HK1171941A1 - Dentifrice composition - Google Patents

Abstract

Disclosed is a dentifrice composition which exhibits excellent bactericidal effect on biofilms, while having excellent hyperesthesia suppressing activity. The dentifrice composition is free from unpleasant taste and provides excellent feeling of use. Specifically disclosed is a dentifrice composition which is characterized by containing (A) isopropyl methyl phenol, (B) one or more substances selected from among potassium nitrate, aluminum lactate and strontium chloride, (C) one or more fragrance material components selected from among 3-octanol, 3-octyl acetate, 3-octanone and fenchone, and (D) an anionic surfactant and/or a nonionic surfactant. The dentifrice composition additionally contains (E) anisaldehyde.

Description

Dentifrice composition

Technical Field

The present invention relates to a dentifrice composition having excellent biofilm bactericidal activity and hypersensitive response alleviating activity, having no unpleasant taste, and having an excellent feeling in use.

Background

Dentinal hypersensitivity is a disease in which gums are atrophied due to progression of periodontal disease or the like, dentin is exposed, and irritation such as rubbing or cold is transmitted to nerves via dentinal tubules, causing pain. Therefore, in order to prevent and suppress dentinal hypersensitivity, it is very effective to use an oral composition having both effects of killing oral biofilm bacteria causing periodontal disease and alleviating pain due to nerve anesthesia or dentinal tubule blocking action using a hypersensitivity alleviating component.

Sterilization of oral biofilm is a method of combating various bacteria in oral biofilm, which are considered to be responsible for two major oral diseases, caries and periodontal disease. Examples of the oral bacteria involved in oral diseases include streptococcus such as streptococcus mutans(s) involved in dental caries, bacteria including obligate anaerobic gram-negative bacteria such as porphyromonas gingivalis (p.gingivalis) involved in periodontitis, and oral bacteria such as fusobacterium nucleatum (f.tuberculosis) involved in causes of halitosis. As a means for effectively preventing and ameliorating oral diseases, it is considered to be useful to keep the number of pathogenic bacteria in an oral biofilm at a low level.

In order to reduce the number of pathogenic bacteria in the oral cavity, it is effective to use a sparingly water-soluble bactericide, a cationic bactericide, an anionic bactericide or the like, and particularly, it is proposed that isopropyl methylphenol having a high osmotic bactericidal effect can exert an effect of inhibiting the oral biofilm for bacteria in the biofilm (patent document 1: Japanese patent laid-open No. 2006-182662, patent document 2: Japanese patent laid-open No. 2006-124315, patent document 3: Japanese patent laid-open No. 2005-179266, patent document 4: Japanese patent laid-open No. 2006-69909).

On the other hand, as measures for preventing dentinal hypersensitivity, there is a technique proposed in the literature for alleviating pain by mixing an oral composition with potassium nitrate, aluminum lactate, strontium chloride, and the like, which are known as active ingredients for preventing hypersensitivity, such as nerve anesthesia and blocking dentinal tubule action. For example, patent document 5 (U.S. Pat. No. 3863006) proposes that tooth sensitivity decreases after several weeks of brushing with a dentifrice containing a potassium salt such as potassium nitrate, and patent document 6 (japanese patent laid-open No. 60-48926) proposes a treatment method in which potassium nitrate is applied to gingival and periodontal ligament tissues. Further, patent document 7 (Japanese patent laid-open No. 5-155745) discloses that dentinal hypersensitivity is inhibited by using an oral composition containing an aluminum salt such as aluminum lactate, and patent document 8 (Japanese patent laid-open No. 2001-172146) proposes an oral composition containing aluminum salts such as potassium nitrate and aluminum lactate at specific concentrations, which is excellent in the effect of preventing and treating dentinal hypersensitivity and good in feeling of use. Patent document 9 (specification of U.S. patent No. 3122483) proposes an oral composition containing strontium chloride.

It is generally considered that when a sparingly water-soluble bactericidal component such as isopropyl methylphenol and a hypersensitive response alleviating component are mixed in a dentifrice composition, the bactericidal effect of periodontal biofilm and the hypersensitive response alleviating effect of dentin can be achieved at the same time. However, when isopropyl methylphenol is used in combination with a hypersensitive component such as potassium nitrate, aluminum lactate, and strontium chloride, a peculiar unpleasant taste is generated, and a composition containing these two components has a drawback that the feeling of use is significantly impaired due to the unpleasant taste, and it is desired to improve this.

To address the problem of the unpleasant taste derived from isopropyl methylphenol, known are: for example, a technique of reducing the odor of an antibacterial component by mixing a specific acyl sarcosinate with phenoxyethanol at a specific mixing ratio in combination (patent document 10: Japanese patent laid-open No. 2007-161613), a technique of reducing the odor and the odor by mixing 1-menthol and sodium chloride in isopropyl methylphenol at a specific mass ratio (patent document 11: Japanese patent laid-open No. 2008-143825). However, when a large amount of acyl sarcosinate is mixed, oral mucosa irritation which is considered to be derived from acyl sarcosinate is caused, and when sodium chloride is mixed, there are new problems that the flavor type is sometimes limited due to salty taste, and the like.

In addition, the following techniques have been proposed to address the problem of unpleasant taste derived from potassium nitrate: a technique of mixing water-soluble polyphosphoric acid with potassium nitrate at a specific ratio and mixing a polyhydric alcohol to improve bitterness, astringency and throat discomfort (patent document 12: Japanese patent laid-open No. 2006-96696), and a technique of mixing a specific organic compound, a plant extract and sodium hydrogen carbonate to mask bitterness (patent document 13: Japanese patent laid-open No. 2002-302450). However, when water-soluble polyphosphoric acid is mixed, there are new problems such as an unpleasant taste derived from water-soluble polyphosphoric acid, and when a plant extract or sodium hydrogen carbonate is mixed, an unpleasant taste derived from both of them.

