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GR3031966T3 - (3R,4R)--g(D)?6 -TETRAHYDROCANNABINOL-7-OIC ACIDS. - Google Patents

(3R,4R)--g(D)?6 -TETRAHYDROCANNABINOL-7-OIC ACIDS.

Info

Publication number
GR3031966T3
GR3031966T3 GR990403059T GR990403059T GR3031966T3 GR 3031966 T3 GR3031966 T3 GR 3031966T3 GR 990403059 T GR990403059 T GR 990403059T GR 990403059 T GR990403059 T GR 990403059T GR 3031966 T3 GR3031966 T3 GR 3031966T3
Authority
GR
Greece
Prior art keywords
tetrahydrocannabinol
oic acids
oic
acids
thc
Prior art date
Application number
GR990403059T
Other languages
Greek (el)
Inventor
Sumner H Burstein
Raphael Mechoulam
Original Assignee
Burstein Sumner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burstein Sumner filed Critical Burstein Sumner
Publication of GR3031966T3 publication Critical patent/GR3031966T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Tires In General (AREA)
  • Glass Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Non-psychoactive derivatives of DELTA 6-THC-7-oic acid are described which have analgesic and anti-inflammatory properties.
GR990403059T 1992-07-14 1999-11-25 (3R,4R)--g(D)?6 -TETRAHYDROCANNABINOL-7-OIC ACIDS. GR3031966T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/913,096 US5338753A (en) 1992-07-14 1992-07-14 (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
PCT/US1993/006580 WO1994001429A1 (en) 1992-07-14 1993-07-13 (3r,4r)-δ6-tetrahydrocannabinol-7-oic acids

Publications (1)

Publication Number Publication Date
GR3031966T3 true GR3031966T3 (en) 2000-03-31

Family

ID=25432922

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990403059T GR3031966T3 (en) 1992-07-14 1999-11-25 (3R,4R)--g(D)?6 -TETRAHYDROCANNABINOL-7-OIC ACIDS.

Country Status (12)

Country Link
US (1) US5338753A (en)
EP (1) EP0650483B1 (en)
JP (1) JP3278159B2 (en)
KR (1) KR100289202B1 (en)
AT (1) ATE183744T1 (en)
AU (1) AU676845B2 (en)
CA (1) CA2140368C (en)
DE (1) DE69326149T2 (en)
DK (1) DK0650483T3 (en)
ES (1) ES2138626T3 (en)
GR (1) GR3031966T3 (en)
WO (1) WO1994001429A1 (en)

Families Citing this family (50)

