[go: up one dir, main page]

GC0000151A - 2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide. - Google Patents

2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide.

Info

Publication number
GC0000151A
GC0000151A GCP20001052A GC0000151A GC 0000151 A GC0000151 A GC 0000151A GC P20001052 A GCP20001052 A GC P20001052A GC 0000151 A GC0000151 A GC 0000151A
Authority
GC
Cooperation Council for the Arab states of the Gulf
Prior art keywords
isobutyramide
morpholin
pyridin
tolyl
trifluoromethyl
Prior art date
Application number
Other languages
English (en)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of GC0000151A publication Critical patent/GC0000151A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GCP20001052 1999-11-29 2000-11-26 2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide. GC0000151A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
GC0000151A true GC0000151A (en) 2005-06-29

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
GCP20001052 GC0000151A (en) 1999-11-29 2000-11-26 2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide.

Country Status (49)

Country Link
EP (1) EP1103545B1 (es)
JP (1) JP3480835B2 (es)
KR (1) KR100390117B1 (es)
CN (1) CN1152016C (es)
AR (1) AR033659A1 (es)
AT (1) ATE253561T1 (es)
AU (1) AU775292B2 (es)
BG (1) BG64622B1 (es)
BR (1) BRPI0005616B8 (es)
CA (1) CA2326529C (es)
CO (1) CO5251405A1 (es)
CZ (1) CZ299286B6 (es)
DE (2) DE60006340T2 (es)
DK (1) DK1103545T3 (es)
DO (1) DOP2000000106A (es)
EA (1) EA004404B1 (es)
ES (2) ES2208205T3 (es)
FR (1) FR2801590A1 (es)
GB (1) GB2356863A (es)
GC (1) GC0000151A (es)
GE (1) GEP20022763B (es)
GT (1) GT200000197A (es)
HR (1) HRP20000809A2 (es)
HU (1) HU224703B1 (es)
ID (1) ID28483A (es)
IL (1) IL139868A (es)
IS (1) IS2212B (es)
IT (1) IT1320120B1 (es)
JO (1) JO2298B1 (es)
MA (1) MA26754A1 (es)
MX (1) MXPA00011672A (es)
MY (1) MY127426A (es)
NO (1) NO317264B1 (es)
NZ (1) NZ508386A (es)
OA (1) OA11513A (es)
PA (1) PA8507201A1 (es)
PE (1) PE20010901A1 (es)
PL (1) PL195957B1 (es)
PT (1) PT1103545E (es)
SG (1) SG97171A1 (es)
SI (1) SI1103545T1 (es)
SK (1) SK285373B6 (es)
SV (1) SV2002000227A (es)
TN (1) TNSN00226A1 (es)
TR (1) TR200302077T4 (es)
UA (1) UA70326C2 (es)
UY (1) UY26458A1 (es)
YU (1) YU73400A (es)
ZA (1) ZA200006964B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0008489A (pt) 1999-02-24 2002-02-05 Hoffmann La Roche Derivados de fenil- e piridinila
DK1035115T3 (da) * 1999-02-24 2005-01-24 Hoffmann La Roche 4-phenylpyridinderivater og anvendelse deraf som NK-1-receptorantagonister
IL153834A0 (en) * 2000-07-14 2003-07-31 Hoffmann La Roche N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
RU2004126440A (ru) * 2002-01-31 2005-08-10 Ф.Хоффманн-Ля Рош Аг (Ch) Генетические полиморфизмы гена препротахикинина
CN1852712B (zh) 2003-07-03 2010-06-09 弗·哈夫曼-拉罗切有限公司 用于治疗精神分裂症的双重nk1/nk3拮抗剂
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
WO2006002860A1 (en) 2004-07-06 2006-01-12 F. Hoffmann-La Roche Ag Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists
RU2007129642A (ru) 2005-02-25 2009-03-27 Ф.Хоффманн-Ля Рош Аг (Ch) Таблетки с улучшенным распределением лекарственного вещества
WO2006099968A1 (en) 2005-03-23 2006-09-28 F. Hoffmann-La Roche Ag Metabolites for nk-i antagonists for emesis
CA2623237C (en) 2005-09-23 2013-07-09 F. Hoffmann-La Roche Ag Novel dosage formulation
CN101641099A (zh) 2007-01-24 2010-02-03 葛兰素集团有限公司 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