In order to solve the problem of unpleasant taste derived from aluminum lactate, a technique has been proposed in which sodium bicarbonate is added to a nonaqueous preparation to reduce bitterness and astringency (patent document 14: Japanese patent laid-open No. 2002-302429). However, such nonaqueous preparations cannot sufficiently obtain the hypersensitive inhibitory effect of potassium nitrate.

There is also a method of reducing the unpleasant taste by masking with a sweetener such as saccharin, but in this case, the unpleasant taste is hard to say that the unpleasant taste can be suppressed because the sweetener has an excessively strong taste.

Patent document 8 is a technique for improving astringency derived from potassium nitrate and from aluminum lactate, and this technique cannot satisfactorily reduce the characteristic unpleasant taste derived from isopropyl methylphenol and a hypersensitive sensation suppressing component.

Further, when a perfume is mixed in order to mask an unpleasant taste derived from isopropyl methylphenol or a hypersensitive sensation inhibitor, the unpleasant taste may be perceived in use due to the unpleasant taste of the perfume itself.

Patent document 11 discloses a technique for mixing isopropyl methylphenol and a perfume component. As a technique for improving the bitterness of potassium nitrate with a flavor component, there is a technique of mixing anethole with eucalyptol, vanillin, citronellal, and cinnamaldehyde (patent document 15: Japanese patent laid-open No. 2003-73282). The compositions obtained by mixing isopropylmethylphenol and anisaldehyde are described in examples 1 to 13 of patent document 1, examples 1 to 3, 6 to 12, and 15 to 20 of patent document 4, example 17 of patent document 16 (pamphlet of International publication No. 2007/69447), and examples 11 to 17, 20, 21, and 23 of patent document 17 (Japanese laid-open patent publication No. 2005-179266).

However, none of these techniques sufficiently improves the unpleasant taste unique to use, which is derived from isopropyl methylphenol and the hypersensitive inhibitory component.

Therefore, a new technology is required to obtain a dentifrice composition which is excellent in not only the biofilm bactericidal activity and the sensory hypersensitivity alleviating effect but also the unpleasant taste derived from the mixed components is effectively reduced and the feeling of use is excellent.

Documents of the prior art

Patent document

Patent document 1: japanese patent laid-open No. 2006-182662

Patent document 2: japanese patent laid-open No. 2006-124315

Patent document 3: japanese patent laid-open No. 2005-179266

Patent document 4: japanese patent laid-open No. 2006-69909

Patent document 5: specification of U.S. Pat. No. 3863006

Patent document 6: japanese patent laid-open No. Sho 60-48926

Patent document 7: japanese patent laid-open No. 5-155745

Patent document 8: japanese patent laid-open No. 2001-172146

Patent document 9: specification of U.S. Pat. No. 3122483

Patent document 10: japanese patent laid-open No. 2007-161613

Patent document 11: japanese patent laid-open No. 2008-143825

Patent document 12: japanese patent laid-open No. 2006-96696

Patent document 13: japanese patent laid-open publication No. 2002-302450

Patent document 14: japanese patent laid-open publication No. 2002-302429

Patent document 15: japanese patent laid-open No. 2003-73282

Patent document 16: international publication No. 2007/69447 pamphlet

Patent document 17: japanese patent laid-open No. 2005-179266

Disclosure of Invention

The present invention has been made in view of the above circumstances, and an object thereof is to provide a dentifrice composition which is excellent in biofilm bactericidal activity and sensory allergy alleviating activity, has no unpleasant taste, and is excellent in feeling of use.

As a result of extensive and intensive studies by the inventors to achieve the above object, it was found that a mixture of (A) isopropyl methylphenol,

(B) Specifically disclosed is a dentifrice composition which is excellent in biofilm bactericidal activity and sensory allergy alleviating activity, has no unpleasant taste and is excellent in feeling of use, and has been completed.

That is, the present invention is a dentifrice composition having excellent feeling of use without unpleasant taste, which can exhibit excellent biofilm bactericidal activity and excellent hypersensitive mitigating action by using isopropyl methylphenol and a specific hypersensitive inhibitor in combination and mixing them into a dentifrice composition containing an anionic surfactant and/or a nonionic surfactant, and can effectively mask unpleasant taste caused by using isopropyl methylphenol and a hypersensitive inhibitor in combination while achieving the above-mentioned effects by using a specific perfume component other than these components in combination and mixing them.

The flavor components of the component (C) all have unique flavors and may be used in small amounts in a blend flavor such as a cheese flavor, but their use as a dentifrice composition flavor is limited due to their unpleasant flavor. The present inventors have found that the use of a specific perfume as component (C) in combination with isopropyl methylphenol and a specific hypersensitive inhibitory component can effectively suppress the unpleasant tastes peculiar to isopropyl methylphenol and a specific hypersensitive inhibitory component, i.e., the unpleasant tastes peculiar to isopropyl methylphenol and the astringent taste of a specific hypersensitive inhibitory component, and that the unpleasant taste of a mixed perfume is not perceived, and that a good use feeling which is difficult to achieve with a perfume generally used in a dentifrice composition at present can be obtained.

In the present invention, the mass ratio of component (B)/component (a) is 2 to 700, whereby the biofilm bactericidal activity and the unpleasant taste suppression effect can be improved.

Further, in the present invention, by mixing (E) anisaldehyde in the dentifrice composition in which the above-mentioned components (a) to (D) are mixed, the unpleasant taste can be further reduced, and the feeling of use can be further improved.

