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GR20000100283A - Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer - Google Patents

Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Info

Publication number
GR20000100283A
GR20000100283A GR20000100283A GR2000100283A GR20000100283A GR 20000100283 A GR20000100283 A GR 20000100283A GR 20000100283 A GR20000100283 A GR 20000100283A GR 2000100283 A GR2000100283 A GR 2000100283A GR 20000100283 A GR20000100283 A GR 20000100283A
Authority
GR
Greece
Prior art keywords
treatment
thrombosis
cancer
thrombin receptor
s42fllr46
Prior art date
Application number
GR20000100283A
Other languages
Greek (el)
Other versions
GR1003885B (en
Inventor
Κωνσταντινος Αλεξοπουλος
Δημητριος Βλαχακος
Μιχαηλ Μαραγκουδακης
Ιωαννης Ματσουκας
Original Assignee
Κωνσταντινος Αλεξοπουλος
Δημητριος Βλαχακος
Μιχαηλ Μαραγκουδακης
Ιωαννης Ματσουκας
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Κωνσταντινος Αλεξοπουλος, Δημητριος Βλαχακος, Μιχαηλ Μαραγκουδακης, Ιωαννης Ματσουκας filed Critical Κωνσταντινος Αλεξοπουλος
Priority to GR20000100283A priority Critical patent/GR20000100283A/en
Publication of GR1003885B publication Critical patent/GR1003885B/en
Publication of GR20000100283A publication Critical patent/GR20000100283A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

he invention relates to novel non peptide compounds (mimetics) based on a thrombin receptor sequence and novel methods for the synthesis of these compounds. These compounds act as agonists or antagonists in a variety of cells including endothelial cells, blood platelets, vascular smooth muscle cells and tumor cells. They are useful in the treatment of thrombosis and cardiovascular diseases and modulation of angiogenesis for cancer treatment or wound healing.
GR20000100283A 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer GR20000100283A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20000100283A GR20000100283A (en) 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20000100283A GR20000100283A (en) 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Publications (2)

Publication Number Publication Date
GR1003885B GR1003885B (en) 2002-05-09
GR20000100283A true GR20000100283A (en) 2002-05-24

Family

ID=10944358

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000100283A GR20000100283A (en) 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Country Status (1)

Country Link
GR (1) GR20000100283A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510726A (en) * 2004-08-20 2008-04-10 エントレメッド インコーポレイテッド Compositions and methods comprising proteinase activated receptor antagonists
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
CA3146857A1 (en) 2019-07-11 2021-01-14 Praxis Precision Medicines, Inc. Formulations of t-type calcium channel modulators and methods of use thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ALEXOPOULOS, KOSTAS ET AL: "A comparative SAR study of thrombin receptor derived non peptide mimetics. Importance of phenyl/guanidino proximity for activity", AMINO ACIDS (1998), 15(3), 211-220, XP001010683 *
ALEXOPOULOS, KOSTAS ET AL: "Design and synthesis of thrombin receptor-derived nonpeptide mimetics utilizing a piperazine scaffold", BIOORG. MED. CHEM. (1999), 7(6), 1033-1041, XP001010695 *
ALEXOPOULOS, KOSTAS ET AL: "Design, Synthesis, and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide Analogues of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH2 Cluster for Receptor Activation and Implications in the Design of Nonpeptide Thromb", J. MED. CHEM. (2001), 44(3), 328-339, XP002177978 *
ALEXOPOULOS, KOSTAS ET AL: "Synthesis and biological activities of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activity", PEPT. 1998, PROC. EUR. PEPT. SYMP., 25TH (1999), MEETING DATE 1998. EDITOR(S): BAJUSZ, SANDOR;HUDECZ, FERENC. PUBLISHER: AKADEMIAI KIADO, BUDAPEST, HUNG., pages 650 - 651, XP001015506 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MATSOUKAS, JOHN ET AL: "Conformational analysis of the thrombin receptor agonist peptides SFLLR and SFLLR-NH2 by NMR: evidence for a cyclic bioactive conformation", XP002177980, retrieved from STN Database accession no. 126:340655 *
J. PROTEIN CHEM. (1997), 16(2), 113-131 *
MISSIRLIS, ELEFTHERIA ET AL: "Peptidomimetic thrombin receptor analogs: effects on angiogenesis and metalloproteinase activation in endothelial cells", BIOMED. HEALTH RES. (1999), 22(BIOACTIVE PEPTIDES IN DRUG DISCOVERY AND DESIGN: MEDICAL ASPECTS), 71-79, XP001015504 *

Also Published As

Publication number Publication date
GR1003885B (en) 2002-05-09

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