HK1156867B - External preparation for skin - Google Patents

Description

External preparation for skin

Technical Field

The present invention relates to an external preparation for skin. More specifically, the present invention relates to an external skin preparation containing an alkylresorcinol having excellent temperature stability (particularly high temperature stability) and excellent light stability.

Background

Alkylresorcinols are known to have a melanin production inhibitory action and an antibacterial action, and are contained in cosmetics for the purpose of whitening, antibacterial, and the like (see, for example, patent documents 1 to 2). As a substance having a whitening effect, L-ascorbic acid and an L-ascorbic acid derivative are known in addition to the above-mentioned alkylresorcinols, and an external preparation for skin containing alkylresorcinols, L-ascorbic acids (═ L-ascorbic acid, an L-ascorbic acid derivative), and the like has been proposed (for example, see patent documents 3 to 4). However, alkylresorcinols and L-ascorbic acids have a problem that they are easily discolored by temperature and light, and thus, a technique for effectively suppressing discoloration of alkylresorcinols and L-ascorbic acids has not been sufficiently studied.

Documents of the prior art

Patent document

Patent document 1: japanese laid-open patent publication No. 2-049715

Patent document 2: japanese laid-open patent publication No. 4-16911

Patent document 3: japanese patent laid-open publication No. 2004-277352

Patent document 4: japanese patent laid-open publication No. 2005-120023

Disclosure of Invention

Problems to be solved by the invention

The purpose of the present invention is to provide an external skin preparation containing an alkylresorcinol and an L-ascorbic acid compound, which is excellent in temperature stability (particularly high-temperature stability) and light stability.

Means for solving the problems

As a result of intensive studies to solve the above problems, the present inventors have found that when only one of alkylresorcinols and L-ascorbic acids is blended, discoloration occurs due to temperature and light, but by combining a specific amount of alkylresorcinols, particularly 4-isobutylresorcinols or salts thereof, with L-ascorbic acids, particularly L-ascorbic acids or salts thereof, and 3-O-alkyl-L-ascorbic acids or salts thereof, very excellent photostability and temperature (high temperature) stability can be exhibited, and have completed the present invention.

That is, the present invention relates to an external preparation for skin, which contains: 0.01 to 5 mass% of (a) 4-isobutylresorcinol or a salt thereof, and 0.01 to 5 mass% of (b) 1 or 2 or more selected from L-ascorbic acid or a salt thereof, and 3-O-alkyl-L-ascorbic acid or a salt thereof.

Among the above, the component (b) is preferably 3-O-alkyl-L-ascorbic acid or a salt thereof.

ADVANTAGEOUS EFFECTS OF INVENTION

The present invention can provide an external skin preparation containing an alkylresorcinol and an L-ascorbic acid derivative, which is excellent in temperature stability (particularly high-temperature stability) and light stability.

Detailed Description

The present invention will be described in detail below. In the following, "POE" represents polyoxyethylene, and "POP" represents polyoxypropylene.

The 4-isobutylresorcinol or a salt thereof used as the component (a) in the present invention is a compound represented by the following formula (I) or a salt thereof.

The salt of 4-isobutylresorcinol represented by the formula (I) is not particularly limited, and examples thereof include alkali metal salts such as sodium salt, potassium salt and lithium salt, alkaline earth metal salts such as magnesium salt and calcium salt, ammonium salt and amino acid salt. However, the present invention is not limited to these examples.

The amount of the component (a) to be incorporated in the skin external preparation of the present invention is 0.01 to 5% by mass, preferably 0.1 to 3% by mass, and more preferably 0.1 to 1% by mass. When the amount is less than 0.01% by mass, the whitening effect, the antibacterial effect and the like are insufficient, while the amount exceeding 5% by mass is not preferable in view of the skin irritation and the like.

The component (b) used in the present invention is 1 or 2 or more selected from the group consisting of L-ascorbic acid or a salt thereof, and 3-O-alkyl-L-ascorbic acid or a salt thereof. Examples of the 3-O-alkyl-L-ascorbic acid or a salt thereof include 3-O-methyl-L-ascorbic acid, 3-O-ethyl-L-ascorbic acid, 3-O-n-propyl-L-ascorbic acid, 3-O-isopropyl-L-ascorbic acid, 3-O-n-butyl-L-ascorbic acid, 3-O-isobutyl-L-ascorbic acid, 3-O-tert-butyl-L-ascorbic acid, 3-O-n-pentyl-L-ascorbic acid, 3-O-n-hexyl-L-ascorbic acid, 3-O-n-heptyl-L-ascorbic acid, and salts thereof, 3-O-alkyl ethers of L-ascorbic acid such as 3-O-n-octyl-L-ascorbic acid and 3-O-n-nonyl-L-ascorbic acid, and salts thereof.

The salt is not particularly limited, and examples thereof include alkali metal salts such as sodium salt, potassium salt and lithium salt, alkaline earth metal salts such as magnesium salt and calcium salt, ammonium salt and amino acid salt. However, the present invention is not limited to these examples.

In the present invention, 3-O-alkyl-L-ascorbic acid or a salt thereof is particularly most preferably 3-O-C_1-6alkyl-L-ascorbic acid or a salt thereof.

The amount of the component (b) to be incorporated in the skin external preparation of the present invention is 0.01 to 5% by mass, preferably 0.05 to 3% by mass, and particularly preferably 0.1 to 3% by mass. When the amount is less than 0.01% by mass, the contribution to the temperature stability is insufficient, while when the amount exceeds 5% by mass, the addition is not preferable in terms of skin irritation.

The skin external preparation of the present invention, which contains the above-mentioned component (a) and component (b) in combination, is excellent not only in temperature stability (high temperature stability), which is an effective suppression of discoloration of both components, but also in effect of suppressing discoloration due to sunlight or xenon in particular.

In the present invention, from the viewpoint of light stability, 1 or 2 or more compounds selected from (c-1) a compound having a sterol skeleton, (c-2) a vitamin E derivative, (c-3) a compound represented by the formula (II) (described later), and (c-4) a compound having a sorbitan skeleton can be used as the component (c) as desired. Salts of these individual compounds may also be used.

Examples of the compound having a sterol skeleton as the component (c-1) include compounds obtained by addition polymerization of Ethylene Oxide (EO), Propylene Oxide (PO), and the like to phytosterols, phytostanols, cholestanols, cholesteryl ethers, and the like. These compounds can be represented by the following formula (IV).

In the formula (IV), R₅Represents any one of a phytosterol residue, a phytostanol residue, a cholestanol residue and a cholesterol ether residue, s represents a numerical value of 0 to 100, and t represents a numerical value of 5 to 100.

Specific examples of the compound having a cholesterol skeleton include polyoxyethylene phytosterols such as POE (5) phytosterol, POE (10) phytosterol, POE (20) phytosterol, POE (25) phytosterol, and POE (30) phytosterol; polyoxyethylene phytosterols such as POE (20) phytostanol, POE (25) phytostanol, and POE (30) phytostanol; polyoxyethylene cholestanols such as POE (20) cholestanol, POE (25) cholestanol, and POE (30) cholestanol; POE (5) cholesterol ether, POE (10) cholesterol ether, POE (15) cholesterol ether, POE (20) cholesterol ether, POE (24) cholesterol ether, POE (30) cholesterol ether and other polyoxyethylene cholesterol ethers. Among these, POE (20) phytosterol, POE (30) cholestanol and the like are preferable from the viewpoint of photostability, and POE (30) phytosterol is particularly preferable.

The vitamin E derivative as the component (c-2) is not particularly limited, but is preferably a compound represented by the following formula (V) or (VI), for example.

In the above formula (V) or (VI), the substituents each have the following meanings. In the formula, EO represents an oxyethylene group, PO represents an oxypropylene group, and BO represents an oxybutylene group.

R₆、R₇、R₈Each independently represents a hydrogen atom or a methyl group. As R₆、R₇、R₈A preferable combination of (2) includes R₆、R₇And R₈Represents a combination of methyl groups (5, 7, 8-trimethyl matrix. in the case where the raw material vitamin E is alpha-tocopherol); r₆And R₈A combination of a methyl group and R7 a hydrogen atom (5, 8-dimethyl group; in the case where the raw material vitamin E is beta-tocopherol); r₆Represents a hydrogen atom, R₇And R₈Represents a combination of methyl groups (7, 8-dimethyl matrix in the case where the raw vitamin E is gamma-tocopherol) or R₆And R₇Represents a hydrogen atomSeed, R₈Represents a combination of methyl groups (8-methyl matrix, in the case where the raw vitamin E is delta-tocopherol).

