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GR3034257T3 - Improved inhibitors of thrombin. - Google Patents

Improved inhibitors of thrombin.

Info

Publication number
GR3034257T3
GR3034257T3 GR20000401944T GR20000401944T GR3034257T3 GR 3034257 T3 GR3034257 T3 GR 3034257T3 GR 20000401944 T GR20000401944 T GR 20000401944T GR 20000401944 T GR20000401944 T GR 20000401944T GR 3034257 T3 GR3034257 T3 GR 3034257T3
Authority
GR
Greece
Prior art keywords
substituted
atoms
bond
group
backbone chain
Prior art date
Application number
GR20000401944T
Other languages
English (en)
Inventor
John M Maraganore
Jo-Ann M Jablonski
Paul R Bourdon
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of GR3034257T3 publication Critical patent/GR3034257T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manipulator (AREA)
  • Pyrane Compounds (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
GR20000401944T 1991-02-08 2000-08-24 Improved inhibitors of thrombin. GR3034257T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/652,929 US5240913A (en) 1989-08-18 1991-02-08 Inhibitors of thrombin
PCT/US1992/000836 WO1992013952A1 (en) 1991-02-08 1992-02-03 Improved inhibitors of thrombin

Publications (1)

Publication Number Publication Date
GR3034257T3 true GR3034257T3 (en) 2000-12-29

Family

ID=24618783

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000401944T GR3034257T3 (en) 1991-02-08 2000-08-24 Improved inhibitors of thrombin.

Country Status (18)

Country Link
US (3) US5240913A (el)
EP (1) EP0529031B9 (el)
JP (1) JPH05506252A (el)
KR (1) KR100259759B1 (el)
AT (1) ATE193325T1 (el)
AU (1) AU659828B2 (el)
BG (1) BG61243B2 (el)
CA (1) CA2079778C (el)
DE (1) DE69231081T2 (el)
DK (1) DK0529031T3 (el)
ES (1) ES2149170T3 (el)
FI (2) FI120348B (el)
GR (1) GR3034257T3 (el)
HU (1) HU218831B (el)
NO (1) NO315710B1 (el)
NZ (1) NZ241557A (el)
TW (1) TW222642B (el)
WO (1) WO1992013952A1 (el)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
US5599307A (en) * 1993-07-26 1997-02-04 Loyola University Of Chicago Catheter and method for the prevention and/or treatment of stenotic processes of vessels and cavities
WO1995017907A1 (en) * 1993-12-27 1995-07-06 Hamilton Civic Hospitals Research Development, Inc. Methods and compositions for inhibiting thrombogenesis
WO1995019359A1 (en) * 1994-01-12 1995-07-20 Massachusetts Institute Of Technology Process for making xanthene or cubane based compounds, and protease inhibitors
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US6759384B1 (en) 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
DE4430204A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung
DE4430205A1 (de) 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
US5747453A (en) * 1995-06-06 1998-05-05 Alza Corporation Method for increasing the electrotransport flux of polypeptides
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
US6333189B1 (en) 1996-06-06 2001-12-25 Alza Corporation Method of making an electrotransport device
JPH1010784A (ja) * 1996-06-27 1998-01-16 Brother Ind Ltd 正帯電性一成分現像剤並びにその現像剤を用いた画像形成装置
GB9613718D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
GB9613719D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Serine protease inhibitors
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
DE10162521A1 (de) * 2001-12-19 2003-07-17 Goetz Nowak Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie
CN102225966B (zh) 2004-10-19 2012-12-26 隆萨股份公司 用于固相肽合成的方法
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same
AU2009288027B2 (en) 2008-09-03 2014-01-16 Scinopharm Taiwan, Ltd. Process for making Bivalirudin
US7803762B1 (en) * 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
AU2017273857B2 (en) 2016-06-01 2021-08-19 Athira Pharma, Inc. Compounds
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
US11992514B2 (en) 2019-05-20 2024-05-28 MAIA Pharmaceuticals, Inc. Ready-to-use bivalirudin compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3501107A1 (de) * 1985-01-15 1986-07-17 Josef 8358 Vilshofen Paul Nutzfahrzeug mit schieberahmenwechselaufbau
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883444B (el) * 1987-05-21 1988-11-16
ZA883443B (en) * 1987-05-21 1988-11-16 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
HUT55799A (en) * 1988-09-29 1991-06-28 Biogen Inc Process for producing hirudine-like peptides
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
JP2669510B2 (ja) * 1990-06-15 1997-10-29 ナショナル・リサーチ・カウンシル・オブ カナダ ヒルジンのアミノ酸配列に基づくトロンビン阻害剤

Also Published As

Publication number Publication date
AU659828B2 (en) 1995-06-01
EP0529031B9 (en) 2007-11-21
HU218831B (hu) 2000-12-28
KR100259759B1 (ko) 2000-06-15
JPH05506252A (ja) 1993-09-16
NO315710B1 (no) 2003-10-13
FI120690B (fi) 2010-01-29
DE69231081T2 (de) 2001-02-01
EP0529031B1 (en) 2000-05-24
HK1005995A1 (en) 1999-02-05
EP0529031A1 (en) 1993-03-03
NO923889D0 (no) 1992-10-07
BG61243B2 (bg) 1997-03-31
CA2079778C (en) 2002-09-03
WO1992013952A1 (en) 1992-08-20
NZ241557A (en) 1996-11-26
ATE193325T1 (de) 2000-06-15
HU9203500D0 (en) 1993-01-28
AU1362192A (en) 1992-09-07
FI924503A7 (fi) 1992-10-06
US5514409A (en) 1996-05-07
ES2149170T3 (es) 2000-11-01
HUT65675A (en) 1994-07-28
NO923889L (no) 1992-12-08
FI120348B (fi) 2009-09-30
US5425936A (en) 1995-06-20
CA2079778A1 (en) 1992-08-09
FI20050027L (fi) 2005-01-11
DK0529031T3 (da) 2000-10-09
DE69231081D1 (de) 2000-06-29
FI924503A0 (fi) 1992-10-06
US5240913A (en) 1993-08-31
TW222642B (el) 1994-04-21

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