[go: up one dir, main page]

GR3034087T3 - Ultrasound-enhanced delivery of material into and through the skin - Google Patents

Ultrasound-enhanced delivery of material into and through the skin

Info

Publication number
GR3034087T3
GR3034087T3 GR20000401782T GR20000401782T GR3034087T3 GR 3034087 T3 GR3034087 T3 GR 3034087T3 GR 20000401782 T GR20000401782 T GR 20000401782T GR 20000401782 T GR20000401782 T GR 20000401782T GR 3034087 T3 GR3034087 T3 GR 3034087T3
Authority
GR
Greece
Prior art keywords
ultrasound
skin
enhanced delivery
sample
assayed
Prior art date
Application number
GR20000401782T
Other languages
English (en)
Inventor
Durairaj Bommannan
Hiroshia Okuyama
Richard Henry Guy
Paul Stauffer
Gordon L Flynn
Original Assignee
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems filed Critical Cygnus Therapeutic Systems
Publication of GR3034087T3 publication Critical patent/GR3034087T3/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N7/02Localised ultrasound hyperthermia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00765Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Materials For Medical Uses (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Electrotherapy Devices (AREA)
  • Stringed Musical Instruments (AREA)
  • Tents Or Canopies (AREA)
  • Sampling And Sample Adjustment (AREA)
GR20000401782T 1990-02-23 2000-08-02 Ultrasound-enhanced delivery of material into and through the skin GR3034087T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/484,560 US5115805A (en) 1990-02-23 1990-02-23 Ultrasound-enhanced delivery of materials into and through the skin
EP91905678A EP0515566B1 (en) 1990-02-23 1991-02-21 Ultrasound enhanced delivery of materials through skin

Publications (1)

Publication Number Publication Date
GR3034087T3 true GR3034087T3 (en) 2000-11-30

Family

ID=23924657

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000401782T GR3034087T3 (en) 1990-02-23 2000-08-02 Ultrasound-enhanced delivery of material into and through the skin

Country Status (15)

Country Link
US (3) US5115805A (el)
EP (2) EP0515566B1 (el)
JP (1) JP2695986B2 (el)
AT (2) ATE148001T1 (el)
AU (1) AU656519B2 (el)
CA (1) CA2075624C (el)
DE (2) DE69124365T2 (el)
DK (1) DK0736305T3 (el)
ES (2) ES2097206T3 (el)
FI (1) FI923743A7 (el)
GR (1) GR3034087T3 (el)
IE (1) IE910613A1 (el)
NZ (1) NZ237197A (el)
PT (1) PT96856A (el)
WO (1) WO1991012772A1 (el)

