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HK1078110A1 - Target binding polypeptide comprising an ig-like vl domain linked to an ig-like vh domain - Google Patents

Target binding polypeptide comprising an ig-like vl domain linked to an ig-like vh domain Download PDF

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Publication number
HK1078110A1
HK1078110A1 HK05112014.2A HK05112014A HK1078110A1 HK 1078110 A1 HK1078110 A1 HK 1078110A1 HK 05112014 A HK05112014 A HK 05112014A HK 1078110 A1 HK1078110 A1 HK 1078110A1
Authority
HK
Hong Kong
Prior art keywords
domain
scfv
binding
polypeptide
target
Prior art date
Application number
HK05112014.2A
Other languages
German (de)
English (en)
Chinese (zh)
Other versions
HK1078110B (en
Inventor
Peter John Hudson
Maria Lah
Alex Andrew Kortt
Robert Alexander Irving
John Leslie Atwell
Robyn Louise Malby
Barbara Elaine Power
Peter Malcolm Colman
Original Assignee
Avipep Pty Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avipep Pty Limited filed Critical Avipep Pty Limited
Publication of HK1078110A1 publication Critical patent/HK1078110A1/en
Publication of HK1078110B publication Critical patent/HK1078110B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (12)

  1. Polypeptide de type fragment variable simple chaîne (scFv) qui s'auto-associe pour former des dimères ou des multimères stables qui se lie à une molécule cible, le polypeptide scFv comprenant un domaine VL d'immunoglobuline lié à un domaine VH d'immunoglobuline, dans lequel ledit domaine VL et ledit domaine VH sont directement liés
  2. Polypeptide scFv selon la revendication 1, dans lequel l'extrémité carboxyle du domaine VH est directement liée à l'extrémité aminée du domaine VL.
  3. Polypeptide scFv selon la revendication 1, dans lequel l'extrémité carboxyle du domaine VL est directement liée à l'extrémité aminée du domaine VH.
  4. Polypeptide scFv selon la revendication 2 ou la revendication 3, dans lequel jusqu'à 13 acides aminés d'un domaine Ig sont supprimés au niveau de la jonction entre les domaines VH et VL.
  5. Dimère ou multimère comprenant deux ou plusieurs polypeptides scFv selon l'une quelconque des revendications 1 à 4.
  6. Dimère ou multimère selon la revendication 5, qui est bifonctionnel.
  7. Multimère selon la revendication 5, qui est polyfonctionnel.
  8. Polypeptide scFv selon l'une quelconque des revendications 1 à 4 ou dimère ou multimère selon l'une quelconque des revendications 5 à 7, dans lequel VL et/ou VH se lient à une cible choisie dans le groupe constitué par la glycophorine, d'autres protéines de surface des globules rouges, la neuraminidase du virus influenza, des antigènes viraux, des anticorps et d'autres membres de la superfamille des Ig, le facteur de croissance transformant α (TGF-α), les marqueurs de tumeur, les protéines de la surface cellulaire et le facteur inhibant les cellules leucémique (LIF).
  9. Construction d'ADN codant un polypeptide scFv selon l'une quelconque des revendications 1 à 4.
  10. Composition pharmaceutique comprenant un dimère ou un multimère selon l'une quelconque des revendications 5 à 7, avec un support pharmaceutiquement acceptable.
  11. Réactif de diagnostic comprenant un dimère ou un multimère selon l'une quelconque des revendications 5 à 7, avec un diluant.
  12. Dimère ou multimère selon l'une quelconque des revendications 5 à 7, utilisable en diagnostic ou en médecine.
HK05112014.2A 1992-09-25 2005-12-28 Target binding polypeptide comprising an ig-like vl domain linked to an ig-like vh domain HK1078110B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPL497392 1992-09-25
AUPL497392 1992-09-25

Publications (2)

Publication Number Publication Date
HK1078110A1 true HK1078110A1 (en) 2006-03-03
HK1078110B HK1078110B (en) 2009-08-07

Family

ID=

Also Published As

Publication number Publication date
EP1550729A1 (fr) 2005-07-06
JPH08504320A (ja) 1996-05-14
WO1994007921A1 (fr) 1994-04-14
EP1550729B1 (fr) 2009-05-27
JP2009148252A (ja) 2009-07-09
EP0672068A1 (fr) 1995-09-20
EP0672068A4 (fr) 1997-02-26
DE69334287D1 (de) 2009-07-09
US5844094A (en) 1998-12-01
CA2145278C (fr) 2009-03-10
SG41929A1 (en) 1997-08-15
CA2145278A1 (fr) 1994-04-14

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120924