Accordingly, the present invention provides the dentifrice compositions described below.

(1) A dentifrice composition characterized by containing

(A) Isopropyl methyl phenol,

(B) 1 or more than 2 of potassium nitrate, aluminum lactate and strontium chloride,

(C) 1 or more than 2 perfume components selected from 3-octanol, 3-octyl acetate, 3-octanone, fenchyl ketone, and

(D) anionic surfactant and/or nonionic surfactant

And (4) preparing the composition.

(2) The dentifrice composition according to (1), wherein the mass ratio of component (B)/component (A) is 2 to 700.

(3) The dentifrice composition according to (1) or (2), wherein the component (D) is an alkyl sulfate, a polyoxyethylene hardened castor oil and/or a polyoxyethylene alkyl ether.

(4) The dentifrice composition according to (1), (2) or (3), which is characterized by comprising 0.01 to 0.2% by mass of the component (A), 0.1 to 15% by mass of the component (B), 0.0001 to 0.1% by mass of the component (C) and 0.1 to 5% by mass of the component (D).

(5) The dentifrice composition according to any 1 of (1) to (4), further comprising (E) anisaldehyde.

(6) The dentifrice composition according to (5), which is characterized by containing the component (E) in an amount of 0.0001 to 0.1% by mass.

(7) A toothpaste prepared by mixing 10 to 70% by mass of a thickening agent, 0.1 to 5% by mass of a binder and 0 to 50% by mass of a polishing agent with the dentifrice composition according to any 1 of (1) to (6).

Effects of the invention

The dentifrice composition of the present invention is excellent in biofilm bactericidal activity and sensory allergy alleviating activity, has no unpleasant taste, and is excellent in feeling of use, and therefore, is effective for the prevention or treatment of dentinal sensory allergy.

Detailed Description

The present invention will be described in more detail below. The dentifrice composition of the present invention is characterized by containing (A) isopropyl methylphenol, (B) 1 or 2 or more kinds selected from potassium nitrate, aluminum lactate and strontium chloride, (C) 1 or 2 or more kinds selected from 3-octanol, 3-octyl acetate, 3-octanone and fenchyl ketone, and (D) an anionic surfactant and/or a nonionic surfactant.

The isopropyl methylphenol (a) used in the present invention is 4-isopropyl-3-methylphenol, and commercially available products such as those sold by osaka chemical company (ltd) can be used.

(A) The amount of isopropyl methylphenol to be mixed is preferably 0.01 to 0.2% by mass (hereinafter, the same applies to the case) of the total composition, more preferably 0.02 to 0.1%. If the content is less than 0.01%, a sufficient bactericidal effect may not be exhibited, and if the content is more than 0.2%, the unpleasant taste derived from isopropyl methylphenol may be enhanced and the taste may be deteriorated.

(B) Potassium nitrate, aluminum lactate and strontium chloride, which are components, are mixed as effective components for preventing or treating dentinal hypersensitivity, and among them, potassium nitrate and aluminum lactate are preferably used from the viewpoint of the hypersensitive sensation inhibitory effect. As the component (B), commercially available products can be used, and potassium nitrate, aluminum lactate, strontium chloride salt, strontium chloride hexahydrate and the like can be mentioned, for example, potassium nitrate commercially available from the trade name of マツモト, aluminum lactate, and pure chemical.

The component (B) may be used alone in combination of 1 kind, but it is desirable to use 2 or 3 kinds in combination. For example, potassium nitrate and aluminum lactate, potassium nitrate and strontium chloride are preferably used in combination, and of these, potassium nitrate and aluminum lactate are desirably used in combination.

(B) The amount of the component (B) is preferably 0.1 to 15%, particularly preferably 0.3 to 10%, particularly preferably 0.5 to 10% of the total amount of the composition. If the content is less than 0.1%, the effect of alleviating hyperesthesia may not be exhibited, and if the content exceeds 15%, the unpleasant taste may be too strong to be used.

The amount of each of the above-mentioned hypersensitive inhibitory components can be suitably adjusted within the range of the amount of the above-mentioned component (B), and if the amount of potassium nitrate is preferably 0.1 to 15%, particularly preferably 1 to 10%, and less than 0.1% of the total composition, the hypersensitive inhibitory action may not be exerted, and in some cases, the effect of inorganic salts used in an emulsified or dispersed state to stably mix an oil phase containing a poorly water-soluble component such as isopropylmethylphenol and a perfume component with an aqueous phase is reduced, thereby enhancing unpleasant taste. If the content exceeds 15%, the unpleasant taste is too strong, and the use is not preferable in some cases.

The amount of aluminum lactate or strontium chloride is preferably 0.1 to 10%, particularly preferably 0.5 to 5%, based on the total composition. If the content is less than 0.1%, the effect of the inorganic salt used for stably mixing the oil phase containing a poorly water-soluble component such as isopropyl methylphenol and a flavor component with the water phase in an emulsified or dispersed state may not be exhibited, and the unpleasant taste may be enhanced. If the content exceeds 10%, the unpleasant taste is too strong, and the use is not preferable in some cases.

In the present invention, the mixing ratio of component (B)/component (A) is preferably 1 to 1000, particularly preferably 2 to 700, in terms of mass ratio. (B) If the content of (a) is less than 1, the unpleasant taste derived from isopropyl methylphenol may be perceived as strong, and if it exceeds 1000, satisfactory biofilm bactericidal activity may not be obtained, and the unpleasant taste derived from component (B) may be perceived as strong and may be perceived as poor.

(C) The component (B) is an effective perfume component for masking the unique unpleasant taste derived from isopropyl methyl phenol and the component (B), and is 1 or more than 2 perfume components selected from 3-octanol, 3-octyl acetate, 3-octanone, and fenchone.