R₉Represents a hydrogen atom, an alkanoyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms, SO₃H radical, P (O) (OH)₂Radical, CH₂COOH groups or COCH₂CH(SO₃H) COOH group.

The alkanoyl group having 1 to 6 carbon atoms may be either straight or branched, and specifically includes, for example, acetyl, propionyl, butyryl, isobutyryl, pivaloyl, and the like, among which acetyl, propionyl, pivaloyl, and the like are preferred, and acetyl is particularly preferred from the viewpoint of synthesis.

The alkyl group having 1 to 6 carbon atoms may be either linear or branched, and specifically includes, for example, methyl, ethyl, propyl, butyl, isobutyl, tert-butyl, pentyl, hexyl and the like, among which methyl, ethyl, propyl, butyl and the like are preferred, and methyl and ethyl are particularly preferred from the viewpoint of synthesis.

SO₃H radical, P (O) (OH)₂Radical, CH₂COOH groups or COCH₂CH(SO₃H) The COOH groups may combine with a base to form a salt. The base is not particularly limited as long as it has low toxicity and does not affect the antioxidant activity, moisture retention, etc. of the vitamin E derivative represented by the above formula (V) or (VI). Examples of such salts include alkali metal salts such as sodium salt, potassium salt, and lithium salt; alkaline earth metal salts such as calcium salts and magnesium salts; metal salts such as aluminum salt, iron salt, zinc salt, copper salt, nickel salt, and cobalt salt; inorganic salts such as ammonium salts; amine salts such as organic salts including t-octylamine salt, dibenzylamine salt, morpholine salt, glucosamine salt, phenylglycine alkyl ester salt, ethylenediamine salt, N-methylglucamine salt, guanidine salt, diethylamine salt, triethylamine salt, dicyclohexylamine salt, N' -dibenzylethylenediamine salt, chloroprocaine salt, procaine salt, diethanolamine salt, N-benzyl-phenethylamine salt, piperazine salt, tetramethylammonium salt, tris (hydroxymethyl) aminomethane salt and the like. However, the present invention is not limited to these columnsAn example is given. Among them, from the viewpoint of synthesis, alkali metal salts, alkaline earth metal salts, ammonium salts and the like are preferable, sodium salts, potassium salts, 1/2 magnesium salts, 1/2 calcium salts, ammonium salts and the like are more preferable, and sodium salts and ammonium salts are particularly preferable.

k. y represents a number of 0 to 30, preferably 0 to 25, and particularly preferably 0 to 20 (where k and y are not 0 at the same time). x represents a number of 1 to 30, preferably 1 to 10, and particularly preferably 1 to 5. Particularly preferred combinations of k, x, and y include combinations in which k and y are each 0 to 20 (where k and y are not 0 at the same time), and x is 1 to 5.

The component (c-3) is a compound represented by the following formula (II).

In the formula (II), R₂Represents a linear or branched alkyl or alkenyl group having 12 to 22 carbon atoms.

n represents a numerical value of 0 or 1. q represents an integer of 1 to 3, and R is 1₃Represents a group represented by the following formula (III) or a sugar residue, and R is R when q is 2 or 3₃Represents a sugar residue.

In the formula (III), R₄Represents a hydrogen atom or an aliphatic acyl group having 12 to 22 carbon atoms, m and p each independently represents an integer of 0 to 40, and m + p is not less than 5.

As the compound represented by the above formula (II), preferable compounds include polyglycerin fatty acid esters, polyoxybutylene polyglycerin alkyl ethers, sucrose fatty acid esters, and the like.

As the polyglycerin moiety of the polyglycerin fatty acid ester, 5 to 20-mer of glycerin is preferably mentioned, and as the fatty acidPartially, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, behenic acid, or the like is preferably used. That is, in the formula (II), n is 1, q is 1, and R is₃Is a group represented by the formula (III) (wherein m is 5 to 20 and p is 0) as R₂Preferably, lauryl, myristyl, palmityl, stearyl, oleyl, linoleyl (linolyl) and the like are used. The preferred esterification degree is 1-3 per 1 molecule on average, and has at least 3 free hydroxyl way. That is, in the polyglycerin fatty acid ester represented by the formula (II), R₃Is a group represented by the formula (III) (wherein m is 5 to 20 and p is 0, and the number of R in the polyglycerin moiety is 1 to 3)₄At least 3R represents an aliphatic acyl group having 12 to 22 carbon atoms₄Is hydrogen. In addition, as R₄The aliphatic acyl group having 12 to 22 carbon atoms is preferably a lauroyl group, a myristoyl group, a palmitoyl group, a stearoyl group, an oleoyl group, a linoleoyl group (linoloyl group), or the like.

A large number of such polyglycerin fatty acid esters are commercially available, and particularly preferred polyglycerin fatty acid esters include decaglyceryl monolaurate, decaglyceryl monooleate, decaglyceryl monostearate, and the like, which are commercially available.

The polyoxybutylene polyglycerol alkyl ether is preferably a polyoxybutylene polyglycerol alkyl ether in which the average number of moles of addition (average polymerization degree) of butylene oxide groups is 10 to 20 and the average number of moles of addition (average polymerization degree) of polyglycerol is 10 to 20. That is, in formula (II), n is 0, q is 1, and R is₃Is a group represented by the formula (III) (wherein m is 10 to 20 and p is 10 to 20) as R₂Preferably stearyl, oleyl and the like.

There are also commercially available polyoxybutylene polyglycerol alkyl ethers, and commercially available products can be used. Particularly preferred commercially available products include polyoxybutylene (13) polyglycerol (14) stearyl ether ("ハイグリオ - ル S-26"; manufactured by Nippon サ - フアクタント Co., Ltd.).

Examples of the sucrose fatty acid ester include sucrose monofatty acid ester with n-1 and q-1, sucrose difatty ester with q-2, and sucrose difatty ester with q-13 sucrose tri-fatty acid ester. Among these, sucrose monofatty acid esters are more preferable. Preferred examples of the fatty acid moiety include lauric acid, palmitic acid, stearic acid, and oleic acid. That is, in the formula (II), R₃Is sucrose in the form of a sugar residue as R₂Lauryl, myristyl, palmityl, stearyl, oleyl and the like are preferred. Specifically, as a preferable sucrose monofatty acid ester, sucrose monolaurate, sucrose monostearate, and the like are particularly preferable.

Examples of the compound having a sorbitan skeleton as the component (c-4) include sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters, and examples of the fatty acid constituting the ester include myristic acid, palmitic acid, isostearic acid, stearic acid, oleic acid, and the like, and among them, stearic acid is particularly preferable from the viewpoint of improving stability. In addition, in the polyoxyethylene sorbitan fatty acid ester, the number of addition mols of polyoxyethylene is preferably 5 to 40, and more preferably 10 to 30. Specific examples of the component (c-4) include polyoxyethylene (20) sorbitan monostearate 60 and the like.

When component (c) is blended, the amount of component (c) blended in the skin external preparation of the present invention is preferably 0.01 to 7% by mass, more preferably 0.05 to 5% by mass, and particularly preferably 0.1 to 3% by mass. When the amount is less than 0.01% by mass, it becomes difficult to prepare a transparent system when the skin external preparation of the present invention is prepared into a transparent cosmetic liquid, while when it exceeds 7% by mass, it is not preferable in terms of usability (increased stickiness) and irritation.

The skin external preparation of the present invention is prepared by using the above components as a base and preparing the base by a conventional method. The external preparation for skin of the present invention may contain, in addition to the above-mentioned components, other components generally used in external preparations for skin, for example, powder components, liquid oils and fats, solid oils and fats, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, moisturizers, water-soluble polymers, skin-coating agents, ultraviolet absorbers, metal ion chelating agents, lower alcohols, polyols, sugars, amino acids, organic amines, polymer emulsions, pH regulators, skin nutrients, vitamins, antioxidants, antioxidant aids, perfumes, water, and the like, as necessary, within a range in which the effects of the present invention are not impaired. Specific components that can be blended are listed below, but the present invention is not limited to these listed examples.