EA037091B1 (ru) 2013-03-15 2021-02-04 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
PL3067349T3 (pl) 2013-11-08 2018-06-29 Kissei Pharmaceutical Co., Ltd. Pochodna karboksymetylopiperydyny
CN114213390A (zh) 2014-02-07 2022-03-22 全球血液疗法股份有限公司 一种化合物的结晶多晶型物
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체
KR102328682B1 (ko) 2018-08-27 2021-11-18 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0916346A3 (en) * 1991-09-20 2000-12-06 Glaxo Group Limited NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
CA2099233A1 (en) * 1992-06-29 1993-12-30 Conrad P. Dorn Morpholine and thiomorpholine tachykinin receptor antagonists
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
CA2178219C (en) * 1993-12-29 2005-03-22 Raymond Baker Substituted morpholine derivatives and their use as therapeutic agents
TW385308B (en) * 1994-03-04 2000-03-21 Merck & Co Inc Prodrugs of morpholine tachykinin receptor antagonists
DE69628484T2 (de) * 1995-03-24 2004-05-19 Takeda Chemical Industries, Ltd. Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
DK1035115T3 (da) * 1999-02-24 2005-01-24 Hoffmann La Roche 4-phenylpyridinderivater og anvendelse deraf som NK-1-receptorantagonister
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
IL153834A0 (en) * 2000-07-14 2003-07-31 Hoffmann La Roche N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
JP3480835B2 (ja) 2003-12-22
SV2002000227A (es) 2002-02-05
UA70326C2 (en) 2004-10-15
MA26754A1 (fr) 2004-12-20
BRPI0005616B1 (pt) 2017-12-12
CO5251405A1 (es) 2003-02-28
CN1152016C (zh) 2004-06-02
BG64622B1 (bg) 2005-09-30
HU0004725D0 (es) 2001-02-28
AR033659A1 (es) 2004-01-07
GB2356863A (en) 2001-06-06
GT200000197A (es) 2002-05-22
EA004404B1 (ru) 2004-04-29
ES2171134A1 (es) 2002-08-16
IL139868A (en) 2009-09-01
GB0028566D0 (en) 2001-01-10
DE10058310A1 (de) 2001-05-31
ZA200006964B (en) 2001-06-05
EP1103545B1 (en) 2003-11-05
JO2298B1 (en) 2005-09-12
BG104992A (en) 2001-11-30
SK285373B6 (sk) 2006-12-07
YU73400A (sh) 2003-02-28
PE20010901A1 (es) 2001-09-20
ITMI20002575A1 (it) 2002-05-29
EP1103545A1 (en) 2001-05-30
PT1103545E (pt) 2004-03-31
ATE253561T1 (de) 2003-11-15
HK1036759A1 (en) 2002-01-18
JP2001151754A (ja) 2001-06-05
CZ20004399A3 (cs) 2001-07-11
CA2326529A1 (en) 2001-05-29
OA11513A (fr) 2004-02-03
IL139868A0 (en) 2002-02-10
SG97171A1 (en) 2003-07-18
IT1320120B1 (it) 2003-11-18
CA2326529C (en) 2009-12-22
KR20010051983A (ko) 2001-06-25
HU224703B1 (en) 2006-01-30
PL195957B1 (pl) 2007-11-30
FR2801590A1 (fr) 2001-06-01
HUP0004725A2 (hu) 2002-04-29
HRP20000809A2 (en) 2001-12-31
NZ508386A (en) 2003-02-28
AU7178700A (en) 2001-05-31
CZ299286B6 (cs) 2008-06-04
PA8507201A1 (es) 2002-02-21
PL344147A1 (en) 2001-06-04
CN1297888A (zh) 2001-06-06
IS5725A (is) 2001-05-29
DK1103545T3 (da) 2004-03-15
GEP20022763B (en) 2002-08-26
EA200001114A3 (ru) 2001-12-24
NO20006012D0 (no) 2000-11-28
TR200302077T4 (tr) 2004-01-21
DOP2000000106A (es) 2002-07-30
DE60006340D1 (de) 2003-12-11
MXPA00011672A (es) 2002-08-20
KR100390117B1 (ko) 2003-07-04
DE60006340T2 (de) 2004-09-09
AU775292B2 (en) 2004-07-29
ES2208205T3 (es) 2004-06-16
IS2212B (is) 2007-02-15
NO20006012L (no) 2001-05-30
NO317264B1 (no) 2004-09-27
SI1103545T1 (en) 2004-02-29
BRPI0005616B8 (pt) 2021-07-06
UY26458A1 (es) 2001-05-31
BR0005616A (pt) 2001-07-17
EA200001114A2 (ru) 2001-08-27
MY127426A (en) 2006-11-30
TNSN00226A1 (fr) 2002-05-30
ID28483A (id) 2001-05-31
SK17932000A3 (sk) 2001-11-06

