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GR1000245B - Μεθοδος παρασκευης ψυχοτροπων δικυκλικων ιμιδιων. - Google Patents

Μεθοδος παρασκευης ψυχοτροπων δικυκλικων ιμιδιων.

Info

Publication number
GR1000245B
GR1000245B GR880100215A GR880100215A GR1000245B GR 1000245 B GR1000245 B GR 1000245B GR 880100215 A GR880100215 A GR 880100215A GR 880100215 A GR880100215 A GR 880100215A GR 1000245 B GR1000245 B GR 1000245B
Authority
GR
Greece
Prior art keywords
carbon atoms
integers
preparation process
haloquinolyl
halopyrazin
Prior art date
Application number
GR880100215A
Other languages
English (en)
Other versions
GR880100215A (en
Inventor
Megid-Abdel Magid Gharbia-Abou
James Edward Podlesny
Paul Gary Stack
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of GR880100215A publication Critical patent/GR880100215A/el
Publication of GR1000245B publication Critical patent/GR1000245B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

Υποκατεστημένα ιμίδια του ακολούθου τύπου είναι αντιψυχωσικά, αγχολυτικά μέσα με πολύ μικρές εξωπυραμιδικές δράσεις: ω
GR880100215A 1987-04-03 1988-04-01 Μεθοδος παρασκευης ψυχοτροπων δικυκλικων ιμιδιων. GR1000245B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/034,525 US4748240A (en) 1987-04-03 1987-04-03 Psychotropic bicyclic imides

Publications (2)

Publication Number Publication Date
GR880100215A GR880100215A (en) 1989-01-31
GR1000245B true GR1000245B (el) 1992-05-12

Family

ID=21876959

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100215A GR1000245B (el) 1987-04-03 1988-04-01 Μεθοδος παρασκευης ψυχοτροπων δικυκλικων ιμιδιων.

Country Status (12)

Country Link
US (1) US4748240A (el)
EP (1) EP0309544B1 (el)
JP (1) JPH01502757A (el)
AT (1) ATE85614T1 (el)
AU (1) AU616656B2 (el)
CA (1) CA1335502C (el)
DE (1) DE3878371T2 (el)
ES (1) ES2009257A6 (el)
GB (1) GB2203431B (el)
GR (1) GR1000245B (el)
PT (1) PT87034B (el)
WO (1) WO1988007530A1 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601364B1 (fr) * 1986-07-09 1988-10-21 Adir Nouveaux derives de la piperazine dione-2,6, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides
US4804751A (en) * 1987-06-30 1989-02-14 American Home Products Corporation Polycyclic hydrocarbon succinimides with psychotropic activity
EP0350145A3 (en) * 1988-04-28 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. Pyridylthiazolidine carboxamide derivatives and their intermediates and production of both
US5242911A (en) * 1988-06-17 1993-09-07 Pfizer Inc. Bridged bicyclic imides as anxiolytics and antidepressants
WO1990002552A1 (en) * 1988-09-16 1990-03-22 Pfizer Inc. Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
ATE112769T1 (de) * 1988-12-28 1994-10-15 Suntory Ltd Benzoxazepinderivate.
US5053508A (en) * 1990-03-09 1991-10-01 American Home Products Corporation Fused heterotricyclic imides with psychotropic activity and intermedrates thereof
SU1825501A3 (ru) * 1990-10-29 1995-12-10 И.В. Комиссаров Dl-3-[(4-[4- (2-пиридил)-1- пиперазинил]бутил)] -1,8,8-триметил -3-азабицикло[3,2,1] октан-2,4-диона дигидрохлорид, проявляющий противотревожную, нейролептическую и противорвотную активность
IE914218A1 (en) * 1991-09-11 1993-03-24 Mcneilab Inc Novel 4-arylpiperazines and 4-arylpiperidines
JPH05345764A (ja) * 1991-11-26 1993-12-27 Asahi Chem Ind Co Ltd 新規アゼピン誘導体、その製造法およびその用途
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
CA2481888A1 (en) * 2002-04-08 2003-10-16 Ranbaxy Laboratories Limited Alpha, omega-dicarboximide derivatives as useful uro-selective a1a adrenoceptor blockers
US20060247249A1 (en) * 2005-11-16 2006-11-02 Mohammad Salman Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers
CN116813547A (zh) * 2023-06-29 2023-09-29 爱斯特（成都）生物制药股份有限公司 一种制备3-氮杂双环[3，2，1]辛烷盐酸盐的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4305944A (en) * 1980-09-08 1981-12-15 Mead Johnson & Company N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
GB2139217B (en) * 1983-02-07 1986-07-09 Bristol Myers Co Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound
JPS6087284A (ja) * 1983-10-19 1985-05-16 Sumitomo Chem Co Ltd コハク酸イミド誘導体及びその酸付加塩
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen

Also Published As

Publication number Publication date
GB2203431B (en) 1991-10-16
GB8807934D0 (en) 1988-05-05
JPH01502757A (ja) 1989-09-21
US4748240A (en) 1988-05-31
AU1594988A (en) 1988-11-02
GR880100215A (en) 1989-01-31
GB2203431A (en) 1988-10-19
AU616656B2 (en) 1991-11-07
DE3878371D1 (de) 1993-03-25
PT87034B (pt) 1992-07-31
ATE85614T1 (de) 1993-02-15
PT87034A (pt) 1988-04-01
EP0309544B1 (en) 1993-02-10
EP0309544A1 (en) 1989-04-05
ES2009257A6 (es) 1989-09-16
CA1335502C (en) 1995-05-09
DE3878371T2 (de) 1993-07-08
WO1988007530A1 (en) 1988-10-06

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