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US5635530A (en) * 1991-09-12 1997-06-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them
IL115245A (en) 1995-09-11 2002-12-01 Yissum Res Dev Co Tumor necrosis factor inhibiting pharmaceuticals
US6132762A (en) * 1997-05-05 2000-10-17 Cristobal; Walter Transcutaneous application of marijuana
US6162829A (en) 1997-10-17 2000-12-19 Atlantic Pharmaceuticals, Inc. (3R,4R)-Δ8 -tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics
GB9807639D0 (en) * 1998-04-14 1998-06-10 Kennedy Rheumatology Inst Anti-inflammatory agents
US5847128A (en) * 1998-05-29 1998-12-08 Virginia Commonwealth University Water soluble derivatives of cannabinoids
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
AU3910700A (en) 1999-03-22 2000-10-09 Immugen Pharmaceuticals, Inc. Treatment of immune diseases
US6448288B1 (en) * 2000-05-17 2002-09-10 University Of Massachusetts Cannabinoid drugs
WO2002026728A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
US7507767B2 (en) * 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
US7067539B2 (en) * 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
WO2003007876A2 (en) * 2001-06-25 2003-01-30 University Of Massachusetts N-fatty acid-amino acid conjugates and therapeutic uses
JP4202250B2 (en) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド Compositions and methods for modulating blood brain barrier transport
WO2003042174A1 (en) 2001-11-14 2003-05-22 Schering Corporation Cannabinoid receptor ligands
PT1477186E (en) 2002-02-19 2010-02-11 Shionogi & Co Antipruritics
WO2003080043A1 (en) * 2002-03-18 2003-10-02 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
CA2487346A1 (en) 2002-06-19 2003-12-31 Schering Corporation Cannabinoid receptor agonists
WO2004048322A1 (en) 2002-11-25 2004-06-10 Schering Corporation Cannabinoid receptor ligands
WO2004058251A1 (en) * 2002-12-19 2004-07-15 University Of Massachusetts Cannabinoid analogs as peroxisome proliferator activated nuclear receptor gamma activators
AR043633A1 (en) * 2003-03-20 2005-08-03 Schering Corp CANABINOID RECEIVERS LINKS
US20050070596A1 (en) * 2003-05-12 2005-03-31 David Baker Methods for treatment of inflammatory diseases using CT-3 or analogs thereof
US6916852B2 (en) * 2003-05-12 2005-07-12 University Of Tennessee Research Foundation Method for regulation of microvascular tone
WO2005019811A2 (en) * 2003-08-26 2005-03-03 Blueshift Biotechnologies, Inc. Time dependent fluorescence measurements
US20050264805A1 (en) * 2004-02-09 2005-12-01 Blueshift Biotechnologies, Inc. Methods and apparatus for scanning small sample volumes
DE602005016929D1 (en) * 2004-06-22 2009-11-12 Schering Corp LIGANDS FOR CANNABINOID RECEPTORS
JP2008505321A (en) 2004-07-02 2008-02-21 ブルーシフト・バイオテクノロジーズ・インコーポレーテッド Search for phosphor microenvironment
US7544714B2 (en) * 2004-07-16 2009-06-09 University Of Massachusetts Lipid-amino acid conjugates and methods of use
WO2006065792A2 (en) * 2004-12-13 2006-06-22 Indevus Pharmaceuticals, Inc. Treatment of interstitial cystitis using cannabinoid analogs
WO2006065793A2 (en) * 2004-12-13 2006-06-22 Indevus Pharmaceuticals, Inc. TREATMENT OF INTERSTITIAL CYSTITIS USING (6aR,10aR)-Δ8-TETRAHYDROCANNABINOL-11-OIC ACIDS
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
US20070037873A1 (en) * 2005-08-08 2007-02-15 Zurier Robert B Airway remodeling treatments
EP2578577A1 (en) 2005-09-29 2013-04-10 Albany Molecular Research, Inc. Sulfonyl esters of tetrahydrocannabinol and derivatives thereof
US20070093519A1 (en) * 2005-10-20 2007-04-26 Indevus Pharmaceuticals, Inc. Anti-emetic uses of cannabinoid analogs
WO2007055806A1 (en) * 2005-10-31 2007-05-18 Indevus Pharmaceuticals, Inc. Anti-emetic uses of (3r,4r)-δ8-tetrahydrocannabinol-11-oic acids
CN101594878A (en) 2006-09-18 2009-12-02 雷普特药品公司 Treatment of liver disorders by administration of receptor-associated protein (RAP)-conjugates
DK3395372T3 (en) 2009-02-20 2022-04-19 Enhanx Biopharm Inc Glutathione-based drug delivery system
CN110075069A (en) 2009-05-06 2019-08-02 实验室护肤股份有限公司 Include activating agent-calcium phosphate granules compound dermal delivery composition and its application
US9066910B2 (en) * 2010-04-15 2015-06-30 Steven Rosenblatt Methods and compositions of cannabis extracts
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
JP6689078B2 (en) 2013-02-12 2020-04-28 コーバス ファーマシューティカルズ インク． Ultra high purity tetrahydrocannabinol-11-acid
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
JP2022545491A (en) 2019-08-22 2022-10-27 イーピーエム（アイピー）， インコーポレイテッド Cannabinoid acid ester compositions and uses thereof
JP2022551863A (en) * 2019-10-11 2022-12-14 コーバス ファーマシューティカルズ インコーポレーテッド Compositions of ajulemic acid and uses thereof
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973603A (en) * 1988-06-16 1990-11-27 Sumner Burstein Platelet activating factor antagonist and methods of use therefor
IL99468A (en) * 1991-09-12 1997-09-30 Yissum Res Dev Co (3s, 4s)-delta- 6-tetrahydrocannabinol- 7-oic acids and derivatives thereof, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US5338753A (en) 1994-08-16
CA2140368C (en) 2004-04-27
JPH08500096A (en) 1996-01-09
CA2140368A1 (en) 1994-01-20
EP0650483A4 (en) 1995-05-10
EP0650483A1 (en) 1995-05-03
ES2138626T3 (en) 2000-01-16
KR950702549A (en) 1995-07-29
AU676845B2 (en) 1997-03-27
DK0650483T3 (en) 2000-03-27
ATE183744T1 (en) 1999-09-15
KR100289202B1 (en) 2001-05-02
AU4675993A (en) 1994-01-31
DE69326149T2 (en) 2000-04-27
DE69326149D1 (en) 1999-09-30
WO1994001429A1 (en) 1994-01-20
HK1010690A1 (en) 1999-06-25
JP3278159B2 (en) 2002-04-30
EP0650483B1 (en) 1999-08-25

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