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GB8913011D0 - Anticonvulsant pyrazines - Google Patents

Anticonvulsant pyrazines

Info

Publication number
GB8913011D0
GB8913011D0 GB898913011A GB8913011A GB8913011D0 GB 8913011 D0 GB8913011 D0 GB 8913011D0 GB 898913011 A GB898913011 A GB 898913011A GB 8913011 A GB8913011 A GB 8913011A GB 8913011 D0 GB8913011 D0 GB 8913011D0
Authority
GB
United Kingdom
Prior art keywords
pyrazines
anticonvulsant
hydrogen
alkyl
dihalo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB898913011A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB898913011A priority Critical patent/GB8913011D0/en
Publication of GB8913011D0 publication Critical patent/GB8913011D0/en
Priority to EP90306096A priority patent/EP0402096B1/en
Priority to JP2145565A priority patent/JP3027762B2/en
Priority to AU56842/90A priority patent/AU628581B2/en
Priority to AT90306096T priority patent/ATE141604T1/en
Priority to DD90341316A priority patent/DD294944A5/en
Priority to CA002018308A priority patent/CA2018308C/en
Priority to NZ233928A priority patent/NZ233928A/en
Priority to ES90306096T priority patent/ES2091796T3/en
Priority to DE69028147T priority patent/DE69028147T2/en
Priority to US07/674,435 priority patent/US5095018A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention discloses a class of novel 1,2,4-triazolo[4,3-a] pyrazines <CHEM> wherein R1 and R2 may be the same or different and are selected from hydrogen, alkyl, branched alkyl, cycloalkyl or cyclopropylmethyl and R3 is hydrogen, halo or dihalo and n is 1 or 2. Pharmaceutical compositions containing them and methods for their preparation. Such compounds are shown to have anticonvulsant properties and, therefore, be useful in the treatment of epilepsy.
GB898913011A 1989-06-06 1989-06-06 Anticonvulsant pyrazines Pending GB8913011D0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB898913011A GB8913011D0 (en) 1989-06-06 1989-06-06 Anticonvulsant pyrazines
DE69028147T DE69028147T2 (en) 1989-06-06 1990-06-05 Anticonvulsive pirazines
AT90306096T ATE141604T1 (en) 1989-06-06 1990-06-05 ANTICONVULSIVE PIRAZINES
JP2145565A JP3027762B2 (en) 1989-06-06 1990-06-05 Anticonvulsant pyrazine
AU56842/90A AU628581B2 (en) 1989-06-06 1990-06-05 1,2,4-triazolo (4,3-a)pyrazine derivatives
EP90306096A EP0402096B1 (en) 1989-06-06 1990-06-05 Anticonvulsant pyrazines
DD90341316A DD294944A5 (en) 1989-06-06 1990-06-05 PROCESS FOR THE PREPARATION OF 1,2,4-TRIAZOLO [4,3-A] PYRAZINES
CA002018308A CA2018308C (en) 1989-06-06 1990-06-05 Anticonvulsant pyrazines
NZ233928A NZ233928A (en) 1989-06-06 1990-06-05 1,2,4-triazolo(4,3-a)pyrazine derivatives and anticonvulsant compositions
ES90306096T ES2091796T3 (en) 1989-06-06 1990-06-05 ANTI-SEIZURE PIRAZINES.
US07/674,435 US5095018A (en) 1989-06-06 1991-03-22 3-benzyl-1,2,4-triazolo[4,3-α] pyrazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898913011A GB8913011D0 (en) 1989-06-06 1989-06-06 Anticonvulsant pyrazines

Publications (1)

Publication Number Publication Date
GB8913011D0 true GB8913011D0 (en) 1989-07-26

Family

ID=10657983

Family Applications (1)

Application Number Title Priority Date Filing Date
GB898913011A Pending GB8913011D0 (en) 1989-06-06 1989-06-06 Anticonvulsant pyrazines

Country Status (11)

Country Link
US (1) US5095018A (en)
EP (1) EP0402096B1 (en)
JP (1) JP3027762B2 (en)
AT (1) ATE141604T1 (en)
AU (1) AU628581B2 (en)
CA (1) CA2018308C (en)
DD (1) DD294944A5 (en)
DE (1) DE69028147T2 (en)
ES (1) ES2091796T3 (en)
GB (1) GB8913011D0 (en)
NZ (1) NZ233928A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ262664A (en) * 1993-02-22 1997-04-24 Merck & Co Inc Heterocyclic substituted derivatives, and medicaments thereof
US5821241A (en) * 1994-02-22 1998-10-13 Merck & Co., Inc. Fibrinogen receptor antagonists
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
TR200001728T2 (en) 1997-11-11 2000-09-21 Ono Pharmaceutical Co., Ltd. Combined pyrazine derivatives
US8329705B2 (en) * 2009-12-30 2012-12-11 Arqule, Inc. Substituted triazolo-pyrazine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1146770A (en) * 1967-02-03 1969-03-26 Ici Ltd S-triazolo[4,3-a]pyrazine derivatives
JPS5129766B2 (en) * 1971-10-04 1976-08-27
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates
US4056632A (en) * 1975-07-21 1977-11-01 Burroughs Wellcome Co. 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use
US4438266A (en) * 1982-05-17 1984-03-20 Merck & Co., Inc. Triazolopyrazinamines useful as adjuncts to radiation therapy
GB8408615D0 (en) * 1984-04-04 1984-05-16 Wellcome Found Heterocyclic compounds
MC1673A1 (en) * 1984-06-27 1986-06-03 Wellcome Found ARYLIC DERIVATIVES OF IMIDAZOLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF DRUGS

Also Published As

Publication number Publication date
CA2018308A1 (en) 1990-12-06
CA2018308C (en) 2000-08-01
DE69028147D1 (en) 1996-09-26
DD294944A5 (en) 1991-10-17
JPH0320276A (en) 1991-01-29
NZ233928A (en) 1992-10-28
EP0402096A3 (en) 1991-09-18
AU5684290A (en) 1990-12-13
JP3027762B2 (en) 2000-04-04
ES2091796T3 (en) 1996-11-16
AU628581B2 (en) 1992-09-17
DE69028147T2 (en) 1997-01-02
US5095018A (en) 1992-03-10
EP0402096A2 (en) 1990-12-12
EP0402096B1 (en) 1996-08-21
ATE141604T1 (en) 1996-09-15

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