Examples of the powder component include inorganic powders (for example, talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite (vermicite), magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soaps (for example, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, and the like); organic powders (e.g., polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red iron oxide), iron titanate, etc.); inorganic brown pigments (e.g., gamma-iron oxide); inorganic yellow pigments (e.g., yellow iron oxide, yellow soil, etc.); inorganic black pigments (e.g., black iron oxide, low-dimensional titanium oxide, etc.); inorganic violet pigments (e.g., manganese violet and cobalt violet); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine blue and berlin blue); pearlescent pigments (e.g., titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lakes (e.g., organic pigments such as red 201, red 202, red 204, red 205, red 220, red 226, red 228, red 405, orange 203, orange 204, yellow 205, yellow 401, and blue 404, and red 3, red 104, red 106, red 227, red 230, red 401, red 505, orange 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3, and blue 1); natural pigments (e.g., chlorophyll, beta-carotene, etc.), and the like.

Examples of the liquid oils and fats include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, torreya oil, rice bran oil, paulownia oil, japanese tung oil, jojoba oil, germ oil, and triglycerin.

Examples of the solid fat and oil include cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, beeswax kernel oil, hydrogenated oil, beef foot fat, beeswax, hydrogenated castor oil, and the like.

Examples of the waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, white wax, spermaceti, montan wax, rice bran wax, lanolin, kapok wax, acetylated lanolin, liquid lanolin, sugar cane wax, isopropyl lanolate, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

Examples of the hydrocarbon oil include liquid paraffin, ceresin, squalane, pristane, paraffin, ceresin, squalene, vaseline, and microcrystalline wax.

Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

Examples of the higher alcohol include straight-chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol (cetostearyl alcohol), and the like); branched alcohols (e.g., monostearyl glyceryl ether (batyl alcohol), 2-decyltetradecylalkyl alcohol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.), and the like.

Examples of the synthetic ester oil include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkanediol monoisostearate, neopentyl glycol didecanoate, diisostearyl malate, di-2-heptylundecyl glyceride, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerol tri-2-ethylhexanoate, isopropyl myristate, decyl myristate, isopropyl myristate, butyl stearate, hexyl laurate, hexyl myristate, decyl lactate, lanolin, isopropyl stearate, isopropyl myristate, isopropyl, Tricaprylin, triisopalmitate, triisostearate trimethylolpropane, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, trimyristin, tri-2-heptylundecanoate, ricinoleic acid methyl ester, oleic acid oleyl ester, acetyl glycerol, palmitic acid 2-heptylundecyl ester, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate, and the like.

Examples of the silicone oil include chain polysiloxanes (e.g., dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (e.g., octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, etc.), silicone resins forming a three-dimensional network structure, silicone rubbers, various modified polysiloxanes (e.g., amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.), and the like.

Examples of the anionic surfactant include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfate ester salts (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfate ester salts (e.g., POE-triethanolamine lauryl sulfate, POE-sodium lauryl sulfate, etc.); n-acyl sarcosines (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyltaurate, sodium coconut fatty acid methyltaurate, sodium lauryl methyltaurate, etc.); phosphate ester salts (POE-sodium oleyl ether phosphate, POE-stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, and the like); alkyl benzene sulfonates (e.g., linear sodium dodecylbenzene sulfonate, linear triethanolamine dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); higher fatty acid ester sulfate salts (e.g., sodium hydrogenated coconut oil fatty acid glycerol sulfate); n-acyl glutamates (e.g., monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., turkish red oil, etc.); POE-alkyl ether carboxylic acids; POE-alkyl allyl ether carboxylate; an alpha-olefin sulfonate; higher fatty acid ester sulfonates; secondary alcohol sulfate salts; higher fatty acid alkylolamide sulfate salts; lauroyl monoethanolamide sodium succinate; n-palmitoyl aspartic acid ditriethanolamine; sodium caseinate, and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetyl pyridinium chloride, etc.); distearyldimethylammonium chloride, dialkyldimethylammonium salts; poly (N, N' -dimethyl-3, 5-methylenepiperidinium) chloride; alkyl quaternary ammonium salts; alkyl dimethyl benzyl ammonium salts; an alkylisoquinolinium salt; a dialkyl morpholinium salt; POE-alkylamine; an alkylamine salt; polyamine fatty acid derivatives; a pentanol fatty acid derivative; benzalkonium chloride; benzethonium chloride, and the like.

Examples of the amphoteric surfactant include imidazoline amphoteric surfactants (e.g., 2-undecyl-N, N, N- (hydroxyethyl carboxymethyl) -2-imidazolinium sodium, 2-coco-2-imidazolinium hydroxide-1-carboxyethoxy disodium salt, etc.); betaine-type surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazoline betaine, lauryl dimethylamino acetate betaine, alkyl betaine, amido betaine, sulfobetaine, etc.), and the like.

Examples of the lipophilic nonionic surfactant include propylene glycol fatty acid esters (e.g., propylene glycol monostearate); hydrogenated castor oil derivatives, and the like.

Examples of the hydrophilic nonionic surfactant include POE sorbitol fatty acid esters (e.g., POE-sorbitol monolaurate, POE-sorbitol monooleate, POE-sorbitol pentaoleate, POE-sorbitol monostearate, etc.); POE-glycerin fatty acid esters (for example, POE-monooleate such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate); POE-fatty acid esters (e.g., POE-distearate, POE-monooleate, ethylene glycol distearate, etc.); POE-alkyl ethers (e.g., POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); pluronic types (e.g., Pluronic, etc.); POE/POP-alkyl ethers (e.g., POE/POP-cetyl ether, POE/POP-2-decyltetradecyl ether, POE/POP-monobutyl ether, POE/POP-hydrogenated lanolin, POE/POP-glyceryl ether, etc.); tetrapolye/tetrapod-ethylenediamine condensates (for example, Tetronic); POE-castor oil hydrogenated castor oil derivatives (e.g., POE-castor oil, POE-hydrogenated castor oil monoisostearate, POE-hydrogenated castor oil triisostearate, POE-hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, POE-hydrogenated castor oil maleic acid, etc.); POE-beeswax/lanolin derivatives (e.g., POE-sorbitol beeswax, etc.); alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid ester; POE-alkylamine; POE-fatty acid amide; sucrose fatty acid ester; alkyl ethoxy dimethyl amine oxide; triolein phosphoric acid and the like.

Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1, 3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucopolysaccharide sulfate, trichosanthes acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile acid salt, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, rosa roxburghii extract, yarrow extract, and sweet clover extract.

Examples of the natural water-soluble polymer include plant-based polymers (e.g., acacia, tragacanth, galactose, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (marmelo), seaweed colloid (seaweed extract), starch (rice, corn, potato, wheat), and glycyrrhizic acid); microbial polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); animal polymers (e.g., collagen, casein, albumin, gelatin, etc.), and the like.

Examples of the semisynthetic water-soluble polymer include starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methyl cellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); alginic acid polymers (e.g., sodium alginate, propylene glycol alginate, etc.), and the like.

Examples of the water-soluble polymer to be synthesized include vinyl polymers (e.g., polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene polymers (e.g., polyoxyethylene polyoxypropylene copolymers of polyethylene glycol 20,000, 40,000, 60,000, etc.); acrylic polymers (for example, sodium polyacrylate, polyethylacrylate, polyacrylamide, etc.); a polyethyleneimine; cationic polymers, and the like.

Examples of the inorganic water-soluble polymer include bentonite, magnesium aluminum silicate (Veegum), laponite, hectorite, and silicic anhydride.

Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers (for example, p-aminobenzoic acid (hereinafter, abbreviated as PABA), PABA monoglyceride, N-dipropoxyppaba ethyl ester, N-diethoxyppaba ethyl ester, N-dimethylppaba butyl ester, N-dimethylppaba ethyl ester, and the like); anthranilic acid-based ultraviolet absorbers (e.g., trimethylcyclohexyl (homomenthyl) -N-acetyl anthranilate); salicylic acid-based ultraviolet absorbers (e.g., amyl salicylate, menthyl salicylate, trimethylcyclohexyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanolphenyl salicylate, etc.); cinnamic acid-based ultraviolet absorbers (for example, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2, 5-diisopropyl cinnamate, ethyl-2, 4-diisopropyl cinnamate, methyl-2, 4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isopentyl-p-methoxy cinnamate, octyl-p-methoxy cinnamate (2-ethylhexyl-p-methoxy cinnamate), 2-ethoxyethyl-p-methoxy cinnamate, cyclohexyl-p-methoxy cinnamate, ethyl- α -cyano- β -phenyl cinnamate, 2-ethylhexyl- α -cyano- β -phenyl cinnamate, methyl-2, 5-diisopropyl cinnamate, isopropyl-p-methoxy cinnamate, isopentyl-p-methoxy cinnamate, octyl-p-methoxy cinnamate, 2-ethylhexyl-p-methoxy cinnamate, cyclohexyl-p-, Glyceryl mono-2-ethylhexanoyl-di-p-methoxycinnamate, etc.); benzophenone-based ultraviolet absorbers (e.g., 2, 4-dihydroxybenzophenone, 2 ' -dihydroxy-4-methoxybenzophenone, 2 ' -dihydroxy-4, 4 ' -dimethoxybenzophenone, 2 ', 4, 4 ' -tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4 ' -methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4 ' -phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octyloxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.); 3- (4' -methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor; 2-phenyl-5-methylbenzoxazole; 2, 2' -hydroxy-5-methylphenylbenzotriazole; 2- (2 '-hydroxy-5' -tert-octylphenyl) benzotriazole; 2- (2 ' -hydroxy-5 ' -methylphenyl benzotriazole, dibenzylazine, dianisinoylmethane, 4-methoxy-4 ' -t-butyldibenzoylmethane, 5- (3, 3-dimethyl-2-norbornenyl) -3-pentan-2-one, and the like.

Examples of the metal ion chelating agent include 1-hydroxyethane-1, 1-bisphosphonic acid, 1-hydroxyethane-1, 1-bisphosphonic acid tetrasodium salt, ethylenediaminetetraacetic acid disodium salt, ethylenediaminetetraacetic acid trisodium salt, ethylenediaminetetraacetic acid tetrasodium salt, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, ethylenediaminetetraacetic acid, ethylenediaminehydroxyethyltriacetic acid trisodium salt, and the like.

Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutanol, and tert-butanol.

Examples of the polyhydric alcohol include dihydric alcohols (e.g., ethylene glycol, propylene glycol, 1, 3-propanediol, 1, 2-butanediol, 1, 3-butanediol, 1, 4-butanediol, 2, 3-butanediol, 1, 5-pentanediol, 2-butene-1, 4-diol, hexanediol, octanediol, etc.); trihydric alcohols (e.g., glycerin, trimethylolpropane, etc.); tetrahydric alcohols (e.g., pentaerythritol such as 1, 2, 6-hexanetriol); pentahydric alcohols (e.g., xylitol, etc.); hexahydric alcohols (e.g., sorbitol, mannitol, etc.); polyol polymers (e.g., diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerol, tetraglycerol, polyglycerin, etc.); glycol alkyl ethers (e.g., ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, etc.); glycol alkyl ethers (e.g., diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, etc.); glycol ether esters (e.g., ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc.); glycerol monoalkyl ethers (e.g., chimyl alcohol, selachyl alcohol, batyl alcohol, etc.); sugar alcohols (e.g., sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, amylolytic sugar, maltose, xylose, amylolytic sugar-reducing alcohol, etc.); glysolid; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP-POE-butyl ether; glyceryl tripropylene oxide ether; POP-glycerol ether; POP-glyceryl ether phosphoric acid; POP-POE-pentaerythritol ether, polyglycerol, etc.

Examples of the monosaccharide include a three-carbon sugar (e.g., D-glyceraldehyde, dihydroxyacetone, etc.); four carbon sugars (e.g., D-erythrose, D-erythrulose, D-threose, erythritol, etc.); five-carbon sugars (e.g., L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc.); six carbon sugar (for example, D-glucose, D-talose, D-psicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); hepta-sugars (e.g., aldoheptose, heptose, etc.); eight-carbon sugars (e.g., octulose, etc.); deoxy sugars (e.g., 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose, etc.); aminosugars (e.g., D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid, etc.); uronic acids (e.g., D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D-galacturonic acid, L-iduronic acid, etc.) and the like.

Examples of oligosaccharides include sucrose, gentiotriose, umbelliferose, lactose, psyllium, isolignins (Isolignose), α -trehalose, raffinose, lignins (Lignose), ulmtilicin, stachyose, and verbascose.

Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucopolysaccharide sulfate, guar gum, dextran, keratin sulfate, locust bean gum, succinoglucan, and trichosanthes acid.

Examples of the amino acid include neutral amino acids (e.g., threonine and cysteine); basic amino acids (e.g., hydroxylysine, etc.), and the like. Examples of the amino acid derivative include sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl β -alanine, glutathione, pyrrolidone carboxylic acid, and the like.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1, 3-propanediol, and 2-amino-2-methyl-1-propanol.

Examples of the polymer latex include acrylic resin latex, polyethylacrylate latex, acrylic resin solution, polyalkylacrylate latex, polyvinyl acetate resin latex, and natural rubber latex.

Examples of the vitamins include vitamins A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, and biotin.

Examples of the antioxidant include tocopherol, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters, and the like.

Examples of the antioxidant auxiliary include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

Examples of other ingredients that can be blended include preservatives (ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, etc.); anti-inflammatory agents (e.g., glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol (hinokitiol), zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, saxifrage extract, arbutin, etc.); various extracts (e.g., phellodendron amurense, goldthread root, chinese herbaceous peony, swertia japonica, birch (birch), sage, loquat, ginseng, aloe, mallow, iris, grape, coix seed, luffa, lily, saffron, chuanxiong rhizome, ginger, forsythia, formononetin, garlic, capsicum, dried orange peel, angelica, seaweed, etc.), activators (e.g., royal jelly, photosensitizer, cholesterol derivative, etc.); blood circulation-promoting agents (e.g., vanillylamide nonanoate (nonillitylamide)), benzyl nicotinate, β -butoxyethyl nicotinate, capsaicin, zingerone, tincture of cantharides, ichthammol, tannic acid, α -borneol, tocopherol nicotinate, inositol hexanicotinate, cyclamate, cinnamylphenylpiperazine, tolazoline, acetylcholine, verapamil, cepharanthine, γ -oryzanol, etc.); anti-lipemic agents (e.g., sulfur, dithionthracene, etc.); anti-inflammatory agents (e.g., tranexamic acid, dipotassium glycyrrhizinate, etc.), and the like.

The formulation of the skin cosmetic of the present invention is arbitrary, and examples thereof include a solubilized type, an emulsified type, a powder dispersed type, an oil-water 2-layer type, and an oil-water-powder 3-layer type, but the present invention is not limited to these formulations. The skin cosmetic of the present invention may be used in any form of product, and may be used for face skin cosmetics, body skin cosmetics, and aromatic skin cosmetics such as lotions, milky lotions, creams, and masks.

Examples

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. The blending amount is not particularly limited, and is expressed by mass% of the component relative to the blending system.

Example 1 Effect of 4-isobutylresorcinol on prevention of discoloration or discoloration of ascorbic acid or a derivative thereof under irradiation with sunlight (50 ℃ C.)

[ color difference (. DELTA.E), L value ]

Samples 1 to 6 shown in Table 1 below were irradiated with sunlight (50MJ, 50 ℃). After the irradiation was completed, the Color difference (. DELTA.E) of each sample after returning to room temperature was measured by a Color difference meter (GretagMacbeth Color-Eye 7000A). A smaller color difference (. DELTA.E) indicates less discoloration. The transparency L value of each sample was measured using an integrating sphere spectrophotometer ("Color-Eye 7000A", manufactured by GretagMacbeth corporation) (the L value was more transparent as it approached 100). The results are shown in Table 1.

[ smell ]

Samples 1 to 6 shown in Table 1 below were irradiated with sunlight (50MJ, 50 ℃). After the completion of the irradiation, each sample returned to room temperature was subjected to sensory evaluation by professional judges (5) on five scales of very good (5 points), good (4 points), normal (3 points), poor (2 points) and very poor (1 point) for odor. The average of the evaluation of 5 panelists was obtained, and the evaluation results are shown according to the following criteria.