Families Citing this family (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956032B1 (en) * 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5679399A (en) * 1987-07-17 1997-10-21 Bio Barrier, Inc. Method of forming a membrane, especially a latex or polymer membrane, including multiple discrete layers
US5549924A (en) * 1987-07-17 1996-08-27 Robin Renee Thill Shlenker Method of forming a membrane, especially a latex or polymer membrane, including a deactivating barrier and indicating layer
US5231975A (en) * 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
SE469778B (sv) * 1992-02-17 1993-09-13 Bertil Olsson Enheten Foer Kar Apparat för arteriell reperfusion genom noninvasiv ultraljudspåverkan
JPH0670987A (ja) * 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
US6315772B1 (en) 1993-09-24 2001-11-13 Transmedica International, Inc. Laser assisted pharmaceutical delivery and fluid removal
SE9301171D0 (sv) * 1993-04-07 1993-04-07 Ab Astra Pharmaceutical composition containing lipophilic drugs
US5667487A (en) * 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
JP3415203B2 (ja) * 1993-07-12 2003-06-09 立花 克郎 治療用超音波発生装置
US5415629A (en) * 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5836940A (en) * 1994-10-25 1998-11-17 Latis, Inc. Photoacoustic drug delivery
US5817144A (en) * 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
AU725269B2 (en) * 1995-07-25 2000-10-12 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5947921A (en) * 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US6002961A (en) * 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
ES2536459T3 (es) * 1995-08-29 2015-05-25 Nitto Denko Corporation Microporación de piel humana para administración de fármacos y aplicaciones de supervisión
US5618275A (en) * 1995-10-27 1997-04-08 Sonex International Corporation Ultrasonic method and apparatus for cosmetic and dermatological applications
AU1339397A (en) * 1995-12-20 1997-07-14 Sonex International Corporation Sonic method and apparatus for cosmetic applications
US7094422B2 (en) 1996-02-19 2006-08-22 Acrux Dds Pty Ltd. Topical delivery of antifungal agents
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US6009343A (en) * 1996-02-23 1999-12-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
EP0925088A2 (en) 1996-06-28 1999-06-30 Sontra Medical, L.P. Ultrasound enhancement of transdermal transport
DE69722414T2 (de) 1996-07-03 2004-05-19 Altea Therapeutics Corp. Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5911223A (en) * 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US6024717A (en) * 1996-10-24 2000-02-15 Vibrx, Inc. Apparatus and method for sonically enhanced drug delivery
WO1998023325A1 (en) * 1996-11-27 1998-06-04 The General Hospital Corporation Compound delivery using impulse transients
DK1314400T3 (da) * 1996-12-31 2007-10-15 Altea Therapeutics Corp Mikroporering af væv til levering af bioaktive midler
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US7108663B2 (en) 1997-02-06 2006-09-19 Exogen, Inc. Method and apparatus for cartilage growth stimulation
US7789841B2 (en) 1997-02-06 2010-09-07 Exogen, Inc. Method and apparatus for connective tissue treatment
US5913833A (en) * 1997-02-07 1999-06-22 Abbott Laboratories Method and apparatus for obtaining biological fluids
US5904659A (en) 1997-02-14 1999-05-18 Exogen, Inc. Ultrasonic treatment for wounds
WO1998048711A1 (en) * 1997-05-01 1998-11-05 Ekos Corporation Ultrasound catheter
US6676626B1 (en) * 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6723063B1 (en) 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6085115A (en) * 1997-05-22 2000-07-04 Massachusetts Institite Of Technology Biopotential measurement including electroporation of tissue surface
JP4441000B2 (ja) * 1997-06-23 2010-03-24 克郎 立花 生体組織処理装置
US5954675A (en) * 1997-07-07 1999-09-21 Dellagatta; Enrico Michael Method of ultrasonic therapy
US20060184071A1 (en) * 1997-12-29 2006-08-17 Julia Therapeutics, Llc Treatment of skin with acoustic energy
US6575956B1 (en) * 1997-12-31 2003-06-10 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US6190315B1 (en) 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US8287483B2 (en) * 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US7273458B2 (en) 1998-01-12 2007-09-25 Georgia Tech Research Corporation Method of applying acoustic energy effective to alter transport or cell viability
