GR3021607T3 - Azatetracyclic compounds - Google Patents

Azatetracyclic compounds

Info

Publication number: GR3021607T3
Authority: GR; Greece
Prior art keywords: compounds; chem; azatetracyclic; azatetracyclic compounds; mammals
Prior art date: 1990-04-27

Application number

GR960402848T

Other languages

English (en)

Inventor

Daniel Paul Becker

Daniel Lee Flynn

Roger Nosal

Dale P Spangler

Daniel Lamar Zabrowski

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-27

Filing date

1996-11-14

Publication date

1997-02-28

1996-11-14 Application filed by Searle & Co filed Critical Searle & Co

1997-02-28 Publication of GR3021607T3 publication Critical patent/GR3021607T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Anesthesiology (AREA)
Nutrition Science (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

GR960402848T 1990-04-27 1996-11-14 Azatetracyclic compounds GR3021607T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US51539190A	1990-04-27	1990-04-27
US07/682,993 US5140023A (en)	1990-04-27	1991-04-12	Azatetracycle compounds

Publications (1)

Publication Number	Publication Date
GR3021607T3 true GR3021607T3 (en)	1997-02-28

Family

ID=27058488

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR960402848T GR3021607T3 (en)	1990-04-27	1996-11-14	Azatetracyclic compounds

Country Status (18)

Country	Link
US (2)	US5140023A (el)
EP (1)	EP0454121B1 (el)
JP (1)	JP3145728B2 (el)
KR (1)	KR0183423B1 (el)
AT (1)	ATE145207T1 (el)
AU (1)	AU630555B2 (el)
CA (1)	CA2041224C (el)
DE (1)	DE69123076T2 (el)
DK (1)	DK0454121T3 (el)
ES (1)	ES2094166T3 (el)
FI (1)	FI94530C (el)
GR (1)	GR3021607T3 (el)
IE (1)	IE76450B1 (el)
IL (1)	IL97952A0 (el)
NO (1)	NO178765C (el)
NZ (1)	NZ237948A (el)
PT (1)	PT97486B (el)
ZA (1)	ZA913135B (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5516782A (en) *	1991-03-07	1996-05-14	G. D. Searle & Co.	New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
AU1578692A (en) *	1991-03-07	1992-10-06	G.D. Searle & Co.	New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5234921A (en) *	1991-03-07	1993-08-10	G. D. Searle & Co.	Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals
US5955470A (en) *	1991-06-11	1999-09-21	Merrell Pharmaceuticals, Inc.	Derivatives of amide analogs of certain methano bridged quinolizines
US5280028A (en) *	1992-06-24	1994-01-18	G. D. Searle & Co.	Benzimidazole compounds
GB9214184D0 (en) *	1992-07-03	1992-08-12	Smithkline Beecham Plc	Pharmaceuticals
US5840903A (en) *	1992-07-27	1998-11-24	G. D. Searle & Co.	4-aminomethyl-1-azaadamantane derived benzamides
US5354757A (en) *	1992-12-15	1994-10-11	G. D. Searle & Co.	Azanoradamantanes
US5541344A (en) *	1994-06-30	1996-07-30	G. D. Searle & Co.	Intermediates useful in a process for the preparation of azanoradamantane benzamides
JP2000026311A (ja) *	1998-07-02	2000-01-25	Amano Pharmaceut Co Ltd	胃排出能亢進剤組成物
US6451806B2 (en)	1999-09-29	2002-09-17	Adolor Corporation	Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en)	1999-11-29	2002-10-22	Adolor Corporation	Methods for the treatment and prevention of ileus
US6638928B1 (en) *	2002-12-03	2003-10-28	Vela Pharmaceuticals, Inc.	Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
GB0321091D0 (en) *	2003-09-09	2003-10-08	Alizyme Therapeutics Ltd	Synthesis
CN101686680B (zh)	2007-03-09	2015-12-09	伊沃泰克美国股份有限公司	作为p2x7调节剂的双环杂芳基化合物及其用途
ES2363998T3 (es) *	2007-03-23	2011-08-22	Abbott Laboratories	Derivados ester y carbamato de azaadamantano y métodos de uso de los mismos.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL59004A0 (en) *	1978-12-30	1980-03-31	Beecham Group Ltd	Substituted benzamides their preparation and pharmaceutical compositions containing them
EP0076592B1 (en) *	1981-10-01	1987-01-28	Beecham Group Plc	Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
EP0093488A3 (en) *	1982-03-18	1984-05-23	Beecham Group Plc	Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
NZ203861A (en) *	1982-04-14	1986-07-11	Beecham Group Plc	Bicyclic heterocyclic compounds and pharmaceutical compositions containing such
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
BG48681A3 (bg) *	1982-12-14	1991-04-15	Ciba - Geigy Ag	Фунгицидно средство
WO1985001048A1 (en) *	1983-08-26	1985-03-14	Sandoz Ag	Aromatic esters or amides of carboxylic acid and sulfonic acid
FR2557110B1 (fr) *	1983-12-23	1989-11-24	Sandoz Sa	Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
ATE86110T1 (de) *	1984-12-20	1993-03-15	Sandoz Ag	Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
CH667657A5 (de) *	1985-01-07	1988-10-31	Sandoz Ag	Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
EP0201165B1 (en) *	1985-03-14	1994-07-20	Beecham Group Plc	Medicaments for the treatment of emesis
GB8523211D0 (en) *	1985-09-19	1985-10-23	Beecham Group Plc	Compounds
EP0220011A3 (en) *	1985-10-12	1990-01-03	Beecham Group Plc	Use of azabicloalkylbenzamides in the treatment of gastrointestinal motility disorders, migraine, emesis, cluster headaches, trigeminal neuralgia and arrhythmia
GB8527052D0 (en) *	1985-11-02	1985-12-04	Beecham Group Plc	Compounds
ES2053451T3 (es) *	1986-01-07	1994-08-01	Beecham Group Plc	Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
EP0235878A3 (en) *	1986-01-16	1989-06-14	Beecham Group Plc	Novel compounds
EP0315390B1 (en) *	1987-11-04	1994-07-20	Beecham Group Plc	Novel 4-oxobenzotriazines and 4-oxoquinazolines
IE63474B1 (en) *	1987-12-24	1995-04-19	Wyeth John & Brother Ltd	Heterocyclic compounds

