing agent.

The plant extract can be selected from birch, hamamelis, sage, hops, rosemary, rose, orange, asparagus, swertia, scutellaria, honeysuckle, perilla, capsicum, pepper, イラクサ (Elachalasa), チヤ (chia), ニンジン (nylon), サボンソウ (Sabaosu), イブキトラノオ (Ebucardranol), ブドウ (Bufodou), seaweed, ダイズ (Daozi), ニワトコ (Nivakukuai) and other plant or crude drug extracts.

Examples of the amino acids include glycine, proline, isoleucine, histidine, alanine, arginine, lysine, serine, cysteine, and acetylcysteine.

Examples of the saccharide include glucose, fructose, galactose, mannitol, and sorbitol.

The vitamins include vitamin F such as vitamin A and its derivatives, vitamin B and its derivatives, vitamin C and its derivatives, vitamin E and its derivatives, and linolenic acid and its derivatives; vitamin K compounds such as vitamin K1 (phytomenadione), vitamin K2, vitamin K3, and vitamin K4; vitamin P such as eriocitrin and hesperidin; in addition, biotin, creatinine, ferulic acid, and the like.

The cosmetic such as a hair cosmetic containing the vesicle composition of the present invention can be formulated into a liquid, emulsion, cream, gel or the like, and the formulation is not particularly limited, and the cosmetic can be used as a hair cosmetic such as a hair external preparation such as a hair lotion, a hair cream, a hair conditioner, a hair tonic or the like, and an internal hair preparation such as a conditioner, a hair pack, a shampoo or the like. In addition, it can also be mixed with spray agent, and used as hair spray or styling agent. It is particularly effective in the form of a shampoo or the like containing a component (D) such as ethanol. In other words, in general, it is difficult to stably blend the component (B) in the emulsion composition in a form in which the component (B) is blended with an increased amount of the component (D), but the form using the vesicle composition of the present invention not only ensures long-term stability but also provides good adhesion to hair, and thus sufficiently exerts the advantages of the constituent of the present invention.

For example, as described above, a cosmetic containing component (D) can be obtained by a method comprising dispersing components (a) and (B) in component (C), cooling to room temperature to prepare a vesicle composition, and adding component (D) to the composition. The vesicle composition can be prepared in the same manner, and the composition can be produced by appropriately adding any of the above-mentioned components depending on the properties thereof, in addition to being expected for the feeling of use and further effects on the hair.

Examples

The present invention will be described in more detail with reference to the following examples. The present invention is not limited to these examples.

Example 1 (inventive product 1 and comparative product 1): vesicle composition

Vesicle compositions (inventive product 1) using the component (a) of the present invention and vesicle compositions (comparative product 1) in which the component (a) was replaced with a conventional 2-chain alkyl quaternary ammonium salt cationic surfactant were prepared according to the formulations shown in the following table and the following preparation methods, and the changes (average particle diameter) of the vesicles were evaluated by confirming the vesicles produced by the following methods and further evaluating the long-term stability. The alkyl quaternary ammonium salt cationic surfactant used in comparative product 1 was distearoyl dimethyl ammonium chloride [ "ア - カ - ド (acarbon) 2H P-75", ライオン - アクゾ (lyo-agua).

[ confirmation of vesicle formation ]

The presence of vesicles (black cross extinction image as an indicator of vesicle formation) was confirmed by observation under a polarizing microscope [ オリンパス (Olympus, DP-70] under crossed Nicol prism. Furthermore, the vesicle composition obtained (an equivalent amount of 1% phosphotungstic acid aqueous solution was added to a dispersion diluted 10 times with purified water, and negative staining) was observed using a transmission electron microscope (HITACHI H-7650, applied voltage: 80 kV). The production of vesicles can be confirmed using multilamellar vesicles that form a multilamellar structure as an indicator.

The present invention product 1 was observed by observation with a polarizing microscope to form many black cross extinction images as indicators of vesicle formation, and was observed by observation with a transmission electron microscope to form multilamellar vesicles.

Fig. 1 shows a transmission electron microscope observation photograph and fig. 2 shows a polarization microscope observation photograph of the inventive product 1.

