GR3035550T3 - A basic protein composition for killing or inhibiting microbial cells - Google Patents
A basic protein composition for killing or inhibiting microbial cellsInfo
- Publication number
- GR3035550T3 GR3035550T3 GR20010400391T GR20010400391T GR3035550T3 GR 3035550 T3 GR3035550 T3 GR 3035550T3 GR 20010400391 T GR20010400391 T GR 20010400391T GR 20010400391 T GR20010400391 T GR 20010400391T GR 3035550 T3 GR3035550 T3 GR 3035550T3
- Authority
- GR
- Greece
- Prior art keywords
- microbial cells
- killing
- enzyme
- cells present
- basic protein
- Prior art date
Links
- 230000000813 microbial effect Effects 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 4
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 108010029541 Laccase Proteins 0.000 abstract 2
- 102000003992 Peroxidases Human genes 0.000 abstract 2
- 102000007327 Protamines Human genes 0.000 abstract 2
- 108010007568 Protamines Proteins 0.000 abstract 2
- 229940088598 enzyme Drugs 0.000 abstract 2
- 229940048914 protamine Drugs 0.000 abstract 2
- 102000012286 Chitinases Human genes 0.000 abstract 1
- 108010022172 Chitinases Proteins 0.000 abstract 1
- 208000034656 Contusions Diseases 0.000 abstract 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 abstract 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 abstract 1
- 102000016943 Muramidase Human genes 0.000 abstract 1
- 108010014251 Muramidase Proteins 0.000 abstract 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 235000013361 beverage Nutrition 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 235000012041 food component Nutrition 0.000 abstract 1
- 239000005417 food ingredient Substances 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 230000001408 fungistatic effect Effects 0.000 abstract 1
- 229960000274 lysozyme Drugs 0.000 abstract 1
- 235000010335 lysozyme Nutrition 0.000 abstract 1
- 239000004325 lysozyme Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
- A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
- A23B2/729—Organic compounds; Microorganisms; Enzymes
- A23B2/733—Compounds of undetermined constitution obtained from animals or plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
- A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
- A23B2/729—Organic compounds; Microorganisms; Enzymes
- A23B2/762—Organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B2/00—Preservation of foods or foodstuffs, in general
- A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
- A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
- A23B2/729—Organic compounds; Microorganisms; Enzymes
- A23B2/783—Microorganisms; Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23B70/00—Preservation of non-alcoholic beverages
- A23B70/10—Preservation of non-alcoholic beverages by addition of preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3719—Polyamides or polyimides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38654—Preparations containing enzymes, e.g. protease or amylase containing oxidase or reductase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Agronomy & Crop Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Birds (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Detergent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK101194 | 1994-09-01 | ||
| PCT/DK1995/000351 WO1996006532A1 (en) | 1994-09-01 | 1995-09-01 | A basic protein composition for killing or inhibiting microbial cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3035550T3 true GR3035550T3 (en) | 2001-06-29 |
Family
ID=8100001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010400391T GR3035550T3 (en) | 1994-09-01 | 2001-03-09 | A basic protein composition for killing or inhibiting microbial cells |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0778733B1 (el) |
| JP (1) | JPH10505592A (el) |
| AT (1) | ATE198119T1 (el) |
| AU (1) | AU3341995A (el) |
| DE (1) | DE69519675T2 (el) |
| DK (1) | DK0778733T3 (el) |
| ES (1) | ES2154344T3 (el) |
| GR (1) | GR3035550T3 (el) |
| PT (1) | PT778733E (el) |
| WO (1) | WO1996006532A1 (el) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4865796A (en) * | 1995-02-17 | 1996-09-04 | Allergan, Inc. | Ophthalmic compositions including peptides and peptide derivatives and methods for using same |
| EP0876102B1 (en) * | 1995-11-03 | 2001-06-20 | Unilever N.V. | Natural composition for combatting fungi |
| AU2091297A (en) * | 1996-03-06 | 1997-09-22 | Novo Nordisk A/S | A method of killing or inhibiting microbial cells |
| MA24175A1 (fr) * | 1996-05-13 | 1997-12-31 | Procter & Gamble | Compositions detergentes comprenant un enzyme laccase |
| US6100080A (en) * | 1996-12-18 | 2000-08-08 | Novo Nordisk A/S | Method for enzymatic treatment of biofilm |
| DE69719568T2 (de) * | 1997-07-09 | 2003-12-24 | The Procter & Gamble Company, Cincinnati | Oxidoreductase enthaltende reinigungszusammensetzungen |