When 2 or more of the perfume ingredients are combined, a combination of 3-octanol and 3-octyl acetate and/or fenchone is suitable.

Even octanol, 1-octanol, which is generally used as a perfume in dentifrice compositions, cannot achieve the object of satisfactorily masking the unpleasant odor derived from isopropylmethylphenol and component (B), and is therefore not suitable as a perfume component of the present invention.

As the component (C), commercially available products can be used, for example, 3-octanol can be produced using tamarind (available from SALT YEARKIN CO., LTD.), 3-octyl acetate and 3-octanone can be produced using wellness spice (available from LTD.), fenchone can be produced using fenchone (available from fenchong corporation), and the like.

(C) The total amount of the components is not particularly limited, but is preferably 0.0001 to 0.1%, particularly preferably 0.0005 to 0.05%, and particularly preferably 0.001 to 0.02%, based on the total amount of the composition. If the amount is less than 0.0001%, the peculiar unpleasant taste of isopropyl methylphenol and component (B) may not be masked, and if the amount exceeds 0.1%, the fragrance of the perfume component itself may be too strong, resulting in an unpleasant taste.

(D) The component (A) is anionic surfactant and/or nonionic surfactant, and can be mixed with 1 or more than 2. In such a case, the anionic surfactant or the nonionic surfactant may be mixed alone (only the anionic surfactant or only the nonionic surfactant), or the anionic surfactant and the nonionic surfactant may be used in combination, but it is desirable to use the anionic surfactant and the nonionic surfactant in combination.

Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate and sodium tetradecyl sulfate, acyl sarcosinates such as sodium lauroyl sarcosinate and sodium tetradecyl sarcosinate, sodium dodecylbenzenesulfonate, sodium monoglyceride monosulfate of hydrogenated coconut fatty acid, sodium lauryl sulfoacetate, N-acyl glutamates such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acyl alaninate and sodium alpha-olefin sulfonate, and among them, alkyl sulfates, especially sodium alkyl sulfate, are preferable in terms of the bactericidal activity of biomembranes, the solubility and dispersibility of the components (A) and (C), and the suppression of unpleasant taste.

Specific examples of the alkyl sulfate include NIKKOL SLS (manufactured by sun light ケミカルズ), and alkyl sulfates having a mixed alkyl group of lauryl and tetradecyl groups, such as エマ - ル 10PT (manufactured by kao corporation) and TEXAPON OC-P (manufactured by Cognis Japan ltd.).

Examples of the nonionic surfactant include polyoxyethylene hardened castor oil, polyoxyethylene alkyl ether, sucrose fatty acid ester, alkanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene polyoxypropylene glycol, alkyl glycoside, and lauric acid decaglyceride. Among them, polyoxyethylene hardened castor oil and polyoxyethylene alkyl ether are preferable from the viewpoint of the capability of sterilizing a biofilm, the solubility and dispersibility of the components (A) and (C), and the suppression of an unpleasant taste.

The average number of moles of ethylene oxide added to the polyoxyethylene hardened castor oil is preferably 10 to 30 moles, particularly preferably 10 to 20 moles, from the viewpoint that the polyoxyethylene hardened castor oil is free from unpleasant taste. If the amount is less than 10 moles, emulsification of the dentifrice composition may be insufficient, and unpleasant taste during use may not be sufficiently suppressed, and the dentifrice composition may not be sold in general markets having an amount of more than 30 moles.

Commercially available products of such polyoxyethylene hardened castor oil can be used. For example, NIKKOL HCO-10 (polyoxyethylene (10) hardened castor oil, manufactured by Sun light ケミカルズ), NIKKOL HCO-20 (polyoxyethylene (20) hardened castor oil, manufactured by Sun light ケミカルズ), NIKKOL HCO-30 (polyoxyethylene (30) hardened castor oil, manufactured by Sun light ケミカルズ), NIKKOL HCO-40 (polyoxyethylene (40) hardened castor oil, manufactured by Sun light ケミカルズ), NIKKOL HCO-60 (polyoxyethylene (60) hardened castor oil, manufactured by Sun light ケミカルズ), NIKKOL HCO-80 (polyoxyethylene (80) hardened castor oil, manufactured by Sun light ケミカルズ), KKNIOLHCO-100 (polyoxyethylene (100) hardened castor oil, manufactured by Sun light ケミカルズ), and the like.

In view of the capability of biofilm sterilization, solubility and dispersibility of the components (A) and (C), and suppression of unpleasant taste, the average molar number of addition of ethylene oxide in the polyoxyethylene alkyl ether is preferably 3 to 40 mol, particularly preferably 5 to 20 mol, and the number of carbon atoms in the alkyl group is preferably 12 to 18, particularly preferably 16 to 18. Specifically, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene lauryl ether and the like having the average number of moles of ethylene oxide added within the above range may be mentioned.