[ TABLE 1 ]

(％)

*1: DEHYQUART L80 (コグニス (Kukuas) Co., Ltd.) is described as a molecular weight converted to ミリストイル [ tetradecanoyl ]: 683 preparation amount

*2: it is described that ア - カ - ト (acarbon) "2 HP-75[ ライオン. アクソ (Laiyoun. Accusol)" manufactured by the company, average molecular weight: 585.5]

*3: ニツスイマリン (Nissemalin) cholesterol (Nippon water souls crack average molecular weight: 386)

*4: the molar ratio of comparative product 1 is the molar ratio of the compound as the substitute component (A)

*5: average particle size of vesicles "-": the vesicle is broken and is in a state where it cannot be quantified

[ PREPARATION METHOD ]

A: heating the components 1-3 to 100 deg.C to dissolve.

B: ingredient 4 was heated to 90 ℃.

C: adding A into B, and mixing and stirring by using a homogenizing stirrer.

D: cooling C to room temperature to obtain the vesicle composition.

[ evaluation of Long-term stability ]

The long-term stability was evaluated by the following method, and the average particle size and the state change of the vesicles were measured (observed) over time, and further judged using the following judgment criteria. The results are shown in the table above in combination.

[ evaluation method ]

The vesicle compositions of invention product 1 and comparative product 1 were heated to 60 ℃ and passed through an extruder (Avanti Polar Lipids) equipped with a PC membrane (pore size: 200nm, manufactured by WHATMAN) at 60 ℃ for 10 cycles to prepare samples.

The average particle size of the prepared samples was measured by dynamic light scattering (Beckman Coulter N5) by standing in an incubator at 30 ℃ for 3 days and 1 month immediately after the preparation.

Further, the degree of change (increase) in the average particle size of the sample and the state change of the vesicles after 1 month were determined for the average particle size of the sample immediately after the preparation by the following 4-stage determination criteria.

[ 4 stage judgment Standard ]

(judgment): (relative to the average particle diameter and the change in state immediately after preparation and after 1 month)

Very good: no visible change, or an average particle diameter of 2 times or less immediately after preparation

O (good): more than 2 times, but less than 5 times

Δ (less good): greater than 5 times, but less than 20 times

X (no good): greater than 20 times, or in an un-quantifiable state due to vesicle rupture

As can be seen from the observation results of the transmission electron microscope and the polarization microscope (fig. 1 and 2) and the results in the above table, the vesicle composition of the present invention product 1 using the component (a) forms a good vesicle composition and is excellent in long-term stability.

On the other hand, the vesicle composition of comparative product 1 in which the component (a) was replaced with 2 long-chain alkyl quaternary ammonium salt cationic surfactants formed vesicles, but the average particle size of the vesicles increased significantly after 1 month, or the vesicles completely ruptured (particle size distribution broadened), and the long-term stability was poor, as compared with the vesicles immediately after preparation.

Example 2 (inventive products 2 to 4): vesicle composition

A vesicle composition (hereinafter referred to as "invention product 2") was prepared in the same manner except that an isopropyl alcohol solution of dipalmitoyloxyethyl hydroxyethyl methylammonium methylsulfate (90%) was used instead of a propylene glycol solution of dicocoyloxyethyl hydroxyethyl methylammonium methylsulfate (80%) which was the component (a) used in the preparation of the above-mentioned invention product 1. Furthermore, the vesicle composition (hereinafter referred to as "product of the present invention 3") was prepared in the same manner by increasing the molar ratio (A)/(B) 7/3 of the product of the present invention 1 to 1/4. Further, isostearic acid was added to the product 3 of the present invention to prepare a vesicle composition (hereinafter referred to as "product 4 of the present invention") in the same manner. The change in the state of the vesicles was evaluated in the same manner as in example 1. The formulations and results are shown in table 2 below.

[ TABLE 2 ]

(production method of inventive products 2-4)

A: heating the components 1-4 to 100 deg.C to dissolve.

B: ingredient 5 was heated to 90 ℃.