1991
- 1991-04-12 US US07/682,993 patent/US5140023A/en not_active Ceased
- 1991-04-25 DE DE69123076T patent/DE69123076T2/de not_active Expired - Fee Related
- 1991-04-25 AT AT91106697T patent/ATE145207T1/de not_active IP Right Cessation
- 1991-04-25 ZA ZA913135A patent/ZA913135B/xx unknown
- 1991-04-25 EP EP91106697A patent/EP0454121B1/en not_active Expired - Lifetime
- 1991-04-25 KR KR1019910006678A patent/KR0183423B1/ko not_active Expired - Fee Related
- 1991-04-25 DK DK91106697.5T patent/DK0454121T3/da active
- 1991-04-25 IL IL97952A patent/IL97952A0/xx not_active IP Right Cessation
- 1991-04-25 NO NO911648A patent/NO178765C/no unknown
- 1991-04-25 FI FI912013A patent/FI94530C/fi not_active IP Right Cessation
- 1991-04-25 CA CA002041224A patent/CA2041224C/en not_active Expired - Fee Related
- 1991-04-25 ES ES91106697T patent/ES2094166T3/es not_active Expired - Lifetime
- 1991-04-26 JP JP09676191A patent/JP3145728B2/ja not_active Expired - Fee Related
- 1991-04-26 NZ NZ237948A patent/NZ237948A/en unknown
- 1991-04-26 AU AU75951/91A patent/AU630555B2/en not_active Ceased
- 1991-04-26 PT PT97486A patent/PT97486B/pt not_active IP Right Cessation
- 1991-04-26 IE IE142091A patent/IE76450B1/en not_active IP Right Cessation
1994
- 1994-08-18 US US08/292,894 patent/USRE35218E/en not_active Expired - Lifetime
1996
- 1996-11-14 GR GR960402848T patent/GR3021607T3/el unknown