Commercially available polyoxyethylene alkyl ethers can be used. For example, the polyoxyethylene cetyl ether may be EMALEX 103 (polyoxyethylene (3) cetyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co.), EMALEX105 (polyoxyethylene (5) cetyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co.), EMALEX107 (polyoxyethylene (7) cetyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co.), and the polyoxyethylene stearyl ether may be EMALEX603 (polyoxyethylene (3) stearyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co., Ltd.), EMALEX605 (polyoxyethylene (5) stearyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co., Ltd.), EMALEX606 (polyoxyethylene (6) stearyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co., Ltd.), EMALEX608 (polyoxyethylene (8) stearyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co., Ltd.), EMALEX 620 (polyoxyethylene (20) stearyl ether, manufactured by NIPPON エマ ル ジ ヨ ン Co., Ltd.), EMAREX630 (polyoxyethylene (30) octadecyl ether, manufactured by japan エマ ル ジ ヨ ン, ltd.), EMAREX640 (polyoxyethylene (40) octadecyl ether, manufactured by japan エマ ル ジ ヨ ン, ltd.), and the like, and the polyoxyethylene lauryl ether may be, for example, EMAREX705 (polyoxyethylene (5) lauryl ether, manufactured by japan エマ ル ジ ヨ ン, EMAREX710 (polyoxyethylene (10) lauryl ether, manufactured by japan エマ ル ジ ヨ ン, ltd.), EMAREX720 (polyoxyethylene (20) lauryl ether, manufactured by japan エマ ル ジ ヨ ン, ltd.), EMAREX730 (polyoxyethylene (30) lauryl ether, manufactured by japan エマ ル ジ ヨ ン, ltd.), and the like.

As a combination of the anionic surfactant and the nonionic surfactant, among them, a combination of an alkyl sulfate and polyoxyethylene hardened castor oil and/or polyoxyethylene alkyl ether is suitable, and a combination of an alkyl sulfate and polyoxyethylene hardened castor oil is particularly suitable.

(D) The amount of the anionic surfactant and/or nonionic surfactant to be mixed is preferably 0.1 to 5%, particularly preferably 0.2 to 3% of the total amount of the composition. If the amount is less than 0.1%, the biofilm bactericidal activity may be reduced, and if it exceeds 5%, the unpleasant taste during use may be enhanced, resulting in poor feeling during use.

Further, in the present invention, it is preferable to mix anisaldehyde as the component (E) and add anisaldehyde in addition to the flavor component of the component (C), whereby the effect of masking the peculiar unpleasant taste derived from the isopropyl methylphenol and the component (B) can be more effectively enhanced and the flavor is more improved.

As the anisaldehyde, commercially available products such as those of the American perfume (trade name) can be used. The amount of the compound is preferably 0.0001 to 0.1%, particularly preferably 0.0005 to 0.05%, particularly preferably 0.001 to 0.02%, based on the total amount of the composition. If the amount is less than 0.0001%, the masking effect of the unpleasant taste derived from the isopropyl methylphenol and the component (B) may not be sufficiently improved, and if it exceeds 0.1%, the odor of anisaldehyde itself may be too strong, which may cause unpleasant taste and give unpleasant feeling to the user.

When the anisaldehyde (E) is blended, the total blending amount of the components (C) and (E) can be set to 0.0002 to 0.15%, particularly 0.002 to 0.03%, from the viewpoint of more enhancing the masking effect of unpleasant taste derived from the isopropyl methylphenol and the component (B) and more improving the flavor. If the total amount is less than 0.0002%, the masking effect of the unpleasant taste may not be sufficiently improved, and if it exceeds 0.2%, the fragrance of the components (C) and (E) itself may be too strong, resulting in an unpleasant taste.

Further, the combination of the component (C) and the component (E) is particularly preferably a combination of 3-octanol and anisaldehyde, whereby a particularly excellent masking effect can be exhibited with respect to a unique unpleasant taste.

The dentifrice composition of the present invention can be suitably formulated into toothpaste, liquid dentifrice and the like, and particularly suitably formulated into toothpaste, and can be mixed with other suitable publicly known ingredients in addition to the ingredients in accordance with the formulation thereof. Examples of the optional components include thickeners, binders, abrasives, and flavors, surfactants, active ingredients, pH adjusters, preservatives, sweeteners, colorants, and the like, which are added as necessary, and they may be mixed within a range not to impair the effects of the present invention. These components may be mixed with water to produce the composition of the present invention according to a conventional method.

The thickener may be one or more than 1 or 2 kinds of sugar alcohols and polyhydric alcohols such as sorbitol, glycerol, polyethylene glycol, propylene glycol, ethylene glycol, 1, 3-butylene glycol, and reduced starch saccharide. The amount of the thickener is preferably 10 to 70% for a toothpaste and 20 to 90% for a liquid dentifrice, based on the total composition.

Examples of the binder include cellulose binders such as sodium carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl ethyl cellulose and methyl cellulose, xanthan gum, carrageenan, guar gum, sodium alginate, cationized cellulose, montmorillonite, gelatin and sodium polyacrylate, and 1 or 2 or more of these binders may be mixed. Generally, the amount to be mixed is 0.1 to 5% based on the total amount of the composition.

In addition to the component (C) and the component (E), other perfumes may be used in combination, natural flavors such as eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, peppermint oil, spearmint oil, mint (ハツカ) oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, shaddock oil, kumquat oil, lavender oil, rosemary oil, bay oil, chamomile oil, caraway oil, marjoram oil, celery oil, bay leaf oil, oregano oil, pine needle oil, orange flower oil, lemongrass oil, rose oil, jasmine oil, patchouli oil, iris extract, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchouli absolute, ginger resin oil, pepper resin oil, persimmon (Capsicum) resin oil, Capsicum extract; and processed (fore-run, after-run, fractional distillation, liquid-liquid extraction, purification, powder flavoring) flavors, limonene, terpenes, butanol, isoamyl alcohol, n-hexenol, cis-3-hexenol, cis-6-nonenol, linalool, alpha-terpineol, menthol, benzyl alcohol, phenethyl alcohol, anethole, thymol, Methyl chavicol (Methyl chavicol), eugenol, carvone, menthone, pulegone, 1, 8-eucalyptol, ionone, watermelon ketone, n-hexanal, trans-2-hexenal, citral, cinnamaldehyde, benzaldehyde, ethyl acetate, ethyl butyrate, isoamyl acetate, hexyl acetate, ethyl 2-methylbutyrate, allyl hexanoate, allyl cyclohexanepropionate, linalyl acetate, menthyl lactate, limonene, terphenyl alcohol, isoamyl acetate, Methyl piperonyl alcohol, eugenol, linalool acetate, linalyl acetate, and the like, Carvacrol acetate, phenoxyethyl isobutyrate, methyl jasmonate, methyl salicylate, ethyl salicylate, methyl cinnamate, methyl anthranilate, phenylethyl glycidate, ethyl lactate, vanillin, maltol, gamma and delta lactones having 4 to 12 carbon atoms, pelargonide, dimethyl sulfide, trimethylpyrazine, ethyl beta-methylthiopropionate, furanone, ethyl cyclopentenone, 3-methylcyclopentane-1, 2-dione (Cyclotene), 2-methylbutyric acid, propionic acid, p-methoxycinnamaldehyde, 3-1-menthoxypropane-1, 2-diol, menthone glycerol acetal, chrysanthenol, monomenthyl succinate, linalool oxide, vanillylbutyl ether, isopulegol, and other simple flavors, and further, strawberry essence, vanillyl butyl ether, isopulegol, and the like can be used in combination, Known flavor materials used in dentifrice compositions include a blend flavor such as apple flavor, melon flavor, banana flavor, peach flavor, raspberry flavor, pineapple flavor, grape flavor, tropical fruit flavor, mango flavor, plum flavor, orange flavor, lemon flavor, grapefruit flavor, tea flavor, butter flavor, milk flavor, and a flavor solvent such as ethanol, propylene glycol, triacetin, glycerin fatty acid ester, and the like. The amount of these perfume materials is not particularly limited, and is preferably 0.000001 to 1% by weight of the composition. In addition, as the perfume for giving fragrance using the above perfume raw material, 0.1 to 2.0% is preferably used in the composition.

The surfactant may be an amphoteric surfactant in addition to the anionic surfactant and the nonionic surfactant of the component (D). As the amphoteric surfactant, for example, lauryl dimethyl amino acetic acid betaine, N-coco fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine, coco fatty acid amide propyl dimethyl amino acetic acid betaine, coco fatty acid amide propyl betaine and the like can be used, but not limited to these. When the amphoteric surfactant is mixed, the amount thereof is usually 0.1 to 5%.

As the various active ingredients, in addition to (A) isopropyl methyl phenol, (B) potassium nitrate, aluminum lactate, strontium chloride, other active ingredients may be mixed, for example, sodium fluoride, sodium monofluorophosphate, tin fluoride and other fluorine compounds, dextranase, mutanase and other enzymes, phosphoric acid potassium salt, sodium salt and other water-soluble phosphoric acid compounds, tranexamic acid, epsilon-aminocaproic acid, allantoin chlorohydroxyaluminum, hinokitiol, sodium lauroyl sarcosinate, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, alpha-bisabolol, chlorhexidine salts, azulene, glycyrrhetinic acid, glycyrrhizic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate and other chelating phosphoric acid compounds, copper gluconate and other copper compounds, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethylene-maleic anhydride copolymer, berberine, hydroxamic acid and its derivatives, Polyvinylpyrrolidone, epidihydrocholesterol, cetylpyridinium chloride, benzethonium chloride, dihydrocholesterol, triclocarban, zinc citrate, radix Angelicae sinensis soft extract, cortex Phellodendri extract, flos Matricariae Chamomillae, flos Caryophylli, herba Rosmarini officinalis, Scutellariae radix, Carthami flos, etc. The amount of these active ingredients to be mixed may be an effective amount within a range not to impair the effects of the present invention.

Examples of the polishing agent include 1 or 2 or more types of silicon-based polishing agents such as silica gel, aluminosilicate, and zirconium aluminate, calcium phosphate-based polishing agents such as calcium monohydrogen phosphate 2 hydrate, calcium monohydrogen phosphate anhydrous compound, calcium phosphate, tetracalcium phosphate, octacalcium phosphate, and calcium pyrophosphate, and 1 or 2 or more types of polishing agents such as aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium phosphate, zeolite, zirconium silicate, hydroxyapatite, fluoroapatite, calcium deficient apatite, and synthetic resin-based polishing agents. In the case of a toothpaste, the amount to be mixed is usually 0 to 50%, particularly 5 to 40%, based on the total amount of the composition, and in the case of a liquid dentifrice, the amount to be mixed is usually 0 to 30%, particularly 2 to 15%, based on the total amount of the composition.

As the pH adjuster, 1 or 2 or more of terephthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, pyrophosphoric acid, glycerophosphoric acid, carbonic acid, potassium salts, sodium salts, ammonium salts thereof, ribonucleic acid, salts thereof, sodium hydroxide, etc. may be added in a usual amount within a range not to impair the effects of the present invention.

Examples of the preservative include parabens such as butyl paraben, propyl paraben, ethyl paraben and methyl paraben, benzoate such as sodium benzoate, and potassium sorbate.

Examples of the sweetening agent include saccharin sodium, aspartame, stevioside, stevia extract, p-methoxycinnamaldehyde, neohesperidin dihydrochalcone, perillatin, and the like.

Examples of the coloring agent include blue No. 1, yellow No. 4 (FD & C, Yellow No.5 (19140)), green No. 3, and red No. 105.

The amount of these components to be mixed may be any amount as long as the effects of the present invention are not impaired.

The material of the container is not particularly limited, and a container generally used for a toothpaste composition or a liquid dentifrice composition can be used.

Examples

The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples,% means mass% unless otherwise specified.

[ examples, comparative examples ]

Dentifrice compositions having compositions shown in tables 1 to 3 were prepared by the following production methods.