| CA2295948A1 (en) * | 1997-07-09 | 1999-01-21 | The Procter & Gamble Company | Cleaning compositions comprising a specific oxygenase |
| DE19731398A1 (de) * | 1997-07-22 | 1999-01-28 | Henkel Ecolab Gmbh & Co Ohg | Verwendung enzymhaltiger Lösungen zum Reinigen von Gär- und Lagertanks |
| WO1999057155A1 (en) * | 1998-05-01 | 1999-11-11 | The Procter & Gamble Company | Laundry detergent and/or fabric care compositions comprising a modified antimicrobial protein |
| DE19860754B4 (de) * | 1998-06-24 | 2004-10-28 | Coty B.V. | Kosmetische Zubereitung |
| US6239088B1 (en) * | 1999-03-19 | 2001-05-29 | Color Access, Inc. | Nonirritating cleansing composition |
| US6465410B1 (en) | 1999-04-30 | 2002-10-15 | The Procter & Gamble | Laundry detergent and/or fabric care composition comprising a modified antimicrobial protein |
| DE19945503A1 (de) * | 1999-09-23 | 2001-04-05 | Henkel Kgaa | Mehrphasiges Reinigungsmittel mit antimikrobieller Wirkung |
| JP2001228444A (ja) * | 2000-02-18 | 2001-08-24 | Chisso Corp | コンタクトレンズの洗浄消毒用溶液 |
| JP2002012536A (ja) * | 2000-06-27 | 2002-01-15 | Lion Corp | 口腔用組成物 |
| WO2002064183A1 (en) * | 2001-02-09 | 2002-08-22 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with antimicrobial cationic peptide and protein coatings |
| WO2002072007A2 (en) | 2001-03-08 | 2002-09-19 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polymers as anti-infective agents |
| ATE415416T1 (de) | 2002-06-14 | 2008-12-15 | Monier Tadros | Methode für die herstellung von protamin |
| EP2471527A3 (en) | 2003-03-17 | 2012-12-12 | The Trustees Of The University Of Pennsylvania | Facially amphiphillc polymers and oligomers and uses thereof |
| JP3876232B2 (ja) * | 2003-04-18 | 2007-01-31 | 有限会社ユーワ商事 | 眼科用製剤、点眼液、人工涙液、コンタクトレンズケアー用品、洗眼液、および眼軟膏 |
| US7314857B2 (en) * | 2003-08-25 | 2008-01-01 | Kane Biotech Inc. | Synergistic antimicrobial compositions and methods of inhibiting biofilm formation |
| JP4659405B2 (ja) * | 2004-07-27 | 2011-03-30 | 雪印乳業株式会社 | 骨形成促進剤 |
| KR101170852B1 (ko) * | 2003-09-30 | 2012-08-02 | 유키지루시 메그밀크 가부시키가이샤 | 골 형성 촉진 및/또는 골 흡수 억제제 |
| CA2554163A1 (en) | 2004-01-23 | 2005-08-11 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof |
| FR2869802B1 (fr) * | 2004-05-04 | 2010-08-20 | I N E A S L | Composition cosmetique et/ou dermatologique possedant des proprietes conservatrices hypoalergeniques |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| NZ600269A (en) | 2009-05-20 | 2014-02-28 | Dec Int Nz Ltd | Delivery device for treatment of mastitis |
| SG177704A1 (en) | 2009-06-26 | 2012-02-28 | Lysando Holding Ag | Antimicrobial agents |
| ES2579806T3 (es) | 2009-06-26 | 2016-08-16 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Agentes antimicrobianos |
| WO2011049201A1 (ja) * | 2009-10-22 | 2011-04-28 | 富士化学株式会社 | 抗菌剤及び抗菌性製品 |
| JP5703617B2 (ja) * | 2010-07-23 | 2015-04-22 | ライオン株式会社 | 口臭消臭製剤 |
| JP2016160350A (ja) * | 2015-03-02 | 2016-09-05 | 花王株式会社 | 食品加工設備又は調理器具用殺菌剤組成物 |
| JP7013233B2 (ja) * | 2017-12-25 | 2022-02-15 | 花王株式会社 | 硬質表面処理剤組成物 |
| EP3806637A1 (en) | 2018-06-15 | 2021-04-21 | Ecolab USA Inc. | On site generated performic acid compositions for teat treatment |
| CN113598198A (zh) * | 2021-08-05 | 2021-11-05 | 天津科技大学 | 一种农作物细菌性软腐病抗病蛋白糖联体的制备方法和产品及其应用 |
| WO2024180552A2 (en) * | 2023-03-01 | 2024-09-06 | Bountica Ltd. | An eco-friendly, sustainable food preservative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823277D0 (en) * | 1988-10-04 | 1988-11-09 | Schering Agrochemicals Ltd | Fungicidal composition |
| AU5685094A (en) * | 1992-12-09 | 1994-07-04 | Allergan, Inc. | Cleaning compositions and method for hydrophilic contact lenses |
-
1995
- 1995-09-01 EP EP95929788A patent/EP0778733B1/en not_active Expired - Lifetime
- 1995-09-01 PT PT95929788T patent/PT778733E/pt unknown
- 1995-09-01 AU AU33419/95A patent/AU3341995A/en not_active Abandoned
- 1995-09-01 WO PCT/DK1995/000351 patent/WO1996006532A1/en not_active Ceased
- 1995-09-01 AT AT95929788T patent/ATE198119T1/de not_active IP Right Cessation
- 1995-09-01 ES ES95929788T patent/ES2154344T3/es not_active Expired - Lifetime
- 1995-09-01 DK DK95929788T patent/DK0778733T3/da active
- 1995-09-01 JP JP8508427A patent/JPH10505592A/ja active Pending
- 1995-09-01 DE DE69519675T patent/DE69519675T2/de not_active Expired - Fee Related
-
2001
- 2001-03-09 GR GR20010400391T patent/GR3035550T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0778733B1 (en) | 2000-12-20 |
| EP0778733A1 (en) | 1997-06-18 |
| ATE198119T1 (de) | 2001-01-15 |
| ES2154344T3 (es) | 2001-04-01 |
| DE69519675D1 (de) | 2001-01-25 |
| JPH10505592A (ja) | 1998-06-02 |
| PT778733E (pt) | 2001-06-29 |
| DE69519675T2 (de) | 2001-09-13 |
| DK0778733T3 (da) | 2001-04-02 |
| WO1996006532A1 (en) | 1996-03-07 |
| AU3341995A (en) | 1996-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |