GB995800A - Pharmaceutical compositions, comprising naphthalene derivatives - Google Patents

Abstract

Pharmaceutical compositions comprise as active ingredient at least one naphthalene derivative of formula <FORM:0995800/A5-A6/1> wherein R1 stands for hydrogen or an alkyl, hydroxyalkyl, cycloalkyl, alkenyl, aralkyl or alkanoyl radical, R2 stands for hydrogen or an alkyl, cycloalkyl, alkenyl, alkynyl or aralkyl radical, any of which may optionally bear one or more substituents selected from hydroxy, alkylamino, dialkylamino, nitrogen-containing heterocyclic, alkoxy, alkoxyalkoxy, aryloxy and halogenoaryloxy radicals, or wherein R1 and R2 are joined together with the adjacent nitrogen atom to form a heterocyclic radical, optionally substituted by one or more alkyl radicals, wherein R3, R4 and R5, which may be the same or different, stand for hydrogen or alkyl radicals, and wherein the naphthalene nucleus may optionally bear one or more additional substituents selected from halogen atoms and alkyl, hydroxyalkyl and acyl radicals, and the esters thereof, and the salts thereof, in admixture with a pharmaceutically-acceptable diluent or carrier. The pharmaceutical compositions may be utilized in the form of tablets, capsules, solutions, suspensions, emulsions or dispersible powders and these forms may be prepared using known pharmaceutical excipients. The compositions when in tablet form may be coated so as to delay disintegration of the compositions in the stomach. The compounds possess b -adrenergic blocking activity and are useful in the treatment or prophylaxis of coronary artery disease. Specification 994,918 is referred to.