Similar Documents

Publication Publication Date Title
GC0000151A (en) 2-(3,5-Bis-trifluoromethyl-phenyl)-n-methyl-n-(6-morpholin-4-o-tolyl-pyridin-3-yl)-isobutyramide.
IL162721A0 (en) 2-(Pyridin-2-ylamino)-pyridoÄ2,3-dÜpyrimidin-7-ones
AP2001002230A0 (en) 2-(4-Pyridyl) amino-6- dialkoxyphenyl-pyrido ¬2,3-d¾ pyrimidin-7-0 nes
GC0000108A (en) 4-Amino substituted-2-substituted-1,2,3,4-tetrahy droquinolines.
MX244506B (es) Herbicidas de piridina sustituidas.
IL163817A0 (en) 2,4-Diaminopyrimidine
PT1056759E (pt) Derivados do 2-(purin-9-il)-tetrahidrofurano-3,4-diolc
IS6248A (is) Pýrimidín-2, 4, 6-tríón málmpróteinasa latar
AU2003275716A1 (en) 3-benzoyl-2,4,5-substituted pyridine derivatives or salts thereof and bactericides containing the same
GB2361235B (en) 2,2,6,6 Diethyl-dimethyl-1-alkoxy-piperidine compounds and their corresponding 1-oxides
AU2003266333A8 (en) 4-(3,3-dihalo-allyloxy) phenol derivatives having pesticidal properties
ZA996615B (en) Truss with alternating metal web.
IL139115A0 (en) 2-(2-methylphenyl)-3,4-dihydro-2h-pyrrol derivatives
MX223829B (es) Benzoilpirazoles sustituidos como herbicidas.
AU3819200A (en) 2,4-diamino-pyrimidine derivatives
ZA200400652B (en) 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[6-((1,1-dioxo-1lambda6-thiomorpholin-4-yl)-4-(2-methyl or 4-fluoro-2-methyl substituted)phenyl-pyridin-3-yl]-N-methyl-isobutyramide.
DE60025958D1 (de) 14,15-beta-methylen substituierte androgene
AU144459S (en) Personal computer.
ZA986189B (en) Substituted 2-(benzaryl)pyridines.
AR027974A1 (es) 1-aril-ciclopropilmetilamino-1,3,5-triazinas substituidas
IL159965A0 (en) Novel 2,4-diaminothiazole derivatives
GB2350361B (en) 3,4,5-tricyanophenyl derivatives
IL159571A0 (en) 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-(1,1,-DIOXO-1lamda6-THIOMORPHOLIN-4-YL)-4-(2-METHYL OR 4-FLUORO-2-METHYL SUBSTITUTED) PHENYL-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE
GB9909482D0 (en) 2-(Purin-9-yl)-tetahydrofuran-3,4-diol derivatives
ZA200007155B (en) Uracil compounds and use thereof.