(evaluation)

Very good: the average value of the evaluation of 5 judges is 4.0-5.0

O: the average value of the evaluation of 5 judges is 3.0-3.9

Δ: the average value of the evaluation of 5 judges is 2.0-2.9

X: the average value of the evaluation of 5 judges is 1.0-1.9

[ color difference reduction ratio (%) ]

In samples 1 to 2, 3 to 4, and 5 to 6, [ { (color difference (. DELTA.E) of sample not containing 4-isobutylresorcinol) }/(color difference (. DELTA.E) of sample not containing 4-isobutylresorcinol) } X100 (%). It is thus found that 4-isobutylresorcinol has a discoloration-preventing effect on L-ascorbic acid or a derivative thereof. The more the color difference reduction rate (%) approaches 100 (%), the more excellent the discoloration prevention effect. The results are shown in Table 1.

[ Table 1]

From the results shown in table 1, it was confirmed that: when 4-isobutylresorcinol is blended alone or ascorbic acid or a derivative thereof is blended alone, the photostability and the temperature (high temperature) stability are poor, but when both are blended together, the photostability effect and the temperature (high temperature) stability effect can be obtained.

The higher the effect of 4-isobutylresorcinol, the more the color difference was reduced (the higher the color difference reduction rate). In conclusion, 4-isobutylresorcinol can prevent discoloration of ascorbic acids, in which samples 3 and 5 using 3-O-ethyl-L-ascorbic acid and L-ascorbic acid as L-ascorbic acids have a high rate of reduction of color difference, and in which sample 3 using 3-O-ethyl-L-ascorbic acid has a rate of reduction of color difference of about 97% and a color difference of 0.091, and discoloration of 3-O-ethyl-L-ascorbic acid can be substantially completely suppressed by 4-isobutylresorcinol.

Example 2 significance of discoloration prevention Effect of 4-isobutylresorcinol among alkylresorcinols

[ color difference (. DELTA.E), L value ]

Samples 7 to 20 shown in Table 2 below were left in a thermostatic bath at 50 ℃ C. (light-shielded) for 2 weeks, and then the Color difference (. DELTA.E) of each sample after returning to room temperature was measured using a Color difference meter (GretagMacbeth Color-Eye 7000A). A smaller color difference (. DELTA.E) indicates less discoloration. The transparency L value of each sample was measured using an integrating sphere spectrophotometer ("Color-Eye 7000A", manufactured by GretagMacbeth corporation) (the L value was more transparent as it approached 100). The results are shown in Table 2.

[ Table 2]

In Table 2, the amount of 4-isobutylresorcinol added was 0.1 mass%, and the amount of other alkylresorcinols was adjusted so that the alkylresorcinols were present in an equimolar amount to the 4-isobutylresorcinol. Since the object of discoloration measurement is alkylresorcinols, the molar numbers of these alkylresorcinols are kept the same.

From the results shown in table 2, it can be confirmed that: sample 15 in the range of the present invention can obtain measurement results showing little discoloration in both color difference and L value, and is found to have the most excellent discoloration prevention effect.

Formulation examples are further shown below.

Example 3 cosmetic Water

(Components Complex) (mass%)

(1) Ethanol 5.0

(2) Glycerol 1.0

(3)1, 3-butanediol 5.0

(4) POE/POP decyl tetradecyl ether 0.2

(5) Sodium hexametaphosphate 0.03

(6) Polyaspartic acid sodium 0.1

(7) 3-O-Ethyl-L-ascorbic acid 5.0

(8) 4-Isobutylresorcinol 0.1

(9) Green tea extract 0.1

(10) Hypericum erectum extract 0.1

(11) Mentha arvensis extract 0.1

(12) Alpha-glucosyl hesperidin 0.01

(13) 0.1 part of extract of Iris pallida

(14) Ethylenediaminetetraacetic acid trisodium 0.1

(15) Carboxyvinyl Polymer 0.05

(16) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 0.05

(17) 0.02 part of potassium hydroxide

(18) Proper amount of phenoxyethanol

(19) Purified water balance

(20) Proper amount of perfume

Example 4 cosmetic liquid

(Components Complex) (mass%)

(1) Ethanol 10.0

(2) Glycerol 2.0

(3) Dipropylene glycol 1.0

(4) Isostearic acid 0.1

(5) POE/POP Methylpolysiloxane copolymer 1.0

(6) Lauryl dimethyl amino acetic acid betaine 0.1

(7) Citric acid 0.01

(8) Sodium citrate 0.09

(9) Sodium hexametaphosphate 0.01

(10) Chamomile extract 0.1

(11) Scutellariae radix extract 0.1

(12) 0.1 part of the leaf extract of elephantopus scaber

(13) 3-O-Ethyl-L-ascorbic acid 0.01

(14) 4-Isobutylresorcinol 0.01

(15) Lavender oil 0.001

(16) Proper amount of phenoxyethanol

(17) Active hydrogen water 1.0

(18) Purified water balance

Example 5 cosmetic liquid

(Components Complex) (mass%)

(1) Ethanol 10.0

(2) Glycerol 2.0

(3) Dipropylene glycol 1.0

(4) Isostearic acid 0.1

(5) POE/POP Methylpolysiloxane copolymer 1.0

(6) Lauryl dimethyl amino acetic acid betaine 0.1

(7) Citric acid 0.01

(8) Sodium citrate 0.09

(9) Sodium hexametaphosphate 0.01

(10) Chamomile extract 0.1

(11) Rosa roxburghii fruit extract 0.1

(12) Scutellariae radix extract 0.1

(13) L-ascorbic acid 1.0

(14) 4-Isobutylresorcinol 1.0

(15) POE (30) Cholesterol 1.0

(16) Lavender oil 0.001

(17) Proper amount of phenoxyethanol

(18) Active hydrogen water 1.0

(19) Purified water balance

Example 6 cosmetic liquid

(Components Complex) (mass%)

(1) Ethanol 10.0

(2) Glycerol 2.0

(3) Dipropylene glycol 1.0

(4) Isostearic acid 0.1

(5) POE/POP Methylpolysiloxane copolymer 1.0

(6) Lauryl dimethyl amino acetic acid betaine 0.1

(7) Citric acid 0.09

(8) Sodium citrate 0.01

(9) Sodium hexametaphosphate 0.01

(10) Rehmanniae radix extract 0.1

(11) Chamomile extract 0.1

(12) Scutellariae radix extract 0.1

(13) 3-O-Ethyl-L-ascorbic acid 1.0

(14) 4-Isobutylresorcinol 0.1

(15) Lavender oil 0.001

(16) Proper amount of phenoxyethanol

(17) Active hydrogen water 1.0

(18) Purified water balance

Example 7 cosmetic liquid

(Components Complex) (mass%)

(1) Ethanol 5.0

(2) Glycerol 1.0

(3)1, 3-butanediol 5.0

(4) POE/POP decyl tetradecyl ether 0.2

(5) Sodium hexametaphosphate 0.03

(6) Polyaspartic acid sodium 0.1

(7) 3-O-Ethyl-L-ascorbic acid 5.0

(8) 4-Isobutylresorcinol 0.01

(9) Green tea extract 0.1

(10) Cortex moutan extract 0.1

(11) Mentha arvensis extract 0.1

(12) Alpha-glucosyl hesperidin 0.01

(13) 0.1 part of extract of Iris pallida

(14) Ethylenediaminetetraacetic acid trisodium 0.1

(15) Carboxyvinyl Polymer 0.05

(16) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 0.05

(17) 0.02 part of potassium hydroxide

(18) Proper amount of phenoxyethanol

(19) Purified water balance

(20) Proper amount of perfume

Example 8 cosmetic liquid

(Components Complex) (mass%)

(1) Ethanol 5.0

(2) Glycerol 1.0

(3)1, 3-butanediol 5.0

(4) POE/POP decyl tetradecyl ether 0.2

(5) Sodium hexametaphosphate 0.03

(6) Polyaspartic acid sodium 0.1

(7) 3-O-Ethyl-L-ascorbic acid 0.01

(8) 4-Isobutylresorcinol 1.0

(9) Green tea extract 0.1

(10) Herba Saxifragae extract 0.1

(11) Mentha arvensis extract 0.1

(12) Alpha-glucosyl hesperidin 0.01

(13) 0.1 part of extract of Iris pallida

(14) Ethylenediaminetetraacetic acid trisodium 0.1

(15) Carboxyvinyl Polymer 0.05

(16) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 0.05

(17) 0.02 part of potassium hydroxide

(18) Proper amount of phenoxyethanol

(19) Purified water balance

(20) Proper amount of perfume

Example 9O/W cream

(Components Complex) (mass%)

