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HK1002034A1 - Extracellular segments of human ige immunoglobulin anchoring peptides and antibodies specific therefor - Google Patents

Extracellular segments of human ige immunoglobulin anchoring peptides and antibodies specific therefor Download PDF

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Publication number
HK1002034A1
HK1002034A1 HK98101073A HK98101073A HK1002034A1 HK 1002034 A1 HK1002034 A1 HK 1002034A1 HK 98101073 A HK98101073 A HK 98101073A HK 98101073 A HK98101073 A HK 98101073A HK 1002034 A1 HK1002034 A1 HK 1002034A1
Authority
HK
Hong Kong
Prior art keywords
ige
cells
antibodies
human
membrane
Prior art date
Application number
HK98101073A
Other languages
German (de)
English (en)
Chinese (zh)
Other versions
HK1002034B (en
Inventor
Wen Chang Tse
Original Assignee
Tanox Biosystems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/468,766 external-priority patent/US5260416A/en
Priority claimed from US07/515,604 external-priority patent/US5274075A/en
Application filed by Tanox Biosystems, Inc. filed Critical Tanox Biosystems, Inc.
Publication of HK1002034B publication Critical patent/HK1002034B/en
Publication of HK1002034A1 publication Critical patent/HK1002034A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (6)

  1. Isoforme du peptide d'ancrage membranaire de la chaîne ε humaine, comprenant un segment peptidique ayant la séquence lorsque l'isoforme est l'isoforme II ou comprenant des modifications du segment peptidique qui n'altèrent pas sensiblement les propriétés immunologiques du peptide.
  2. Fragment nucléotidique codant l'un quelconque des segments peptidiques selon la revendication 1.
  3. Fragment d'ADN selon la revendication 2, comprenant la séquence : ou une séquence correspondante qui code le même peptide.
  4. Anticorps monoclonal dirigé contre l'un quelconque des peptides selon la revendication 1, les anticorps anti-isoforme I du peptide d'ancrage membranaire de la chaîne ε humaine étant exclus.
  5. Anticorps monoclonal selon la revendication 4, qui est un anticorps humain ou un anticorps chimère murin/humain ou un fragment d'anticorps.
  6. Anticorps anti-idiotype dirigé contre l'un quelconque des anticorps selon la revendication 4.
HK98101073A 1990-01-23 1998-02-12 Extracellular segments of human ige immunoglobulin anchoring peptides and antibodies specific therefor HK1002034A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/468,766 US5260416A (en) 1987-12-31 1990-01-23 Antigenic epitopes present on membrane-bound but not secreted IgE
US468766 1990-01-23
US515604 1990-04-27
US07/515,604 US5274075A (en) 1987-12-31 1990-04-27 Newly identified human epsilon immunoglobulin peptides and related products
US63007790A 1990-12-19 1990-12-19
US630077 1990-12-19

Publications (2)

Publication Number Publication Date
HK1002034B HK1002034B (en) 1998-07-24
HK1002034A1 true HK1002034A1 (en) 1998-07-24

Family

ID=27413084

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98101073A HK1002034A1 (en) 1990-01-23 1998-02-12 Extracellular segments of human ige immunoglobulin anchoring peptides and antibodies specific therefor

Country Status (12)

