GB889648A - Novel heparin process - Google Patents
Novel heparin processInfo
- Publication number
- GB889648A GB889648A GB33240/59A GB3324059A GB889648A GB 889648 A GB889648 A GB 889648A GB 33240/59 A GB33240/59 A GB 33240/59A GB 3324059 A GB3324059 A GB 3324059A GB 889648 A GB889648 A GB 889648A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radicals
- water
- salt
- carbon atoms
- heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 5
- 229960002897 heparin Drugs 0.000 title abstract 5
- 229920000669 heparin Polymers 0.000 title abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 235000015278 beef Nutrition 0.000 abstract 2
- -1 double bonds Chemical compound 0.000 abstract 2
- 210000004185 liver Anatomy 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000001198 duodenum Anatomy 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 210000004347 intestinal mucosa Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Heparin is isolated in the form of a waterinsoluble heparin complex from an aqueous animal tissue extract containing it by treating the extract with a quaternary ammonium salt having a solubility in water of at least 2%, and in which one of the valencies of the nitrogen atom of the salt carries an essentially aliphatic hydrocarbon chain of at least 8 carbon atoms. The quaternary ammonium salt may have the formula <FORM:0889648/IV (a)/1> wherein X is any anion that does not render the salt water-insoluble, e.g. chloride, bromide or sulphate, and R is the essentially aliphatic hydrocarbon chain of at least 8 carbon atoms which may be part of a heterocyclic system together with other R1 radicals and which may be interrupted by oxygen, double bonds, nitrogen and aromatic rings, and wherein the R1 radicals may be alkyl containing 1-7 carbon atoms or aralkyl, alkenyl, alkoxy, polyalkoxy, or chloroalkyl radicals. The three R1 radicals may be the same or different. Many such compounds are specified of which the chief used in the examples is a commercial-mixture containing 90% hexadecyl trimethyl ammonium chloride, 6% octadecyl trimethyl ammonium chloride, and 4% octadecenyl trimethyl ammonium chloride. The water-insoluble heparin complex thus obtained may be redissolved in a salt solution and the free heparin precipitated with a water-miscible organic solvent. The initial animal tissue may be beef small intestines, beef lung, hog duodenum, hog liver, hog intestinal mucosa and dog liver.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US889648XA | 1958-10-01 | 1958-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB889648A true GB889648A (en) | 1962-02-21 |
Family
ID=22214541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33240/59A Expired GB889648A (en) | 1958-10-01 | 1959-09-30 | Novel heparin process |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB889648A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012524A1 (en) * | 1992-11-30 | 1994-06-09 | Celsus, Inc. | Protein hydrolysate derived from mucosal tissue |
| WO2004000035A1 (en) * | 2002-06-19 | 2003-12-31 | Can Technologies, Inc. | Animal feed composition_comprising mucosa byproduct |
| CN114014956A (en) * | 2021-12-06 | 2022-02-08 | 潢川县鹏升畜产品有限公司 | A kind of heparin sodium salt-free extraction and preparation technology |
-
1959
- 1959-09-30 GB GB33240/59A patent/GB889648A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012524A1 (en) * | 1992-11-30 | 1994-06-09 | Celsus, Inc. | Protein hydrolysate derived from mucosal tissue |
| US5607840A (en) * | 1992-11-30 | 1997-03-04 | Celsus, Inc. | Protein hydrolysate derived from mucosa tissue |
| WO2004000035A1 (en) * | 2002-06-19 | 2003-12-31 | Can Technologies, Inc. | Animal feed composition_comprising mucosa byproduct |
| US7326424B2 (en) | 2002-06-19 | 2008-02-05 | Can Technologies, Inc. | Animal feed composition |
| CN114014956A (en) * | 2021-12-06 | 2022-02-08 | 潢川县鹏升畜产品有限公司 | A kind of heparin sodium salt-free extraction and preparation technology |
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