US20020055702A1 (en) * 1998-02-10 2002-05-09 Anthony Atala Ultrasound-mediated drug delivery
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
CA2265119C (en) 1998-03-13 2002-12-03 Cygnus, Inc. Biosensor, iontophoretic sampling system, and methods of use thereof
US6030374A (en) * 1998-05-29 2000-02-29 Mcdaniel; David H. Ultrasound enhancement of percutaneous drug absorption
WO1999051296A1 (en) * 1998-04-03 1999-10-14 Mcdaniel David H Ultrasound enhancement of percutaneous drug absorption
US6066123A (en) * 1998-04-09 2000-05-23 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of bioavailability by use of focused energy delivery to a target tissue
JP2002513661A (ja) 1998-05-06 2002-05-14 エクソジェン インコーポレイテッド 超音波包帯
AU5117699A (en) 1998-07-21 2000-02-14 Acoustic Sciences Associates Synthetic structural imaging and volume estimation of biological tissue organs
ATE280615T1 (de) 1998-08-31 2004-11-15 Johnson & Johnson Consumer Elektrotransportvorrichtung mit klingen
IL141774A0 (en) 1998-09-04 2002-03-10 Powderject Res Ltd Monitoring methods using particle delivery methods
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
EP1102561B1 (en) 1998-09-17 2003-11-26 Cygnus, Inc. Press device for a gel/sensor assembly
US6312402B1 (en) 1998-09-24 2001-11-06 Ekos Corporation Ultrasound catheter for improving blood flow to the heart
US6180416B1 (en) 1998-09-30 2001-01-30 Cygnus, Inc. Method and device for predicting physiological values
US6326160B1 (en) 1998-09-30 2001-12-04 Cygnus, Inc. Microprocessors for use in a device for predicting physiological values
US6391643B1 (en) 1998-10-28 2002-05-21 Cygnus, Inc. Kit and method for quality control testing of an iontophoretic sampling system
DE19850517B4 (de) * 1998-11-03 2004-02-12 Lts Lohmann Therapie-Systeme Ag Verwendung eines wirkstoffhaltigen transdermalen therapeutischen Systems in einer Kombinationsbehandlung mit und ohne Ultraschall
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US6283956B1 (en) * 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6231528B1 (en) * 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
WO2000047109A1 (en) 1999-02-12 2000-08-17 Cygnus, Inc. Devices and methods for frequent measurement of an analyte present in a biological system
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US7127285B2 (en) * 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
FR2791249B1 (fr) * 1999-03-25 2001-06-15 Edap Technomed Milieu de couplage pour ultrasons de puissance
JP4180244B2 (ja) 1999-04-16 2008-11-12 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド 内部センサを有する電気的な移動による送出装置系
EP1064046A1 (en) 1999-04-22 2001-01-03 Cygnus, Inc. Methods and devices for removing interfering species
KR100803810B1 (ko) 1999-05-21 2008-02-14 엑조겐 인코포레이티드 초음파 및 전자기적으로 조직을 치료하는 장치
EP1408853A1 (en) 1999-06-14 2004-04-21 Exogen, Inc. Method and kit for cavitation-induced tissue healing with low intensity ultrasound
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
ES2282123T3 (es) 1999-07-08 2007-10-16 JOHNSON & JOHNSON CONSUMER COMPANIES, INC. Dispositivo de administracion por via topica exomerico.
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US20030229331A1 (en) * 1999-11-05 2003-12-11 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6885883B2 (en) * 2000-05-16 2005-04-26 Cygnus, Inc. Methods for improving performance and reliability of biosensors
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
ATE392178T1 (de) 2000-08-18 2008-05-15 Animas Technologies Llc Vorrichtung zum vorhersagen von hypoglyecemiefällen
US6553244B2 (en) 2000-08-18 2003-04-22 Cygnus, Inc. Analyte monitoring device alarm augmentation system
WO2002015961A2 (en) * 2000-08-24 2002-02-28 Encapsulation Systems, Inc. Ultrasonically enhanced substance delivery method
US6964647B1 (en) * 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6487447B1 (en) 2000-10-17 2002-11-26 Ultra-Sonic Technologies, L.L.C. Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation
AU3267902A (en) 2000-10-25 2002-05-27 Exogen Inc Transducer mounting assembly