(production method)

The dentifrice composition is prepared by dissolving a water-soluble substance such as sodium saccharin, sodium monofluorophosphate, or sorbitol solution in pure water, adding a liquid obtained by dispersing a binder in propylene glycol separately thereto, and stirring. Then, polyoxyethylene hardened castor oil, polyoxyethylene (5) octadecyl ether dissolved by heating, a flavor, a polishing agent, sodium alkyl sulfate, and the like are added thereto, and the mixture is stirred under reduced pressure (pressure 4kPa) to obtain a dentifrice composition. A homogenizer (ユニミキサ one) (FM-SR-25, POWEREX CORPORATION) was used for the production.

These dentifrice compositions were prepared by using isopropyl methylphenol (manufactured by Osaka chemical Co., Ltd.), potassium nitrate (manufactured by マツモト Co., Ltd.), aluminum lactate (manufactured by Wucang Yedo chemical Co., Ltd.), strontium chloride (manufactured by genuine chemical Co., Ltd.), 3-octanol (manufactured by salt spice Co., Ltd.), octyl 3-acetate and 3-octanone (manufactured by Kyoho spice Co., Ltd.), fenchone (manufactured by Xiangrongxing Co., Ltd.), anisaldehyde (manufactured by Dayang spice Co., Ltd.), 1-octanol (manufactured by Gaosha spice Co., Ltd.), sodium lauryl sulfate (manufactured by Sun ケミカルズ (manufactured by Nikkol SLS.), polyoxyethylene (20) hardened castor oil (sun ケミカルズ (manufactured by Sun), NIkkol HCO-20), polyoxyethylene (5) octadecyl ether (manufactured by Japan エマ ル ジ ヨ ン (manufactured by L., Ltd.), EMA 605 (manufactured by LEX605), Silicon dioxide (ロ - デイア Niuhua, manufactured by Nippon Kasei corporation, TIXOSIL 73), sorbitol (manufactured by Toho Kasei Kogyo Co., Ltd., D-sorbitol solution (70% aqueous solution)), sodium carboxymethylcellulose (ダイセル chemical Industrial Co., Ltd., CMC1250), sodium monofluorophosphate, propylene glycol, sodium saccharin, titanium dioxide, and pure water, and those suitable for use in quasi-drug raw material specification (medicine and external product raw material size) 2006.

For sorbitol, dentifrice compositions were formulated using a 70% aqueous solution. The perfumes were prepared by using the perfume components shown in table 5 and mixing the perfume compositions a to I shown in table 4.

50g of the dentifrice composition thus obtained was charged into a 26mm diameter laminate tube (LDPE55/PET12/LDPE 20/white LDPE60/EMAA20/AL10/EMAA30/LDPE20/LLDPE30, 257 μm thick (manufactured by Dainippon printing Co., Ltd.) whose innermost layer was composed of linear low-density polyethylene.

Abbreviations and names in the layer structure of the laminated tube used are shown below, and numerals connected after the abbreviations represent thicknesses (μm) of the respective layers.

LDPE (Low-Density polyethylene): low density polyethylene

White LDPE: white low density polyethylene

LLDPE: linear low-density polyethylene

AL: aluminium

PET: polyethylene terephthalate

EMAA: ethylene-methacrylic acid copolymer resin

The obtained dentifrice composition was evaluated for biofilm bactericidal activity, sensory hypersensitivity inhibitory effect, and the degree of unpleasant taste by the following methods. The results are also shown in tables 1 to 3.

(1) Method for evaluating sterilization effect of model biological membrane

A Hydroxyapatite (HA) plate having a diameter of 7mm was treated with human non-irritating saliva filtered through a 0.45 μm filter for 4 hours, and 5 mixed strains of Streptococcus mutans (Streptococcus mutans), Actinomyces naeslundii (Actinomyces naeslundii), Veillonella parvulus (Veillonella parvula), Fusobacterium nucleatum (Fusobacterium nucleatum), and Porphyromonas gingivalis (Porphyromonas givitis) were continuously cultured in tryptone soy broth medium supplemented with hemin and menadione for 2 weeks,model biofilms were formed on the HA plates. After 2 weeks of culture, 1 time per day 1 time, 2 times the mass of saliva (50mmol/L KCl +1 mmol/LKH) was added to the dentifrice preparation shown in the following Table₂PO₄+1mmol/L CaCl₂+0.1mmol/L MgCl₂(pH7.0)), and the centrifuged supernatant after dispersion was used as a test reagent solution, and the model biofilm was immersed in the solution for 3 minutes and further cultured for 3 days. When the culture was completed, the model biofilm was removed, dispersed, and cultured on an agar plate, whereby the viable cell count of each strain in the model biofilm was determined. The number of viable bacteria varied somewhat depending on the culture conditions, and when the test agent was replaced with saliva of the population, it was about 8.5log cfu (colony forming unit/HA plate), and when it was less than 6.0log cfu/HA plate, it was judged that the biofilm had high bactericidal activity.

Model biological film sterilization effect evaluation benchmark

Very good: less than 5.0log cfu/HA plate

O: more than 5.0log cfu/HA plate to less than 6.0log cfu/HA plate

And (delta): more than 6.0log cfu/HA plate and less than 7.0log cfu/HA plate

X: 7.0log cfu/HA plate or more

(2) Inhibitory effect on sensory hypersensitivity

The test dentifrice composition was continuously used for 4 weeks in a 10-person hypersensitivity panel in which the teeth were perceived to be frozen when cold water was held in the mouth, and then the test dentifrice composition filled in the laminated tube was extruded 1cm onto a toothbrush, and the teeth were brushed for 2 minutes in the same manner as usual, and evaluated according to the evaluation criterion-1 shown below. The average score of 10 persons was evaluated according to evaluation criterion-2.

