GB889378A - Production of hydrocortisone - Google Patents
Production of hydrocortisoneInfo
- Publication number
- GB889378A GB889378A GB33033/60A GB3303360A GB889378A GB 889378 A GB889378 A GB 889378A GB 33033/60 A GB33033/60 A GB 33033/60A GB 3303360 A GB3303360 A GB 3303360A GB 889378 A GB889378 A GB 889378A
- Authority
- GB
- United Kingdom
- Prior art keywords
- broth
- mediolanum
- blakesleeana
- micro
- cultured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 title abstract 4
- 229960000890 hydrocortisone Drugs 0.000 title abstract 2
- 235000010633 broth Nutrition 0.000 abstract 7
- 241000134727 Agromyces mediolanus Species 0.000 abstract 4
- 241000010216 Cunninghamella blakesleeana Species 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 235000015097 nutrients Nutrition 0.000 abstract 2
- 229930003448 Vitamin K Natural products 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 229960003654 desoxycortone Drugs 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 abstract 1
- 235000019168 vitamin K Nutrition 0.000 abstract 1
- 239000011712 vitamin K Substances 0.000 abstract 1
- 150000003721 vitamin K derivatives Chemical class 0.000 abstract 1
- 229940046010 vitamin k Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Hydrocortisone is prepared by culturing an aqueous nutrient medium containing 5-pregnene-3b ,17a ,21-triol-20-one or its 3,21-diacetate or its 3- or 21-acetate with Corynebacterium mediolanum under aerated conditions to produce a cultured broth containing 17a -hydroxy-desoxycorticosterone and treating the resulting broth with a broth of the micro-organism Cunninghamella blakesleeana cultured in a nutrient culture medium. The ratio of broths is preferably between 14 : 1 and 4 : 1 by volume (C. blakesleeana to C. mediolanum). Vitamin K may be added when the broth containing the microorganisms C. mediolanum is mixed with that containing the C. blakesleeana micro-organisms. In addition, a mixture of equal parts of 95% ethanol and acetone by volume may be added to the C. mediolanum broth when it is mixed with the C. blakesleeana broth. Detailed examples are given. Specification 789,862 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT889378X | 1959-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB889378A true GB889378A (en) | 1962-02-14 |
Family
ID=11331324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33033/60A Expired GB889378A (en) | 1959-09-30 | 1960-09-26 | Production of hydrocortisone |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB889378A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008035187A3 (en) * | 2006-09-21 | 2008-07-10 | Dow Global Technologies Inc | Alcohol dehydrogenase from agromyces sp. and a method of producing a chiral secondary alcohol using same |
| CN113583073A (en) * | 2021-08-17 | 2021-11-02 | 华中药业股份有限公司 | Purification and extraction method of hydrocortisone |
-
1960
- 1960-09-26 GB GB33033/60A patent/GB889378A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008035187A3 (en) * | 2006-09-21 | 2008-07-10 | Dow Global Technologies Inc | Alcohol dehydrogenase from agromyces sp. and a method of producing a chiral secondary alcohol using same |
| CN113583073A (en) * | 2021-08-17 | 2021-11-02 | 华中药业股份有限公司 | Purification and extraction method of hydrocortisone |
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