GB888525A - New aryloxy-aliphatic hydrazines - Google Patents
New aryloxy-aliphatic hydrazinesInfo
- Publication number
- GB888525A GB888525A GB40850/59A GB4085059A GB888525A GB 888525 A GB888525 A GB 888525A GB 40850/59 A GB40850/59 A GB 40850/59A GB 4085059 A GB4085059 A GB 4085059A GB 888525 A GB888525 A GB 888525A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- substituted
- hydrazines
- group
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002429 hydrazines Chemical class 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- QWAVNXZAQASOML-UHFFFAOYSA-N 1-phenoxypropan-2-one Chemical compound CC(=O)COC1=CC=CC=C1 QWAVNXZAQASOML-UHFFFAOYSA-N 0.000 abstract 2
- JVQBFZMPFQQOMQ-UHFFFAOYSA-N 2-phenoxyethylhydrazine Chemical compound NNCCOC1=CC=CC=C1 JVQBFZMPFQQOMQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- OFLXLNCGODUUOT-UHFFFAOYSA-N acetohydrazide Chemical compound C\C(O)=N\N OFLXLNCGODUUOT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 125000003700 epoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005597 hydrazone group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises monoaliphatically substituted hydrazines the aliphatic radical of which is substituted by an aryloxy radical and acyl derivatives of these hydrazines with the exception of 2-phenoxyethylhydrazine and physiologically tolerable acid addition salts of these compounds. The aryl residue may be substituted by a halogen atom, a hydroxyl group substituted by a C1-6 aliphatic or cycloaliphatic hydrocarbon radical or by a C1-6 alkyl radical. The aliphatic radical may be substituted by free hydroxyl groups. The compounds are prepared by treating an aryloxyaliphatic compound whose aliphatic residue contains a radical replaceable by or convertable into a hydrazine group which may be acylated so as to replace or convert the said radical into a hydrazine group. A radical replaceable by a hydrazino group is especially an epoxy group or a reactive esterified hydroxyl group and a radical convertable into a hydrazino group is a hydrazone group. The hydrazines may be acylated or acyl desivatives hydrolysed. 1-Phenoxypropyl-(2)-chloride is prepared by reducing phenoxyacetone to 1-phenoxypropanol-(2) with sodium borohydride and reacting the alkanol with thionyl chloride. N - [1 - Phenoxypropylidene - (2)] - N1 - acetylhydrazine is prepared from phenoxyacetone and acetylhydrazine.ALSO:Pharmaceutical compositions comprise monoaliphatically substituted hydrazines, the aliphatic radical of which is substituted by an aryloxy radical, and acyl derivatives of these hydrazines with the exception of 2-phenoxyethyl hydrazine and physiologically tolerable acid. Addition salts of these compounds with organic and inorganic acids in admixture or in conjunction with a pharmaceutical carrier suitable for enteral or parenteral administration. The compositions which may contain further therapeutically valuable substances may be in the form of tablets, dragees, suspensions or emulsions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH888525X | 1958-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB888525A true GB888525A (en) | 1962-01-31 |
Family
ID=4545481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40850/59A Expired GB888525A (en) | 1958-12-01 | 1959-12-01 | New aryloxy-aliphatic hydrazines |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB888525A (en) |
-
1959
- 1959-12-01 GB GB40850/59A patent/GB888525A/en not_active Expired
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