Evaluation criteria-1

And 5, dividing: after brushing teeth, when cold water is in the mouth, the teeth do not feel frozen at all

And 4, dividing: after brushing teeth, when cold water is in the mouth, teeth do not feel frozen

And 3, dividing: after brushing, when cold water is held in the mouth, the teeth feel little to no freezing and no problematic levels

And 2, dividing: after brushing teeth, teeth feel frozen when cold water is held in the mouth

1 minute: after brushing teeth, when cold water is in the mouth, the teeth feel frozen obviously

Evaluation criteria-2

Very good: the average score of 10 people is more than 4.0

O: the average score of 10 people is more than 3.0 and less than 4.0

And (delta): the average score of 10 people is more than 2.0 and less than 3.0

X: the average score of 10 persons is less than 2.0

(3) Evaluation of whether there was an unpleasant taste

Sensory tests were performed using a 10-person expert panel. About 1g of the dentifrice composition was placed on a commercial toothbrush and brushed for 3 minutes, and the presence or absence of unpleasant taste in use was evaluated according to the following score. The average of the evaluation results of 10 persons was obtained, and the dentifrice composition ensuring the x and o evaluations was judged as a dentifrice composition having no unpleasant taste according to the following criteria.

(rating)

And 4, dividing: completely free of unpleasant taste

And 3, dividing: hardly has unpleasant taste

And 2, dividing: slightly unpleasant taste

1 minute: has unpleasant taste

(evaluation criteria)

Very good: 3.7 to 4.0 minutes inclusive

Excellent to o: more than 3.3 minutes to less than 3.7 minutes

O: more than 3.0 minutes and less than 3.3 minutes

And (delta): more than 2.0 minutes and less than 3.0 minutes

X: less than 2.0 minutes

[ TABLE 1-1 ]

[ TABLE 1-2 ]

[ TABLE 1-3 ]

[ TABLE 2 ]

[ TABLE 3-2 ]

[ TABLE 3-3 ]

[ TABLE 3-4 ]

As is clear from the results in tables 1 to 3, when any of the components (a) to (D) is absent or the amount of these components mixed is inappropriate, any one of the biofilm bactericidal activity, the sensory hypersensitivity inhibitory action and the presence or absence of unpleasant taste is deteriorated, whereas the dentifrice composition of the present invention (example) is excellent in the biofilm bactericidal activity and the sensory hypersensitivity inhibitory action, free from unpleasant taste and good in use feeling, and has these excellent characteristics. In examples 1 to 80, the same results were obtained by replacing the fragrance composition A with any of the fragrance compositions B to I.

[ TABLE 4 ]

*: the spice composition does not contain 3-octanol, 3-octyl acetate, 3-octanone, fenchyl ketone and anisaldehyde.

[ TABLE 5-1 ]

< composition of essence 1 >

[ TABLE 5-2 ]

< composition of essence 2 >

[ TABLE 5-3 ]

<Essence 3 composition>
		Wintergreen oil	1 part by mass
Mastic oil	1
		Neroli oil	1
Lemongrass oil	1
		Rose oil	1
Rose absolute oil	1
		Mango absolute	1
Iris extract	1
		Neroli absolute	1
Ethanol	1
		Total up to	10 parts by mass

[ TABLE 5-4 ]

<4 composition of essence>
		Menthyl lactate	1 part by mass
3-1-menthoxypropane-1, 2-diol	1
		Menthone glycerol ether	1
Chrysanthemum alcohol	1
		Monomenthyl succinate	1
Linalool oxide	1
		Vanillyl butyl ether	1
Isopulegol	1
		Capsicum extract	1
Ginger resin oil	1
		Pepper resin oil	1
Persimmon pepper resin oil	1
		Ethanol	1
Total up to	13 parts by mass

[ TABLE 5-5 ]

<Essence 5 composition>
		Furanones	1 part by mass
Ethyl cyclopentenolone	1
		3-methylcyclopentane-1, 2-dione	1
2-methyl butyric acid	1
		Propionic acid	1
P-methoxy cinnamic aldehyde	1
		Ethanol	1
Total up to	7 parts by mass

[ TABLE 5-6 ]

< composition of essence 6 >

Claims (7)

1. A dentifrice composition characterized by containing

(A) Isopropyl methyl phenol,

(B) 1 or more than 2 of potassium nitrate, aluminum lactate and strontium chloride,

(C) 1 or more than 2 perfume components selected from 3-octanol, 3-octyl acetate, 3-octanone, fenchyl ketone, and

(D) anionic surfactant and/or nonionic surfactant

And (4) preparing the composition.

2. The dentifrice composition according to claim 1, wherein the mass ratio of component (B)/component (A) is 2 to 700.

3. The dentifrice composition according to claim 1 or 2, wherein the component (D) is an alkyl sulfate, a polyoxyethylene hardened castor oil and/or a polyoxyethylene alkyl ether.

4. The dentifrice composition according to claim 1, 2 or 3, which comprises 0.01 to 0.2% by mass of the component (A), 0.1 to 15% by mass of the component (B), 0.0001 to 0.1% by mass of the component (C) and 0.1 to 5% by mass of the component (D).

5. The dentifrice composition according to any 1 of claims 1 to 4, further comprising (E) anisaldehyde.

6. The dentifrice composition according to claim 5, which comprises the component (E) in an amount of 0.0001 to 0.1% by mass.

7. A toothpaste prepared by mixing 10 to 70% by mass of a thickening agent, 0.1 to 5% by mass of a binder and 0 to 50% by mass of a polishing agent with the dentifrice composition according to any 1 of claims 1 to 6.