GB932378A - Antacid preparation and the method for producing same - Google Patents
Antacid preparation and the method for producing sameInfo
- Publication number
- GB932378A GB932378A GB3266159A GB3266159A GB932378A GB 932378 A GB932378 A GB 932378A GB 3266159 A GB3266159 A GB 3266159A GB 3266159 A GB3266159 A GB 3266159A GB 932378 A GB932378 A GB 932378A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbonate
- aluminium
- skim
- laxatives
- antacids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title abstract 4
- 229940069428 antacid Drugs 0.000 title abstract 4
- 239000003159 antacid agent Substances 0.000 title abstract 4
- 230000001458 anti-acid effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000008141 laxative Substances 0.000 abstract 2
- 229940125722 laxative agent Drugs 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 235000020183 skimmed milk Nutrition 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 235000008939 whole milk Nutrition 0.000 abstract 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 abstract 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 abstract 1
- BVCOHOSEBKQIQD-UHFFFAOYSA-N 2-tert-butyl-6-methoxyphenol Chemical compound COC1=CC=CC(C(C)(C)C)=C1O BVCOHOSEBKQIQD-UHFFFAOYSA-N 0.000 abstract 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 abstract 1
- 239000010369 Cascara Substances 0.000 abstract 1
- 235000006693 Cassia laevigata Nutrition 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 241001528248 Frangula Species 0.000 abstract 1
- 241000556215 Frangula purshiana Species 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 108010009736 Protein Hydrolysates Proteins 0.000 abstract 1
- 241000219061 Rheum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 241000735631 Senna pendula Species 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 abstract 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 abstract 1
- 229940001007 aluminium phosphate Drugs 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- FIUBOPPLFYFRMW-UHFFFAOYSA-E aluminum;trimagnesium;carbonate;heptahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Al+3].[O-]C([O-])=O FIUBOPPLFYFRMW-UHFFFAOYSA-E 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 abstract 1
- 229910052797 bismuth Inorganic materials 0.000 abstract 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 229940058505 cascara Drugs 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 239000008121 dextrose Substances 0.000 abstract 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 abstract 1
- 239000002198 insoluble material Substances 0.000 abstract 1
- 229940070765 laurate Drugs 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000001095 magnesium carbonate Substances 0.000 abstract 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 abstract 1
- 239000000395 magnesium oxide Substances 0.000 abstract 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000391 magnesium silicate Substances 0.000 abstract 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 abstract 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- -1 polyoxyethylene stearate Polymers 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000003531 protein hydrolysate Substances 0.000 abstract 1
- 229940124513 senna glycoside Drugs 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 229940035044 sorbitan monolaurate Drugs 0.000 abstract 1
- 239000001593 sorbitan monooleate Substances 0.000 abstract 1
- 235000011069 sorbitan monooleate Nutrition 0.000 abstract 1
- 229940035049 sorbitan monooleate Drugs 0.000 abstract 1
- 239000012798 spherical particle Substances 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 abstract 1
