[go: up one dir, main page]

GR81986B - - Google Patents

Info

Publication number
GR81986B
GR81986B GR74529A GR840174529A GR81986B GR 81986 B GR81986 B GR 81986B GR 74529 A GR74529 A GR 74529A GR 840174529 A GR840174529 A GR 840174529A GR 81986 B GR81986 B GR 81986B
Authority
GR
Greece
Prior art keywords
peptide
vibrio cholerae
modified strains
nontoxinogenic
plasmids
Prior art date
Application number
GR74529A
Other languages
English (en)
Inventor
John J Mekalanos
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of GR81986B publication Critical patent/GR81986B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/909—Vibrio

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR74529A 1983-04-29 1984-04-27 GR81986B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/489,958 US4882278A (en) 1983-04-29 1983-04-29 Non-toxinogenic vibrio cholerae mutants

Publications (1)

Publication Number Publication Date
GR81986B true GR81986B (el) 1984-12-12

Family

ID=23945983

Family Applications (1)

Application Number Title Priority Date Filing Date
GR74529A GR81986B (el) 1983-04-29 1984-04-27

Country Status (20)

Country Link
US (1) US4882278A (el)
EP (1) EP0125228B1 (el)
JP (1) JPH0740921B2 (el)
AT (1) ATE35152T1 (el)
AU (1) AU585481B2 (el)
CA (1) CA1326218C (el)
DE (1) DE3472114D1 (el)
DK (1) DK213784A (el)
DZ (1) DZ634A1 (el)
EG (1) EG17879A (el)
ES (1) ES531986A0 (el)
GR (1) GR81986B (el)
IE (1) IE57266B1 (el)
IL (1) IL71652A (el)
PH (1) PH25301A (el)
PT (1) PT78478B (el)
YU (1) YU45616B (el)
ZA (1) ZA843142B (el)
ZM (1) ZM2884A1 (el)
ZW (1) ZW6884A1 (el)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399494A (en) * 1983-03-04 1995-03-21 The University Of Maryland System Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof
US5470729A (en) * 1983-03-04 1995-11-28 University Of Maryland At Baltimore Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof
US5882653A (en) * 1983-03-04 1999-03-16 The University Of Maryland System Vibrio cholerae 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroup vaccine strains, methods of making same and products thereof
US5308835A (en) * 1984-07-09 1994-05-03 Praxis Biologics, Inc. Production of the E. coli LT-B enterotoxin subunit
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
CA1340372C (en) * 1984-07-09 1999-02-02 John D. Clements Production of e. coli lt-b enterotoxin subunit
EP0249449A1 (en) * 1986-06-11 1987-12-16 Enterovax Research Pty. Ltd. Bacterial strain for live vaccines
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
SE462285B (sv) * 1988-09-16 1990-05-28 Jan Roland Holmgren Expression av koleratoxinets bindande subenhet med hjaelp av fraemmande promotor- och/eller ledarpeptidstrukturer
EP0485591B1 (en) * 1990-06-05 1996-11-06 The University Of Maryland At Baltimore Method for isolating deletion mutants of vibrio cholerae and cultures containing vibrio cholerae
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
DK0672116T3 (da) * 1992-07-06 2003-10-06 Avant Immunotherapeutics Inc Deletionsmutanter som vacciner mod kolera
US5874088A (en) * 1992-07-06 1999-02-23 President And Fellows Of Harvard College Deletion mutants of cholera vaccines expressing heterologous antigens
AU683454B2 (en) * 1993-02-22 1997-11-13 General Hospital Corporation, The Heterologous antigens in live cell vaccine strains
US6203799B1 (en) 1993-07-01 2001-03-20 Presidents And Fellows Of Harvard College Vibrio cholerae mutants which are soft-agar penetration defective and lack a functional CtxA subunit