Also Published As

Publication number	Publication date
NO178765B (no)	1996-02-19
USRE35218E (en)	1996-04-23
EP0454121B1 (en)	1996-11-13
NO911648D0 (no)	1991-04-25
AU7595191A (en)	1991-11-07
NZ237948A (en)	1994-05-26
FI912013A0 (fi)	1991-04-25
US5140023A (en)	1992-08-18
DK0454121T3 (da)	1996-12-02
EP0454121A3 (en)	1992-07-08
JP3145728B2 (ja)	2001-03-12
JPH04225979A (ja)	1992-08-14
DE69123076T2 (de)	1997-04-03
DE69123076D1 (de)	1996-12-19
ATE145207T1 (de)	1996-11-15
CA2041224A1 (en)	1991-10-28
AU630555B2 (en)	1992-10-29
FI94530B (fi)	1995-06-15
NO178765C (no)	1996-05-29
EP0454121A2 (en)	1991-10-30
FI94530C (fi)	1995-09-25
IE76450B1 (en)	1997-10-22
CA2041224C (en)	2002-07-09
ES2094166T3 (es)	1997-01-16
IL97952A0 (en)	1992-06-21
KR0183423B1 (ko)	1999-05-01
KR910018382A (ko)	1991-11-30
PT97486A (pt)	1992-01-31
ZA913135B (en)	1992-07-29
PT97486B (pt)	1998-08-31
IE911420A1 (en)	1991-11-06
NO911648L (no)	1991-10-28
FI912013L (fi)	1991-10-28

Publication	Publication Date	Title
EP0454121A3 (en)	1992-07-08	Azatetracyclic compounds
FI915920A0 (fi)	1991-12-16	Serotoninantagonister.
TW269678B (el)	1996-02-01
EP0525197A4 (en)	1993-04-07	3-benzylidene-1-carbamoyl-2-pyrrolidone analog
FI933641A0 (fi)	1993-08-18	Substituerade bensylaminoderivat, vilka innehaoller en kvaevehaltig icke-aromatisk heterocyklisk grupp
ZA935892B (en)	1994-03-10	Novel 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
GR3036070T3 (en)	2001-09-28	New process for the production of cephalosporines and novel intermediates in this process.
PL308545A1 (en)	1995-08-21	Novel substituted azethydinones as anti-inflammatory and anti-degenerative agents
IL94027A0 (en)	1991-01-31	Diaminoethylene compounds
GB9302046D0 (en)	1993-03-24	Antiumoral compound-v
NO913769D0 (no)	1991-09-25	Forbindelse, fremstilling og anvendelse.
DK325188D0 (da)	1988-06-15	Hidtil ukendte benzazepinderivater
HU906010D0 (en)	1991-03-28	New substituted alkyl-piperidine derivatives
EP0601191A4 (en)	1994-08-17	Novel tetracyclic compound.
IL89324A0 (en)	1989-09-10	Therapeutic agents for the treatment of peptic ulcer disease containing xanthine derivatives
IT1252039B (it)	1995-05-29	Policondensati della 2,4,6-triammino-1,3,5-triazina come agenti antifiamma
GR3006438T3 (el)	1993-06-21
FI901277A0 (fi)	1990-03-14	2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
IL98919A0 (en)	1992-07-15	Substituted piperidines and their use as inhibitors of cholesterol synthesis
EP0357109A3 (en)	1990-12-19	Platinum-(ii)-diamine complex, method for the preparation of this compound, preparation with an anti-tumour action which contains this compound and also shaped preparations with an anti-tumour action
GR3007091T3 (el)	1993-07-30
DK0381114T3 (da)	1994-10-24	Exo-3,4-O-benzyliden-3"-demethylchartreusin og salte deraf
ZW15387A1 (en)	1987-11-18	Dopamine-b-hydroxylase inhibitors
EP0258009A3 (en)	1989-04-26	2,6-bis(chloromethyloxycarbonyloxymethyl)pyridine