(1) Liquid Paraffin 3.0

(2) Vaseline 1.0

(3) Dimethylpolysiloxane 1.0

(4) Stearyl alcohol 1.8

(5) Behenyl alcohol 1.6

(6) Macadamia nut oil 2.0

(7) Hydrogenated palm oil 3.0

(8) Squalane 6.0

(9) Stearic acid 2.0

(10) 2-Ethyl hexanoic acid cetyl ester 4.0

(11) POE hydrogenated Castor oil 0.5

(12) Self-emulsifying glyceryl monostearate 3.0

(13) 4-tert-butyl-4' -methoxydibenzoylmethane 0.05

(14) Proper amount of p-hydroxybenzoate

(15) Di-p-methoxy cinnamic acid glycerol mono-2-ethylhexanoate 0.05

(16) 3-O-Ethyl-L-ascorbic acid 5.0

(17) 4-Isobutylresorcinol 5.0

(18) Sucrose stearate 7.0

(19) 0.15 part of potassium hydroxide

(20) Sodium hexametaphosphate 0.05

(21) Trimethylglycine 2.0

(22) Glycerol 8.0

(23) Dipropylene glycol 5.0

(24) Sweet tea extract 0.1

(25) Yeast extract 0.1

(26) Ethylenediaminetetraacetic acid trisodium 0.05

(27) Carboxyvinyl Polymer 0.05

(28) Mica titanium 0.1

(29) Proper amount of colorant

(30) Purified water balance

Example 10 skin firming W/O cream

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 3.0

(2) Decamethylcyclopentasiloxane 13.0

(3) Decamethylcyclohexasiloxane 5.0

(4) POE Methylpolysiloxane copolymer 1.0

(5) Proper amount of p-hydroxybenzoate

(6) Appropriate amount of L-menthol

(7) Trimethylsiloxysilicates 2.0

(8) Ethanol 2.0

(9) Glycerol 3.0

(10) Dipropylene glycol 5.0

(11) Polyethylene glycol 60005.0

(12) 3-O-Ethyl-L-ascorbic acid 0.01

(13) 4-Isobutylresorcinol 0.01

(14) Sodium hexametaphosphate 0.05

(15) Caffeine 0.1

(16) 0.1 part of Fennel extract

(17) Hamamelis mollis extract 0.1

(18) Ginseng radix extract 0.1

(19) Ethylenediaminetetraacetic acid trisodium 0.05

(20) Dimorpholinopyridazinone 0.01

(21) Trimethoxycinnamic acid methyl bis (trimethylsilane) silyl isoamyl ester 0.1

(22) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 5.0

(23) Proper amount of yellow ferric oxide

(24) Proper amount of cobalt titanate

(25) Distearyldimethylammonium hectorite 1.5

(26) Polyvinyl alcohol 0.1

(27) Hydroxyethyl cellulose 0.1

(28) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1

(29) (Acryloyldimethylammonium taurate/VP) copolymer (Aristoflex xVCTM; manufactured by Clariant Co., Ltd.) 0.1

(30) Proper amount of perfume

(31) Purified water balance

Example 11O/W emulsion

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 3.0

(2) Decamethylcyclopentasiloxane 4.0

(3) Ethanol 5.0

(4) Glycerol 6.0

(5)1, 3-butanediol 5.0

(6) Polyoxyethylene methyl glucoside 3.0

(7) Sunflower oil 1.0

(8) Squalane 2.0

(9) 0.1 part of potassium hydroxide

(10) Sodium hexametaphosphate 0.05

(11) Hydroxypropyl-beta-cyclodextrin 0.1

(12) L-ascorbic acid 1.0

(13) 4-Isobutylresorcinol 5.0

(14) POE/POB diol-mono-DL-alpha-tocopherol [ formula (VI) ]. Wherein k + y is 30(k is 16, y is 14), x is 2, and R is₆、R₇、R₈Is CH₃，R₉Is H] 1.0

(15) Dipotassium glycyrrhizinate 0.05

(16) Loquat leaf extract 0.1

(17) L-glutamic acid sodium 0.05

(18) 0.1 part of Fennel extract

(19) Lavender oil 0.1

(20) Rehmanniae radix extract 0.1

(21) Mortierella globalpina Oil (Mortierella Oil) 0.5

(22) Sodium acetylhyaluronate 0.1

(23) 0.1 part of sweet marjoram extract

(24) Dimorpholinopyridazinone 0.1

(25) Xanthan gum 0.1

(26) Carboxyvinyl Polymer 0.1

(27) Acrylic acid/alkyl methacrylate copolymer (ペミユレン TR-2. TM.) 0.1

(28) (Acryloyldimethylammonium taurate/VP) copolymer (Aristoflex xVCTM; manufactured by Clariant Co., Ltd.) 1.0

(29) Proper amount of red lead

(30) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 1.0

(31) Mica titanium 0.1

(32) Proper amount of p-hydroxybenzoate

(33) Purified water balance

Example 12W/O daily emulsion

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 2.0

(2) Decamethylcyclopentasiloxane 25.0

(3) Decamethylcyclohexasiloxane 10.0

(4) Polyoxyethylene-methylpolysiloxane copolymer 1.5

(5) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9045Silicone Elastomer Blend TM: manufactured by Dow Corning Co., Ltd.) 5.0

(6) Trimethylsiloxysilicates 1.0

(7)1, 3-butanediol 5.0

(8) Squalane 0.5

(9) Talc 5.0

(10) Dipotassium glycyrrhizinate 0.1

(11) Yeast extract 0.1

(12) 3-O-Ethyl-L-ascorbic acid 5.0

(13) 4-Isobutylresorcinol 0.1

(14) L-serine 1.0

(15) Medulla Tetrapanacis extract 0.1

(16) Ethylenediaminetetraacetic acid trisodium 0.05

(17) 4-tert-butyl-4' -methoxydibenzoylmethane 1.0

(18) 2-ethylhexyl p-methoxycinnamate 5.0

(19) Di-p-methoxy cinnamic acid glycerol mono-2-ethylhexanoate 1.0

(20) Silicone-coated Fine particle titanium oxide (40nm) 4.0

(21) Disteardimonium hectorite 0.5

(22) Spherical polyethylene powder 3.0

(23) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1

(24) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 1.0

(25) Mica titanium 0.1

(26) Proper amount of phenoxyethanol

(27) Purified water balance

(28) Proper amount of perfume

Example 13 mask

(Components Complex) (mass%)

(1) Ethanol 10.0

(2)1, 3-butanediol 6.0

(3) Polyethylene glycol 40002.0

(4) Olive oil 1.0

(5) Macadamia nut oil 1.0

(6) Hydroxystearic acid phytosterol 0.05

(7) Lactic acid 0.05

(8) Sodium lactate 0.1

(9) 3-O-Ethyl-L-ascorbic acid 0.01

(10) 4-Isobutylresorcinol 0.01

(11) POE/POP diol-mono-DL-alpha-tocopherol [ formula (V). Wherein k + y is 30(k is 16, y is 14), x is 2, and R is₆、R₇、R₈Is CH₃，R₉Is H] 1.0

(12) Fish collagen 0.1

(13) Molasses extract 1.0

(14) Chondroitin sulfate sodium 0.1

(15) Yeast extract 3.0

(16) Sodium carboxymethylcellulose 0.2

(17) Polyvinyl alcohol 12.0

(18) (Acryloyldimethylammonium taurate/VP) copolymer (Aristoflex xVCTM; manufactured by Clariant Co., Ltd.) 2.0

(19) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1

(20) Dimethylpolysiloxane Complex of alkyl Cross-Linked polymethylsiloxane (Dow Corning 9041 Silicone Elastomer Blend TM manufactured by Dow Corning Co., Ltd.) 3.0

(21) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 5.0

(22) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 1.0

(23) Proper amount of p-hydroxybenzoate

(24) Purified water balance

(25) Proper amount of perfume

Example 14 powder solid Foundation make-up

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 5.0

(2) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9045Silicone Elastomer Blend TM: manufactured by Dow Corning Co., Ltd.) 5.0

