GB984517A - New derivatives of 5-amino-isoindoline - Google Patents
New derivatives of 5-amino-isoindolineInfo
- Publication number
- GB984517A GB984517A GB19368/63A GB1936863A GB984517A GB 984517 A GB984517 A GB 984517A GB 19368/63 A GB19368/63 A GB 19368/63A GB 1936863 A GB1936863 A GB 1936863A GB 984517 A GB984517 A GB 984517A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- cor111
- amino
- hydrogen atom
- isoindoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YTIFSHPDDSIFRO-UHFFFAOYSA-N 2,3-dihydro-1h-isoindol-5-amine Chemical class NC1=CC=C2CNCC2=C1 YTIFSHPDDSIFRO-UHFFFAOYSA-N 0.000 title abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 2
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 2
- 230000001754 anti-pyretic effect Effects 0.000 abstract 2
- 239000002221 antipyretic Substances 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UYSFPRNOPWMPJW-UHFFFAOYSA-N 5-nitro-2,3-dihydro-1h-isoindole Chemical compound [O-][N+](=O)C1=CC=C2CNCC2=C1 UYSFPRNOPWMPJW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- -1 araliphatic Chemical group 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 5-amino isoindolines of the general formula <FORM:0984517/C2/1> wherein R1 is a hydrogen atom and R11 is a COR111 group, R111 being a hydrogen atom or an aliphatic, araliphatic, aromatic, or heterocyclic radical; or R1 is a COR111 group and R11 is a hydrogen atom a COR111 group or an aliphatic radical; salts thereof with physiologically acceptable acids and the preparation of such compounds when R is a hydrogen atom and R11 is a COR11 group, by acylating 5 -nitro-isoindoline and reducing the aromatic nitro group; when R1 is a COR111 group and R11 is a hydrogen atom, by providing the heterocyclic nitrogen atom with a protective grouping, acylating the 5-amino group and then removing the protective group; when R1 is COR111 and R11 is an aliphatic radical, by acylating a 5-amino isoindoline bearing an aliphatic radical in the 2-position; and when both R1 and R11 are both COR111 radicals, by acylating 5-amino-isoindoline.ALSO:Pharmaceutical compositions having analgesic, antipyretic and antiphlogistic properties comprise compounds of the formula <FORM:0984517/A5-A6/1> and their salts with physiologically acceptable acids, either alone or in admixture with known analgesic, antipyretic and/or antiphlogistic compounds (whereby such mixtures can also exhibit synergism). The compositions may be in the form of solutions for parenteral or dropwise administration, tablets or dragees.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE634851D BE634851A (en) | 1963-05-15 | ||
| GB19368/63A GB984517A (en) | 1963-05-15 | 1963-05-15 | New derivatives of 5-amino-isoindoline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19368/63A GB984517A (en) | 1963-05-15 | 1963-05-15 | New derivatives of 5-amino-isoindoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB984517A true GB984517A (en) | 1965-02-24 |
Family
ID=10128179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19368/63A Expired GB984517A (en) | 1963-05-15 | 1963-05-15 | New derivatives of 5-amino-isoindoline |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE634851A (en) |
| GB (1) | GB984517A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0014792A1 (en) * | 1979-01-22 | 1980-09-03 | Eli Lilly And Company | Tetrahydro-2H-benzo(c)pyrroles, their preparation, pharmaceutical compositions containing them and the compounds for use as therapeuticals |
| WO1997048683A1 (en) * | 1996-06-17 | 1997-12-24 | Smithkline Beecham Plc | Substituted benzamide derivatives and their use as anticonvulsants |
| WO2002014277A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| WO2002014276A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| WO2008038053A1 (en) * | 2006-09-29 | 2008-04-03 | Lectus Therapeutics Limited | Ion channel modulators & uses thereof |