Country Link
EP (1) EP0512064B1 (fr)
JP (1) JP3449712B2 (fr)
AT (1) ATE154637T1 (fr)
AU (2) AU645783B2 (fr)
CA (1) CA2074089C (fr)
DE (1) DE69126607T2 (fr)
DK (1) DK0512064T3 (fr)
ES (1) ES2107454T3 (fr)
GR (1) GR3024563T3 (fr)
HK (1) HK1002034A1 (fr)
SG (1) SG70982A1 (fr)
WO (1) WO1991011456A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU95105899A (ru) * 1992-07-08 1997-03-20 Унилевер Н.В. (NL) Способ иммобилизации фермента, полинуклеотид, вектор, химерный блок, низшие эукариоты, способ осуществления ферментативного процесса
ATE228536T1 (de) * 1993-03-11 2002-12-15 Tanox Biosystems Inc Antigene epitope von ige repräsentierenden peptiden auf der b-zell-oberfläche aber nicht auf oberflächen von basophilen
US5552537A (en) * 1993-03-24 1996-09-03 The Regents Of The University Of California IgE isoforms and methods of use
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
IL116436A (en) * 1995-12-18 2006-12-31 Yissum Res Dev Co Fc?Á-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES AND
CN1174998C (zh) 1996-03-01 2004-11-10 诺瓦提斯公司 用于预防和治疗过敏的肽免疫原
US6913749B2 (en) 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
GB9908533D0 (en) 1999-04-14 1999-06-09 Novartis Ag Organic compounds
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
CA2486464A1 (fr) 2002-05-21 2003-11-27 Resistentia Pharmaceuticals Ab Polypeptides d'ige chimeres et cellules hotes
DK2298815T3 (en) 2005-07-25 2015-06-15 Emergent Product Dev Seattle B-CELL REDUCTION USING CD37 SPECIFIC AND CD20 SPECIFIC BINDING MOLECULES
US8137670B2 (en) 2005-09-29 2012-03-20 Medimmune, Llc Method of identifying membrane IgE specific antibodies and use thereof for targeting IgE producing precursor cells
JP2009536217A (ja) * 2006-05-03 2009-10-08 ガスリー ファンデーション フォー エデュケーション アンド リサーチ Ｂ細胞障害の治療における免疫グロブリン結合細胞表面決定基
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
AR065368A1 (es) 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
KR101555068B1 (ko) 2007-03-22 2015-10-06 제넨테크, 인크. 막 결합형 ｉｇｅ에 결합하는 세포자멸성 항-ｉｇｅ 항체
RS51975B (sr) 2008-04-11 2012-02-29 Emergent Product Development Seattle Llc. Cd37 imunoterapeutski proizvod i njegova kombinacija sa bifunkcionalnim hemoterapeutskim sredstvom
HUE036920T2 (hu) 2009-02-25 2018-08-28 Academia Sinica Anti-C[epszilon]mX-ellenanyagok, amelyek képesek B-limfocitákon humán mlgE-hez kötõdni
US9140698B2 (en) 2011-04-06 2015-09-22 The Board Of Regents Of The University Of Texas System Modulating bacterial MAM polypeptides in pathogenic disease
WO2013158274A1 (fr) 2012-04-20 2013-10-24 Academia Sinica Anticorps anti-mige (ige liées à la membrane) qui se lient à la jonction entre les domaines ch4 et cεmx
WO2015013668A1 (fr) * 2013-07-26 2015-01-29 Ke Zhang Anticorps anti-immunoglobuline e et leurs méthodes d'utilisation
TWI603979B (zh) * 2013-12-05 2017-11-01 中央研究院 抗人類膜錨定型免疫球蛋白a抗體能夠溶解帶有膜錨定型免疫球蛋白a的b淋巴球與降低免疫球蛋白a 的生產
EP3352760A4 (fr) 2015-09-21 2019-03-06 Aptevo Research and Development LLC Polypeptides de liaison à cd3
CN111741768B (zh) 2017-10-31 2024-12-27 合一生技股份有限公司 治疗IgE介导的过敏性疾病

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT89107A (pt) * 1987-11-30 1989-11-30 Idec Pharma Corp Metodo e meios para a seleccao de anticorpos anti-idiotipos e seu uso para o diagnostico, monitorizacao, tratamento e/ou prevencao de doencas cancerosas, da autoimunidade ou infecciosas
DE122006000007I2 (de) 1987-12-31 2008-03-27 Tanox Inc -tragenden b-lymphocyten befinden.

Also Published As

Publication number Publication date
JP3449712B2 (ja) 2003-09-22
SG70982A1 (en) 2000-03-21
WO1991011456A1 (fr) 1991-08-08
DK0512064T3 (da) 1997-12-15
DE69126607T2 (de) 1998-01-15
CA2074089A1 (fr) 1991-07-24
DE69126607D1 (de) 1997-07-24
EP0512064B1 (fr) 1997-06-18
AU5214893A (en) 1994-03-03
AU7317991A (en) 1991-08-21
ATE154637T1 (de) 1997-07-15
JPH05504482A (ja) 1993-07-15
AU645783B2 (en) 1994-01-27
EP0512064A4 (en) 1993-02-17
CA2074089C (fr) 2001-04-10
GR3024563T3 (en) 1997-12-31
ES2107454T3 (es) 1997-12-01
EP0512064A1 (fr) 1992-11-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040123

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)