C: adding A into B, and mixing and stirring by using a homogenizing stirrer.

D: cooling C to room temperature to obtain the vesicle composition.

[ evaluation of Permeability into the interior of Hair (Observation of Hair Cross section) ]

Example 3 (inventive product 5 and comparative products 2 to 4)

Next, a vesicle composition (sample) containing pyrene (pyrene), a marker of fluorescence, was prepared according to the formulation shown in the following table and the following preparation method, and the permeability into the hair was evaluated by the following preparation method.

[ TABLE 3]

(％)

The molar ratio of comparative product 4 is the molar ratio of the compound in place of component (a).

[ PREPARATION METHOD ]

A: heating the components 1-5 to 100 deg.C to dissolve.

B: ingredient 6 was heated to 90 ℃.

C: adding A into B, and mixing and stirring by using a homogenizing stirrer.

D: the sample was prepared by cooling C to room temperature.

[ evaluation method ]

(1) Soaking hair tresses (hairs) in a sample of pyrene-containing vesicle composition or the like prepared by the above table and the above preparation method for 12 hours;

(2) taking out the hair from the step (1), embedding the hair by resin, and making a section of a hair cross section by a slicer;

(3) the section of the hair cross section of (2) was observed with a fluorescence microscope (observation conditions of fluorescence microscope: excitation filter 330-385 nm; fluorescence filter 420 nm; exposure time: 0.20S).

With respect to the obtained vesicle composition, the permeability of the fluorescent marker pyrene into the interior of the hair was observed, and the permeability of the vesicle composition (cholesterol) into the interior of the hair was evaluated.

Fig. 3 shows the observation result (photograph) of the fluorescence microscope of (3) above.

In the photograph of FIG. 3, FIG. 3-1, FIG. 3-2, FIG. 3-3, and FIG. 3-4 are sectional views of hair soaked in the samples of inventive product 5, comparative product 2 (no addition of pyrene, a fluorescent marker), comparative product 3, and comparative product 4, respectively.

In the photograph of fig. 3, a silver white light portion (white portion visible on a black-and-white screen) indicates the presence of a fluorescent marker pyrene.

According to fig. 3, fig. 3-2 soaked in comparative product 2 not containing pyrene was hardly visible (the shape of the cut hair could not be distinguished), fig. 3-3 soaked in comparative product 3 containing only pyrene-containing hydrocarbon oil showed only slightly hazy blue color (white color in black and white), and fig. 3-4 soaked in comparative product 4 containing 2 long-chain alkyl quaternary ammonium salt cationic surfactants instead of component (a) was slightly stronger than silver white (white color in black and white) of the sample soaked in comparative product 3, and slightly distinguished the state of the cut hair, but did not differ.

Accordingly, in FIG. 3-1, which was immersed in the vesicle composition of inventive product 5, the hair section was clearly silvery white (white in the case of black-and-white pictures) as compared with the sample immersed in the comparative example, and the hair section was quite bright up to the center of the hair.

In other words, it was found that the vesicle composition of the present invention product 5 formulated using the component (a) had very high permeability into the hair.

This is considered to be because ester bonds in lipophilic groups of the component (a) have microscopic polarity, and the membrane fluidity of the vesicle membrane (deformability of the vesicle membrane) is improved, and the membrane easily penetrates into the hair, thereby causing high permeability.

[ Experimental conditions and results relating to Water-Retention Properties ]

The hair was soaked with the product 5 of the present invention prepared as described above, and the ratio of bound water in the hair was determined. Fig. 4 shows the results thereof. The effect is correlated with the effect of the moisturized texture produced by the hair cosmetic (shampoo) on the hair. Further, a near infrared spectrophotometer "Spectrum 400" (manufactured by Perkin Elmer) was used to measure a hair bundle (about 5g) composed of hairs of the same person as the sample to be tested. Specifically, the following is described.

The present invention product 5 was applied to a hair strand and sufficiently dried to obtain a hair sample. As a comparative control, a hair tress (about 5g) of the same person was coated with purified water and sufficiently dried to obtain a hair sample for reference. At 5350cm^-1To 4950cm^-1Near infrared spectroscopic measurement was performed in the range of (1), and the peak area of the obtained spectrum was applied to the following formula 1 to calculate the bound water ratio in the hair.