US5945285A (en) * 1996-06-27 1999-08-31 President And Fellows Of Harvard College Vibrio cholerae having increased sensitivity to antibiotics
WO1998023763A1 (en) * 1996-11-29 1998-06-04 The General Hospital Corporation Heterologous antigens in live cell v. cholerae strains
JP4086945B2 (ja) * 1996-12-10 2008-05-14 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 非毒性Ｖ．Ｃｈｏｌｅｒａｅ株の単離法およびその株由来のコレラワクチンの製造法
EP0928831B1 (en) * 1997-12-10 2006-05-03 Council of Scientific and Industrial Research Cholera organisms, vaccines and preparation thereof
US6541011B2 (en) 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
AU2674299A (en) * 1998-02-11 1999-08-30 Maxygen, Inc. Targeting of genetic vaccine vectors
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
WO2000011181A1 (en) 1998-08-20 2000-03-02 Connaught Laboratories Limited NUCLEIC ACID MOLECULES ENCODING INCLUSION MEMBRANE PROTEIN C OF $i(CHLAMYDIA)
US6693087B1 (en) 1998-08-20 2004-02-17 Aventis Pasteur Limited Nucleic acid molecules encoding POMP91A protein of Chlamydia
US6686339B1 (en) * 1998-08-20 2004-02-03 Aventis Pasteur Limited Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia
RU2155227C1 (ru) * 1999-06-07 2000-08-27 Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока Штамм бактерий vibrio cholerae cholerae 5 серовара огава - продуцент антител холерной огава сыворотки
ES2306670T3 (es) 1999-10-22 2008-11-16 Sanofi Pasteur Limited Procedimiento de induccion y/o intensificacion de la respuesta inmunitaria frente a antigenos tumorales.
EP1792995A3 (en) 2000-05-08 2007-06-13 Sanofi Pasteur Limited Chlamydia secretory locus orf and uses thereof
ATE513913T1 (de) 2000-05-10 2011-07-15 Sanofi Pasteur Ltd Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen
CN1484700A (zh) * 2000-11-02 2004-03-24 �¼��¹�����ѧ aopB基因,蛋白,同系物,片段和它们的变体,以及它们在细胞表面展示方面的应用
EP1864691B1 (en) 2002-04-09 2011-07-20 Sanofi Pasteur Limited Modified CEA nucleic acid and expression vectors
AU2004280608B2 (en) * 2002-04-09 2012-04-05 Sanofi Pasteur, Inc. Modified CEA/B7 vector
RU2222594C1 (ru) * 2002-07-15 2004-01-27 Федеральное государственное учреждение Российский научно-исследовательский противочумный институт "Микроб" Штамм бактерий vibrio cholerae км206 классического биовара серовара огава - продуцент протективных антигенов
AU2003256240A1 (en) * 2002-08-29 2004-03-19 National University Of Singapore Recombinant nucleic acid useful for inducing protective immune response against allergens
US20060099229A1 (en) * 2004-11-05 2006-05-11 Universiti Sains Malaysia Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
US7049423B2 (en) 2003-12-19 2006-05-23 The General Hospital Corporation Use of the RTX secretion system to achieve heterologous polypeptide secretion by Vibrio cholerae

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264737A (en) * 1978-09-21 1981-04-28 President And Fellows Of Harvard College Method of making genetically stable mutants of vibrio cholerae
US4328209A (en) * 1979-04-11 1982-05-04 Board Of Regents, The University Of Texas System Cholera vaccine
JPS5893837A (ja) * 1981-11-30 1983-06-03 Toyota Motor Corp 複合材料及びその製造方法
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
ZA841557B (en) * 1983-03-04 1984-10-31 Univ Maryland Method of isolating restriction fragment deletions in vibrio chlolerae,and products thereof
US5135862A (en) * 1983-03-04 1992-08-04 University Of Maryland Method of isolating restriction fragment deletions in vibrio cholerae, products thereof