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6761729B2 (en) 2000-12-22 2004-07-13 Advanced Medicalapplications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6533803B2 (en) 2000-12-22 2003-03-18 Advanced Medical Applications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US7914470B2 (en) * 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US6960173B2 (en) * 2001-01-30 2005-11-01 Eilaz Babaev Ultrasound wound treatment method and device using standing waves
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
US6503209B2 (en) 2001-05-18 2003-01-07 Said I. Hakky Non-invasive focused energy blood withdrawal and analysis system
NZ512367A (en) * 2001-06-14 2005-05-27 Horticulture & Food Res Inst Non-invasive transudate extraction
WO2003000127A2 (en) * 2001-06-22 2003-01-03 Cygnus, Inc. Method for improving the performance of an analyte monitoring system
US7429248B1 (en) 2001-08-09 2008-09-30 Exogen, Inc. Method and apparatus for controlling acoustic modes in tissue healing applications
US6908448B2 (en) * 2001-08-24 2005-06-21 Dermisonics, Inc. Substance delivery device
US6795727B2 (en) 2001-10-17 2004-09-21 Pedro Giammarusti Devices and methods for promoting transcutaneous movement of substances
US7220239B2 (en) 2001-12-03 2007-05-22 Ekos Corporation Catheter with multiple ultrasound radiating members
CA2473725A1 (en) * 2002-01-15 2004-06-24 Bruce K. Redding, Jr. A wearable, portable sonic applicator for inducing the release of bioactive compounds from internal organs
TWI220386B (en) 2002-01-21 2004-08-21 Matsushita Electric Works Ltd Ultrasonic transdermal permeation device
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
AU2003220143A1 (en) * 2002-03-11 2003-09-29 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
US20030235817A1 (en) 2002-03-22 2003-12-25 Miroslaw Bartkowiak Microprocessors, devices, and methods for use in analyte monitoring systems
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US6801041B2 (en) * 2002-05-14 2004-10-05 Abbott Laboratories Sensor having electrode for determining the rate of flow of a fluid
JP4243499B2 (ja) * 2002-06-11 2009-03-25 富士通株式会社 貼合せ基板製造装置及び貼合せ基板製造方法
US20030233085A1 (en) 2002-06-18 2003-12-18 Pedro Giammarusti Optimization of transcutaneous active permeation of compounds through the synergistic use of ultrasonically generated mechanical abrasion of the skin, chemical enhancers and simultaneous application of sonophoresis, iontophoresis, electroporation, mechanical vibrations and magnetophoresis through single application devices
US7099713B2 (en) 2002-06-28 2006-08-29 Battelle Memorial Institute Skin conduction and transport systems
US7150975B2 (en) * 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
WO2004032963A2 (en) * 2002-10-04 2004-04-22 Photokinetix Inc. Photokinetic delivery of biologically active substances using pulsed incoherent light
AU2003284096A1 (en) 2002-10-10 2004-05-04 Visualsonics Inc. High frequency high frame-rate ultrasound imaging system
US6921371B2 (en) 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
US6860852B2 (en) * 2002-10-25 2005-03-01 Compex Medical S.A. Ultrasound therapeutic device
WO2004073647A2 (en) * 2003-02-19 2004-09-02 Second Stage Ventures, Inc. Ultrasonically enhanced saline treatment for burn damaged skin
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
CA2531099A1 (en) * 2003-04-10 2004-10-28 Light Bioscience, Llc Photomodulation methods and devices for regulating cell proliferation and gene expression
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
ES2346306T3 (es) 2003-06-13 2010-10-14 THE PROCTER & GAMBLE COMPANY Dispositivo para el cuidado de la piel por sonoforesis.
US20050149150A1 (en) * 2003-07-31 2005-07-07 Light Bioscience L.L.C. System and method for the photodynamic treatment of burns, wounds, and related skin disorders
WO2005018443A1 (en) 2003-08-15 2005-03-03 Animas Technologies Llc Microprocessors, devices, and methods for use in monitoring of physiological analytes
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US20050137520A1 (en) * 2003-10-29 2005-06-23 Rule Peter R. Catheter with ultrasound-controllable porous membrane