(3) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 0.5

(4) Isostearic acid 0.5

(5) 3-O-Ethyl-L-ascorbic acid 1.0

(6) 4-Isobutylresorcinol 5.0

(7) Sucrose stearate 3.0

(8) Diisostearate malate 3.0

(9) Tri 2-ethylhexanetriol 1.0

(10) Sorbitan sesquiisostearate 1.0

(11) Spherical PMMA-coated mica 6.0

(12)Prismtone powder YR 1.0

(13) Fine particulate zinc oxide 0.5

(14) Fine particulate titanium oxide 2.0

(15) Synthetic phlogopite 2.0

(16) Metal soap treated talc 8.0

(17) Spherical anhydrous silicic acid 5.0

(18) Fructus Rosae Normalis extract 0.1

(19) Yeast extract 0.1

(20) Proper amount of p-hydroxybenzoate

(21) Trimethoxycinnamic acid methyl bis (trimethylsilane) silyl isoamyl ester 1.0

(22) 2-ethylhexyl p-methoxycinnamate 3.0

(23) Spherical polyalkylacrylate powder 6.0

(24) The balance of methyl hydrogen polysiloxane coated talc

(25) Methylhydrogenpolysiloxane coated sericite 5.0

(26) Methylhydrogenpolysiloxane-coated titanium oxide 15.0

(27) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 10.0

(28) Mica titanium 1.0

(29) Methylhydrogenpolysiloxane coated pigment (colorant) 5.0

Example 15 powder solid Foundation make-up

(Components Complex) (mass%)

(1) 0.5% of ceresin

(2) Dimethylpolysiloxane 2.0

(3) Methylphenylpolysiloxane 1.0

(4) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 5.0

(5) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9040 Silicone Elastomer Blend TM: manufactured by Dow Corning Co., Ltd.) 5.0

(6) Squalane 7.0

(7) Squalane (vegetable) 1.0

(8) Sorbitan sesquiisostearate 1.0

(9) Glycerol-modified Silicone resin-coated calcined sericite 16.0

(10) Glycerol-modified Silicone resin-coated sericite 7.0

(11) Yellow iron oxide-coated mica titanium 0.1

(12) Fine particulate titanium oxide 5.0

(13) Talc 10.0

(14) Titanium oxide-coated sericite 0.1

(15) Boron nitride 2.5

(16) Iron lead coated mica titanium 0.1

(17) Phytosterol 0.1

(18) Ascorbyl dipalmitate 0.1

(19) 3-O-Ethyl-L-ascorbic acid 5.0

(20) 4-Isobutylresorcinol 0.1

(21) POE (30) phytosterol 7.0

(22) Yeast extract 0.1

(23) Proper amount of p-hydroxybenzoate

(24) 2-ethylhexyl p-methoxycinnamate 1.0

(25) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 10.0

(26) Spherical polyalkylacrylate powder 8.0

(27) The rest of the methyl hydrogen polysiloxane coated mica

(28) Sintered methylhydrogenpolysiloxane-coated iron oxide-titanium oxide 5.0

(29) Methylhydrogenpolysiloxane coated sericite 5.0

(30) Methylhydrogenpolysiloxane-coated titanium oxide 4.0

(31) Methylhydrogenpolysiloxane-coated flake titanium oxide 5.0

(32) Methylhydrogenpolysiloxane coated pigment (colorant) 5.0

(33) Proper amount of perfume

Example 16 powder solid Foundation

(Components Complex) (mass%)

(1) Alpha-olefin oligomer 3.0

(2) Vaseline 3.0

(3) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 5.0

(4) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9040 Silicone Elastomer Blend TM: manufactured by Dow Corning Co.) 3.0

(5) Macadamia nut oil 0.1

(6) Sorbitan sesquiisostearate 1.0

(7) Alkyl modified silicone resin coated yellow iron oxide 2.0

(8) Alkyl modified silicone resin coated red iron oxide 1.0

(9) Alkyl modified silicone resin coated black iron oxide 0.5

(10) L-ascorbic acid 1.0

(11) 4-Isobutylresorcinol 0.01

(12) Yellow iron oxide coated mica titanium 5.0

(13) Synthetic phlogopite 5.0

(14) Titanium oxide 1.0

(15) Zinc oxide 1.0

(16) Low temperature calcination of zinc oxide 4.0

(17) Calcined sericite 10.0

(18) Phlogopite 1.0

(19) Alumina 1.0

(20) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 15.0

(21) The balance of talc

(22) Synthetic phlogopite 5.0

(23) Cross-linking type Silicone powder (トレフイル E-506 TM: Dow Corning Toray Silicone Co., Ltd.) 10.0

(24) Yeast extract 5.0

(25) Proper amount of p-hydroxybenzoate

(26) 2-ethylhexyl p-methoxycinnamate 1.0

(27) Calcium alginate powder 1.0

(28) Proper amount of perfume

Example 17 solid Foundation make-up

(Components Complex) (mass%)

(1) Alpha-olefin oligomer 10.0

(2) Microcrystalline wax 0.5

(3) Dimethylpolysiloxane Complex of alkyl Cross-Linked polymethylsiloxane (Dow Corning 9041 Silicone Elastomer Blend TM manufactured by Dow Corning Co., Ltd.) 3.0

(4) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 1.0

(5) Ceresin 5.0

(6) Dimethylpolysiloxane 15.0

(7) Methylphenylpolysiloxane 10.0

(8) Macadamia nut oil 0.1

(9) Carnauba wax 0.1

(10) Glycerol tris 2-ethylhexanoate 7.0

(11) 2-Ethyl caproic acid cetyl ester 10.0

(12) Sorbitan sesquiisostearate 1.5

(13) Mica 0.5

(14) Aluminum stearate 1.0

(15) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 3.0

(16) Cross-linking type Silicone powder (トレフイル E-506 TM: Dow Corning Toray Silicone Co., Ltd.) 8.0

(17) N-lauroyl-L-lysine 0.1

(18) 3-O-Ethyl-L-ascorbic acid 0.01

(19) 4-Isobutylresorcinol 5.0

(20) Yeast extract 0.1

(21) Proper amount of iron oxide red

(22) Proper amount of yellow ferric oxide

(23) Calcium alginate powder 1.0

(24) The balance of nylon powder

(25) Spherical anhydrous silicic acid 1.0

(26) Titanium oxide 1.0

Example 18 emulsion Foundation

(Components Complex) (mass%)

(1) Microcrystalline wax 1.0

(2) Dimethylpolysiloxane 15.0

(3) Decamethylcyclopentasiloxane 2.0

(4) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9045Silicone Elastomer Blend TM: manufactured by Dow Corning Co.) 3.0

(5) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 0.5

(6)1, 3-butanediol 6.0

(7) Candelilla wax 3.0

(8) Isostearic acid 1.0

(9) 3-O-Ethyl-L-ascorbic acid 0.01

(10) 4-Isobutylresorcinol 0.1

(11)Polysorbate 60 7.0

(12) Ethylene glycol fatty acid ester 0.1

(13) Lanolin fatty acid octyl dodecyl ester 0.5

(14) 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazoline betaine 4.0

(15) Titanium oxide 7.5

(16) Barium sulfate 5.0

(17) Titanium oxide 7.0

(18) Talc 3.0

(19) Anhydrous silicic acid 4.0

(20) Cross-linking type Silicone powder (トレフイル E-506 TM: Dow Corning Toray Silicone Co., Ltd.) 0.1

(21) Sodium hexametaphosphate 0.1

(22) Hydroxypropyl-beta-cyclodextrin 0.1

(23) Hamamelis mollis extract 0.1

(24) Radix Paeoniae extract 0.1

(25) Chondroitin sulfate sodium 0.1

(26) Yeast extract 0.1

(27) 0.1 part of Catechu extract

(28) Proper amount of p-hydroxybenzoate

(29) Proper amount of red lead

(30) Proper amount of yellow ferric oxide

(31) Proper amount of black iron oxide

(32) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 1.0

(33) Xanthan gum 0.1

(34) Sodium carboxymethylcellulose 0.1

(35) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 0.5

(36) Purified water balance

Example 19W/O Foundation

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 3.0

(2) Decamethylcyclopentasiloxane 10.0

(3) POE/Methylpolysiloxane copolymer 3.0

(4) Decamethylcyclohexasiloxane 5.0

(5) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 0.1

(6) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9040 Silicone Elastomer Blend TM: manufactured by Dow Corning Co., Ltd.) 5.0