Also Published As

Publication number Publication date
ATE35152T1 (de) 1988-07-15
PT78478B (en) 1986-05-27
DZ634A1 (fr) 2004-09-13
JPH0740921B2 (ja) 1995-05-10
DK213784A (da) 1984-10-30
AU585481B2 (en) 1989-06-22
PT78478A (en) 1984-05-01
CA1326218C (en) 1994-01-18
DE3472114D1 (en) 1988-07-21
IL71652A0 (en) 1984-07-31
DK213784D0 (da) 1984-04-27
ES8600649A1 (es) 1985-09-01
EP0125228B1 (en) 1988-06-15
IL71652A (en) 1988-11-30
YU76384A (en) 1989-08-31
EP0125228A1 (en) 1984-11-14
ZA843142B (en) 1985-03-27
IE57266B1 (en) 1992-07-01
PH25301A (en) 1991-04-30
ES531986A0 (es) 1985-09-01
EG17879A (en) 1991-08-30
AU2727084A (en) 1984-11-01
JPS6037980A (ja) 1985-02-27
YU45616B (sh) 1992-07-20
IE841043L (en) 1984-10-29
ZM2884A1 (en) 1985-04-22
US4882278A (en) 1989-11-21
ZW6884A1 (en) 1984-09-19

Similar Documents

Publication Publication Date Title
EG17879A (en) Non-toxinogenic vibrio cholerae nutants
ES8705036A1 (es) Procedimiento para preparar una vacuna que comprende un polipeptido fijado a una membrana
DK219087D0 (da) Vektorsystem til brug ved transformation af trichoderma, transformerede trichodermastammer og fremgangsmaade til fremstilling af proteiner heri
GB2303854B (en) Helicobacter proteins and vaccines
DE3276374D1 (en) Plasmids coding for b. thuringiensis crystal protein, their production and their use in creating genetically engineered bacterial strains, the aforesaid strains per se and their use in producing said protein, said protein so-produced, insecticidal formulations comprising the same and a method of producing an insecticidal effect
AU6733487A (en) Mammalian interleukin-4
DE3266201D1 (en) Infectious-bronchitis vaccines for poultry, combined infectious-bronchitis vaccines, process for preparing such vaccines and infectious-bronchitis virus strain
KR970009347B1 (en) Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3
GR80840B (en) Novel polypeptide with a - amylase inhibiting effect, method for the preparation thereof, use and pharmaceutical preparations thereof
AU5280186A (en) Canine parvovirus vaccines
CA2089753A1 (en) Interleukin-2-leukotoxin gene fusions and uses therefor
AU7492187A (en) Improved stabilizers for live vaccines, process for their preparation and vaccines containing them
BG41137A3 (bg) Метод за получаване на днк преносен вектор,предназначен за поддържане и репликация на дезоксинуклеотидна последо- вателност,кодираща човешки препроинсулин
DK160565C (da) Plasmid p sg 2, fremgangsmaade til dets fremstilling og dets anvendelse
SE8205247D0 (sv) Fiskvacciner
JO1343B1 (en) Non-toxic gene variant strains of vibro cholera
AU1321988A (en) The cloning of malaria-specific dna sequences: isolation of the gene for the 140 kd protein
WO1990012807A3 (en) Purified, highly specific antibodies against gene products including retinoblastoma and method
AR224831A1 (es) Un procedimiento para la elaboracion de preparados de paredes celulares o preparaciones de celulas completas de propionibacterium granulosum dsm 1773,propionibacterium avidum dms 1772 y/o propionibacterium acnes atcc 6919
GB2022573A (en) New antibiotics from micromonospora globosa, and pharmaceutical compositions containing them
IT7830203A0 (it) Procedimento per rinforzare prodotti di carbone dolce.
SU1380209A1 (ru) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК PUR 291-HAV 22, КОДИРУЮЩАЯ СИНТЕЗ ГИБРИДНОГО ПОЛИПЕПТИДА АНТИГЕННЫХ ДЕТЕРМИНАНТ ВИРУСА ГЕПАТИТА А С β -ГАЛАКТОЗИДАЗОЙ
AU2713488A (en) Process for manufacturing antigens, vaccines and sera to combat bacterial or viral diseases and composition for implementing said process
AU7384387A (en) Avirulent bacterial strains used in live vaccine preparation