US20060058708A1 (en) * 2003-12-24 2006-03-16 Gill Heart Method and apparatus for ultrasonically increasing the transportation of therapeutic substances through tissue
US20050148907A1 (en) * 2003-12-24 2005-07-07 Gregory Skover Treatment of skin using a benefit agent and an apparatus
JP2008506701A (ja) * 2004-07-15 2008-03-06 フリーダム−2・エル・エル・シー 改変された組織マーキング顔料および組織マーキング顔料を改変するための方法
GB0422525D0 (en) 2004-10-11 2004-11-10 Luebcke Peter Dermatological compositions and methods
US20060094944A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US7785277B2 (en) * 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
EP1928304B1 (en) 2005-09-30 2012-10-24 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
JP2009519758A (ja) * 2005-12-16 2009-05-21 バイエル・ヘルスケア・エルエルシー デュアル経皮アナライトセンサアセンブリおよびその使用方法
US20080177220A1 (en) * 2006-01-06 2008-07-24 The Curators Of The University Of Missouri Ultrasound-Mediated Transcleral Drug Delivery
US20080031833A1 (en) * 2006-03-13 2008-02-07 Oblong John E Combined energy and topical composition application for regulating the condition of mammalian skin
US7662177B2 (en) * 2006-04-12 2010-02-16 Bacoustics, Llc Apparatus and methods for pain relief using ultrasound waves in combination with cryogenic energy
US20080183200A1 (en) * 2006-06-07 2008-07-31 Bacoustics Llc Method of selective and contained ultrasound debridement
US7431704B2 (en) 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
US8562547B2 (en) * 2006-06-07 2013-10-22 Eliaz Babaev Method for debriding wounds
CN101500640B (zh) * 2006-06-15 2013-10-16 海鸥Ip有限公司 递送系统和方法
AU2014200299B2 (en) * 2006-06-15 2015-04-02 Polypharma Pty Ltd A delivery system and process
US8192363B2 (en) 2006-10-27 2012-06-05 Ekos Corporation Catheter with multiple ultrasound radiating members
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
WO2008079379A1 (en) * 2006-12-22 2008-07-03 Celleration, Inc. Apparatus to prevent applicator re-use
US8491521B2 (en) * 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
WO2008085911A1 (en) * 2007-01-04 2008-07-17 Celleration, Inc. Removable multi-channel applicator nozzle
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
RU2444980C2 (ru) * 2007-03-07 2012-03-20 Эко Терапьютикс, Инк. Трансдермальная система мониторинга аналита и способы детекции аналита
WO2008115224A2 (en) * 2007-03-20 2008-09-25 Bayer Healthcare Llc Method of analyzing an analyte
KR101211252B1 (ko) 2007-04-27 2012-12-12 에코 테라퓨틱스, 인크. 경피 피분석물 감지 또는 경피 약제 전달용 피부 침투장치
EP2494932B1 (en) 2007-06-22 2020-05-20 Ekos Corporation Apparatus for treatment of intracranial hemorrhages
US20090187137A1 (en) * 2007-12-14 2009-07-23 Kim Volz Ultrasound pulse shaping
EP2231279A1 (en) * 2007-12-28 2010-09-29 Celleration, Inc. Methods for treating inflammatory skin disorders
CA2725264C (en) 2008-05-30 2017-06-20 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
EP2299904B1 (en) 2008-06-06 2019-09-11 Intuity Medical, Inc. Medical measurement method
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US20100022919A1 (en) * 2008-07-22 2010-01-28 Celleration, Inc. Methods of Skin Grafting Using Ultrasound
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US11607407B2 (en) 2010-04-13 2023-03-21 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2′,6′-pipecoloxylidide and method of use
WO2011162823A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
EP2688634A1 (en) 2011-03-23 2014-01-29 Bruce K. Redding, Jr. Systems and methods for enhancing the delivery of compounds to skin pores using ultrasonic waveforms
US11458290B2 (en) 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system
ITGE20110067A1 (it) * 2011-06-30 2012-12-31 Esaote Spa Dispositivo per il rilevamento di immagini ad ultrasuoni
EP3407064B1 (en) 2011-08-03 2020-04-22 Intuity Medical, Inc. Body fluid sampling arrangement
JP2016522070A (ja) 2013-06-21 2016-07-28 インテュイティ メディカル インコーポレイテッド 可聴フィードバックを用いた分析物モニタリングシステム
EP3074089B1 (en) 2013-11-26 2025-03-05 Alliqua Biomedical, Inc. Systems for producing and delivering ultrasonic therapies for wound treatment and healing
US10092742B2 (en) 2014-09-22 2018-10-09 Ekos Corporation Catheter system
US10656025B2 (en) 2015-06-10 2020-05-19 Ekos Corporation Ultrasound catheter
EP3606612A4 (en) * 2017-04-03 2021-05-26 MDSG Innovation Ltd. DEVICE AND METHOD FOR TREATMENT OF KIDNEY