Formula 1

Bound water ratio (%) - [ peak area 1/(peak area 1+ peak area 2) ] × 100

Peak area 1(5150 cm)^-1To 4950cm^-1): strongly bound water (indicating difficulty in water evaporation from hair)

Peak area 2(5350 cm)^-1To 5150cm^-1): weakly bound water (indicating that evaporation of water from hair is likely to occur)

According to the results shown in fig. 4, the proportion of bound water in the hair coated with the inventive article 5 is understood to be deliberately increased compared with the reference hair sample coated with refined water. This indicates that the water retention property of the hair is improved by coating the present invention product 5, in other words, it is understood that this effect is a cause of giving the hair a moist texture.

Example 4 (evaluation of Long-term stability of vesicle composition)

The following samples were prepared separately: 1 part by mass of dipalmitoyloxyethyl hydroxyethylmethylammonium methylsulfate (DEQ) was dispersed in 99 parts by mass of water, vesicle sample 1 (i.e., DEQ/CL: 10/0 (molar ratio)) was obtained, DEQ and Cholesterol (CL) were mixed in advance at molar ratio 7/3, 1 part by mass thereof was dispersed in 99 parts by mass of water, vesicle sample 2 (i.e., DEQ/CL-7/3 (molar ratio)) was obtained, 1 part by mass of distearyldimethylammonium chloride (DSAC) was dispersed in 99 parts by mass of water, vesicle sample 3 (i.e., DSAC/CL: 10/0 (molar ratio)) was obtained, DSAC and Cholesterol (CL) were mixed in advance at molar ratio 7/3, and 1 part by mass thereof was dispersed in 99 parts by mass of water to obtain vesicle sample 4 (i.e., DSAC/CL: 7/3 (molar ratio)). The reagents used for preparing each sample were the same as those used in the examples.

In the preparation of each sample, each component was dissolved in Tetrahydrofuran (THF), the solvent (THF) was removed by a rotary evaporator, the solution was heated to 80 ℃, purified water was poured, and ultrasonic irradiation was performed for 30 minutes using a probe ultrasonic irradiator (VCX130PB) (SONIC & MATERIALS). The solid content concentrations of the obtained samples were 1 mass% in a unified manner. The obtained vesicle dispersion was treated several times in an extruder, and after the average particle diameter was uniformized, the secular change in the average particle diameter was observed.

Further, each sample was observed with a polarizing microscope, and a black cross extinction image, that is, the formation of vesicles was confirmed at the initial stage.

Fig. 5 and 6 show the results, respectively.

From the results shown in FIG. 5, it can be understood that the vesicle composition containing dipalmitoyloxyethyl hydroxyethylmethylammonium methylsulfate (DEQ), which is an example of the component (A) relating to the present invention, shows no change in the size of the vesicle particles in comparison with the sample 1 to which no cholesterol was added, and the long-term stability is good.

On the other hand, from the results shown in fig. 6, it can be understood that the vesicle composition containing distearyldimethylammonium chloride (DSAC) having a long-chain alkyl group without an ester bond significantly decreased the long-term stability of sample 4 due to the addition of cholesterol.

In addition, fig. 7 shows the results of measurement by differential scanning calorimetry for the vesicle sample 1 (i.e., DEQ/CL-10/0 (molar ratio)) and the vesicle sample 2 (i.e., DEQ/CL-7/3 (molar ratio)) prepared as described above. The measurement was carried out using "DSC 7020" (SII), alumina powder as a reference substance, and a temperature rise condition of 1 ℃/min, in a range of 30 ℃ to 110 ℃.

According to the DSC curve shown in fig. 7, the endothermic peak (circled portion in the figure) accompanying the DEQ gel-liquid crystal transition in the vesicle sample 1 was observed at around 35 ℃ to 45 ℃, but disappeared in the vesicle sample 2, indicating that DEQ and CL are compatible at the molecular level, forming a thermally stable gel-liquid crystal intermediate.