-
0
- BE BE634851D patent/BE634851A/xx unknown
-
1963
- 1963-05-15 GB GB19368/63A patent/GB984517A/en not_active Expired
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0014792A1 (en) * | 1979-01-22 | 1980-09-03 | Eli Lilly And Company | Tetrahydro-2H-benzo(c)pyrroles, their preparation, pharmaceutical compositions containing them and the compounds for use as therapeuticals |
| DK155600B (en) * | 1979-01-22 | 1989-04-24 | Lilly Co Eli | ANALOGUE PROCEDURE FOR THE PREPARATION OF TETRAHYDRO-2H-BENZO (C) PYRROLES AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF AND THE INTERMEDIATE USE OF THE PROCEDURE |
| WO1997048683A1 (en) * | 1996-06-17 | 1997-12-24 | Smithkline Beecham Plc | Substituted benzamide derivatives and their use as anticonvulsants |
| US6110934A (en) * | 1996-06-17 | 2000-08-29 | Smithkline Beecham P.L.C. | Substituted benzamide derivatives and their use as anticonvulsants |
| WO2002014277A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| WO2002014276A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| WO2008038053A1 (en) * | 2006-09-29 | 2008-04-03 | Lectus Therapeutics Limited | Ion channel modulators & uses thereof |
| WO2008038051A3 (en) * | 2006-09-29 | 2008-06-19 | Lectus Therapeutics Ltd | Use of ion channel modulators in the prophylaxis and treatment of inflammatory and immunological diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| BE634851A (en) | 1900-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2081120T3 (en) | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF BACATINE III AND DESACETIL-10 BACATINE III. | |
| AU2001272666A1 (en) | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission | |
| GB984517A (en) | New derivatives of 5-amino-isoindoline | |
| ES399808A1 (en) | N-acyl biscarbamate herbicides | |
| JPS5283380A (en) | Synthesis of thiocarbostyril derivatives | |
| ES392093A1 (en) | 2-amino-5-chloro-thiazole derivatives | |
| NO922151L (en) | GINGEROL AND GINGERDIOLD DERIVATIVES AS HYPOCOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | |
| ES430676A1 (en) | 2-Substituted -1,2,4-thiadiazolo-(2,3-a)benzimidazoles and process for their preparation | |
| ES435413A1 (en) | (Trifluoromet hylphenoxy)-phenylurea compounds and herbicidal compositions | |
| ES381691A1 (en) | Procedure to influence the growth of higher plants. (Machine-translation by Google Translate, not legally binding) | |
| JPS5266626A (en) | Non-medical fungicide and anti-phytophagineae agent, and their prepara tion | |
| ES346350A1 (en) | Benzothiopyrone compounds | |
| JPS54129132A (en) | Remedy and prophylactic for prostatomegaly | |
| ES456048A1 (en) | Pyridoxine derivatives | |
| GB992222A (en) | Hypoglycemic compositions containing acyl disulphides and their esters | |
| ES442547A1 (en) | Heterocyclic substituted chromenopyrazoles | |
| ES271763A1 (en) | Procedure for the preparation of amino fluorate derivatives (Machine-translation by Google Translate, not legally binding) | |
| ES294368A1 (en) | Procedure for the preparation of nitro coloring pigments (Machine-translation by Google Translate, not legally binding) | |
| GB1388638A (en) | Compositions containing n-alkyl or n,n-dialkyl-2,2-bis rho-chlorophenoxy acetamides | |
| FR1541415A (en) | Biocidal compositions containing 1, 2, 3, -thiadiazole, novel 1, 2, 3-thiadiazole derivatives, and their preparation | |
| ES370226A1 (en) | Cycloheptimidazolone derivatives and process for the preparation thereof | |
| JPS5251362A (en) | Preparation of optically active pyrrolidine derivatives | |
| JPS52148076A (en) | Preparations of oxathiazole derivatives | |
| DE69215900D1 (en) | Cyclopropyl-n-hydroxyharnstoff als lypoxygenaseinhibitoren | |
| GB1164004A (en) | Novel Insecticidal Compositions |