GR3036669T3 - O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same - Google Patents
O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the sameInfo
- Publication number
- GR3036669T3 GR3036669T3 GR20010401529T GR20010401529T GR3036669T3 GR 3036669 T3 GR3036669 T3 GR 3036669T3 GR 20010401529 T GR20010401529 T GR 20010401529T GR 20010401529 T GR20010401529 T GR 20010401529T GR 3036669 T3 GR3036669 T3 GR 3036669T3
- Authority
- GR
- Greece
- Prior art keywords
- phenylalaninol
- carbamoyl
- substituent
- preparing
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019950008310A KR0173863B1 (ko) | 1995-04-10 | 1995-04-10 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| PCT/KR1996/000051 WO1996032375A1 (en) | 1995-04-10 | 1996-04-10 | O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3036669T3 true GR3036669T3 (en) | 2001-12-31 |
Family
ID=19411865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010401529T GR3036669T3 (en) | 1995-04-10 | 2001-09-19 | O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6140532A (el) |
| EP (1) | EP0820438B1 (el) |
| JP (1) | JP4016081B2 (el) |
| KR (1) | KR0173863B1 (el) |
| CN (1) | CN1071741C (el) |
| CA (1) | CA2217771C (el) |
| DE (1) | DE69613466T2 (el) |
| DK (1) | DK0820438T3 (el) |
| ES (1) | ES2160237T3 (el) |
| GR (1) | GR3036669T3 (el) |
| PT (1) | PT820438E (el) |
| WO (1) | WO1996032375A1 (el) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998047870A1 (en) * | 1997-04-24 | 1998-10-29 | American Home Products Corporation | Process for the synthesis of 4-[6-(hexylcarbamoyloxy) hexylcarbamoyloxy]-piperidine-1- carboxylic acid 4-phenoxyphenyl ester |
| JP4565747B2 (ja) * | 1999-02-04 | 2010-10-20 | エスケー ホルディングス カンパニー リミテッド | テトラヒドロイソキノリンアルカノール誘導体及びそれを含む薬学的組成物 |
| US20050080268A1 (en) * | 2003-10-08 | 2005-04-14 | Yong-Moon Choi | Process of preparing O-carbamoyl compounds in the presence of active amine group |
| CA2587481A1 (en) * | 2004-10-28 | 2006-05-11 | Sk Corporation | Phenylalkylamino carbamates adjunctive therapy for depression |
| WO2006133393A1 (en) | 2005-06-08 | 2006-12-14 | Sk Holdings Co., Ltd. | Treatment of sleep-wake disorders |
| KR20090082213A (ko) * | 2006-10-13 | 2009-07-29 | 얀센 파마슈티카 엔.브이. | 페닐알킬아미노 카바메이트 조성물 |
| ITTO20070391A1 (it) * | 2007-06-05 | 2008-12-06 | Medestea Res & Production S P | Composizione di integratore alimentare,farmaco o dispositivo medicale e suo impiego per sopprimere l'appetito, migliorare tono ed umore, con attivita antidepressiva naturale e con effetto antiastenico |
| US20100151066A1 (en) * | 2007-06-05 | 2010-06-17 | Merizzi Giulia Federica | Composition for suppressing appetite, improving tone and mood, with a natural antidepressant activity and with an antiasthenic effect |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| KR20120098578A (ko) * | 2009-06-22 | 2012-09-05 | 에스케이바이오팜 주식회사 | 피로의 치료 또는 예방 방법 |
| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| ES2743153T3 (es) | 2009-11-06 | 2020-02-18 | Sk Biopharmaceuticals Co Ltd | Métodos para tratar el síndrome de fibromialgia |
| US8895609B2 (en) * | 2009-11-06 | 2014-11-25 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating attention-deficit/hyperactivity disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| BR112015022197B1 (pt) | 2013-03-13 | 2022-06-07 | Sk Biopharmaceuticals Co., Ltd. | Uso de um composto para o tratamento de cataplexia |
| KR20210152011A (ko) * | 2013-07-12 | 2021-12-14 | 에스케이바이오팜 주식회사 | 금연의 촉진 |
| CN110638804A (zh) | 2013-07-18 | 2020-01-03 | 爵士制药国际Iii有限公司 | 治疗肥胖 |
| US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
