GB981372A - Pharmaceutical formulations for oral administration to animals - Google Patents
Pharmaceutical formulations for oral administration to animalsInfo
- Publication number
- GB981372A GB981372A GB1568860A GB1568860A GB981372A GB 981372 A GB981372 A GB 981372A GB 1568860 A GB1568860 A GB 1568860A GB 1568860 A GB1568860 A GB 1568860A GB 981372 A GB981372 A GB 981372A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sorbitol
- polyoxyethylated
- wafer
- animals
- humectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241001465754 Metazoa Species 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 5
- 235000012431 wafers Nutrition 0.000 abstract 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 2
- 241000206672 Gelidium Species 0.000 abstract 2
- FBPFZTCFMRRESA-NQAPHZHOSA-N Sorbitol Polymers OCC(O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-NQAPHZHOSA-N 0.000 abstract 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 2
- 230000001070 adhesive effect Effects 0.000 abstract 2
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 2
- 239000003906 humectant Substances 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 239000004014 plasticizer Substances 0.000 abstract 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 239000000600 sorbitol Substances 0.000 abstract 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract 1
- 244000215068 Acacia senegal Species 0.000 abstract 1
- 229920001817 Agar Polymers 0.000 abstract 1
- 241000416162 Astragalus gummifer Species 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- 229920000569 Gum karaya Polymers 0.000 abstract 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
- 239000004115 Sodium Silicate Substances 0.000 abstract 1
- 229920001615 Tragacanth Polymers 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000000205 acacia gum Substances 0.000 abstract 1
- 235000010419 agar Nutrition 0.000 abstract 1
- 229940072056 alginate Drugs 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 210000005178 buccal mucosa Anatomy 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 229930182478 glucoside Natural products 0.000 abstract 1
- 150000002314 glycerols Polymers 0.000 abstract 1
- 150000002334 glycols Polymers 0.000 abstract 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
- 108010059642 isinglass Proteins 0.000 abstract 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 abstract 1
- 235000010494 karaya gum Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052627 muscovite Inorganic materials 0.000 abstract 1
- 229920013716 polyethylene resin Polymers 0.000 abstract 1
- -1 propylene glycol glucoside Chemical class 0.000 abstract 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052911 sodium silicate Inorganic materials 0.000 abstract 1
- 235000019794 sodium silicate Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Landscapes
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
A solid wafer formulation, which readily adheres to the tongue or buccal mucosa of animals, comprises a physiologically active substance, a solid non-toxic adhesive and a non-toxic humectant and plasticizer. Preferably the wafers have a surface area greater than 300 square millilitres and a thickness from 0,2 to 1,0 mm. A wafer for piglets is prepared by drying a sheet of paste containing iron powder and copper powder suspended in an aqueous solution of sorbitol and sodium carboxymethylcellulose. In a second example, the active substance is calcium dioxytetracyclinne and the wafer is prepared from sodium carboxymethylcellulose, sorbitol and polyoxyethylated sorbitol. Other adhesives are hydroxyethylcellulose, a water-soluble polyethylene resin, gum tragacanth, gum arabic, gum Karaya, sodium silicate, hydrated aluminium silicate, isinglass, agar-agar, water-soluble alginate, gelatine, casein and albumen. The humectant and plasticizer may by glycerol, propylene glycol, dipropylene glycol, polyoxyethylated sorbitol, polyoxyethylated glycol, polyoxyethylated glycerol, a -methylglycerol, corn syrup or propylene glycol glucoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1568860A GB981372A (en) | 1960-05-04 | 1960-05-04 | Pharmaceutical formulations for oral administration to animals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1568860A GB981372A (en) | 1960-05-04 | 1960-05-04 | Pharmaceutical formulations for oral administration to animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB981372A true GB981372A (en) | 1965-01-27 |
Family
ID=10063653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1568860A Expired GB981372A (en) | 1960-05-04 | 1960-05-04 | Pharmaceutical formulations for oral administration to animals |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB981372A (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231369A (en) | 1977-05-24 | 1980-11-04 | Coloplast International A/S | Sealing material for ostomy devices |
| GB2133284A (en) * | 1983-01-07 | 1984-07-25 | English Grains Limited | Resilient pharmaceutical unit for treating mouth ulcers |
| EP0106107A3 (en) * | 1982-09-10 | 1985-09-04 | Teikoku Seiyaku Kabushiki Kaisha | Sheet-shape adhesive preparation |
| EP0159602A3 (en) * | 1984-04-11 | 1987-01-21 | Ici Australia Limited | Compositions and methods for the therapeutic treatment of trace element deficiencies in ruminant animals |
| EP0245952A3 (en) * | 1986-04-11 | 1988-02-10 | Reckitt And Colman Products Limited | Buccal tablet comprising etorphine or a salt thereof |
