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GR900100112A - Μεθοδος παρασκευης ενωσεων πυριμιδο-πυριμιδινης αναστολεων της λιποξυγενασης. - Google Patents

Μεθοδος παρασκευης ενωσεων πυριμιδο-πυριμιδινης αναστολεων της λιποξυγενασης.

Info

Publication number
GR900100112A
GR900100112A GR900100112A GR900100112A GR900100112A GR 900100112 A GR900100112 A GR 900100112A GR 900100112 A GR900100112 A GR 900100112A GR 900100112 A GR900100112 A GR 900100112A GR 900100112 A GR900100112 A GR 900100112A
Authority
GR
Greece
Prior art keywords
pyrimido
pyrimidine
preparation
inhibiting compounds
lipoxygenase inhibiting
Prior art date
Application number
GR900100112A
Other languages
English (en)
Inventor
Anwer Basha
W Dee Brooks
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of GR900100112A publication Critical patent/GR900100112A/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Εδώ περιγράφονται ενώσεις του τύπου : ω
GR900100112A 1989-02-22 1990-02-15 Μεθοδος παρασκευης ενωσεων πυριμιδο-πυριμιδινης αναστολεων της λιποξυγενασης. GR900100112A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/314,008 US4963541A (en) 1989-02-22 1989-02-22 Pyrimido-pyrimidine lipoxygenase inhibiting compounds

Publications (1)

Publication Number Publication Date
GR900100112A true GR900100112A (el) 1991-06-28

Family

ID=23218140

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100112A GR900100112A (el) 1989-02-22 1990-02-15 Μεθοδος παρασκευης ενωσεων πυριμιδο-πυριμιδινης αναστολεων της λιποξυγενασης.

Country Status (5)

Country Link
US (1) US4963541A (el)
EP (1) EP0460023A4 (el)
CA (1) CA2050295A1 (el)
GR (1) GR900100112A (el)
WO (1) WO1990009996A1 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
GB9706618D0 (en) * 1997-04-01 1997-05-21 Univ Newcastle Ventures Ltd Pyrimidopyrimidine compounds
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US9643971B2 (en) 2013-03-15 2017-05-09 Galleon Pharmaceuticals, Inc. Breathing control modulating compounds, and methods of using same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA678353A (en) * 1964-01-21 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Cardiac-active pharmaceutical compositions
FR736917A (fr) * 1932-03-31 1932-12-05 Caleçon à fermeture réglable
GB807826A (en) * 1955-03-14 1959-01-21 Thomae Gmbh Dr K Derivatives of pyrimido[5,4-d] pyrimidine and production thereof
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
SU429582A3 (ru) * 1968-07-31 1974-05-25 Йозеф РОХ СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 2,6-5ЯС- (ДИАЛКАНОЛАМИНО)ПИРИМИДО[5,4-с{] ПИРИМИДИНА1Предлагается способ получения новых производных пиримидо[5,4-(^] пиримидина, которые но сравнению с аналогичными производными лирИ1Мидо[5,4-??] пиримидина, описанными в литературе, обладают лучшими фармакологическими свойствами.Известен способ получения пи1римидо[5,4-й]- пиримидинов общей формулыпутем восстановления соединения общей формулы-1 Б10где два из радикалов Ri, R2, Rs и R4 —свободная или замещенная аминогруппа или свободная или замещенная гидразино- или гуани- диногруппа, а два других — водород или галоген, алкильный или арильный радикал, оксигруппа, свободная или замещенная алкил-, Эри.;!- ил'И диэтиламииоэтилгруппой, меркапто- группа, свободная или замещенная алкильным или арильным радикалом.152025где, по меньшей мере, один из радикалов Zi, 7.2, 2з и Z4 — галоген, другой из радикалов Zi, Za, Zs и Z4 — свободная или замещенная аминогруппа или свободная или замещ,енная гуанидино- или гидразиногруппа и еще один из радикалов Zi, Z^, Zg и Z4 — водород иди галоген, алкил или арил, оксигруппа, свободная или замещенная ал1кил-, арил- или диэтилами- ноэтилгруппой, .меркаптогруппа, свободная или замещенная алкильным или арильным радикалом, или свободная или замещенная аминогруппа.Предлагается спосо.б .получения новых производных 2,6-б«с-(диал1каноламино)пи1римидо- [5,4-а!]пиримидИ'На общей формулы
DE2300661C3 (de) * 1973-01-08 1979-10-31 Dr. Karl Thomae Gmbh, 7950 Biberach Pyrimido [5,4-d] pyrimidine, deren physiologisch verträgliche Säureadditionssalze, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
US4393075A (en) * 1980-04-14 1983-07-12 Takeda Chemical Industries, Ltd. Quinone compounds and their use in suppressing the production of SRS-A in mammals
US4478883A (en) * 1982-07-14 1984-10-23 International Business Machines Corporation Conditioning of a substrate for electroless direct bond plating in holes and on surfaces of a substrate
US4497827A (en) * 1982-08-30 1985-02-05 Syntex (U.S.A.) Inc. Arachidonic acid analogues as anti-inflammatory and anti-allergic agents
JPH0613515B2 (ja) * 1983-03-14 1994-02-23 杏林製薬株式会社 ピラゾロ〔１，５−ａ〕ピリジン誘導体及びそれを含有する治療剤
JPS59210021A (ja) * 1983-05-12 1984-11-28 Kyowa Hakko Kogyo Co Ltd リポキシゲナ−ゼ代謝産物に起因する疾患の予防治療剤
DE3426615A1 (de) * 1984-07-19 1986-01-30 Boehringer Ingelheim KG, 6507 Ingelheim Neue verwendung von substituierten pyrimido-(5,4-d)pyrimidinen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARZNEIMITTEL-FORSCHUNG, vol. 15, no. 5, 1965, pages 558-563; F. EICHHOLTZ et al.: "Einfluss von Pyrimidopyrimidin- und Pteridin-Derivaten auf Phosphat- und Adenosin-Permeabilit{t menschlicher Erythrocyten" *
CHEMICAL ABSTRACTS, vol. 105, 1986, abstract no. 56869u, Columbus, Ohio, US; A.M. ARDEKANI et al.: "The inhibition of luminol-dependent chemiluminescence of lipoxygenase, myeloperoxidase, and human neutrophils by dipyridamole", & MICROCHEM. J. 1986, 33(3), 309-15 *
CHEMICAL ABSTRACTS, vol. 73, 1970, pages 384,385, abstract no. 120666a, Columbus, Ohio, US; & ZA-A-69 05 504 (Dr. KARL THOMAE GmbH) 13-02-1970 *
CLAIMS SEARCHED: ALL *

Also Published As

Publication number Publication date
US4963541A (en) 1990-10-16
WO1990009996A1 (en) 1990-09-07
EP0460023A4 (en) 1992-04-08
CA2050295A1 (en) 1990-08-23
EP0460023A1 (en) 1991-12-11

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