(7) Glycerol 4.0

(8)1, 3-butanediol 5.0

(9) Palmitic acid 0.5

(10) L-ascorbic acid 5.0

(11) 4-Isobutylresorcinol 0.01

(12) Distearoyl dimethyl ammonium chloride 0.2

(13) Metal soap treated talc 2.0

(14) Cross-linking type Silicone powder (トレフイル E-506 TM: Dow Corning Toray Silicone Co., Ltd.) 0.1

(15) Iron lead coated mica titanium 0.5

(16) N-lauroyl-L-serine 2.0

(17) L-glutamic acid sodium 2.0

(18) Proper amount of p-hydroxybenzoate

(19) Phenoxyethanol 0.2

(20) Spherical nylon powder 1.0

(21) Spherical polyalkylacrylate powder 3.0

(22) Rhizoma Belamcandae extract 1.0

(23) Yeast extract 5.0

(24) Purified water balance

(25) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 2.0

(26) Dextrin fatty acid ester treated Talc 3.0

(27) Dextrin fatty acid ester treated titanium dioxide 15.0

(28) Dextrin fatty acid ester treated yellow ferric oxide 3.0

(29) Dextrin fatty acid ester treated black iron oxide 0.5

Example 20O/W Foundation

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 8.0

(2) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9040 Silicone Elastomer Blend TM: manufactured by Dow Corning Co.) 20.0

(3) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 5.0

(4) Behenyl alcohol 0.5

(5) Batyl alcohol 0.5

(6)1, 3-butanediol 5.0

(7) Macadamia nut oil 0.1

(8) Isostearic acid 1.5

(9) Stearic acid 1.0

(10) 3-O-Ethyl-L-ascorbic acid 1.0

(11) 4-Isobutylresorcinol 5.0

(12) Behenic acid 0.5

(13) 2-Ethyl hexanoic acid cetyl ester 5.0

(14) Polyoxyethylene glyceryl monostearate 1.0

(15) Self-emulsifying glyceryl monostearate 1.0

(16) Yellow iron oxide coated mica titanium 2.0

(17) Titanium oxide 4.0

(18) Talc 0.5

(19) Kaolin 3.0

(20) Synthetic phlogopite 0.1

(21) Cross-linking type Silicone powder 0.1

(22) Anhydrous silicic acid 5.0

(23) 0.2 part of potassium hydroxide

(24) Triethanolamine 0.8

(25) Yeast extract 0.1

(26) Herba Thymi Japonici extract 0.1

(27) Proper amount of p-hydroxybenzoate

(28) 2-ethylhexyl p-methoxycinnamate 1.0

(29) Proper amount of red lead

(30) Proper amount of yellow ferric oxide

(31) Proper amount of black iron oxide

(32) Xanthan gum 0.1

(33) Sodium acrylate/2-acrylamido-2-methylpropanesulfonic acid copolymer 1.0

(34) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 5.0

(35) Bentonite 1.0

(36) Sodium carboxymethylcellulose 0.1

(37) Purified water balance

(38) Proper amount of perfume

Example 21 powder Foundation

(Components Complex) (mass%)

(1) Decamethylcyclohexasiloxane 15.0

(2) Decamethylcyclopentasiloxane balance

(3) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 5.0

(4) Dimethylpolysiloxane Complex of alkyl Cross-Linked polymethylsiloxane (Dow Corning 9041 Silicone Elastomer Blend TM: manufactured by Dow Corning Co., Ltd.) 30.0

(5) Ethanol 10.0

(6) Isostearic acid 0.5

(7) Myristic acid treated Zinc oxide 0.5

(8) Dextrin palmitate coated titanium oxide 10.0

(9) Dextrin palmitate coated Talc 7.0

(10) Silicone surface treatment titanium oxide (30nm) 5.0

(11) Cross-linking type Silicone powder 1.0

(12) Spherical anhydrous silicic acid 2.0

(13) 3-O-Ethyl-L-ascorbic acid 0.01

(14) 4-Isobutylresorcinol 0.1

(15) 0.1 part of Sophora flavescens Aiton extract

(16) Bupleuri radix extract 1.0

(17) Yeast extract 2.0

(18) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 1.0

(19) 2-ethylhexyl p-methoxycinnamate 5.0

(20) Proper amount of dextrin palmitate coated red lead

(21) Proper amount of dextrin palmitate coated yellow ferric oxide

(22) Proper amount of dextrin palmitate coated black iron oxide

(23) Proper amount of perfume

Example 22 base cream

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 5.0

(2) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 0.1

(3) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9045Silicone Elastomer Blend TM: manufactured by Dow Corning Co., Ltd.) 30.0

(4) Decamethylcyclopentasiloxane balance

(5) Ethanol 8.0

(6) Cyanotic coated mica titanium 0.5

(7) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 5.0

(8) Methylsiloxane network Polymer 5.0

(9) Cross-linking type Silicone powder (トレフイル E-506 TM: Dow Corning Toray Silicone Co., Ltd.) 5.0

(10) Citric acid 0.02

(11) Sodium citrate 0.08

(12) 3-O-Ethyl-L-ascorbic acid 5.0

(13) 4-Isobutylresorcinol 0.01

(14) POE/POP diol-mono-DL-alpha-tocopherol [ formula (V). Wherein k + y is 30(k is 16, y is 14), x is 2, and R is₆、R₇、R₈Is CH₃，R₉Is H] 0.01

(15) Radix Curcumae extract 0.01

(16) Yeast extract 0.1

(17) Purified Water 1.0

(18) POE/POP methylpolysiloxane copolymer 5.0

Example 23 primer cream

(Components Complex) (mass%)

(1) Dimethylpolysiloxane 5.0

(2) Decamethylcyclopentasiloxane complex of alkyl-crosslinked polymethylsiloxane (Dow Corning 9040 Silicone Elastomer Blend TM: manufactured by Dow Corning Co., Ltd.) 5.0

(3) 3-tris (trimethylsiloxy) silylpropylcarbamate amylopectin 5.0

(4) Decamethylcyclopentasiloxane 25.0

(5) Polyoxyethylene/methylpolysiloxane copolymer 3.0

(6) Glycerol 1.0

(7)1, 3-butanediol 5.0

(8) Xylitol 0.5

(9) Isostearic acid 0.5

(10) Inorganic composite powder (カバ - リ - フ AR-80 TM; manufactured by CATALYST FORMATION INDUSTRIAL CO., LTD.) 10.0

(11) 2.0 Anhydrous silicic acid coated with alkyl-modified Silicone resin

(12) Talc 0.5

(13) L-ascorbic acid 1.0

(14) 4-Isobutylresorcinol 5.0

(15) Aluminum stearate 1.0

(16) Iron lead coated mica titanium 0.1

(17) Sodium hexametaphosphate 0.05

(18) Dipotassium glycyrrhizinate 0.1

(19) L-serine 0.1

(20) Hypericum erectum extract 0.1

(21) Fructus Rosae Normalis extract 0.1

(22) Radix Paeoniae extract 0.1

(23) Lysolecithin 0.01

(24) Herba Saxifragae extract 0.1

(25) Yeast extract 0.1

(26) Proper amount of p-hydroxybenzoate

(27) Proper amount of phenoxyethanol

(28) Dextrin palmitate coated yellow iron oxide 0.1

(29) Distearyldimethylammonium hectorite 1.0

(30) Purified water balance

(31) Trimethylsiloxysilicates 1.5

(32) Spherical anhydrous silicic acid 1.0

(33) Spherical polyethylene powder 5.0

(34) Proper amount of perfume

Industrial applicability

The external preparation for skin of the present invention is excellent in temperature stability (particularly high temperature stability) and light stability, even when it contains alkylresorcinols and L-ascorbic acids which are conventionally liable to be discolored by temperature and light.

Claims (2)

1. An external preparation for skin, comprising: 0.01 to 5 mass% of (a) 4-isobutylresorcinol or a salt thereof, and 0.01 to 5 mass% of (b) 1 or 2 or more selected from L-ascorbic acid or a salt thereof, and 3-O-ethyl-L-ascorbic acid or a salt thereof.

2. The external preparation for skin according to claim 1, wherein the component (b) is 3-O-ethyl-L-ascorbic acid or a salt thereof.