| EP0306454A3 (en) * | 1987-08-31 | 1989-05-10 | Warner-Lambert Company | Tablets having improved bioadhesion to mucous membranes |
| WO2000019987A1 (en) * | 1998-10-02 | 2000-04-13 | 3M Innovative Properties Company | Mucosal originated drug delivery systems and animal applications |
| US7001609B1 (en) | 1998-10-02 | 2006-02-21 | Regents Of The University Of Minnesota | Mucosal originated drug delivery systems and animal applications |
| DE102005015128A1 (en) * | 2005-03-31 | 2006-10-05 | Lts Lohmann Therapie-Systeme Ag | Wafers containing steroid hormones |
| WO2006133134A2 (en) | 2005-06-03 | 2006-12-14 | Prezacor, Inc. | Compositions comprising elemental metals and uses therefor |
| EP1516615A3 (en) * | 1994-08-04 | 2007-10-31 | Quadrant Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US7579019B2 (en) | 1996-10-18 | 2009-08-25 | Arius Two, Inc. | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
| US8703177B2 (en) | 2011-08-18 | 2014-04-22 | Biodelivery Sciences International, Inc. | Abuse-resistant mucoadhesive devices for delivery of buprenorphine |
| AU2012216851B2 (en) * | 2005-06-03 | 2015-05-07 | Prezacor, Inc. | Compositions comprising elemental metals and uses therefor |
| US9597288B2 (en) | 2006-07-21 | 2017-03-21 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
| US10905894B2 (en) | 2013-03-15 | 2021-02-02 | Prezacor, Inc. | Therapeutic bioelectromagnetic fields, pain relief devices, and related methods |
-
1960
- 1960-05-04 GB GB1568860A patent/GB981372A/en not_active Expired
Cited By (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231369A (en) | 1977-05-24 | 1980-11-04 | Coloplast International A/S | Sealing material for ostomy devices |
| US4767787A (en) * | 1982-09-10 | 1988-08-30 | Kaken Pharmaceutical Co., Ltd. | Sheet-shape adhesive preparation |
| EP0106107A3 (en) * | 1982-09-10 | 1985-09-04 | Teikoku Seiyaku Kabushiki Kaisha | Sheet-shape adhesive preparation |
| GB2133284A (en) * | 1983-01-07 | 1984-07-25 | English Grains Limited | Resilient pharmaceutical unit for treating mouth ulcers |
| EP0159602A3 (en) * | 1984-04-11 | 1987-01-21 | Ici Australia Limited | Compositions and methods for the therapeutic treatment of trace element deficiencies in ruminant animals |
| US4829056A (en) * | 1986-04-11 | 1989-05-09 | Reckitt & Colman Products Limited | Buccal tablet comprising etorphine or a salt thereof |
| EP0245952A3 (en) * | 1986-04-11 | 1988-02-10 | Reckitt And Colman Products Limited | Buccal tablet comprising etorphine or a salt thereof |
| EP0306454A3 (en) * | 1987-08-31 | 1989-05-10 | Warner-Lambert Company | Tablets having improved bioadhesion to mucous membranes |
| EP1516615A3 (en) * | 1994-08-04 | 2007-10-31 | Quadrant Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US7579019B2 (en) | 1996-10-18 | 2009-08-25 | Arius Two, Inc. | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
| WO2000019987A1 (en) * | 1998-10-02 | 2000-04-13 | 3M Innovative Properties Company | Mucosal originated drug delivery systems and animal applications |
| AU768040B2 (en) * | 1998-10-02 | 2003-11-27 | Entrega Labs, Llc | Mucosal originated drug delivery systems and animal applications |
| US7001609B1 (en) | 1998-10-02 | 2006-02-21 | Regents Of The University Of Minnesota | Mucosal originated drug delivery systems and animal applications |
| DE102005015128B4 (en) * | 2005-03-31 | 2008-12-11 | Bayer Schering Pharma Aktiengesellschaft | Wafers containing steroid hormones |
| DE102005015128A1 (en) * | 2005-03-31 | 2006-10-05 | Lts Lohmann Therapie-Systeme Ag | Wafers containing steroid hormones |
| US9763960B2 (en) | 2005-03-31 | 2017-09-19 | Lts Lohmann Theraple-Systeme Ag | Wafer comprising steroid hormones |
| US9173900B2 (en) | 2005-06-03 | 2015-11-03 | Prezacor, Inc. | Compositions comprising elemental metals |
| US10195148B2 (en) | 2005-06-03 | 2019-02-05 | Prezacor, Inc. | Pain relieving compositions comprising elemental metals |
| EP2508341A1 (en) * | 2005-06-03 | 2012-10-10 | Prezacor, Inc. | Compositions comprising elemental metals and uses therefor |
| JP2013006872A (en) * | 2005-06-03 | 2013-01-10 | Prezacor Inc | Composition containing elemental metal, and use of the same |
| EP1904297A4 (en) * | 2005-06-03 | 2009-02-18 | Prezacor Inc | Compositions comprising elemental metals and uses therefor |
| AU2012216851B2 (en) * | 2005-06-03 | 2015-05-07 | Prezacor, Inc. | Compositions comprising elemental metals and uses therefor |
| WO2006133134A2 (en) | 2005-06-03 | 2006-12-14 | Prezacor, Inc. | Compositions comprising elemental metals and uses therefor |
| JP2008545758A (en) * | 2005-06-03 | 2008-12-18 | プレザーコール， インコーポレイテッド | Compositions containing elemental metals and uses thereof |
| US9597288B2 (en) | 2006-07-21 | 2017-03-21 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| US9655843B2 (en) | 2006-07-21 | 2017-05-23 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| US8703177B2 (en) | 2011-08-18 | 2014-04-22 | Biodelivery Sciences International, Inc. | Abuse-resistant mucoadhesive devices for delivery of buprenorphine |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
| US10905894B2 (en) | 2013-03-15 | 2021-02-02 | Prezacor, Inc. | Therapeutic bioelectromagnetic fields, pain relief devices, and related methods |
| US12102837B2 (en) | 2013-03-15 | 2024-10-01 | Gary A. Karpf | Therapeutic bioelectromagnetic fields, pain relief devices, and related methods |
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