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GT200300031A - Indazoles substitutos, composiciones que los contienen, procedimiento de fabricacion y utilizacion - Google Patents

Indazoles substitutos, composiciones que los contienen, procedimiento de fabricacion y utilizacion

Info

Publication number
GT200300031A
GT200300031A GT200300031A GT200300031A GT200300031A GT 200300031 A GT200300031 A GT 200300031A GT 200300031 A GT200300031 A GT 200300031A GT 200300031 A GT200300031 A GT 200300031A GT 200300031 A GT200300031 A GT 200300031A
Authority
GT
Guatemala
Prior art keywords
indazols
substitute
compositions
contain
manufacturing
Prior art date
Application number
GT200300031A
Other languages
English (en)
Inventor
Dominique Damour
Corinne Terrier
Patrick Nemecek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200300031A publication Critical patent/GT200300031A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A INDAZOLES SUSTITUIDOS DE FÓRMULA GENERAL I EN DONDE R1,Z,X, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS MODULAN LA ACTIVIDAD DE LAS PROTEINAS, EN PARTICULAR DE LAS QUINASAS POR LO QUE SON DE UTILIDAD EN ESTADOS DE CRECIMIENTO CELULAR ANORMAL TALES COMO CÁNCER.
GT200300031A 2002-03-11 2003-02-06 Indazoles substitutos, composiciones que los contienen, procedimiento de fabricacion y utilizacion GT200300031A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation

Publications (1)

Publication Number Publication Date
GT200300031A true GT200300031A (es) 2006-05-26

Family

ID=27763684

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200300031A GT200300031A (es) 2002-03-11 2003-02-06 Indazoles substitutos, composiciones que los contienen, procedimiento de fabricacion y utilizacion

Country Status (29)

Country Link
US (2) US6858638B2 (es)
EP (1) EP1487803A1 (es)
JP (1) JP4643910B2 (es)
KR (1) KR20040091128A (es)
CN (1) CN100369899C (es)
AR (1) AR038914A1 (es)
AU (1) AU2003242808B2 (es)
BR (1) BR0308339A (es)
CA (1) CA2478540A1 (es)
EC (1) ECSP045286A (es)
FR (1) FR2836914B1 (es)
GT (1) GT200300031A (es)
HN (1) HN2003000094A (es)
HR (1) HRP20040825A2 (es)
IL (2) IL163805A0 (es)
MA (1) MA27176A1 (es)
MX (1) MXPA04008446A (es)
NO (1) NO20044261L (es)
OA (1) OA12784A (es)
PA (1) PA8566701A1 (es)
PE (1) PE20040071A1 (es)
PL (1) PL372389A1 (es)
RU (1) RU2004130280A (es)
SV (1) SV2003001493A (es)
TN (1) TNSN04175A1 (es)
TW (1) TW200303863A (es)
UY (1) UY27712A1 (es)
WO (1) WO2003078402A1 (es)
ZA (1) ZA200406730B (es)

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GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
EP1778669A2 (en) 2004-08-18 2007-05-02 Takeda San Diego, Inc. Kinase inhibitors
PT1797042E (pt) * 2004-09-29 2009-02-12 Hoffmann La Roche Derivados de indozolona como inibidores de 11b-hsd1
ATE479687T1 (de) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinaseinhibitoren
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SE0402762D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Indazole sulphonamide derivatives
CA2620257A1 (en) * 2005-08-25 2007-03-01 F. Hoffmann-La Roche Ag P38 map kinase inhibitors and methods for using the same
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
RU2442777C2 (ru) 2006-01-31 2012-02-20 Эррэй Биофарма Инк. Ингибиторы киназ и способы их применения
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
JP2010505961A (ja) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
WO2009012312A1 (en) 2007-07-16 2009-01-22 Abbott Laboratories Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
BR122019016429B1 (pt) * 2009-05-26 2020-03-24 Abbvie Ireland Unlimited Company Compostos inibidores da atividade de proteínas bcl-2 antiapoptótica e composição farmacêutica compreendendo ditos compostos
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
ES2699205T3 (es) 2010-10-29 2019-02-07 Abbvie Inc Dispersiones sólidas que contienen un agente que induce la apoptosis
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
NZ708508A (en) 2010-11-23 2016-06-24 Abbvie Bahamas Ltd Methods of treatment using selective bcl-2 inhibitors
AU2011332043C1 (en) 2010-11-23 2016-11-10 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2719446C2 (ru) * 2014-11-03 2020-04-17 Айомет Фарма Лтд Фармацевтическое соединение
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
CA3070112A1 (en) * 2017-07-21 2019-01-24 Kadmon Corporation, Llc Inhibitors of rho associated coiled-coil containing protein kinase
CN111479805B (zh) 2017-08-29 2024-08-13 罗格斯新泽西州立大学 治疗性吲唑
CN118715205A (zh) * 2022-01-12 2024-09-27 艾福姆德尤股份有限公司 用于治疗与sting活性相关的病症的化合物和组合物
JP2025509180A (ja) 2022-03-04 2025-04-11 上海瓔黎薬業有限公司 五員ヘテロアリール環構造含有化合物、その医薬組成物及び使用
CN114605329B (zh) * 2022-03-28 2024-01-26 河南中医药大学 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途
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JPWO2002100833A1 (ja) 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
EP1401831A1 (en) * 2001-07-03 2004-03-31 Chiron Corporation Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
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Also Published As

Publication number Publication date
OA12784A (fr) 2006-07-10
BR0308339A (pt) 2005-02-01
US20040106667A1 (en) 2004-06-03
PE20040071A1 (es) 2004-02-13
US20050059722A1 (en) 2005-03-17
NO20044261L (no) 2004-11-25
KR20040091128A (ko) 2004-10-27
ZA200406730B (en) 2005-08-24
AU2003242808A1 (en) 2003-09-29
FR2836914B1 (fr) 2008-03-14
IL163805A0 (en) 2005-12-18
SV2003001493A (es) 2003-07-10
PA8566701A1 (es) 2003-12-10
US7473701B2 (en) 2009-01-06
EP1487803A1 (fr) 2004-12-22
HRP20040825A2 (en) 2005-06-30
JP4643910B2 (ja) 2011-03-02
MXPA04008446A (es) 2004-12-06
CN1642922A (zh) 2005-07-20
ECSP045286A (es) 2004-10-26
PL372389A1 (en) 2005-07-25
AR038914A1 (es) 2005-02-02
TW200303863A (en) 2003-09-16
UY27712A1 (es) 2003-09-30
WO2003078402A1 (fr) 2003-09-25
IL163805A (en) 2009-08-03
HN2003000094A (es) 2003-12-15
RU2004130280A (ru) 2005-06-27
CA2478540A1 (fr) 2003-09-25
US6858638B2 (en) 2005-02-22
CN100369899C (zh) 2008-02-20
TNSN04175A1 (fr) 2007-03-12
JP2005533004A (ja) 2005-11-04
MA27176A1 (fr) 2005-01-03
AU2003242808B2 (en) 2008-09-18
FR2836914A1 (fr) 2003-09-12

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