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GB9816575D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
GB9816575D0
GB9816575D0 GBGB9816575.6A GB9816575A GB9816575D0 GB 9816575 D0 GB9816575 D0 GB 9816575D0 GB 9816575 A GB9816575 A GB 9816575A GB 9816575 D0 GB9816575 D0 GB 9816575D0
Authority
GB
United Kingdom
Prior art keywords
novel compounds
synthesis
mps
link
transition metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB9816575.6A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Priority to GBGB9816575.6A priority Critical patent/GB9816575D0/en
Publication of GB9816575D0 publication Critical patent/GB9816575D0/en
Priority to JP2000563601A priority patent/JP2002522403A/en
Priority to AT99936819T priority patent/ATE235444T1/en
Priority to PCT/GB1999/002499 priority patent/WO2000007966A1/en
Priority to US09/744,908 priority patent/US6821783B1/en
Priority to AU51795/99A priority patent/AU5179599A/en
Priority to EP99936819A priority patent/EP1100759B1/en
Priority to DE69906307T priority patent/DE69906307T2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
    • C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

The invention relates to new traceless linkers which use transition metal complexes to link a pi-orbital containing substrate for subsequent synthesis by, for example, combinatorial chemistry or multiple parallel synthesis (MPS) to a support.
GBGB9816575.6A 1998-07-31 1998-07-31 Novel compounds Ceased GB9816575D0 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GBGB9816575.6A GB9816575D0 (en) 1998-07-31 1998-07-31 Novel compounds
JP2000563601A JP2002522403A (en) 1998-07-31 1999-07-29 Transition metal complexes as linkers
AT99936819T ATE235444T1 (en) 1998-07-31 1999-07-29 TRANSITION METAL COMPLEXES AS A LINKER GROUP
PCT/GB1999/002499 WO2000007966A1 (en) 1998-07-31 1999-07-29 Transition metal complexes as linkers
US09/744,908 US6821783B1 (en) 1998-07-31 1999-07-29 Transition metal complexes as linkers
AU51795/99A AU5179599A (en) 1998-07-31 1999-07-29 Transition metal complexes as linkers
EP99936819A EP1100759B1 (en) 1998-07-31 1999-07-29 Transition metal complexes as linkers
DE69906307T DE69906307T2 (en) 1998-07-31 1999-07-29 TRANSITION METAL COMPLEXES AS A LEFT GROUP

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9816575.6A GB9816575D0 (en) 1998-07-31 1998-07-31 Novel compounds

Publications (1)

Publication Number Publication Date
GB9816575D0 true GB9816575D0 (en) 1998-09-30

Family

ID=10836413

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9816575.6A Ceased GB9816575D0 (en) 1998-07-31 1998-07-31 Novel compounds

Country Status (8)

Country Link
US (1) US6821783B1 (en)
EP (1) EP1100759B1 (en)
JP (1) JP2002522403A (en)
AT (1) ATE235444T1 (en)
AU (1) AU5179599A (en)
DE (1) DE69906307T2 (en)
GB (1) GB9816575D0 (en)
WO (1) WO2000007966A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60044846D1 (en) 1999-03-05 2010-09-30 Massachusetts Inst Technology LINKER FOR THE SYNTHESIS OF OLIGOSACCHARIDES ON SUPPLEMENTS
KR101687771B1 (en) * 2009-10-15 2017-01-02 한화케미칼 주식회사 The preparation method of scaffold materials-transition metal hydride complexes and intermediates therefor
AU2012223494B2 (en) 2011-02-28 2017-04-06 Dsm Nutritional Products, Llc Polymeric acid catalysts and uses thereof
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
US9238845B2 (en) 2012-08-24 2016-01-19 Midori Usa, Inc. Methods of producing sugars from biomass feedstocks
MA45328A (en) 2016-04-01 2019-02-06 Avidity Biosciences Llc NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
WO2018129384A1 (en) 2017-01-06 2018-07-12 Avidity Biosciences Llc Nucleic acid-polypeptide compositions and methods of inducing exon skipping
AU2018289581C1 (en) 2017-06-23 2025-01-30 VelosBio Inc. ROR1 antibody immunoconjugates
GB201711809D0 (en) 2017-07-21 2017-09-06 Governors Of The Univ Of Alberta Antisense oligonucleotide
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
SG11202003126VA (en) 2017-10-04 2020-05-28 Avidity Biosciences Inc Nucleic acid-polypeptide compositions and uses thereof
CN118667812A (en) 2017-12-06 2024-09-20 艾维迪提生物科学公司 Compositions and methods for treating muscular atrophy and tonic muscular dystrophy
IL319265A (en) 2018-12-21 2025-04-01 Avidity Biosciences Inc Anti-transferrin receptor antibodies and uses thereof
JP2022523333A (en) 2019-01-30 2022-04-22 トゥルーバインディング，インコーポレイテッド Anti-GAL3 antibody and its use
JP7592034B2 (en) 2019-06-06 2024-11-29 アビディティー バイオサイエンシーズ，インク． Nucleic Acid Polypeptide Compositions and Uses Thereof
KR20220019259A (en) 2019-06-06 2022-02-16 어비디티 바이오사이언시스 인크. UNA amidite and uses thereof
EP4121063A4 (en) 2020-03-19 2024-07-03 Avidity Biosciences, Inc. Compositions and methods of treating facioscapulohumeral muscular dystrophy
JP7748962B2 (en) 2020-03-27 2025-10-03 アビディティー バイオサイエンシーズ，インク． Compositions and methods for treating muscular dystrophy
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3
EP4370555A4 (en) 2021-07-13 2025-11-12 Truebinding Inc METHOD FOR PREVENTING PROTEIN AGREGATION
KR20240055874A (en) 2021-09-16 2024-04-29 어비디티 바이오사이언시스 인크. Compositions and methods for treating facioscapulohumeral muscular dystrophy
JP2024544508A (en) 2021-11-09 2024-12-03 トゥルーバインディング，インコーポレイテッド Methods for Treating or Inhibiting Cardiovascular Disease - Patent application
WO2023122347A2 (en) 2021-12-23 2023-06-29 Mirecule, Inc. Compositions for delivery of polynucleotides
US12071621B2 (en) 2022-04-05 2024-08-27 Avidity Biosciences, Inc. Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
JP2025528052A (en) 2022-07-29 2025-08-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Compositions and methods for transferrin receptor (TFR)-mediated delivery to brain and muscle
EP4619438A2 (en) 2022-11-14 2025-09-24 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
US12491257B2 (en) 2023-06-27 2025-12-09 Avidity Biosciences, Inc. Compositions and methods of using PRKAG2-targeting antibody-oligonucleotide conjugates
US12409230B2 (en) 2023-06-30 2025-09-09 Avidity Biosciences, Inc. Compositions comprising PLN-targeting anti-transferrin receptor antibody-polynucleotides and methods of use thereof to treat cardiomyopathy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057465A (en) * 1997-05-22 2000-05-02 Glaxo Wellcome Inc. Arene-transition metal linkers for solid phase synthesis

Also Published As

Publication number Publication date
WO2000007966A1 (en) 2000-02-17
EP1100759B1 (en) 2003-03-26
US6821783B1 (en) 2004-11-23
EP1100759A1 (en) 2001-05-23
ATE235444T1 (en) 2003-04-15
AU5179599A (en) 2000-02-28
DE69906307D1 (en) 2003-04-30
JP2002522403A (en) 2002-07-23
DE69906307T2 (en) 2004-02-12

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)