Example 5 (inventive products 6 to 10 and comparative products 5 to 7): hair cosmetic (shampoo)

A hair cosmetic was prepared by the following formulation shown in the table below and the following preparation method, and the long-term stability (イ), (ロ) adhesion to hair, (ハ) penetration into hair, and (ニ) moist texture were evaluated by the following methods. The results are shown in the table below.

[ TABLE 4 ]

(％)

The molar ratios of the respective comparative products 5 to 7 are the molar ratios of the respective components to the compound replacing the components (A) and (B)

[ PREPARATION METHOD ]

A: heating the components 1-5 to 100 deg.C to dissolve.

B: ingredient 8 was heated to 90 ℃.

C: adding A into B, and mixing and stirring by using a homogenizing stirrer.

D: cool C to room temperature.

E: adding 6, 7 into D to obtain hair cosmetic (shampoo emulsion).

[ evaluation method ]

(イ) Long term stability

The long-term stability was judged (evaluated) by the same method as in example 1.

[ evaluation method ]

(ロ) attachment to Hair

(ハ) feeling of penetration into the hair

(ニ) the moist texture produced

The test was conducted by 10 panelists, and the adhesion to hair (ロ), (ハ) penetration into hair, and (ニ) moist texture were absolutely evaluated by the following 5-stage evaluation criteria, and the average value was calculated from the scores of all panelists of each sample, and further judged by the following 4-stage evaluation criteria.

[ 5-stage evaluation criteria ]

(score): (evaluation)

And 5, dividing: very good/very strong feeling

And 4, dividing: good/strong feeling

And 3, dividing: general/general feeling

And 2, dividing: not too good/hardly felt

1 minute: bad/no feeling

[ 4 stage judgment Standard ]

(judgment): (average score of scores)

Very good: 4.5 or more

O: greater than or equal to 3.5 and less than 4.5

And (delta): 1.5 or more and 3.5 or less

X: less than 1.5

As is clear from the results shown in the above table, the hair cosmetic compositions of any one of the products 6 to 10 of the present invention have better long-term stability than the hair cosmetic compositions of the comparative products 5 to 7, and can be applied to the hair quickly and applied thereto, so that the penetration of the cosmetic composition into the hair can be reliably perceived, and the moist texture can be produced well. Among them, the products 9 and 10 of the present invention blended with the component (D) which originally tends to be difficult to ensure long-term stability are excellent in use feeling such as adhesion to hair, penetration into hair, and wet texture and also exhibit sufficient long-term stability, and particularly the product 9 of the present invention blended with ethanol as the component (D) is excellent in penetration feeling by quickly adhering to hair after application.

On the other hand, comparative examples 5 and 7, which used a general 2-long-chain alkyl quaternary ammonium salt cationic surfactant, included stearyl alcohol instead of the component(B)Comparative product obtained by blending6Both of them are poor in long-term stability and poor in the feeling of penetration into the hair.

Further, comparative product 4, in which component (B) was replaced with a higher alcohol, had poor long-term stability and penetration into the hair, and had poor moisturized texture, even when component (a) was used.

Example 6: vesicle composition

4, v: DEHYQUART AU56/G (molecular weight: 751, manufactured by コグニス (Kukuconis) Co., Ltd.)

5, a step of: phytosterol (エ - ザイ (leaf-material) company production average molecular weight: 409.4)

[ PRODUCTION METHOD ]

A: heating the components 1-3 to 100 deg.C to dissolve.

B: ingredient 4 was heated to 90 ℃.

C: add a to B and emulsify with a homogenizing mixer.

D: cooling C to room temperature to obtain the vesicle composition.

The vesicle composition of example 6 was evaluated in the same manner as in example 1, and the vesicle formation was good, and a black cross extinction image was observed. In addition, the change of the average particle diameter with time was small, and the stability was also good.

In addition, in the vesicle composition of example 6, the molar ratio (a)/(B) of the component (a) to the component (B) was 4.

Example 7: hair cosmetic (shampoo)

[ PRODUCTION METHOD ]

A: ingredients 1, 2 and 3 were dissolved by heating to 100 ℃.

B: ingredient 5 was heated to 90 ℃.

C: adding A into B, and mixing and stirring by using a homogenizing stirrer.

D: cooling C to room temperature to obtain the vesicle composition.

E: ingredient 4 was added to D and cooled to room temperature.

F: adding E into the container to obtain hair cosmetic (shampoo).

The hair cosmetic (shampoo) of example 7 was evaluated in the same manner as in examples 1 and 3, and a black cross extinction image was observed, indicating that favorable vesicles were formed. In addition, the long-term stability, adhesion to hair, penetration feel, and wet texture were also excellent.

In addition, in the hair cosmetic (shampoo) of example 7, the molar ratio (a)/(B) of the component (a) to the component (B) was 1.8.

Example 8: hair cosmetic (shampoo)

[ PRODUCTION METHOD ]

A: ingredients 1, 2 and 5 were dissolved by heating to 100 ℃.

B: ingredient 3 was heated to 90 ℃.

C: adding A into B, and mixing and stirring by using a homogenizing stirrer.

D: cooling C to room temperature to obtain the vesicle composition.

E: adding the components 4 and 6 into the mixture D, and uniformly mixing.

F: adding the components 7-9 into the mixture E, and uniformly mixing.

G: f was filled into a container to obtain a cosmetic for hair (shampoo).

The cosmetic hair preparation (shampoo) of example 8 was evaluated in the same manner as in examples 1 and 3, and a good black cross extinction image was observed, indicating that good vesicles were formed. In addition, the long-term stability, adhesion to hair, penetration feel, and wet texture were also excellent.

In the cosmetic for hair of example 8, the molar ratio (a)/(B) of the component (a) to the component (B) was 3.8.

Example 9: hair cosmetic (Hair care essence)

[ PRODUCTION METHOD ]

A: ingredients 1, 2 were mixed well at room temperature.

B: adding the components 3-6 and 7 into the A, and uniformly mixing.

C: and filling the container with the B to obtain a hair cosmetic (hair care essence).

The hair cosmetic (hair care essence) of example 9 was evaluated in the same manner as in example 3 and was excellent in long-term stability, adhesion to hair, penetration feeling, and moisturized texture.

Example 10: hair cosmetic (Hair spray)

[ PRODUCTION METHOD ]

A: the components 1-3 were mixed well at room temperature.

B: filling A into the container to obtain cosmetic for hair.

The hair cosmetic (hair care spray) of example 10 was evaluated in the same manner as in example 3 and was excellent in long-term stability, adhesion to hair, penetration feeling, and moisturized texture.

Example 11: moisture-retaining cosmetic for body

[ PRODUCTION METHOD ]

A: the components 1-4 were mixed well at room temperature.

B: filling A into a container to obtain the body moisturizing cosmetic.

The body moisturizing cosmetic of example 11 was evaluated in the same manner as in example 3 and was excellent in long-term stability, adhesion to the skin, penetration feeling, and moist texture.

Claims (6)

1. A vesicle composition characterized by comprising the following components (A) to (C):

(A) a cationic surfactant represented by the following general formula (1),

the following general formula (1)

In the formula, R¹CO-、R²CO-is identical or different and is saturated with 8 to 22 carbon atomsAnd or an unsaturated aliphatic acyl group; r³is-CH₃or-CH₂OH or-C₂H₄OH; m and n are the same or different and are 2 or 3; x is halogen, methyl sulfate, ethyl sulfate or methyl phosphate,

(B) a sterol compound selected from the group consisting of sterols,

(C) and (3) water.

2. The vesicle composition according to claim 1, wherein the molar ratio (A)/(B) of the component (A) to the component (B) is in the range of 100/1 to 1/4.

3. The vesicle composition according to claim 1 or 2, wherein the component (B) is cholesterol and/or phytosterol.

4. A cosmetic preparation comprising the vesicle composition according to any one of claims 1 to 3.

5. The cosmetic according to claim 4, wherein the cosmetic is applied to hair.

6. The cosmetic according to claim 4 or 5, which further comprises a monovalent lower alcohol as the component (D).