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6409245A (el) * 1964-06-17 1966-02-14
US3710779A (en) * 1970-01-16 1973-01-16 Hoffmann La Roche Method of ultrasonic coupling
US4002221A (en) * 1972-09-19 1977-01-11 Gilbert Buchalter Method of transmitting ultrasonic impulses to surface using transducer coupling agent
US3941122A (en) * 1974-04-08 1976-03-02 Bolt Beranek And Newman, Inc. High frequency ultrasonic process and apparatus for selectively dissolving and removing unwanted solid and semi-solid materials and the like
GB1577551A (en) * 1976-02-09 1980-10-22 Fahim M Medication for topical application by ultrasound
US4309989A (en) * 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
DE2756460A1 (de) * 1977-12-17 1979-06-21 Fraunhofer Ges Forschung Verfahren zur lokal begrenzten applikation von therpeutika durch die oberflaeche von lebenden koerpern oder koerperorganen
SU799750A1 (ru) * 1978-05-03 1981-01-30 Сочинский Научно-Исследовательс-Кий Институт Курортологии И Физи-Отерапии Способ лечени больных дегене-РАТиВНО-диСТРОфичЕСКиМи зАбОлЕВА-Ни Ми пОзВОНОчНиКА
SU770496A1 (ru) * 1978-12-29 1980-10-15 Mo Vysshee Tekhnicheskoe Uchil Способ стерилизации биологических тканей 1
SU878268A1 (ru) * 1979-11-19 1981-11-07 Московское Ордена Ленина И Ордена Трудового Красного Знамени Высшее Техническое Училище Им. Н.Э.Баумана Способ лечени инфицированных ран
SU884700A1 (ru) * 1980-03-10 1981-11-30 Ордена Трудового Красного Знамени Институт Медицинской Паразитологии И Тропической Медицины Им.Е.И.Марциновского Способ лечени глубоких микозов
US4372296A (en) * 1980-11-26 1983-02-08 Fahim Mostafa S Treatment of acne and skin disorders and compositions therefor
US4484569A (en) * 1981-03-13 1984-11-27 Riverside Research Institute Ultrasonic diagnostic and therapeutic transducer assembly and method for using
SU1111759A1 (ru) * 1981-12-16 1984-09-07 Белорусский Государственный Научно-Исследовательский Институт Неврологии,Нейрохирургии И Физиотерапии Способ лечени импотенции у больных с хронической окклюзией брюшной аорты
SU1142121A1 (ru) * 1983-03-05 1985-02-28 Киевский государственный институт усовершенствования врачей Способ лечени отомикозов
SU1153917A1 (ru) * 1983-03-05 1985-05-07 Киевский государственный институт усовершенствования врачей Способ лечени кохлеарного неврита
US5158070A (en) * 1983-12-14 1992-10-27 Edap International, S.A. Method for the localized destruction of soft structures using negative pressure elastic waves
CA1237482A (en) * 1984-03-09 1988-05-31 Frank B. Stiles Catheter for effecting removal of obstructions from a biological duct
SU1286201A1 (ru) * 1984-04-10 1987-01-30 Саратовский научно-исследовательский институт травматологии и ортопедии Способ лечени травматических повреждений суставов
SU1181664A1 (ru) * 1984-05-21 1985-09-30 Киевский государственный институт усовершенствования врачей Способ лечени фурункула носа
FR2584916B1 (fr) * 1985-07-19 1990-05-25 Satelec Soc Appareil de curetage ou d'exerese de tissus biologiques par un instrument vibrant a des frequences ultrasonores
FR2587893B1 (fr) * 1985-09-27 1990-03-09 Dory Jacques Procede et dispositif de reperage permettant, au cours d'une lithotripsie, d'apprecier le degre de fragmentation des calculs
SU1512607A1 (ru) * 1986-06-27 1989-10-07 Научно-Исследовательский Институт Курортологии И Физиотерапии Им.А.А.Акопяна Способ лечени гипертонической болезни 1Б-11А стадии
US4767402A (en) * 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
US4791915A (en) * 1986-09-29 1988-12-20 Dynawave Corporation Ultrasound therapy device
JPS63135179A (ja) * 1986-11-26 1988-06-07 立花 俊郎 薬物の経皮投与具
US4787888A (en) * 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US4780212A (en) * 1987-07-31 1988-10-25 Massachusetts Institute Of Technology Ultrasound enchancement of membrane permeability
DE3736072A1 (de) * 1987-09-24 1989-04-13 Soft Electrics & Cosmetics Ver Verfahren und geraet zur foerderung des wohlbefindens des menschen und zur kosmetischen behandlung der haut
JP2907342B2 (ja) * 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア イオン滲透非侵襲的サンプリングまたは送出装置
US5143063A (en) * 1988-02-09 1992-09-01 Fellner Donald G Method of removing adipose tissue from the body
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5231975A (en) * 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin

Also Published As

Publication number Publication date
ATE192344T1 (de) 2000-05-15
US5323769A (en) 1994-06-28
DE69132175T2 (de) 2000-09-28
EP0736305A3 (en) 1998-08-19
DE69132175D1 (de) 2000-06-08
DE69124365D1 (de) 1997-03-06
FI923743L (fi) 1992-08-20
US5115805A (en) 1992-05-26
FI923743A0 (fi) 1992-08-20
EP0736305B1 (en) 2000-05-03
JPH06501855A (ja) 1994-03-03
PT96856A (pt) 1991-11-29
JP2695986B2 (ja) 1998-01-14
DE69124365T2 (de) 1997-05-28
ATE148001T1 (de) 1997-02-15
EP0515566B1 (en) 1997-01-22
WO1991012772A1 (en) 1991-09-05
ES2146339T3 (es) 2000-08-01
CA2075624A1 (en) 1991-08-24
ES2097206T3 (es) 1997-04-01
NZ237197A (en) 1997-04-24
EP0515566A1 (en) 1992-12-02
IE910613A1 (en) 1991-08-28
FI923743A7 (fi) 1992-08-20
AU7488391A (en) 1991-09-18
EP0736305A2 (en) 1996-10-09
US5636632A (en) 1997-06-10
CA2075624C (en) 1997-11-18
DK0736305T3 (da) 2000-12-04
AU656519B2 (en) 1995-02-09
EP0515566A4 (en) 1993-02-03

Similar Documents

Publication Publication Date Title
GR3034087T3 (en) Ultrasound-enhanced delivery of material into and through the skin
HUT45247A (en) Process for producing thiazolidinediones with hypolycaemic effect and pharmaceutical compositions comprising the same
MY109875A (en) Novel formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight surfactants.
HUT62798A (en) Process for producing pharmaceutical composition with slimming activity
WO1993017646A3 (de) Verfahren und anordnung zur therapie von gewebe mit ultraschall
EP0224934A3 (en) Contrast agent, process for its preparation and its use for ultrasonic imaging
AU5003990A (en) Method and device for the controlled local, non-invasive application of dc pulses to human tissues
ATE65703T1 (de) Anordnung zur beseitigung von aktiven mitteln, oertlich verwendet gegen feste tumoren.
CA2045594A1 (en) Immunogenic compositions against gastrin peptides
WO2001026704A3 (en) Targeted drug activation
AU3861989A (en) Method for the treatment and the diagnosis of coronary heart disease
IT1236081B (it) "macchina e procedimento per la raccolta meccanica di frutti mediante scuotimento"
IT8984980A0 (it) Procedimento per la realizzazione di cingoli in gomma e cingolo cosi'.
EP0399358A3 (en) Butenoic acid derivatives
IT8903621A0 (it) Metodo e dispositivo per l'avanzamento in successione di prodotti appiattiti
IT9021537V0 (it) "dispositivo a corsa continuata per il trattamento di pelli e mate- riali analoghi"
DE3280277D1 (de) Verfahren zur herstellung eines spezifisch auf das ernaehrungszentrum wirkenden appetitregelnden wirkstoffes sowie der nach diesem verfahren erhaeltliche wirkstoff.
EP0409473A3 (en) A process for obtaining the gangliosides from nervous tissue of mammalians and for the treatment of psychoorganic diseases with said material compositons
IT8719958A0 (it) Procedimento e dispositivo per produrre un corpo sagomato di materia artificiale.
BE904358A (fr) Procede et dispositif pour l'elimination controlee d'obstructions biologiques.
FR2648814B1 (fr) L'alpha (tert-butyl-aminomethyl-3,4-dichlorobenzyl)thioacetamide, son procede de preparation et son application en therapeutique
IL91392A0 (en) Method of increasing the ovulation rate in swine
CS304488A1 (en) Method of components' capillary openings' ultrasonic clearing especially hypodermic needles' cannulas
UA28769A (uk) Спосіб лікування променевих ушкоджень шкіри
RU94010421A (ru) Способ лечения невропатии лицевого нерва среднетяжелой и тяжелой степени

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees