GR3031095T3 - 3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION. - Google Patents

3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION.

Info

Publication number: GR3031095T3
Authority: GR; Greece
Prior art keywords: carboxamides; alkyloxy; aryloxy; arylalkyloxybenzo; thiophene
Prior art date: 1992-02-24

Application number

GR990402178T

Other languages

English (en)

Inventor

Diane Boschelli

David Thomas Connor

Clifford Dean Wright

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-24

Filing date

1999-08-26

Publication date

1999-12-31

1992-02-24 Priority claimed from US07/840,361 external-priority patent/US5208253A/en

1999-08-26 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1999-12-31 Publication of GR3031095T3 publication Critical patent/GR3031095T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)

GR990402178T 1992-02-24 1999-08-26 3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION. GR3031095T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/840,361 US5208253A (en)	1992-02-24	1992-02-24	3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion
US08/015,005 US5356926A (en)	1992-02-24	1993-02-09	3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
PCT/US1993/001672 WO1993017008A1 (en)	1992-02-24	1993-02-23	3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO[b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION

Publications (1)

Publication Number	Publication Date
GR3031095T3 true GR3031095T3 (en)	1999-12-31

Family

ID=26686829

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR990402178T GR3031095T3 (en)	1992-02-24	1999-08-26	3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION.

Country Status (18)

Country	Link
US (1)	US5356926A (el)
EP (2)	EP0628038B1 (el)
JP (1)	JP3329460B2 (el)
AT (2)	ATE239718T1 (el)
AU (1)	AU665631B2 (el)
CA (1)	CA2128701A1 (el)
CZ (1)	CZ290968B6 (el)
DE (2)	DE69332961T2 (el)
DK (2)	DK0628038T3 (el)
ES (2)	ES2198639T3 (el)
FI (1)	FI943850A7 (el)
GR (1)	GR3031095T3 (el)
HU (1)	HUT68655A (el)
NO (1)	NO307051B1 (el)
NZ (1)	NZ249756A (el)
PT (1)	PT916666E (el)
RU (1)	RU2117665C1 (el)
WO (1)	WO1993017008A1 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4317076A1 (de) *	1993-05-21	1994-11-24	Bayer Ag	Benzthiophencarbonsäureamid-S-oxide
US5484808A (en) *	1995-02-09	1996-01-16	Eli Lilly And Company	Methods of inhibiting cell-cell adhesion
DE19642451A1 (de) *	1996-10-15	1998-04-16	Merck Patent Gmbh	Aminothiophencarbonsäureamide
TR199901280T2 (xx) *	1996-12-13	1999-10-21	Shionogi & Co., Ltd.	Benzotiofenekarboksamid t�revleri ve bunlar� i�eren PGD2 antagonistleri.
FR2777886B1 (fr) *	1998-04-27	2002-05-31	Adir	Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2001277731A1 (en)	2000-08-09	2002-02-18	Welfide Corporation	Fused bicyclic amide compounds and medicinal use thereof
AR037097A1 (es)	2001-10-05	2004-10-20	Novartis Ag	Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
RU2316591C2 (ru) *	2001-11-09	2008-02-10	Джорджтаун Юниверсити	Новые изоформы ингибитора роста васкулярных эндотелиальных клеток
JP2005194192A (ja) *	2002-01-11	2005-07-21	Meiji Seika Kaisha Ltd	（４−オキソピペリジン−１−イル）安息香酸誘導体およびこれを用いたインテグリンαｖβ３阻害剤の製造法
US7674822B2 (en) *	2004-11-24	2010-03-09	Wyeth	PTP1b inhibitors
WO2006101454A1 (en) *	2005-03-21	2006-09-28	S*Bio Pte Ltd	Benzothiophene derivatives: preparation and pharmaceutical applications

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4703053A (en) *	1985-10-28	1987-10-27	Warner-Lambert Company	Benzothiophenes and benzofurans and antiallergic use thereof
US4761424A (en) *	1985-10-01	1988-08-02	Warner-Lambert Company	Enolamides, pharmaceutical compositions and methods for treating inflammation
US4800211A (en) *	1986-08-18	1989-01-24	Merck & Co., Inc.	5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors
DE3832848A1 (de) *	1988-09-28	1990-03-29	Bayer Ag	Benzothiophen-2-carboxamid-s,s-dioxide
DE3832846A1 (de) *	1988-09-28	1990-03-29	Bayer Ag	Verwendung von benzothiophen-2-carboxamid-s,s-dioxiden zur behandlung von krankheiten
WO1995005170A1 (en) *	1993-08-13	1995-02-23	Warner-Lambert Company	Methods of inhibiting hiv and inhibiting the activation of hiv

1993
- 1993-02-09 US US08/015,005 patent/US5356926A/en not_active Expired - Fee Related
- 1993-02-23 CA CA002128701A patent/CA2128701A1/en not_active Abandoned
- 1993-02-23 HU HU9402421A patent/HUT68655A/hu unknown
- 1993-02-23 PT PT98123718T patent/PT916666E/pt unknown
- 1993-02-23 DE DE69332961T patent/DE69332961T2/de not_active Expired - Fee Related
- 1993-02-23 ES ES98123718T patent/ES2198639T3/es not_active Expired - Lifetime
- 1993-02-23 AT AT98123718T patent/ATE239718T1/de not_active IP Right Cessation
- 1993-02-23 AT AT93906217T patent/ATE182890T1/de not_active IP Right Cessation
- 1993-02-23 FI FI943850A patent/FI943850A7/fi not_active IP Right Cessation
- 1993-02-23 RU RU94045150A patent/RU2117665C1/ru not_active IP Right Cessation
- 1993-02-23 AU AU37331/93A patent/AU665631B2/en not_active Ceased
- 1993-02-23 ES ES93906217T patent/ES2137253T3/es not_active Expired - Lifetime
- 1993-02-23 DK DK93906217T patent/DK0628038T3/da active
- 1993-02-23 DK DK98123718T patent/DK0916666T3/da active
- 1993-02-23 EP EP93906217A patent/EP0628038B1/en not_active Expired - Lifetime
- 1993-02-23 DE DE69325899T patent/DE69325899T2/de not_active Expired - Fee Related
- 1993-02-23 WO PCT/US1993/001672 patent/WO1993017008A1/en not_active Ceased
- 1993-02-23 NZ NZ249756A patent/NZ249756A/en unknown
- 1993-02-23 EP EP98123718A patent/EP0916666B1/en not_active Expired - Lifetime
- 1993-02-23 CZ CZ19942017A patent/CZ290968B6/cs not_active IP Right Cessation
- 1993-02-23 JP JP51506593A patent/JP3329460B2/ja not_active Expired - Fee Related
1994
- 1994-08-24 NO NO943126A patent/NO307051B1/no not_active IP Right Cessation
1999
- 1999-08-26 GR GR990402178T patent/GR3031095T3/el unknown

Also Published As

Publication number	Publication date
CZ9402017A3 (en)	1995-04-12
AU3733193A (en)	1993-09-13
RU94045150A (ru)	1996-08-10
ATE239718T1 (de)	2003-05-15
NO943126D0 (no)	1994-08-24
EP0916666A1 (en)	1999-05-19
DK0916666T3 (da)	2003-09-01
DE69325899D1 (de)	1999-09-09
FI943850A0 (fi)	1994-08-22
DE69332961D1 (de)	2003-06-12
EP0916666B1 (en)	2003-05-07
HUT68655A (en)	1995-07-28
FI943850L (fi)	1994-10-19
CA2128701A1 (en)	1993-09-02
ATE182890T1 (de)	1999-08-15
FI943850A7 (fi)	1994-10-19
NO943126L (no)	1994-08-24
ES2137253T3 (es)	1999-12-16
DE69332961T2 (de)	2004-03-11
ES2198639T3 (es)	2004-02-01
EP0628038A1 (en)	1994-12-14
JP3329460B2 (ja)	2002-09-30
JPH07504199A (ja)	1995-05-11
AU665631B2 (en)	1996-01-11
NO307051B1 (no)	2000-01-31
EP0628038B1 (en)	1999-08-04
CZ290968B6 (cs)	2002-11-13
NZ249756A (en)	1996-05-28
DE69325899T2 (de)	2000-02-24
HU9402421D0 (en)	1994-10-28
US5356926A (en)	1994-10-18
RU2117665C1 (ru)	1998-08-20
WO1993017008A1 (en)	1993-09-02
DK0628038T3 (da)	2000-02-28
PT916666E (pt)	2003-08-29

Publication	Publication Date	Title
HU9602451D0 (en)	1996-11-28	Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv
OA09785A (en)	1994-04-15	Antiviral or antibacterial compound and method of use
EP0675899A4 (en)	1996-01-24	NEW INHIBITORS FROM FACTOR Xa.
RU94038043A (ru)	1996-11-20	Применение замещенных производных аденина для лечения множественного склероза
GR3033103T3 (en)	2000-08-31	Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases
AU3496297A (en)	1998-01-14	Anticoagulant agents
GR3031095T3 (en)	1999-12-31	3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION.
NZ331484A (en)	2000-01-28	Serine protease inhibitors having an alkynylamino side chain for use in treatment of thrombin related diseases
ATE220904T1 (de)	2002-08-15	2-phenyl-3-azoylbenzothiophene zur erhöhung der thrombomodulin expression
GR3018304T3 (en)	1996-03-31	Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones.
DE69500511D1 (de)	1997-09-11	Phosphatdiester zur Behandlung von proliferativen Erkrankungen der Epidermis
ATE161725T1 (de)	1998-01-15	Verwendung von phosphatdiestern zur behandlung von erkrankungen der retina
HUT56559A (en)	1991-09-30	Process for producing ascorbinic acid derivatives and pharma
MY115877A (en)	2003-09-30	Cyclopeptolides
MX9602996A (es)	1998-01-31	Benzotiofeno, benzofurano e indolo-tiazepinones, oxazepinones y diazepinones como inhibidores de la adhesion celular y como inhibidores de vih.