- 229940038773 trisodium citrate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Antacid preparations in the form of small (1-10 m ), substantially spherical particles comprising particles of water-insoluble antacids coated with a dry, uniform covering of the solid content of skim or whole milk are prepared by dispersing the insoluble material in skim, whole milk or skim milk to which hydrogenated oils have been added optionally in the presence of a non-ionic surface active agent and "atomizing" the dispersion e.g. by spray-drying. Specified antacids are magnesium oxide, carbonate and trisilicate; aluminium hydroxide (dry gel), aluminium phosphate (gel), aluminium dihydroxyaminoacetate, aluminium basic carbonate; calcium carbonate, aluminium hydroxide-magnesium carbonate co-precipitate and the basic nitrate, carbonate and gallate of bismuth and anionic resins e.g. polyamidemethylene resin NNR. Specified surface active agents are polyoxyethylene stearate, laurate, sorbitan mono-oleate and sorbitan monolaurate. Other substances which may be present are natural and synthetic gums, protein hydrolysates, laxatives e.g. liquid extracts of frangula, cascara, rhubarb and senna, and synthetic laxatives, antioxidants e.g. ascorbic and trisodium citrate, tert-butyl hydroxy anisole, tocophenols, citric acid, lecithins, excipients e.g. sucrose, dextrose, maltose, dextrin, flavours and sweetening agents. The spray dried powders may be tableted.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3266159A GB932378A (en) | 1959-09-25 | 1959-09-25 | Antacid preparation and the method for producing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3266159A GB932378A (en) | 1959-09-25 | 1959-09-25 | Antacid preparation and the method for producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB932378A true GB932378A (en) | 1963-07-24 |
Family
ID=10342093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3266159A Expired GB932378A (en) | 1959-09-25 | 1959-09-25 | Antacid preparation and the method for producing same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB932378A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2052976A1 (en) * | 1969-06-16 | 1971-04-16 | Lepetit Spa | |
| GB2195890A (en) * | 1986-10-06 | 1988-04-20 | Procter & Gamble | Improving palatability of pharmaceutical chewable tablets |
| GB2195892A (en) * | 1986-10-06 | 1988-04-20 | Procter & Gamble | Improving palatability of pharmaceutical chewable tablets |
| GB2195891A (en) * | 1986-10-06 | 1988-04-20 | Procter & Gamble | Improving palatability of pharmaceutical chewable tablets |
| WO2002034069A3 (en) * | 2000-10-26 | 2003-03-13 | Banner Pharmacaps Inc | Supplement and method for nutritional supplementation of calcium, including a prophylactic motility agent |
| WO2003053415A1 (en) * | 2001-12-20 | 2003-07-03 | Alpex Pharma Sa | Pharmaceutical composition comprising skim milk powder |
| EP1352566A1 (en) * | 2002-04-10 | 2003-10-15 | Ulrich Thomet | Process for the manufacture of a preparation containing active principles from cannabis |
| EP1542659A4 (en) * | 2002-08-14 | 2008-03-26 | Du Pont | Process for coating a pharmaceutical particle |
| WO2009068301A1 (en) * | 2007-11-30 | 2009-06-04 | Pharmathen S.A | Pharmaceutical formulation containing lipophilic drugs and milk as a solubilizing/dispersing agent and method for the preparation thereof |
-
1959
- 1959-09-25 GB GB3266159A patent/GB932378A/en not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2052976A1 (en) * | 1969-06-16 | 1971-04-16 | Lepetit Spa | |
| GB2195890A (en) * | 1986-10-06 | 1988-04-20 | Procter & Gamble | Improving palatability of pharmaceutical chewable tablets |
| GB2195892A (en) * | 1986-10-06 | 1988-04-20 | Procter & Gamble | Improving palatability of pharmaceutical chewable tablets |
| GB2195891A (en) * | 1986-10-06 | 1988-04-20 | Procter & Gamble | Improving palatability of pharmaceutical chewable tablets |
| WO2002034069A3 (en) * | 2000-10-26 | 2003-03-13 | Banner Pharmacaps Inc | Supplement and method for nutritional supplementation of calcium, including a prophylactic motility agent |
| WO2003053415A1 (en) * | 2001-12-20 | 2003-07-03 | Alpex Pharma Sa | Pharmaceutical composition comprising skim milk powder |
| EP1352566A1 (en) * | 2002-04-10 | 2003-10-15 | Ulrich Thomet | Process for the manufacture of a preparation containing active principles from cannabis |
| EP1542659A4 (en) * | 2002-08-14 | 2008-03-26 | Du Pont | Process for coating a pharmaceutical particle |
| WO2009068301A1 (en) * | 2007-11-30 | 2009-06-04 | Pharmathen S.A | Pharmaceutical formulation containing lipophilic drugs and milk as a solubilizing/dispersing agent and method for the preparation thereof |
| US8435982B2 (en) | 2007-11-30 | 2013-05-07 | Pharmathen S.A. | Pharmaceutical formulation containing lipophilic drugs and milk as a solubilizing/dispensing agent and method for the preparation thereof |
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