| TWI698415B (zh) | 2014-02-28 | 2020-07-11 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
| TWI707677B (zh) * | 2014-07-18 | 2020-10-21 | 南韓商愛思開生物製藥股份有限公司 | 肥胖之治療 |
| US10195151B2 (en) | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| CA3036071A1 (en) | 2016-09-06 | 2018-03-15 | Jazz Pharmaceuticals International Iii Limited | Solvate form of (r)-2-amino-3-phenylpropyl carbamate |
| CN110049966A (zh) | 2016-10-06 | 2019-07-23 | 杰资制药国际三期有限公司 | 氨基甲酰基苯丙氨醇化合物及其用途 |
| JP2020528075A (ja) | 2017-06-02 | 2020-09-17 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 過度の眠気を処置するための方法および組成物 |
| CA3071779A1 (en) | 2017-07-31 | 2019-02-07 | Jazz Pharmaceuticals Ireland Limited | Carbamoyl phenylalaninol analogs and uses thereof |
| CN110655500B (zh) * | 2018-06-28 | 2020-12-08 | 浙江京新药业股份有限公司 | 氨基甲酸酯衍生物及其制备方法和用途 |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
| KR102390194B1 (ko) | 2020-08-03 | 2022-04-25 | 셀라이온바이오메드 주식회사 | 페닐알킬 카바메이트 화합물을 포함하는 Kca3.1채널 매개질환 치료용 조성물 |
| WO2024249560A1 (en) | 2023-05-30 | 2024-12-05 | Axsome Therapeutics, Inc. | Solriamfetol for treating cognitive impairment in a subject with impaired cognition associated with obstructive sleep apnea and excessive daytime sleepiness |
| WO2025006965A1 (en) | 2023-06-29 | 2025-01-02 | Axsome Therapeutics, Inc. | Methods of administering solriamfetol to lactating women |
| WO2025042959A1 (en) | 2023-08-21 | 2025-02-27 | Axsome Therapeutics, Inc. | Use of solriamfetol for the treatment of orphan diseases |
| WO2025165760A1 (en) | 2024-01-29 | 2025-08-07 | Axsome Therapeutics, Inc. | Phenylalkylamino carbamates for use in the treatment of attention deficit/hyperactivity disorder |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1434826A (en) * | 1973-11-14 | 1976-05-05 | Gallardo Antonio Sa | Esters and carbamates of aminoalkanols |
| US5130464A (en) * | 1989-05-31 | 1992-07-14 | Nkk Corporation | Method of manufacturing aromatic urethanes |
| KR0173862B1 (ko) * | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| US5756817C1 (en) * | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
-
1995
- 1995-04-10 KR KR1019950008310A patent/KR0173863B1/ko not_active Expired - Lifetime
-
1996
- 1996-04-09 US US08/629,620 patent/US6140532A/en not_active Expired - Lifetime
- 1996-04-10 CA CA002217771A patent/CA2217771C/en not_active Expired - Lifetime
- 1996-04-10 WO PCT/KR1996/000051 patent/WO1996032375A1/en not_active Ceased
- 1996-04-10 DK DK96909388T patent/DK0820438T3/da active
- 1996-04-10 EP EP96909388A patent/EP0820438B1/en not_active Expired - Lifetime
- 1996-04-10 JP JP53090596A patent/JP4016081B2/ja not_active Expired - Lifetime
- 1996-04-10 DE DE69613466T patent/DE69613466T2/de not_active Expired - Lifetime
- 1996-04-10 CN CN96193142A patent/CN1071741C/zh not_active Expired - Lifetime
- 1996-04-10 ES ES96909388T patent/ES2160237T3/es not_active Expired - Lifetime
- 1996-04-10 PT PT96909388T patent/PT820438E/pt unknown
-
2001
- 2001-09-19 GR GR20010401529T patent/GR3036669T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0820438B1 (en) | 2001-06-20 |
| EP0820438A1 (en) | 1998-01-28 |
| KR960037649A (ko) | 1996-11-19 |
| WO1996032375A1 (en) | 1996-10-17 |
| CN1181064A (zh) | 1998-05-06 |
| ES2160237T3 (es) | 2001-11-01 |
| DE69613466D1 (de) | 2001-07-26 |
| JPH11503447A (ja) | 1999-03-26 |
| KR0173863B1 (ko) | 1999-04-01 |
| DE69613466T2 (de) | 2002-04-25 |
| CN1071741C (zh) | 2001-09-26 |
| CA2217771C (en) | 2009-02-10 |
| CA2217771A1 (en) | 1996-10-17 |
| PT820438E (pt) | 2001-12-28 |
| JP4016081B2 (ja) | 2007-12-05 |
| US6140532A (en) | 2000-10-31 |
| DK0820438T3 (da) | 2001-10-15 |
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