GR1000522B - Preparation method of new analogue nucleozites - Google Patents
Preparation method of new analogue nucleozitesInfo
- Publication number
- GR1000522B GR1000522B GR880100685A GR880100685A GR1000522B GR 1000522 B GR1000522 B GR 1000522B GR 880100685 A GR880100685 A GR 880100685A GR 880100685 A GR880100685 A GR 880100685A GR 1000522 B GR1000522 B GR 1000522B
- Authority
- GR
- Greece
- Prior art keywords
- nucleozites
- preparation
- anaraka
- ch2oh
- och3
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Μια ένωση του τύπου (χημικός τύπος) όπου οι ρίζες A, X, R1, R2και R3 ορίζονται όπως ακολου?εί: A: (χημικός τύπος) X: (a) O (β) S (γ) R1:H, αλκύλιο που περιέχει 1-3 άτομα άν?ρακα (χημικοί τύποι) R2:h ή R2: αποτελεί μαζί με R3 ένα δεσμό άν?ρακα-άν?ρακα R3:H, F, Cl, Br, I, N3, N-CH, OH, OCH3, CH2OH και όταν R3 είναι F, Cl, Br, I, N3, CN, C-CH, OH, OCH3 ή CH2OH μπορεί να έχει είτε την CIS-απεικόνιση ή την TRANS-απεικόνιση σε σχέση με την χαρακτηριστική ομάδα υδροξυμε?υλίου στην ?έση 4', ή R3 αποτελεί μαζί με R2 ένα δεσμό άν?ρακα- άν?ρακα, και ?εραπευτικά αποδεκτά αλάτια της, για χρήση σε ?εραπεία ειδικά για την αγωγή μολύνσεων του HIV. ωA compound of the formula (chemical formula) wherein the radicals A, X, R1, R2 and R3 are defined as follows: A: (chemical formula) X: (a) O (b) S (c) R1:H, alkyl which contains 1-3 inorganic atoms (chemical formulas) R2:h or R2: forms together with R3 an inorganic-organic bond R3:H, F, Cl, Br, I, N3, N-CH, OH , OCH3, CH2OH and when R3 is F, Cl, Br, I, N3, CN, C-CH, OH, OCH3 or CH2OH it can have either the CIS-representation or the TRANS-representation with respect to the hydroxy group material in the 4' position, or R3 constitutes together with R2 an anaraka-anaraka bond, and therapeutically acceptable salts thereof, for use in therapy specifically for the treatment of HIV infections. oh
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR88100685 | 1988-10-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR880100685A GR880100685A (en) | 1990-11-29 |
| GR1000522B true GR1000522B (en) | 1992-08-25 |
Family
ID=10938871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR880100685A GR1000522B (en) | 1988-10-11 | 1988-10-11 | Preparation method of new analogue nucleozites |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR1000522B (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2930904A1 (en) * | 1979-07-30 | 1981-02-19 | Kailash Kumar Dr Gauri | Antitumour use of 5-alkyl-pyrimidine nucleoside derivs. - as potentiators of 5-fluoro-uracil |
| DE3002197A1 (en) * | 1980-01-22 | 1981-07-23 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia |
| DE3045375A1 (en) * | 1980-12-02 | 1982-07-01 | Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen | 5-Substd. pyrimidine nucleoside derivs. - useful as antiviral agents |
| EP0217580A3 (en) * | 1985-09-17 | 1990-11-07 | The Wellcome Foundation Limited | Therapeutic nucleosides |
| SE8704298D0 (en) * | 1987-11-03 | 1987-11-03 | Astra Ab | COMPOUNDS FOR USE IN THERAPY |
| SE8802687D0 (en) * | 1988-07-20 | 1988-07-20 | Astra Ab | NUCLEOSIDE DERIVATIVES |
-
1988
- 1988-10-11 GR GR880100685A patent/GR1000522B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR880100685A (en) | 1990-11-29 |
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